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Current Ketamine News and Events, Ketamine News Articles.
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New study finds river wildlife contain cocaine, pharmaceuticals and pesticides
For the first time, researchers at King's College London, in collaboration with the University of Suffolk, have found a diverse array of chemicals, including illicit drugs and pesticides in UK river wildlife. The study published today in Environment International, looked at the exposure of wildlife, such as the freshwater shrimp Gammarus pulex, to different micropollutants (chemicals found at exceptionally low levels) and the levels of these compounds in the animals. (2019-04-30)

Why is ketamine an antidepressant?
Delving deep inside the neural circuitry of 'depressed' mice, researchers have revealed how ketamine works in cells to achieve its fast-acting antidepressant effect. (2019-04-11)

Ketamine reverses neural changes underlying depression-related behaviors in mice
Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice. Ketamine treatment restored lost dendritic spines and rescued coordinated neural activity in the Prefrontal Cortex of the mice -- findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study was funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. (2019-04-11)

Experimental drug shows promise for opioid withdrawal symptoms
While medicines are available to relieve withdrawal symptoms in people recovering from opioid addiction, they cause side effects and can maintain the brain changes that led to addiction in the first place, which can lead to relapse before treatment is completed. New research offers hope that a better solution may be on the horizon. Rapastinel, an experimental drug originally developed as an antidepressant, substantially reversed acute signs of opioid withdrawal in rats in just three days. (2019-04-07)

Researchers discover a critical receptor involved in response to antidepressants like ketamine
Effective treatment of clinical depression remains a major mental health issue, with roughly 30 percent of patients who do not respond to any of the available treatments. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered a crucial receptor called mGlu2 that is critical to the mechanism of fast-acting antidepressants such as ketamine when used to treat depression. (2019-03-28)

Fingermark imaging for drug detection
In a paper to be published in the forthcoming issue in NANO, researchers from Zhejiang have uncovered a novel method of using nanocarrier-based biological fluorescent probes for detecting amphetamine and ketamine in latent fingermark, in a bid to combat drug abuse. This method has the potential to be extended to other drugs and molecules. (2019-03-14)

Not all sleep is equal when it comes to cleaning the brain
New research shows how the depth of sleep can impact our brain's ability to efficiently wash away waste and toxic proteins. Because sleep often becomes increasingly lighter and more disrupted as we become older, the study reinforces and potentially explains the links between aging, sleep deprivation, and heightened risk for Alzheimer's disease. (2019-02-27)

MDMA users more empathetic than other drug users
Long-term MDMA users have higher levels of empathy than cannabis and other drugs users, new research suggests. (2019-02-08)

Research pushes back on benefits of compounded topical pain creams
In an effort to reduce chronic pain, many people look for hope by paying $20 to thousands of dollars for a tube of prescription topical pain cream or gel. (2019-02-05)

BDNF-VEGF interplay key to rapid antidepressant actions
A study by researchers at Yale University reveals a complex interplay of two different growth factors in the rapid and long-lasting antidepressant effects of ketamine. (2019-01-31)

Marmoset study gives insights into loss of pleasure in depression
'Anhedonia' (the loss of pleasure) is one of the key symptoms of depression. An important component of this symptom is an inability to feel excitement in anticipation of events; however the brain mechanisms underlying this phenomenon are poorly understood. Now, in a study involving marmosets, scientists at the University of Cambridge have identified the region of the brain that contributes to this phenomenon, and shown that the experimental antidepressant ketamine acts on this region, helping explain why this drug may prove effective at treating anhedonia. (2018-12-04)

Ketamine is a safe, effective alternative to opioids in treating acute pain in the ED
Intravenous, low-dose ketamine (LDK) is as effective as intravenous morphine in the control of acute pain in adults in the emergency department (ED). (2018-10-15)

Study identifies effective ketamine doses for treatment-resistant depression
A study led by Massachusetts General Hospital investigators identifies two subanesthetic dosage levels of the anesthetic drug ketamine that appear to provide significant symptom relief to patients with treatment-resistant depression. (2018-10-11)

Focus on neuroscience, nociception to improve anesthesia, paper says
By focusing on nervous system circuits of nociception, the body's sensing of tissue damge, anesthesiologists can achieve unconsciousness in patients using less drug and manage post-operative pain better, leading to less need for opioids. (2018-10-01)

