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Current Ketamine News and Events, Ketamine News Articles.
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UT Southwestern researchers uncover why ketamine produces a fast antidepressant response
UT Southwestern Medical Center scientists are shedding new light on why the anesthetic drug ketamine produces a fast-acting antidepressant response in patients with treatment-resistant depression. (2011-06-16)

Uncovering the neurobiological basis of general anesthesia
A review article in the Dec. 30 New England Journal of Medicine brings together for the first time information from a range of disciplines, including neuroscience and sleep medicine, to lay the groundwork for more comprehensive investigations of processes underlying general anesthesia. (2010-12-29)

Study reveals superior sedation method for children
Procedural sedation and analgesia is an essential element of care for children requiring painful procedures in the emergency department. Research led by Drs. Amit Shah, Gregory Mosdossy and Michael Rieder of the University of Western Ontario and Lawson Health Research Institute provides evidence that when compared to ketamine alone, patients who receive a combination of ketamine and propofol have a slightly faster recovery time and suffer from less severe side effects. (2010-10-19)

Selective strategy could lead to new approaches against schizophrenia
A new class of compounds identified by researchers could be developed into drugs for the treatment of schizophrenia. The compounds enhance signaling by molecules in the brain called NMDA receptors, which scientists believe are functioning at low levels in people with schizophrenia. (2010-10-11)

Yale team describes secrets of 'magic' antidepressant
Yale researchers have discovered how a novel antidepressant can take effect in hours, rather than the weeks or months usually required for most drugs currently on the market. The findings, described in the Aug. 20 issue of the journal Science, should speed development of a safe and easy-to-administer form of the antidepressant ketamine, which has already proven remarkably effective in treating severely depressed patients. (2010-08-19)

Ketamine may relieve depression quickly for those with treatment-resistant bipolar disorder
A single intravenous dose of the anesthetic agent ketamine appears to reduce symptoms of depression within 40 minutes among those with bipolar disorder who have not responded to other treatments, according to a report in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals. (2010-08-02)

A new generation of rapid-acting antidepressants?
In a new issue of Biological Psychiatry, published by Elsevier, researchers from the National Institutes of Health report that another medication, scopolamine, also appears to produce replicable rapid improvement in mood. (2010-03-01)

Drug users know their stuff
Drug users are well informed about the harms associated with the drugs they use, and perceive alcohol and tobacco to be amongst the most dangerous substances, according to a survey by UCL and Imperial College London researchers. The findings, published in the Journal of Psychopharmacology, suggest that the current system of classifying psychoactive drugs in the UK may need to be revisited. (2009-11-24)

Researchers begin to decipher metabolism of sexual assault drug
It's a naturally occurring brain chemical with an unwieldy name: 4-hydroxybutyrate (4-HB). Taken by mouth, it can be abused or used as a date-rape drug. Now, a team of Ohio and Michigan scientists have determined new routes by which 4-HB is metabolized by the body. (2009-11-20)

First ever large-scale study of ketamine users published
The first ever large-scale, longitudinal study of ketamine users has been published online today in the journal Addiction. With Ketamine (K, Special K) use increasing faster than any other drug in the UK (British Crime Survey, 2008) this research showing the consequences of repeated ketamine use provides valuable information for users and addiction professionals alike. (2009-11-16)

NYU Langone Medical Center awarded $10 million NIMH grant
NYU Langone Medical Center has received a five-year, $10 million grant from the National Institute of Mental Health to establish a Silvio O. Conte Center for the Neuroscience of Mental Disorders. (2009-10-14)

Ketamine reduces suicidality in depressed patients
Drug treatment options for depression can take weeks for the beneficial effects to emerge, which is clearly inadequate for those at immediate risk of suicide. (2009-09-10)

