Current Leptin News and Events

Current Leptin News and Events, Leptin News Articles.
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Early weight gain in children linked to ability to produce the hormone leptin
The brain controls weight by measuring levels of leptin in the blood, which is released by fat cells. In adults, leptin treatments have so far proved ineffective at treating obesity. New genetics research by scientists at the University of Copenhagen suggests that leptin plays a stronger role in controlling the weight of children than in adults. (2020-11-23)

Adipose tissue may be the source of inflammatory factors that aggravate COVID-19
Preliminary results of patient tissue analysis show that the virus infects adipocytes and alters the quantity of signaling molecules released by these cells into the bloodstream. (2020-11-20)

Fatty liver disease despite a normal weight
Researchers from the University of Tsukuba found significant differences in the clinical presentation of non-obese patients with non-alcoholic fatty liver disease (NAFLD) based on their sex and body mass index. They found that non-obese NAFLD patients had lower muscle mass and strength (pre-sarcopenia) compared to obese NAFLD patients. Further, fat accumulation in muscles was more common among women. These findings help us understand the clinical presentation of NAFLD. (2020-08-03)

Why is obesity so common in COVID-19 patients?
A hormone that connects the body's metabolism and immune response system may explain why COVID-19 is so dangerous for people with obesity. (2020-07-24)

How neurons reshape inside body fat to boost its calorie-burning capacity
Scientists have found that a hormone tells the brain to dramatically restructure neurons embedded in fat tissue. Their work widens our understanding of how the body regulates its energy consumption, and how obesity might be treated in the future. (2020-07-22)

Studies suggest a fasting diet could boost breast cancer therapy
A USC-led team of scientists has found that a fasting-mimicking diet combined with hormone therapy has the potential to help treat breast cancer, according to newly published animal studies and small clinical trials in humans. (2020-07-21)

The leptin activator: New study reveals brain receptor key to burning brown fat
In a new study published in Nature Communications, Michigan researchers reveal a pathway by which the hormone leptin contributes to weight loss. (2020-03-31)

Cellular stress makes obese mothers have obese babies
Maternal obesity increases the risk for obesity and metabolic perturbations in their offspring, but what are the mechanisms? In a new study published March 12 in the open-access journal PLOS Biology, Sebastien Bouret of the French National Institute of Health and Medical Research (INSERM) in Lille, France, and colleagues show that a key step in the process is the triggering of stress in a complex membrane system within all cells called the endoplasmic reticulum (ER). (2020-03-13)

Nine researchers receive EMBO Installation Grants to establish independent laboratories
EMBO is pleased to announce that nine life scientists have been selected to receive Installation Grants, which will support them in establishing independent laboratories in the Czech Republic, Poland, Portugal and Turkey. (2020-01-15)

Silica particles may lead to new treatments for obesity and diabetes
Engineered ingestible molecular traps created from mesoporous silica particles (MSPs) introduced to the gut can have an effect on food efficiency and metabolic risk factors. The results from studies on mice, published in Nanomedicine, demonstrate the potential to reduce the energy uptake into the body and could lead to new treatments for obesity and diabetes. (2020-01-14)

MRI reveals brain damage in obese teens
Researchers using MRI have found signs of damage that may be related to inflammation in the brains of obese adolescents, according to a new study. (2019-11-25)

Study helps explain why exercise guards against heart disease
Researchers have identified a previously unknown biological pathway that promotes chronic inflammation and may help explain why sedentary people have an increased risk for heart disease and strokes. (2019-11-07)

Diabetes: A next-generation therapy soon available?
Insulin is normally produced by pancreatic β cells. In many people with diabetes, pancreatic cells are not functional, causing a chronic and potentially fatal insulin deficiency that can only be controlled through daily insulin injections. However, this approach has serious adverse effects. In order to improve therapy, researchers (UNIGE) have identified a protein called S100A9 which seems to act as a blood sugar and lipid regulator while avoiding the most harmful side effects of insulin. (2019-10-16)

