Current Kidney Disease News and Events

Current Kidney Disease News and Events, Kidney Disease News Articles.
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Mechanisms in the kidney that control magnesium and calcium levels discovered
The gene KCTD1 directs production of a protein that functions in the kidney to maintain a normal balance of magnesium and calcium in blood. Loss of KCTD1 impairs the ability of the kidney to properly absorb magnesium and calcium from urine in the kidney, leading to abnormally low magnesium and calcium blood levels, thereby triggering the parathyroid glands to secrete excess parathyroid hormone that in turn leads to metabolic bone disease. (2021-01-12)

First-degree relative with kidney disease increases disease risk by three-fold
In a large population-based family study, family history of kidney disease was strongly associated with increased risk of chronic kidney disease. (2021-01-12)

Fetal-maternal discordance in APOL1 genotype contributes to preeclampsia risk
Fetal APOL1 kidney risk alleles are associated with increased risk for preeclampsia in African Americans and maternal fetal genotype discordance is also associated with this risk. (2021-01-12)

Prevalence of patients receiving dialysis in China may exceed 800,000 by 2025
Study projects that prevalence of patients receiving dialysis in China will increase from 384.4 patients per million (PPM) in 2017 to 629.7 PMP in 2025 with a predicted 874,373 patients receiving dialysis in 2025. (2021-01-12)

Autoimmune diseases: similar molecular signatures in target tissues
A study conducted by Professor Decio L. Eizirik's group - ULB Center for Diabetes Research - and published in Sciences Advances shows that autoimmune diseases, including type 1 diabetes, must be studied in their entirety, taking into account not only the immune system but also the target tissues. Indeed, the key mechanisms induced by inflammation, potentially shared between type 1 diabetes, systemic lupus erythematosus, multiple sclerosis and rheumatoid arthritis, could generate similar molecular signatures at the target tissue level. (2021-01-07)

Shiga toxin's not supposed to kill you
E. coli food poisoning is one of the worst food poisonings, causing bloody diarrhea and kidney damage. But all the carnage might be just an unintended side effect, report researchers from UConn Health. Their findings might lead to more effective treatments for this potentially deadly disease. (2021-01-06)

Dental experts discover biological imbalance is the link between gum and kidney disease
An imbalance of the body's oxygen producing free radicals and its antioxidant cells could be the reason why gum disease and chronic kidney disease affect each other, a new study led by the University of Birmingham has found. (2021-01-05)

Stopping RAS inhibitors tied to worse outcomes in patients with chronic kidney disease
Small studies have suggested that a group of medications called RAS inhibitors may be harmful in persons with advanced chronic kidney disease, and physicians therefore often stop the treatment in such patients. Researchers at Karolinska Institutet now show that although stopping the treatment is linked to a lower risk of requiring dialysis, it is also linked to a higher risk of cardiovascular events and death. The results are published in The Journal of the American Society of Nephrology. (2020-12-29)

Study finds patients with kidney failure are ready and willing to use mobile health
* In a survey of adults with kidney failure who were receiving dialysis, most owned mobile devices and had intermediate or advanced mobile health proficiency. * The main reasons for using mobile health were for making appointments, communicating with healthcare personnel, and obtaining laboratory results. (2020-12-22)

Virtual kidney transplant evaluation allows patients to be evaluated from home
A virtual telehealth platform is allowing the surgery program at the Medical University of South Carolina to evaluate and wait-list patients for kidney transplantation despite reductions in direct, in-person health care visits brought about by the COVID-19 pandemic. (2020-12-21)

Impaired blood vessel and kidney function underlie heart disease risk in people with HIV
People living with human immunodeficiency virus (HIV) have impaired blood vessel function, which increases risk of heart and blood vessel-disease. The increased heart disease risk is especially pronounced in people with HIV who also have kidney disease. The increased heart disease risk remains regardless of HIV severity or use of antiretroviral therapy. (2020-12-17)

Proenkephalin (penKid®) included in the ADQI consensus statements publication as functional kidney biomarker for the management of AKI patients
The Acute Disease Quality Initiative (ADQI) recommends the use of novel biomarkers for AKI management, including functional biomarkers as penKid®. (2020-12-16)

Novel MRI contrast agent sidesteps toxic effects of current products
Researchers are developing an alternative MRI contrast agent based on manganese, an essential element in human nutrition, that is easily processed and eliminated by the body. Manganese has magnetic properties similar to those of gadolinium, but without gadolinium's toxicity. (2020-12-15)