Ketamine safe and valuable alternative sedative for inserting tubing for emergency airway control in critically ill patients
Critically ill patients often need tubing inserted into their airways to help control their breathing during treatment. Ketamine is a safe and valuable alternative to conventional etomidate to use as a sedative to during this intubation. This is among the conclusions of an article published online first and in an upcoming edition of the Lancet. (2009-06-30)

News tips from the Journal of Neuroscience
The following articles are featured in the Jan. 21 issue of the Journal of Neuroscience: (2009-01-20)

People are more suggestible under laughing gas
The pain-relieving effects of nitrous oxide -- laughing gas -- may be enhanced by suggestion or hypnosis, according to a new study by UCL. The study's findings -- that people are more suggestible under the gas -- mean that dental patients may benefit from being coached to relax while undergoing sedation. (2009-01-09)

Cooling the brain prevents cell death in young mice exposed to anesthesia
New research from Washington University School of Medicine in St. Louis suggests cooling the brain may prevent the death of nerve cells that has been observed in infant mice exposed to anesthesia. The effects of anesthesia on human infants and young children have been debated among neuroscientists, but growing evidence suggests exposure to anesthetic drugs during brain development may contribute to behavioral and developmental delays. (2008-11-17)

New brain link as cause of schizophrenia
A lack of specific brain receptors has been linked with schizophrenia in new research by scientists at Newcastle University. (2008-10-27)

Effects of anesthesia on the heart
Researchers at Rhode Island Hospital have created the first animal model that can reveal the side effects of anesthetic agents (the substances used to block pain during surgery) in individuals genetically predisposed to sudden cardiac death. The researchers also found that some anesthetic agents may trigger arrhythmias. The study appears in an upcoming issue of the American Journal of Physiology - Heart Circulation Physiology and is currently available online. (2008-10-27)

Millisecond brain signals predict response to fast-acting antidepressant
Images of the brain's fastest signals reveal an electromagnetic marker that predicts a patient's response to a fast-acting antidepressant. Such use of a brain scanner could someday minimize trial-and-error prescribing and speed delivery of care, say NIMH researchers. Depressed patients showed increased activity in a mood-regulating hub near the front of the brain while viewing flashing frightful faces -- the more the increase, the better their response to an experimental fast-acting medication called ketamine. (2008-10-02)

Patterns of normal brain activity may predispose individuals to different symptoms of psychosis
A new study released today offers a potential predictive technique to anticipate how individuals might behave during a psychotic episode. The study, in the June 18 issue of the Journal of Neuroscience, related the brain activity of healthy participants to how they behaved after exposure to ketamine (a psychosis-inducing drug that mimics schizophrenia symptoms). The findings help explain why schizophrenia symptoms vary greatly from person to person and may ultimately help personalize diagnosis and intervention. (2008-06-17)

News tips from the Journal of Neuroscience
The following articles are featured in the June 18 issue of the Journal of Neuroscience: Major new class of vomeronasal stimuli; Robos and slits in inferior olive development; Predicting psychotic symptoms; and Energy balance and neurodegeneration. (2008-06-17)

Researchers explore the antidepressant effects of ketamine
Drug treatments for depression can take many weeks for the beneficial effects to emerge. The excruciating and disabling nature of depression highlights the urgency of developing treatments that act more rapidly. (2008-02-21)

Study shows new strategy for developing antidepressants
Researchers may be able to develop an antidepressant which takes effect almost immediately by directly targeting novel molecules in the brain instead of taking a less direct route, which can lead to longer times for medication to take effect, according to a new study presented at the American College of Neuropsychopharmacology Annual Meeting. (2007-12-08)

Knowing how ketamine impairs brain circuitry may lead to new therapies for schizophrenia
Scientists know that the drug ketamine -- street name (2007-12-06)

Faster-acting antidepressants closer to becoming a reality
An earlier study showed that ketamine, used experimentally, kicked depression in hours instead of weeks. This study showed that a boost in the AMPA receptor is a necessary ingredient. The glutamate system is implicated further in depression. (2007-07-24)