Discovered new regulation for infant growth
Researchers at the University of Bergen in Norway have identified new genetic signals for the regulation of how infants grow. This may be a crucial step in the fight against growth-related diseases. (2019-10-01)

Researchers discover new, treatable pathway known to cause hypertension in obese people
There's no question that as body weight increases, so too does blood pressure. Now, in a study of mice, Johns Hopkins researchers have revealed exactly which molecules are likely responsible for the link between obesity and blood pressure. Blocking one of these molecules -- a signaling channel that's found in a tiny organ on the side of your neck -- effectively lowers blood pressure in obese mice, the researchers reported recently in the journal Circulation Research. (2019-09-26)

Why young females with obesity are at early risk for cardiovascular disease
In the face of obesity, the sex hormone progesterone that helps females get and stay pregnant appears to also put them at increased, early risk for cardiovascular disease, investigators report. (2019-09-11)

Overweight kids actually eat less right after stressful events
People often react to stress by binging on sweets or fattening comfort foods, cravings fueled by the appetite-stimulating stress hormone cortisol. (2019-09-03)

High fat diet during pregnancy slows learning in offspring, rat study suggests
In a bid to further explore how a mother-to-be's diet might affect her offspring's brain health, Johns Hopkins Medicine researchers have found that pregnant and nursing rats fed high fat diets have offspring that grow up to be slower than expected learners and that have persistently abnormal levels of the components needed for healthy brain development and metabolism. (2019-08-27)

Gut-brain connection helps explain how overeating leads to obesity
A multi-institutional team led by researchers at Baylor College of Medicine reveals a previously unknown gut-brain connection that helps explain how those extra servings lead to weight gain. (2019-08-12)

Researchers find new mutation in the leptin gene
Texas Biomed Staff Scientist Raul Bastarrachea, M.D., is part of a team that discovered a new mutation in the gene that regulates the key hormone suppressing hunger called leptin. This new mutation could help researchers understand why people develop excess of body fat. Dr. Bastarrachea's research is aimed at helping tackle metabolic disorders like cardiovascular disease and diabetes which are fueled by obesity and impact millions of people around the world. (2019-06-21)

Yale-led study reveals biology of leptin, the hunger hormone
In a new study, Yale researchers offer insight into leptin, a hormone that plays a key role in appetite, overeating, and obesity. Their findings advance knowledge about leptin and weight gain, and also suggest a potential strategy for developing future weight-loss treatments, they said. (2019-06-18)

Obesity worsens disability in multiple sclerosis
Obesity is an aggravating factor in relapsing-remitting multiple sclerosis, the most common form of the disease. A recent study by the Unit of Neurology and Neurorehabilitation of the I.R.C.C.S. Neuromed in Pozzilli (Italy) confirms that lipid metabolism can have a role in determining the severity of multiple sclerosis. (2019-06-05)

Don't overdo omega-6 fat consumption during pregnancy
New research in The Journal of Physiology showed that eating a diet with three times the recommended daily intake of linoleic acid might be harmful in pregnancy. (2019-05-24)

Growth hormone acts to prevent weight loss
A Brazilian study shows that, like leptin, growth hormone contributes directly to energy conservation when the body loses weight. (2019-04-12)

Studies explore mechanisms behind obesity-cancer link
Research findings presented at the American Association for Cancer Research Annual Meeting 2019 explore biological mechanisms behind obesity and its link with cancer. (2019-03-30)

Scientists identify genetic factors that may cause some people to become obese
New research on leptin, a hormone that regulates appetite, reveals a previously unknown mechanism that may be responsible for at least 10 percent of obesity cases. The findings could help identify individuals with treatable forms of the condition. (2019-03-06)

How celastrol sensitizes brains to leptin, curbing hunger and obesity
Celastrol's potent anti-obesity effects were widely reported in 2015. Derived from the roots of the thunder god vine, the drug curbed food intake in obese mice by nearly 80 percent, producing up to a 45 percent weight loss. (2019-03-04)

