Current Ldl Cholesterol News and Events

Current Ldl Cholesterol News and Events, Ldl Cholesterol News Articles.
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Déjà brew? Another shot for lovers of coffee
In a world first genetic study, researchers from the Australian Centre for Precision Health at the University of South Australia found that that long-term, heavy coffee consumption - six or more cups a day - can increase the amount of lipids (fats) in your blood to significantly heighten your risk of cardiovascular disease (CVD). (2021-02-18)

Researchers uncover new information on the effects of antidepressants
The findings of a new study challenge the prevailing thinking on the primary role of serotonin and other neurotransmitters in the effects of antidepressants. (2021-02-18)

Association of maternal cardiovascular health during pregnancy with later health of offspring in adolescence
The observational study examined associations between maternal cardiovascular health during pregnancy (as measured by body mass index, blood pressure, total cholesterol level, glucose level and smoking) with the later cardiovascular health of their offspring at ages 10 to 14 years old (as measured by body mass index, blood pressure, total cholesterol level and glucose level). (2021-02-16)

Mother's heart health in pregnancy impacts child's heart health in adolescence
A mother's heart health while she is pregnant may have a significant impact on her child's cardiovascular health in early adolescence (ages 10 to 14), according to a new study. It is the first study to examine the implications of a mother's cardiovascular health during pregnancy for offspring health in the longer term. (2021-02-16)

How healthy lifestyle behaviours can improve cholesterol profiles
Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife. (2021-02-16)

Combination therapy with radiation shows promise in treating glioblastoma
In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma (2021-02-09)

Vegan diet better for weight loss and cholesterol control than Mediterranean diet
A vegan diet is more effective for weight loss than a Mediterranean diet, according to a groundbreaking new study that compared the diets head to head. The randomized crossover trial, which was published in the Journal of the American College of Nutrition, found that a low-fat vegan diet has better outcomes for weight, body composition, insulin sensitivity, and cholesterol levels, compared with a Mediterranean diet. (2021-02-05)

How vitamins, steroids and potential antivirals might affect SARS-CoV-2
Evidence is emerging that vitamin D -- and possibly vitamins K and A -- might help combat COVID-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they - and other antiviral drugs -- might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so might reduce SARS-CoV-2 infectivity. (2021-01-29)

Cholesterol starvation kills lymphoma cells
Scientists have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol -- which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death. The study was in lymphoma cells but could be effective in ovarian and kidney cancer. (2021-01-25)

New perspectives challenge the idea that saturated fats cause heart disease
Why do saturated fats increase blood cholesterol, and why should this be dangerous? After all, saturated fats occur naturally in a wide variety of foods, including breast milk. (2021-01-22)

The important role of pharmacists for older adults' health
Pharmacists play an important role in managing medication-based therapies for older community-dwelling patients, according to a study published in the British Journal of Clinical Pharmacology. (2021-01-21)

Important cause of preeclampsia discovered
New findings show that cholesterol crystals in the uterine wall are the villain that researchers have been looking for. These crystals cause intensified inflammation in people who become ill. (2021-01-21)

Vegan diet significantly remodels metabolism in young children
University of Helsinki researchers report a comprehensive pilot study on the metabolic effects of full vegan diet on young children. The study found vegan children to have remarkably altered metabolism and lower vitamin A and D status compared to children with no special diet. (2021-01-21)

Diabetes powerfully associated with premature coronary heart disease in women
To understand what factors put younger individuals at higher risk of premature coronary heart disease, researchers from Brigham and Women's Hospital and the Mayo Clinic analyzed more than 50 risk factors in 28,024 women who participated in the decades-long Women's Health Study. Notably, women under 55 with type-2 diabetes had a tenfold greater risk of having CHD over the next two decades, with lipoprotein insulin resistance proving to be a strong, predictive biomarker as well. (2021-01-20)

General health checkups may detect early signs of Parkinson's disease
A research team led by Nagoya University in Japan has found that blood pressure, the hematocrit, and serum cholesterol levels change in patients with Parkinson's disease long before the onset of motor symptoms. This finding may pave the way for early diagnosis and treatment of the disease. (2021-01-19)

Large transporter protein linked to schizophrenia
Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens. Now, Kazumitsu Ueda of Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and colleagues in Japan have provided evidence that mice with disrupted ABCA13 protein demonstrate a hallmark behaviour of schizophrenia. The team investigated ABCA13's functions and published their findings in the Journal of Biological Chemistry. (2020-12-29)

