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Current Ketamine News and Events, Ketamine News Articles.
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World-first ketamine trial shows promise for geriatric depression
Australian researchers have completed the world's first randomised control trial (RCT) assessing the efficacy and safety of ketamine as a treatment for depression in elderly patients. (2017-07-22)

Study answers why ketamine helps depression, offers target for safer therapy
UT Southwestern Medical Center scientists have identified a key protein that helps trigger ketamine's rapid antidepressant effects in the brain, a crucial step to developing alternative treatments to the controversial drug being dispensed in a growing number of clinics across the country. (2017-06-21)

Drug believed to reduce postoperative pain and delirium does neither
Anesthesiologists routinely give surgery patients low doses of the drug ketamine to blunt postoperative pain and reduce the need for opioid drugs. Recent research even has suggested ketamine might protect older patients from postsurgical delirium and confusion. But an international, multicenter trial led by investigators at Washington University School of Medicine in St. Louis and the University of Michigan has found that ketamine does neither. (2017-05-30)

Study: Ketamine doesn't affect delirium or pain after surgery
A new study, with an accompanying editorial, published today in The Lancet sought to discover what effect ketamine has on delirium and pain -- two serious postoperative complications. (2017-05-30)

First large-scale population analysis reinforces ketamine's reputation as antidepressant
Researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego mined the FDA Adverse Effect Reporting System (FAERS) database for depression symptoms in patients taking ketamine for pain. They found that depression was reported half as often among the more than 41,000 patients who took ketamine, as compared to patients who took any other drug or drug combination for pain. (2017-05-03)

First evidence for higher state of consciousness found
Scientific evidence of a 'higher' state of consciousness has been found in a study led by the University of Sussex. (2017-04-19)

Emergency departments administering more medications through the nose
Administering medications through the nose as an alternative to injections or IVs is becoming increasingly popular in emergency departments and ambulances, according to a paper by Loyola Medicine pharmacists. The intranasal route 'is easy, fast and noninvasive,' emergency department pharmacist Megan A. Rech, Pharm.D., M.S., and colleagues write in the journal Annals of Emergency Medicine. (2017-04-18)

Schizophrenia signs in mice linked to uncoordinated firing of brain cells, says study
Researchers at Columbia University have discovered that a small group of neurons fired haphazardly in mice with signs of schizophrenia. The findings suggest that a breakdown in the synchronized behavior of these brain cells could produce the classic disordered thinking and perceptions associated with the disease.  The study, which may be the first to test the idea that schizophrenia arises from disruptions in small networks of neurons, was published April 5 in Neuron. (2017-04-05)

ER docs can pick your nose
The range of options for medicating emergency patients intranasally has greatly expanded in recent years and can even be preferable for certain patients, including children, according to the results of a paper published online last Thursday in Annals of Emergency Medicine ('When to Pick the Nose: Out-of-Hospital and Emergency Department Intranasal Administration of Medications'). (2017-04-04)

Mount Sinai researchers review progress of treating glutamate signalling in depression
Major depressive disorder (MDD) impacts 15 million Americans and is the leading cause of disability, yet current treatments possess limited efficacy. Ketamine, which has been repurposed as a rapidly acting antidepressant, has emerged as an experimental and potentially promising compound to treat severe depression through a novel drug action mechanism that blocks glutamate receptors. (2017-03-17)

PTSD symptoms may be prevented with ketamine
Columbia University researchers have evidence that giving a small dose of ketamine one week before a psychologically traumatic event may help prevent PTSD. The study, in mice, may have implications for soldiers who are at risk for trauma and PTSD. (2017-02-08)

Antidepressant effects of ketamine
New preclinical evidence was put forward by investigators in a series of presentations at the recent meeting of the American College of Neuropsychopharmacology suggest that the a metabolite of ketamine can produce antidepressant-like effects in a mouse model of depression. The metabolite is produced when ketamine is broken down in the body. This finding may lead to further research to better understand ketamine's efficacy in depression and its potential side effects. (2016-12-08)

Ketofol an alternative deep sedative for emergency departments
Researchers have shown in a large clinical trial that 'ketofol'- - a combination of ketamine and propofol -- can be used safely and effectively to sedate adults in the emergency department. Knowing that ketofol is a viable alternative to propofol will give clinicians more options, especially as ketamine has pain relieving properties, which may reduce the need for other opiates. The trial also debunked the widely-held idea that ketamine caused frequent adverse psychological reactions in adults. (2016-11-08)