Too many donor kidneys are discarded in U.S. before transplantation
a large portion of the discarded kidneys would function acceptably if transplanted, according to a new study from a team led by researchers in the Perelman School of Medicine at the University of Pennsylvania and the Paris Translational Research Center for Organ Transplantation. (2020-12-15)

COVID-19 patients at higher risk of death, health problems than those with flu
A deep dive into federal data by researchers at Washington University School of Medicine in St. Louis reveals a clearer distinction between COVID-19 and the flu: Among hospitalized patients, COVID-19 was associated with an increased need for ventilators, more admissions into intensive care units, longer hospital stays and nearly five times the risk of death than faced by those with the flu. (2020-12-15)

One-year kidney allograft outcomes do not differ by hepatitis C status of donor
Study published in AJKD shows that kidney allograft outcomes one year post-transplantation in hepatitis C virus (HCV)-negative recipients do not differ by the HCV status of the donor. (2020-12-14)

Higher variability in glomerular filtration rate is associated with higher mortality
In this paper published in the American Journal of Kidney Diseases (AJKD), researchers evaluated associations between eGFR variability and subsequent cardiovascular disease (CVD) events and all-cause mortality among SPRINT participants. They found that greater eGFR variability was associated with higher risk of all-cause mortality independent of baseline eGFR, albuminuria, and other risk factors. (2020-12-14)

Low blood pressure during hemodialysis may indicate peripheral vascular disease
Using a large nationwide registry of patients receiving maintenance hemodialysis, this study published in the American Journal of Kidney Diseases found that higher frequency of low blood pressure episodes during hemodialysis was associated with a higher incidence of diagnosed peripheral arterial disease. (2020-12-11)

Calibrating kidney function for cancer patients
A new model to evaluate kidney function can help clinicians find the right balance between treating cancer and avoiding chemotherapy's dangerous side effects. (2020-12-10)

UL, Ireland, research finds promising treatment to protect kidney function in diabetes
A clinical trial involving researchers at University of Limerick, Ireland has demonstrated the potential benefits of new drugs in protecting kidney function in diabetes. (2020-12-09)

Ability to predict C-diff mortality nearly doubled with new guidelines
Updated national guidelines for treating infections caused by the deadly superbug Clostridioides difficile (C. diff) have been examined and approved by a nationally renowned C. diff researcher at University of Houston and his team of students. (2020-12-09)

Glyphosate can create biomarkers predicting disease in future generations
Exposure to the widely used weed-killer glyphosate makes genetic changes to rats that can be linked to increased disease in their grandchildren and great-grandchildren. These glyphosate-induced changes to sperm from exposed rats could be used as biomarkers for determining propensity in subsequent generations for prostate and kidney diseases as well as obesity and incurring multiple diseases at once. (2020-12-09)

Large US study confirms COVID-19 complications: lung, kidney and cardiovascular issues
A large study of patients in the United States who contracted coronavirus disease 2019 (COVID-19) confirms many complications of the disease, according to new research in CMAJ (Canadian Medical Association Journal). (2020-12-08)

Kidney injury in diabetic ketoacidosis linked to brain injury
Researchers have identified factors that make children with diabetic ketoacidosis more likely to experience acute kidney injury. Analyzing data from a large, multicenter clinical trial, the researchers also found that children who experience acute kidney injury are more likely to also experience subtle cognitive impairment and demonstrate lower IQ scores, suggesting a pattern of multiple organ injury. (2020-12-04)

Patients with kidney disease may delay AVF creation
Many patients start hemodialysis with temporary vascular access despite regular kidney care and pre-dialysis education. Delay is often related to patient choice but research on patients' perspectives is limited. In this study, researchers surveyed pre-dialysis patients and their family members about their perceptions of chronic kidney disease (CKD) and their intentions to undergo access creation. They also report on a new survey instrument to measure attitudes towards hemodialysis preparation. (2020-12-03)

Rethinking race and kidney function
Removing race from clinical tools that calculate kidney function could have both advantages and disadvantages for Black patients. (2020-12-02)

Kidney disease leading risk factor for COVID-related hospitalization
An analysis of Geisinger's electronic health records has revealed chronic kidney disease to be the leading risk factor for hospitalization from COVID-19. (2020-12-02)