A new 'matrix of harm' for drugs of abuse
A new study published today in the Lancet proposes that drugs should be classified by the amount of harm that they do, rather than the sharp A, B and C divisions in the UK Misuse of Drugs Act. The new ranking places alcohol and tobacco in the upper half of the league table. These socially accepted drugs were judged more harmful than cannabis, and substantially more dangerous than the Class A drugs LSD and ecstasy. (2007-03-22)

Experimental medication kicks depression in hours instead of weeks
Current antidepressants take weeks to work. Aiming at a different brain-cell target than the ones current medications hit, scientists kicked depression in treatment-resistant patients in hours. (2006-08-07)

Study suggests anesthetic agent may have rapid antidepressant effects
A single intravenous infusion of a drug known as ketamine, which is a general anesthetic agent, may relieve symptoms of depression within two hours and remain effective for up to one week, according to a report in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals. (2006-08-07)

'Survival' genes hold key to healthy brains in babies and the elderly
Completing a daily crossword and enjoying a range of activities and interests has long been accepted as a recipe for maintaining a healthy brain in older age, but the reasons for this have never been clear. Now, scientists at the University of Edinburgh are seeking to identify brain's 'survival' genes which lie dormant in unused brain cells, but are re-awakened in active brain cells. (2005-12-05)

Yale study reconciles two models of schizophrenia
Study shows interplay of two brain signaling systems, glutamate and dopamine, in psychosis and cognitive function. (2005-09-12)

The Lancet calls for open debate on illegal drug use
Open debate about illegal drug use is needed to gain accurate, impartial information about the true extent of usage and the acute and long-term health effects, states an editorial in this week's issue of The Lancet. (2005-06-16)

Recreational use of an erectile dysfunction drug can be risky for some
Although the drugs used to treat Erectile Dysfunction, Sildenafil (Viagra), Tadalafil (Cialis) and Vardenafil (Levitra), have generally been proven safe, recreational use of these drugs is associated with higher risks of sexually-transmitted diseases (STD's), including HIV. In a study in the current issue of The American Journal of Medicine, researchers from the San Francisco Department of Public Health evaluated 14 studies of Sildenafil use among men who have sex with men (MSM). (2005-05-26)

Study reports genetic susceptibility to alcoholism in NMDA receptor
Receptors in the brain that are highly sensitive to alcohol may function differently in a person with a family history of alcoholism. (2004-10-20)

Severe pain relief may be possible with a common anesthetic drug
A novel treatment using a common anesthetic drug has shown success in reducing the severe pain caused by Complex Regional Pain Syndrome (CRPS), according to a study published in the September 2004 issue of Pain Medicine. (2004-10-12)

Low doses of a common intravenous anesthetic may relieve debilitating pain syndrome
Limited, low-dose infusions of a widely used anesthetic drug may relieve the often intolerable and debilitating pain of Complex Regional Pain Syndrome (CRPS), a Penn State Milton S. Hershey Medical Center researcher found. (2004-09-23)

Study finds cannabis triggers transient schizophrenia-like symptoms
The principal active ingredient in marijuana causes transient schizophrenia-like symptoms ranging from suspiciousness and delusions to impairments in memory and attention, according to a Yale research study. (2004-06-14)

Chemical receptor key to fetal development
A chemical receptor in the brain associated with learning and memory probably also plays a key role in fetal development of the respiratory system, MIT researchers and colleagues report in the May 1 Journal of Neuroscience. The work indicates that pregnant women should avoid prolonged exposure to substances affecting this receptor. (2000-04-30)

Pain Killers Advocated Over Restraints For Children In Emergency Rooms
Pediatricians at Washington University School of Medicine in St. Louis have compared two regimens for sedating children in emergency rooms. One of them -- involving the drugs ketamine and midazolam -- was safer and slowed breathing less than the other. Both are alternatives to the papoose board. (1999-01-27)

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