Compound shown to reduce brain damage caused by anesthesia in early study
An experimental drug prevented learning deficits in young mice exposed repeatedly to anesthesia. (2016-06-22)

Study shows patients require less painkilling medication after breast-cancer surgery if they have opiate-free anesthesia
New research presented at Euroanaesthesia 2016 shows that patients undergoing breast cancer surgery need less painkilling medication post-surgery if they have anesthesia that is free of opioid drugs. (2016-05-29)

New meta-analysis shows ketamine effective against persistent post-surgical pain and could provide major cost-savings globally
A new meta-analysis showing the effectiveness of ketamine for dealing with persistent post-surgical pain (PPSP) is to be presented at Euroanaesthesia 2016. Ketamine, a cheap and safe drug, may have the potential to save health systems billions of dollars globally by being used in place of other drugs to prevent PPSP. (2016-05-26)

How depression and antidepressant drugs work
New research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease. The brings together two hypotheses: 1) that depression results from deficits in GABA signaling and 2) that depression results from deficits in glutamate signaling. It shows that the depression-like behavior in the research mice results from the reduction of both GABA and glutamate, and importantly, that both can be restored with a single dose of ketamine. (2016-05-18)

A 'communication breakdown' during general anesthesia
When ketamine is used for general anesthesia, two connected parts of the cortex turn to 'isolated cognitive islands.' (2016-05-11)

Intravenous ketamine may rapidly reduce suicidal thinking in depressed patients
Repeat intravenous treatment with low doses of the anesthetic drug ketamine quickly reduced suicidal thoughts in a small group of patients with treatment-resistant depression. (2016-05-10)

Researchers identify potentially revolutionary antidepressant compound
Ketamine can treat depression rapidly. But it has major side effects, including hallucinations. Now, researchers have identified a metabolite of ketamine that quickly reverses depression in mice, without ketamine's side effects. (2016-05-04)

Ketamine lifts depression via a byproduct of its metabolism
A chemical byproduct, or metabolite, created as the body breaks down ketamine likely holds the secret to its rapid antidepressant action. This metabolite singularly reversed depression-like behaviors in mice without triggering any of the anesthetic, dissociative, or addictive side effects associated with ketamine. The discovery fundamentally changes scientists' understanding of how this rapid antidepressant mechanism works and holds promise for improved treatments. (2016-05-04)

New effects of ketamine abuse uncovered
Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder. (2016-03-18)

Ketamine for the difficult-to-sedate ER patient
For the small segment of the emergency population whose acute behavioral disturbance does not respond to traditional sedation, ketamine appears to be effective and safe, according to an Australian study published online last Thursday in Annals of Emergency Medicine. (2016-02-24)

VUMC study may offer answers for treating depression in alcoholics
A study by researchers at Vanderbilt University Medical Center is offering a glimmer of hope to alcoholics who find it hard to remain sober because their abstinence is hounded by stubborn, difficult-to-treat depression. (2016-02-01)

Inflammation markers could guide depression treatments
Depressed patients with signs of systemic inflammation have elevated levels of glutamate in regions of the brain that are important for motivation. The findings suggest which forms of depression may respond best to drugs that target glutamate, such as the anesthetic ketamine. (2016-01-12)

New type of antidepressant found to act quickly in mice
The compound CGP3466B, already proven nontoxic for people, may effectively and rapidly treat depression, according to results of a study in mice. (2016-01-12)

Overeating and depressed? Yale team finds connection -- and maybe a solution
Chronic overeating and stress are tied to an increased risk of depression and anxiety, and in a new study, Yale researchers explain why that happens and suggest a possible solution. The researchers report that the anesthetic ketamine reverses depression-like symptoms in rats fed a high-fat diet in a similar way it combats depression and synaptic damage of chronic stress in people. (2015-12-21)

Team IDs brain circuit involved in party drug's antidepressant effect
A fast-acting medication without side effects is needed for depression, and a research finding from the School of Medicine at the University of Texas Health Science Center at San Antonio may be one step toward such a novel medication. (2015-12-21)