Cancer cases are rising in adolescents and young adults
Cancer cases in adolescents and young adults have risen by 30% during the last four decades, with kidney cancer rising at the greatest rate, according to researchers at Penn State College of Medicine. The team said further research into screening, diagnosis and treatment are needed to address the growing trend in this age group. (2020-12-01)

The number of times a person gives birth may affect how quickly they age
Having children doesn't just make you feel like you've aged overnight -- a new study led by Penn State researchers found that the number of times a person gives birth may also affect the body's physical aging process. (2020-11-30)

A tricky kidney puzzle
By analyzing the gene expression of single cells, algorithms are able to not only reconstruct their original location in the tissue, but also to determine details about their function. Teams led by Kai Schmidt-Ott and Nikolaus Rajewsky have published their findings in JASN, using the kidney as an example. (2020-11-27)

Survival protein may prevent collateral damage during cancer therapy
Australian researchers have identified a protein that could protect the kidneys from 'bystander' damage caused by cancer therapies. The 'cell survival protein', called BCL-XL, was required in laboratory models to keep kidney cells alive and functioning during exposure to chemotherapy or radiotherapy. Kidney damage is a common side effect of these widely used cancer therapies, and the discovery has shed light on how this damage occurs at the molecular level. (2020-11-25)

RASi associated with reduced risk of KRT compared with CCB in CKD patients
In a population-based Swedish database, researchers studied the clinical outcomes of starting renin-angiotensin system inhibitor (RASi) or calcium channel blockers (CCB) in 2,458 patients with CKD G4-5. Compared with CCB, RASi initiation was associated with a lower risk of KRT, but similar risks of mortality and major adverse cardiovascular events. These findings suggest that RASi initiation might slow the progression of kidney disease compared with CCB in patients with advanced CKD, and offer similar cardiovascular protection. (2020-11-24)

Non-invasive electrolyte levels' measuring method can prevent sudden cardiac death
Researchers from Kaunas University of Technology (KTU), Lithuania came up with the idea on how to measure fluctuating blood potassium levels non-invasively, through electrocardiogram. The researchers claim that their method may become a digital biomarker in the future for managing electrolyte levels. This would be a huge step towards preventing potentially life-threatening conditions among people who suffer from chronic kidney disease. (2020-11-23)

Researchers use cutting edge technology to bioprint mini-kidneys
Researchers have used cutting edge technology to bioprint miniature human kidneys in the lab, paving the way for new treatments for kidney failure and possibly lab-grown transplants. (2020-11-23)

Afro-Caribbean patients with severe kidney disease at greater risk of hospitalisation from COVID-19
Afro-Caribbean people with end stage kidney disease (ESKD) are more likely to be hospitalised with COVID-19 than other ethnicities, a study has found. (2020-11-19)

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease. Researchers say the results of this randomized clinical trial provide evidence that SGLT2 inhibitors should be part of the standard of care for people with Type 2 diabetes and chronic kidney disease. (2020-11-17)

New medication helps heart health in people with chronic kidney disease, Type 2 diabetes
Results of a large, international clinical trial on the novel medication finerenone indicate it reduced the rate of death, heart attack, stroke and hospitalization for heart failure among patients with chronic kidney disease and Type 2 diabetes. Finerenone helped patients with chronic conditions improve their heart health, regardless of if they had a history of cardiovascular disease. (2020-11-17)

SCORED and SOLOIST trials add to evidence for treating diabetes with SGLT2 inhibitors
In these two paired trials, teams of investigators led by Brigham cardiologist Deepak L. Bhatt, MD, MPH, evaluated sotagliflozin, a drug that inhibits SGLT2 and SGLT1. Results of the trials are both published in The New England Journal of Medicine and presented by Bhatt simultaneously at the Late-Breaking Clinical Trial Sessions of the American Heart Association Scientific Sessions. (2020-11-16)

How to ensure patients manage their chronic kidney disease
A Singapore study finds patients with chronic kidney disease need tailored nutrition guidance, as well as better communication with doctors and family support, to empower them to manage their condition. (2020-11-13)

Rats also capable of transmitting hantavirus
A group of researchers from Charité -- Universitätsmedizin Berlin have confirmed Germany's first-ever case of animal-to-human transmission involving a specific species of virus known as the 'Seoul virus'. Working alongside colleagues from Friedrich-Loeffer-Institut (FLI), the researchers were able to confirm the presence of the virus in a young female patient and her pet rat. (2020-11-12)

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