Current Kidney Cancer News and Events

Current Kidney Cancer News and Events, Kidney Cancer News Articles.
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New blood pressure-lowering guidelines could benefit 25 million americans with chronic kidney disease
A recommendation for more intensive blood pressure management from an influential global nonprofit that publishes clinical practice guidelines in kidney disease could, if followed, benefit nearly 25 million Americans. (2021-02-23)

Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

New model helping identify pregnant women whose previous kidney injury puts them, babies at risk
Young pregnant women, who appear to have fully recovered from an acute injury that reduced their kidney function, have higher rates of significant problems like preeclampsia and low birthweight babies, problems which indicate their kidneys have not actually fully recovered. MCG scientists have developed a rodent model that is enabling studies to better understand, identify and ideally avoid this recently identified association. (2021-02-22)

LSU Health study finds psychosocial factors may drive peritoneal dialysis patient dropout
A retrospective study conducted by LSU Health New Orleans reports that contrary to previous research, most patients who drop out of peritoneal dialysis may do so for psychosocial reasons. The findings are published in The American Journal of the Medical Sciences. The paper inspired a companion editorial. (2021-02-19)

Addressing the biological causes of racial disparities in prostate cancer
A new review published in Cancer Reports examines the biological differences in the development of prostate cancer across ethnicities. (2021-02-18)

Real world data on hospital readmissions of patients with heart failure
In an analysis of information on 448 patients with heart failure who were discharged from a hospital in Sweden, 20.3% of patients were readmitted to the hospital within 30 days, and 60.9% were readmitted within 1 year. The ESC Heart Failure analysis found that most of the patients who needed to be rehospitalized were readmitted for heart failure. (2021-02-18)

Physical conditions linked to psychological distress in patients with cancer
Among patients with cancer, having additional physical comorbidities was linked with a higher risk of experiencing psychological distress. The finding comes from a Psycho-Oncology analysis of 2017 data from the National Health Survey of Spain. (2021-02-18)

MSK physician shares kidney cancer research at annual ASCO GU Symposium
Memorial Sloan Kettering's Robert Motzer presented positive data from a phase III randomized study that assessed two different treatment combinations as first-line therapies that may benefit people with advanced kidney cancer. (2021-02-16)

IU researchers find disease-related gene changes in kidney tissue
Researchers from Indiana University have identified key genetic changes in the interstitial kidney tissue of people with diabetes, a discovery that signifies the potential for a revolutionary new genetic approach to the treatment of kidney disease. They will contribute their findings to the Kidney Precision Medicine Project's (KPMP) ''cell atlas,'' a set of maps used to classify and locate different cell types and structures within the kidney. (2021-02-16)

Exercise now proven to have mental health benefits for prostate cancer
New Edith Cowan University (ECU) research has found that exercise not only has physical benefits for men with prostate cancer, it also helps reduce symptoms of depression and anxiety. (2021-02-15)

Cabozantinib most effective treatment for metastatic papillary kidney cancer
In a SWOG Cancer Research Network trial that put three targeted drugs to the test, the small molecule inhibitor cabozantinib was found most effective in treating patients with metastatic papillary kidney cancer - findings expected to change medical practice. (2021-02-13)

Immunotherapy -- targeted drug combination improves survival in advanced kidney cancer
Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial. (2021-02-13)

New class of drug leads to 30% reduced risk of death for bladder cancer patients
A new type of drug that helps target chemotherapy directly to cancer cells has been found to significantly increase survival of patients with the most common form of bladder cancer, according to results from a phase III clinical trial led in the UK by Queen Mary University of London and Barts Health NHS Trust. (2021-02-12)

New study discovers possible early detection method for elusive ovarian cancer
A study led by researchers at the University of Minnesota Medical School found a way to detect the presence of ovarian cancer in patients using Pap test samples, normally used to detect cervical cancer. (2021-02-09)

Identification of three genes that determine the stemness of gastric tissue stem cells
Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages. However, detailed analysis in vivo is difficult, so the molecular mechanisms underlying the stemness of gastric tissue stem cells have remained a mystery. Here, by using organoids that mimic tissue structure and function in vivo and GeCKO screening to inactivate arbitrary genes, Alk, Bclaf3 and Prkra have been identified as genes regulating stemness. (2021-02-08)

Study describes the diversity of genetic changes that cause inherited kidney disease
A study has described genetic changes in patients with the most common form of hereditary kidney disease that affects an estimated 12.5 million people worldwide. The research, which focussed on Polycystic Kidney Disease (PKD) in Ireland, provides insights into PKD that will assist doctors and patients in the management of this of inherited condition. (2021-02-08)

SARS-CoV-2 under the helium ion microscope for the first time
Scientists at Bielefeld University's Faculty of Physics have succeeded for the first time in imaging the SARS-CoV-2 coronavirus with a helium ion microscope. In contrast to the more conventional electron microscopy, the samples do not need a thin metal coating in helium ion microscopy. This allows interactions between the coronaviruses and their host cell to be observed particularly clearly. The findings have been published in the Beilstein Journal of Nanotechnology. (2021-02-04)

Researchers assess cognitive impairment in patients with breast cancer
A recent analysis of published studies in Psycho-Oncology estimates that one-quarter of adults with breast cancer have cognitive impairment before starting therapy. (2021-02-03)

More than half of cancer survivors have underlying medical conditions associated with severe COVID
New study finds more than half (56.4%) of cancer survivors in the United States reported having additional underlying medical conditions associated with severe COVID-19 illness. (2021-02-03)