New research: Ketamine activates opioid system to treat depression
A new study appearing online today from the American Journal of Psychiatry finds that ketamine's acute antidepressant effect requires opioid system activation, the first time that a receptor site has been shown in humans to be necessary for any antidepressant's mechanism of action. While opioids have been used historically to treat depression, they are known to carry a high risk of dependence. (2018-08-29)

Ketamine has potential therapeutic role in adolescents with treatment-resistant depression
A new study has shown a significant average decrease in the Children's Depression Rating Scale (42.5 percent) among adolescents with treatment-resistant depression (TRD) who were treated with intravenous ketamine. (2018-08-01)

Low-dose ketamine may be an effective alternative to opioids
Opioids are commonly prescribed in the emergency department (ED) for the treatment of acute pain, but due to the epidemic of opioid misuse, analgesic alternatives are being explored. A new Academic Emergency Medicine analysis of relevant studies found that low-dose ketamine is as effective as opioids for the control of acute pain in the ED. (2018-07-18)

Complexity of NMDA receptor drug discovery target revealed
NMDA receptor assemblies containing the GluN2C subunit are predominant in the cerebellum, and have distinct electrochemical properties, Emory scientists found. (2018-06-28)

Ketamine acts fast to treat depression and its effects last -- but how?
Researchers led by Mark Rasenick in the University of Illinois at Chicago College of Medicine, describe the molecular mechanisms behind ketamine's ability to squash depression and keep it at bay. They report their findings in the journal Molecular Psychiatry. (2018-06-21)

Psychedelic drugs, ketamine change structure of neurons
In a paper published on June 12 in the journal Cell Reports, UC Davis researchers show that a wide range of psychedelic drugs, including LSD and MDMA, impact the structure and function of neurons, potentially leading to new treatments for depression, anxiety, and related disorders. (2018-06-12)

Psychedelic drugs promote neural plasticity in rats and flies
Psychedelic drugs may have mind-altering powers in the physical sense, too. A new study, published June 12 in the journal Cell Reports, found psychedelics, specifically DOI, DMT, and LSD, can change brain cells in rats and flies, making neurons more likely to branch out and connect with one another. The work supports the theory that psychedelics could help to fight depression, anxiety, addiction, and post-traumatic stress disorder. (2018-06-12)

Pilot study examines the effects of virtual reality on reducing anxiety and improving pregnancy rate of women having fertility treatment
New research presented at this year's Euroanaesthesia congress in Copenhagen, Denmark, shows that giving women different types of virtual reality (VR) sessions prior to sedation for IVF treatment (to become pregnant) reduces their anxiety and could improve successful pregnancy rate. (2018-06-01)

Chemsex linked with increased diagnoses of HIV and other sexually transmitted infections
Chemsex -- the use of crystallized methamphetamine, mephedrone, ╬│-hydroxybutyrate or ╬│-butyrolactone and to a lesser extent cocaine and ketamine to facilitate sex -- has emerged as a new phenomenon in the UK and across Europe among gay, bisexual and other men who have sex with men (GBMSM). (2018-05-23)

Paramedics find better drug to tame violent patients
Australian paramedics are using a new drug to quickly calm violent patients and they have the data to prove it works. In a world-first research evaluation, researchers found the sedative, droperidol, was a safer and faster option for paramedics to use compared with the internationally accepted, midazolam. The drug is also easier to administer. Other ambulance services from around the world are now looking to make the change. (2018-05-02)

Study shows fast-acting benefits of ketamine for depression and suicidality
A nasal spray formulation of ketamine shows promise in the rapid treatment of symptoms of major depression and suicidal thoughts, according to a new study published online today in The American Journal of Psychiatry (AJP). The double-blind study compared the standard treatment plus an intranasal formulation of esketamine, part of the ketamine molecule, to standard treatment plus a placebo for rapid treatment of symptoms of major depression, including suicidality, among individuals at imminent suicide risk. (2018-04-16)

Study casts doubt on ketamine nasal sprays for depression
Researchers from UNSW Sydney and the Black Dog Institute have questioned the efficacy and safety of intranasal ketamine for depression, with their pilot trial stopped early due to poor side effects in patients. (2018-03-16)