The ABCs of species evolution
Almost four decades of research have led scientists at Japan's Institute for Integrated Cell-Material Sciences (iCeMS) to propose that a family of transporter proteins has played an important role in species evolution. One protein in particular, called ABCA1, was likely crucial for vertebrate evolution by helping regulate when signals involved in cell proliferation, differentiation and migration enter a cell. This process was necessary for vertebrates to develop into more complex organisms with sophisticated body structures. (2020-12-23)

Protecting against atherosclerosis at the molecular level
Researchers from the University of Tsukuba identified a novel mechanism by which CREB3L3 protects against atherosclerosis. By studying the absence or overexpression of the protein in mice prone to develop atherosclerosis, the researchers demonstrated that the absence of CREB3L3 exacerbates the formation of atherosclerosis, whereby the overexpression protects against atherosclerosis. At the molecular level, CREB3L3 exhibited its protective effects by inhibiting SREBP. This study could help develop a novel molecular target against atherosclerosis. (2020-12-20)

Fish oil supplements don't raise bad cholesterol
The Fatty Acid Research Institute (FARI) has published a new research paper in conjunction with The Cooper Institute on the omega-3s EPA and DHA in fish oil and low density lipoprotein cholesterol (LDL-C). (2020-12-17)

Mission to MAARS: Long non-coding RNA may play a key role in cardiovascular disease
Through utilization of genetically modified high-risk atherosclerotic mice, a research team from Brigham and Women's Hospital identified and characterized Macrophage-Associated Atherosclerosis lncRNA Sequence (MAARS), which is expressed specifically in macrophages in atherosclerotic plaques and contributes to the progression of the disease. (2020-12-17)

Carrots are healthy, but active enzyme unlocks full benefits
Carrots are a good source of beta-carotene, which is a precursor of vitamin A. But to get the full health benefits of this superfood, you need an active enzyme to produce this vitamin. (2020-12-11)

How blood and wealth can predict future disability
Research shows that blood tests for biomarkers such as cholesterol and inflammation can predict disability in five years. Researchers studied blood biomarkers of 5,286 participants involved in the UK Household Longitudinal Study - and found that biological health can predict disability and healthcare demand in five years' time. They also found that people on higher-incomes were more likely to seek GP appointments and outpatient treatments for their medical problems. (2020-12-09)

Ancient migration was choice, not chance
The degree of intentionality behind ancient ocean migrations, such as that to the Ryukyu Islands between Taiwan and mainland Japan, has been widely debated. Researchers used satellite-tracked buoys to simulate ancient wayward drifters and found that the vast majority failed to make the contested crossing. They concluded that Paleolithic people 35,000-30,000 years ago must therefore have made the journey not by chance but by choice. (2020-12-03)

Clinical trial results address concerns about pharmacogenetic testing
Researchers conducted a randomized controlled trial of pharmacogenetic testing related to cholesterol-lowering medications called statins.After one year, the cholesterol levels in the group who received their pharmacogenetic results were not higher than those in the group who did not receive their results, and they were not less likely to receive medical care meeting recommended guidelines. (2020-12-03)

CNIC scientists identify a new diagnostic and therapeutic target for cardiovascular disease
Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified a mitochondrial protein as a potential marker for the diagnosis of cardiovascular disease (CVD) and as a possible target for future treatments. The study is published today in the journal Nature. (2020-12-02)

Clothing, tattoos could be used to monitor patient health
A shirt that monitors your blood pressure or a pair of socks that can keep track of your cholesterol levels might be just a few years away from becoming reality. In Applied Physics Reviews, researchers examine the use of microfibers and nanofibers as wearable monitors that could keep track of a patient's vital signs. The microfiber- and nanofiber-based technology addresses growing concerns in the medical community about monitoring chronic illnesses as the population ages. (2020-12-01)

Plant-based diet ramps up metabolism, according to new study
A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine. (2020-11-30)

A gene mutation that protects against disease
Called PCSK9Q152H, the mutation of the PCSK9 gene was initially thought to protect against cardiovascular diseases. Recent studies reveal that it may protect against other human illnesses, mainly liver diseases. It may allow the PCSK9Q152H mutant subjects to stay in good health and live longer. (2020-11-19)

Children with familial hypercholesterolemia are diagnosed late and under-treated
Children born with a common genetic condition, familial hypercholesterolemia (FH), are at increased risk for atherosclerotic cardiovascular disease (ASCVD) early in life. Despite long-standing national guidelines, cholesterol screening -- for children at age 2 for those with a family history of heart disease and between the ages of nine to 11 for all children -- is not being implemented . (2020-11-18)