On the dot: Novel quantum sensor provides new approach to early diagnosis via imaging
A phenomenon called 'oxidative stress' is seen in affected organs during the early stages of certain difficult-to-treat diseases like cancer and kidney dysfunction. Detecting oxidative stress could thus enable early diagnosis and preventive treatments. But, the in vivo measurement of oxidative stress caused by both oxidation and reduction has historically been difficult. Now, scientists have developed an advanced quantum sensor technology that can detect 'oxidative stress' non-invasively throughout the body using fluorescent imaging and MRI. (2021-02-03)

Study examines role of biomarkers to evaluate kidney injury in cancer patients
A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells. (2021-02-03)

Solving a puzzle
University of New Mexico scientists tease out the underlying mechanism of tuberous sclerosis complex (2021-02-03)

Study shows aspirin before a diagnosis may lower colorectal cancer mortality
A new study finds that long-term aspirin use before a diagnosis of colorectal cancer (CRC) may be associated with lower CRC-specific mortality. (2021-02-02)

Biomedical basis of the Barker hypothesis uncovered
A research group at Inselspital, Bern University Hospital and the University of Bern has published an extensive study on prenatal causes of kidney disease in adults in Nature Communications. The findings reveal that the serum protein fetuin-A plays a key role in attenuating local inflammation and microcalcifications in the fetal kidney, which have consequences for kidney function later in adulthood. The study results provide indications for clinical use of fetuin-A in kidney diseases. (2021-02-02)

New protein neutralizes COVID in tiny human kidney
Northwestern Medicine scientists have developed a new protein that acts as a trickster to neutralize the COVID-19 infection in a human kidney organoid, a miniature organ made from stem cells in the lab. (2021-02-01)

Researchers discover mechanism to overcome drug-resistance in leukemia
In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published online today in the Proceedings of the National Academy of Sciences. (2021-02-01)

New weapon for inflammation
Flinders University researchers have discovered a new anti-inflammatory role for well-known blood clot protein fibrinogen, which could support targeted new treatments for kidney, heart and other common diseases. The study in Redox Biology describes how fibrinogen can be protective against hypochlorite - a chemical generated by the body during inflammation - and so act as a kind of antioxidant in blood plasma. (2021-01-31)

Researchers illustrate the need for anti-racism in kidney care, research
There is a growing awareness of systematic inequality and structural racism in American society. Science and medicine are no exception, as evidenced by historical instances of discrimination and overt racism. In a perspective piece in the Journal of the American Society of Nephrology, researchers from Boston University School of Medicine (BUSM), take an honest look at how the current practice of nephrology (kidney medicine) may have elements rooted in racist ideologies. (2021-01-29)

Cancer deaths attributable to cigarette smoking in 152 US metropolitan and micropolitan areas
A new study shows 4 in 10 cancer deaths are attributable to cigarette smoking in parts of the South region and Appalachia. (2021-01-26)

Nixing bone cancer fuel supply offers new treatment approach, mouse study suggests
An innovative approach to treating bone tumors - starving cancer cells of the energy they need to grow - could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. (2021-01-26)

Concordia researchers find melatonin is effective against polycystic kidney disease
Melatonin, a hormone commonly associated with sleep-wake regulation, has been found to reduce cysts in fruit flies, according to Concordia researchers. It's a finding that may affect the way we treat some kidney diseases and reduce the need for kidney transplants. (2021-01-26)

Cholesterol starvation kills lymphoma cells
Scientists have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol -- which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death. The study was in lymphoma cells but could be effective in ovarian and kidney cancer. (2021-01-25)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Study updates breast cancer risk estimates for women with no family history
A new multi-institution study led by Fergus Couch, Ph.D., a Mayo Clinic pathologist, provides more accurate estimates of breast cancer risk for U.S. women who harbor inherited mutations in breast cancer predisposition genes. The findings of the CARRIERS Consortium study, published Jan. 20 in The New England Journal of Medicine, may allow health care providers to better assess the risk of breast cancer in women ? many of whom have no family history of breast cancer. (2021-01-21)

Study reveals new insights into the link between sunlight exposure and kidney damage
A new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington and published in the Proceedings of the National Academy of Sciences (PNAS), reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus. (2021-01-21)

Researchers uncover potentially promising therapeutic combination for renal cell carcinoma
Investigators have demonstrated that ACE2 expression is a good prognostic factor in RCC, that loss of ACE2 mediates resistance to classical treatments, and that in preclinical models, treatment with a drug that is downstream of ACE2 can improve tumor responses in RCC and significantly prolong survival. (2021-01-20)

Cancer-related suicide declined in the US during the past two decades
Despite increases in overall suicide rates in the United States during the past two decades, cancer-related suicides declined by 2.8% per year, according to a new study by the American Cancer Society. (2021-01-19)

Single-cell test can reveal precisely how drugs kill cancer cells
Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) have developed a method named D2O-probed CANcer Susceptibility Test Ramanometry (D2O-CANST-R) to see, at single-cell/organelle level, how pharmaceuticals induce cancer cell death and how cancer cells adapt. (2021-01-19)

Report shows alcohol consumption linked to portion of cancer incidence and mortality
A new study finds that alcohol consumption accounts for a considerable portion of cancer incidence and mortality in all 50 states and the District of Columbia. (2021-01-19)

Esophageal cancer patients show abundance of oral pathogens
DNA from various oral bacterial pathogens has been found in tumors from esophageal cancer patients. Researchers led by Tokyo Medical and Dental University (TMDU) examined bacterial pathogens in plaque and saliva from esophageal cancer patients, determining that a prevalence of three species in particular, along with alcohol consumption, is associated with a high risk of esophageal cancer. Screening of oral pathogens could therefore be used for early disease detection. (2021-01-14)

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