Regulation of feeding behavior and energy metabolism by galanin-like peptide (GALP)
Galanin-like peptide (GALP) is composed of 60 amino acid residues and its sequence is highly homologous across species. GALP is produced in the hypothalamic arcuate nucleus and has diverse physiological effects such as the regulation of feeding, energy metabolism, and reproductive behavior. In this review article, the researchers summarize their recent research focusing on the mechanism whereby GALP regulates feeding and energy metabolism. (2018-12-24)

Debate: Is the gut or the brain more important in regulating appetite and metabolism?
Whether gut or brain hormones are more important for the regulation of appetite and metabolism is not clearly defined. Imbalances in the control of appetite and metabolism can lead to obesity and diabetes, which have a negative impact on people's health and healthcare costs. In a live debate to be held at the Society for Endocrinology annual conference in Glasgow, leading experts will debate this issue in a session entitled, 'This house believes that the gut is the conductor of the endocrine orchestra.' (2018-11-18)

Low carb diets can help maintain weight loss by increasing number of calories burned
A low carbohydrate diet could help people maintain their weight loss by increasing the number of calories burned, finds a large US feeding trial published by The BMJ today. (2018-11-14)

Obesity both feeds tumors and helps immunotherapy kill cancer
A groundbreaking new study by UC Davis researchers has uncovered why obesity both fuels cancer growth and allows blockbuster new immunotherapies to work better against those same tumors. (2018-11-12)

Nasal delivery of weight-loss hormone eases breathing problems in sleeping mice
Experimenting with mice, Johns Hopkins Medicine researchers have added to evidence that a hormone best known for helping regulate hunger and body weight might also ease breathing problems experienced during sleep more effectively when given through the nose. (2018-11-07)

Weight loss success linked with active self-control regions of the brain
New research suggests that higher-level brain functions have a major role in losing weight. In a study among 24 participants at a weight-loss clinic, those who achieved greatest success in terms of weight loss demonstrated more activity in the brain regions of the lateral prefrontal cortex associated with self-control. The results of the study were published in Cell Metabolism on Oct. 18. (2018-10-18)

Found: A destructive mechanism that blocks the brain from knowing when to stop eating
Researchers have uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity: leptin resistance. They found that mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This blocks leptin from binding to its receptors. This in turn keeps the neurons from signaling that your stomach is full and you should stop eating. (2018-08-22)

Older adults who get physical can lower their heart disease risk
Adults in their early 60s, who spend less time sitting and more time engaged in physical activity have healthier levels of heart and vessel disease indicators. The results from increased physical activity were found to be particularly good among women. (2018-08-08)

Switching off insatiable hunger
In a new study researchers from the Institute for Experimental Pediatric Endocrinology of the Charité - Universitätsmedizin Berlin have successfully treat patients whose obesity is caused by a genetic defect. Aside from its beneficial effects on the patients, the researchers also provided insights into the fundamental signaling pathways regulating satiety of the new drug. The results of this research have been published in Nature Medicine*. (2018-05-08)

Leptin's neural circuit identified
Scientists identified a neural circuit in the hypothalamus as the primary mechanism mediating the hormone leptin's anti-obesity and anti-diabetes effects and found two mechanisms underlying leptin's inhibition of appetite. The work in mice advances efforts to treat human obesity and diabetes. (2018-04-18)

Fat-sensing hormone helps control tadpole metamorphosis
When tadpoles are but tadpoles, they're voracious eaters, chomping down all of the plant matter in their paths. (2018-03-29)

Race, pre-pregnancy BMI may help predict maternal weight gain
Race and pre-pregnancy body mass index (BMI) both affect leptin and adiponectin levels, and leptin levels in mid-pregnancy may be an important predictor of weight gain during pregnancy, new research suggests. The results will be presented on in a poster on Sunday, March 18 at ENDO 2018, the 100th annual meeting of the Endocrine Society in Chicago, Ill. (2018-03-18)

Brain-cell 'antenna' may be key to understanding obesity
UC San Francisco researchers have discovered that the brain's ability to regulate body weight depends on a novel form of signaling in the brain's 'hunger circuit' via antenna-like structures on neurons called primary cilia. (2018-01-08)

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