Remotely delivered program improves blood pressure, cholesterol control in 5,000 patients
A team from Brigham and Women's Hospital and Mass General Brigham Health System, led by Brigham cardiologist Benjamin Scirica, MD, MPH, developed a program that provides an end-to-end solution to improve blood pressure and cholesterol levels across a broad population of patients at high cardiovascular risk. (2020-11-17)

Algorithm-driven digital program helped lower patients' cholesterol, blood pressure
Researchers enrolled 5,000 patients across the Mass General Brigham health system in Boston, Massachusetts in a remote, cholesterol and blood pressure management program utilizing care navigators and pharmacists, supported by specialists and using specialist-designed algorithms to initiate and adjust medications. Participants who completed the cholesterol program achieved a 52 mg/dl (42%) reduction in LDL cholesterol levels. Participants who completed the blood pressure program saw an average systolic and diastolic blood pressure reduction compared to baseline of 14mmHg and 6mmHg, respectively. (2020-11-17)

Obese people found to be at increased risk of COVID-19
A new study led by researchers at Queen Mary University of London uses a novel approach to investigate the effects of cardiovascular risk factors on the risk of COVID-19 infection. (2020-11-16)

A novel monoclonal antibody therapy cuts LDL cholesterol by half in a high-risk patient population,
The investigational drug evinacumab reduced low-density lipoprotein (LDL) cholesterol--the so-called ''bad'' cholesterol--by 50 percent in patients with severe hypercholesterolemia whose condition is resistant to standard treatments, a phase 2 study from the Icahn School of Medicine of Mount Sinai and other global academic sites has found. (2020-11-15)

Side effects often attributed to statins were the same for those taking a placebo
Study participants who reported side effects from cholesterol-lowering medications known as statins also reported the same side effects when they unknowingly took placebo pills. These side effects are real, and it appears may be mostly due to the psychological rather than the pharmacological effects of statins since symptoms were consistent when taking the placebo. (2020-11-15)

American Heart Association Scientific Sessions to feature Brigham breakthroughs
Leading cardiologists worldwide will convene virtually from November 13-17 at the American Heart Association's 2020 Scientific Sessions, sharing the latest advancements in cardiovascular science and clinical care. The three studies highlighted below represent only a sample of the cutting-edge research Brigham experts in the field will present at the conference. (2020-11-13)

New study confirms combo pill alone and with aspirin lowers heart disease risk
A ''polypill'' is a single pill that includes multiple medications to control more than one health risk factor (such as heart disease, high blood pressure, high cholesterol, Type 2 diabetes, kidney disease, stroke). In this large, international trial, the polypill included blood pressure and cholesterol lowering medications for people at risk for heart disease. Results from the randomized, placebo-controlled trial show that the combination of a polypill plus aspirin reduced cardiovascular disease by 31%, and the polypill without aspirin reduced CVD by 21%. (2020-11-13)

Most type 2 diabetes patients are at high risk of a fatal heart attack or stroke
'The most striking result of our study was that the vast majority of patients (93%) had a high or very high risk of fatal events within a decade. Half of patients in the very high-risk group had no history of heart disease, meaning they would not be receiving medications to prevent heart attacks and strokes,' said study author Dr. Manel Mata-Cases, a general practitioner for the Catalan Institute of Health in Sant Adrià de Besòs. (2020-11-13)

Amgen announces new FOURIER analysis showing Repatha® (evolocumab) reduced cardiovascular events in patients with prior percutaneous intervention at AHA 2020
Amgen (NASDAQ:AMGN) today announced a new analysis from the Repatha® (evolocumab) cardiovascular (CV) outcomes study (FOURIER) that evaluated the effectiveness of Repatha in atherosclerotic cardiovascular disease (ASCVD) patients on statin therapy with prior percutaneous coronary intervention (PCI), also known as coronary angioplasty. (2020-11-13)

The Lancet: Older adults are at greater risk of cardiovascular events than younger people, and benefit at least as much from cholesterol-lowering medications, two studies suggest
Peer-reviewed / 1 Observational study + 1 Systematic review and meta-analysis / People (2020-11-10)

Down Syndrome-associated gene suppresses age-related corneal clouding
Down syndrome and hypercholesterolemia mouse models suggest that the DSCR-1 gene protects against abnormal cornea vascularization and associated blindness by suppressing oxidized LDL cholesterol production and downstream angiogenic signaling during chronic high cholesterol. While the neurological pathology of Down syndrome patients worsens with age, they are less susceptible to age-related vascular diseases. The responsible genes and mechanisms are not yet clear, but DSCR-1 is a strong candidate for a wide range of vascular diseases. (2020-11-05)

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