Multimodal approach to pain management reduces opioids, prescriptions after joint replacement
A multimodal approach to pain management (using two or more different methods or medications to manage pain) rather than using opioids alone was associated with a decrease in opioid use, opioid prescriptions and common opioid-related complications in patients undergoing total hip or knee replacements, according to a study published today in the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA). (2018-03-01)

Ketamine works for female rats, too
A first of its kind study in female rats finds that a single, low dose of ketamine promotes resilience to future adverse events as it does in male rats. Published in eNeuro, the research addresses a critical gap in understanding and developing treatments for stress-related disorders, which disproportionately afflict females. (2018-02-26)

Antidepressant response within hours? Experts weigh evidence on ketamine as fast-acting treatment for depression in Harvard Review of Psychiatry
Recent studies suggest that ketamine, a widely used anesthetic agent, could offer a wholly new approach to treating severe depression -- producing an antidepressant response in hours rather than weeks. Two reviews of recent evidence on ketamine and related drugs for treating depression appear in the Harvard Review of Psychiatry, published by Wolters Kluwer. (2018-02-22)

How electroconvulsive therapy relieves depression per animal experiments
In a study using genetically engineered mice, Johns Hopkins researchers have uncovered some new molecular details that appear to explain how electroconvulsive therapy (ECT) rapidly relieves severe depression in mammals, presumably including people. The molecular changes allow more communication between neurons in a specific part of the brain also known to respond to antidepressant drugs. (2017-12-18)

Suicidal thoughts rapidly reduced with ketamine, finds study
Ketamine was significantly more effective than a commonly used sedative in reducing suicidal thoughts in depressed patients, according to researchers at Columbia University Medical Center (CUMC). They also found that ketamine's anti-suicidal effects occurred within hours after its administration. (2017-12-14)

Schizophrenia drug development may be 'de-risked' with new research tool
Researchers have identified biomarkers that can help with development of better treatments for schizophrenia. (2017-11-22)

Intranasal ketamine has more minor side effects than intranasal fentanyl in children with acute pain
Minor adverse events (e.g., bad taste in the mouth and dizziness) occur more frequently with intranasal ketamine than with intranasal fentanyl in children with suspected extremity fractures. (2017-11-22)

Depressed with a chronic disease? Consider alternative therapies
Scientists are finding more evidence that commonly prescribed antidepressants aren't effective in people battling both depression and a chronic medical disease, raising a critical question of whether doctors should enact widespread changes in how they treat millions of depressed Americans. (2017-11-06)

Ketamine may help treat migraine pain unresponsive to other therapies
Ketamine may help alleviate migraine pain in patients who have not been helped by other treatments, suggests a study being presented at the ANESTHESIOLOGY 2017 annual meeting. (2017-10-21)

Hip and knee replacement patients using fewer opioids to manage pain after surgery
Opioid use in patients recovering from hip and knee replacement decreased by one-third between 2006 and 2014, reflecting success in efforts to promote a multimodal approach to pain management (using a variety of methods to manage pain) rather than using opioids alone, reveals new research being presented at the ANESTHESIOLOGY® 2017 annual meeting. (2017-10-21)

CHEO researchers identify practices leading to safer outcomes in procedural sedation for children
This study represents the largest and most robust prospective emergency department procedural sedation cohort to date. It includes children from six emergency departments across Canada, sedated with six different medication combinations. The results of the study show that choice of sedation medication had the biggest impact on the incidence of adverse events and need for significant interventions in response to those events. (2017-08-21)

Clinical appearance and unusual imaging findings of pediatric ketamine overdose
Case report on a 10-month-old infant who inadvertently ingested ketamine. The paper offers detailed clinical information and unusual MRI findings. (2017-08-15)

Will ketamine treat your depression? Check your activity monitor
During a depressive episode, people often report having reduced energy, feeling slowed down and having reduced interest in activities. As their mood lifts, energy and activity return to their usual levels. A new study in Biological Psychiatry reports altered measures of daily activity in patients whose depressive symptoms improved in response to the fast-acting antidepressant ketamine. (2017-08-15)

Ketamine for depression encouraging, but questions remain around long-term use
A world-first systematic review into the safety of ketamine as a treatment for depression, published in the prestigious Lancet Psychiatry, shows the risks of long-term ketamine treatment remain unclear. (2017-07-27)

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