Studies reveal better options for managing status epilepticus in children
Status epilepticus -- continuous seizure activity for 30 minutes or more -- is a medical emergency with a high mortality rate. Prompt and effective treatment is key, but defining the best treatments is an area of intense debate. Three studies presented at the American Epilepsy Society's 69th Annual Meeting clarify the benefits and drawbacks of commonly used strategies for managing status epilepticus in pediatric patients. (2015-12-07)

New 'party pill' test could help authorities keep up with trends in drug (ab)use
A new test for club drugs like ketamine can detect low levels of drugs in urine and plasma, making it faster, easier and cheaper to identify them. The authors of the study, published in Journal of Chromatography B, say it could give authorities the boost they need to keep up with trends drug (ab)use. (2015-11-25)

Depressed females have over-active glutamate receptor gene
Numerous genes that regulate the activity of a neurotransmitter in the brain have been found to be abundant in brain tissue of depressed females. This could be an underlying cause of the higher incidence of suicide among women, according to research at the University of Illinois at Chicago. (2015-07-30)

Adolescents, drugs and dancing
A new NYU study is the first to examine the sociodemographic correlates of rave attendance and relationships between rave attendance and recent (12-month) use of various drugs in a representative US sample of high school seniors. (2015-05-18)

Penn Medicine: New receptors could underlie the many actions of the anesthetic ketamine
Penn Medicine researchers are continuing their work in trying to understand the mechanisms through which anesthetics work to elicit the response that puts millions of Americans to sleep for surgeries each day. Their most recent study looked at ketamine, an anesthetic discovered in the 1960s and recently prescribed as an anti-depressant at low doses. Researchers have identified an entirely new class of receptors that ketamine binds in the body, which may underlie its diverse actions. (2015-04-01)

Rett Syndrome Research Trust awards $1.3 million for clinical trial
A surgical sedative may hold the key to reversing the devastating symptoms of a neurodevelopmental disorder found almost exclusively in females. Ketamine, used primarily for operative procedures, has shown such promise in mouse models that Case Western Reserve and Cleveland Clinic researchers soon will launch a two-year clinical trial using low doses of the medication in up to 35 individuals with Rett Syndrome. (2015-03-23)

Reviving drugs with anti-stroke potential, minus side effects
Emory scientists have found NMDA receptor antagonists that can limit damage to the brain in animal models of stroke, apparently without the pronounced side effects seen with similar drugs. (2015-02-27)

Levels of 'Molly,' aka ecstasy, spike in rivers near music festival
The illicit drug called 'Molly' or ecstasy is a serious concern for parents, law enforcement and now for environmentalists. Scientists report in the ACS journal Environmental Science & Technology that a major music festival in Taiwan coincides with a spike in the drug's levels in nearby rivers. Not only does this highlight drug abuse at the concert, but the scientists say it also focuses attention on potential effects the substance could have on aquatic life. (2015-01-14)

Teen contraband smokers more likely to use illicit drugs: Study
A University of Alberta economics professor has discovered a link between contraband cigarette use and illicit drug use among Canadian teens. (2014-12-16)

ER docs can treat pediatric pain without a needle
Children in emergency departments can safely be treated for pain from limb injuries using intranasal ketamine, a drug more typically used for sedation, according to the results of the first randomized, controlled trial comparing intranasal analgesics in children in the emergency department. The study was published online last month in Annals of Emergency Medicine. (2014-12-04)

Brain & Behavior Research Foundation awards NARSAD Distinguished Investigator Grants
The Brain & Behavior Research Foundation today announced the award of NARSAD Distinguished Investigator Grants valued at $1.5 million to 15 scientists, who are full professors or the equivalent, conducting innovative projects in diverse areas of neurobiological and behavioral research. Recipients of the $100,000, one-year grants are seeking new potential targets for understanding and treating psychiatric disorders that affect one in four people, including schizophrenia, depression, anxiety, bipolar disorder and forms of substance abuse. (2014-11-12)

Drug tests on mothers' hair links recreational drug use to birth defects
Drug tests on 517 mothers in English inner city hospitals found that nearly 15 percent had taken recreational drugs during pregnancy and that mothers of babies with birth defects of the brain were significantly more likely to have taken drugs than mothers with normal babies. The study found no significant links between recreational drug use and any other type of birth defect. (2014-10-31)

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