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Current Leukemia Cells News and Events, Leukemia Cells News Articles.
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Study reveals surprising benefit of clonal hematopoiesis in allogeneic transplants
Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don't have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative health outcomes, including heart attacks and strokes. (2020-12-05)

CAR T-cell therapy found highly effective in patients with high-risk non-Hodgkin lymphoma
A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting. (2020-12-05)

Venetoclax added to standard treatments shows promise in high-risk myeloid blood cancers
The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute. (2020-12-05)

Donor stem cell transplant shown to improve survival in older patients with MDS
A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting. (2020-12-04)

Genetically engineered T cells could lead to therapies for autoimmune diseases
University of Arizona Health Sciences immunobiologists have created a five-module chimeric antigen receptor T cell that is showing early potential to fight Type 1 diabetes. (2020-12-03)

Octapharma presents results of study on Octagam® 10% for severe COVID-19 patients at ASH
Clinical research presented by Octapharma USA at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition will highlight the investigational use of high-dose Octagam® 10% [Immune Globulin Intravenous (Human)] for the most severe COVID-19 patients. Octapharma's intravenous immunoglobulin (IVIg) portfolio also will be featured in a study design poster focused on primary infection prophylaxis in patients with chronic lymphocytic leukemia during ASH, to be held virtually December 5 - 8 due to the coronavirus pandemic. (2020-12-02)

More evidence that cellular 'death by iron' could be promising avenue of cancer treatment
Genetic mutations that give cancers a metabolic boost may also leave them vulnerable to drugs that promote a particular form of cell death, Sloan Kettering Institute researchers have found. (2020-12-01)

Survival protein may prevent collateral damage during cancer therapy
Australian researchers have identified a protein that could protect the kidneys from 'bystander' damage caused by cancer therapies. The 'cell survival protein', called BCL-XL, was required in laboratory models to keep kidney cells alive and functioning during exposure to chemotherapy or radiotherapy. Kidney damage is a common side effect of these widely used cancer therapies, and the discovery has shed light on how this damage occurs at the molecular level. (2020-11-25)

Early trial hints CAR T cells may combat solid tumors in children with neuroblastoma
A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue. (2020-11-25)

Stem cell transplantation: undesirable rejection mechanism identified
In the treatment of leukaemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions - especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A team of researchers in Vienna has now identified an immune mechanism that is partially responsible for this. (2020-11-19)

Animation reveals secrets of critical tumour protein
The latest animation technology has revealed the molecular detail of how our bodies are protected from cancer by a key 'tumour suppressor' protein called p53. (2020-11-11)

The natural artistry of disease: a wintry landscape in the eye
Researchers from Tokyo Medical and Dental University (TMDU) report a case of frosted branch angiitis in a woman presenting years after being treated for leukemia-lymphoma with allogeneic human stem cell transplant. The relevance of this ocular finding is discussed and its value as an early warning sign of immune activation following therapeutic immunological interventions is highlighted. (2020-11-09)

Young survivors of acute myeloid leukemia have long-term complications from treatment
Adolescent and young adult (AYA) patients treated for acute myeloid leukemia (AML) have a high risk of developing several long-term health complications after treatment, a study led by UC Davis Comprehensive Cancer Center researchers has found. The most common complications were cardiovascular, endocrine and respiratory diseases. The complications - known as late effects - were more present among non-white AYA patients and those living in more deprived neighborhoods. (2020-11-09)

Blocking energy pathway reduces GVHD while retaining anti-cancer effects of T-cells
MUSC Hollings Cancer Center researchers identified that blocking an alternative energy pathway for T-cells after hematopoietic stem cell transplant helps reduce graft-versus-host disease in an animal model of leukemia. (2020-11-05)

'BAH-code' reader senses gene-silencing tag in cells
UNC Comprehensive Cancer Center researchers and colleagues have identified an evolutionarily conserved pathway responsible for ''closing down'' gene activity in the mammalian cell. The finding is closely related to the Polycomb pathway defined decades ago by a set of classic genetic experiments carried out in fruit flies. They repor the BAHCC1 protein is critically involved in silencing genes and acts as an integral component of the Polycomb gene-repressive pathway in mammalian cells. (2020-11-02)

Microbes in the gut could be protective against hazardous radiation exposure
A study by scientists at UNC Lineberger Comprehensive Cancer Center and colleagues showed that mice exposed to potentially lethal levels of total body radiation were protected from radiation damage if they had specific types of bacteria in their gut. They demonstrated that the bacteria mitigated radiation exposure and enhanced the recovery of blood cell production as well as repair of the gastrointestinal tract. (2020-10-30)

Scientists discover second key pathway in colon cancer stem cell growth
Scientists have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The scientists identified the link between the retinoic acid or RA signaling pathway and another pathway critical to tumor development, called the Wingless-related integration site or WNT pathway. WNT signaling gone wrong is associated with numerous cancers, likely contributing to drug resistance and tumor recurrence. (2020-10-28)

Baking soda treatment may help prevent leukemia relapse after stem cell transplants
Scientists have discovered that sodium bicarbonate - also known as baking soda or bicarbonate of soda - can reprogram T cells in leukemia patients to resist the immune-suppressing effects of cancer cells, which can drive leukemia relapse after stem cell transplants. (2020-10-28)

Cancer's dangerous renovations to our chromosomes revealed
Cancer remodels the architecture of our chromosomes so the disease can take hold and spread, new research reveals. (2020-10-27)

Study in Nature Medicine shows superior patient outcomes in LLS's Beat AML clinical trial
Study in Nature Medicine shows superior outcomes for patients in LLS's paradigm-shifting beat AML clinical trial. (2020-10-27)

Why do certain chemotherapies increase the likelihood of blood cancer?
MSK investigators uncover new findings about the relationship between clonal hematopoiesis in cancer patients and the risk of later developing a treatment-related blood cancer. (2020-10-26)

New therapeutic approach against leukemia
Using an RNA molecule complex, researchers can prevent retention of cancer stem cell in their tumor supporting niche (2020-10-23)

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications. (2020-10-22)

UT Southwestern leads national efforts around childhood blood disorders
When a child has a rare blood disorder, clinicians can struggle to find the best diagnostic and treatment methods. New research led by UT Southwestern shows the effectiveness of a treatment for aplastic anemia and reveals the range of diagnosis and treatment options used by hospitals around the country for a related disease - myelodysplastic syndrome (MDS). (2020-10-15)

Oncotarget: Genomic markers of midostaurin drug sensitivity in leukemia patients
Oncotarget Volume 11, Issue 29 reported that acute myeloid leukemia is a heterogeneous malignancy with the most common genomic alterations in NPM1, DNMT3A, and FLT3. Midostaurin was the first FLT3 inhibitor FDA approved for AML and is standard of care for FLT3 mutant patients undergoing induction chemotherapy. (2020-10-14)

Anticancer compounds for B cell cancer therapy targeting cellular stress response
Wistar and collaborators from the University of Notre Dame are developing anticancer compounds targeting a pathway of the endoplasmic reticulum (ER) stress response implicated in the development of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and lymphoma. (2020-10-13)

Scientists develop new precise therapeutic leukemia vaccine
Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences and Zhujiang Hospital of Southern Medical University have developed a new type of precise therapeutic vaccine against leukemia. It utilizes self-healing polylactic acid microcapsules for co-encapsulating a new epitope peptide and PD-1 antibody. (2020-10-12)

New biomarker to prevent graft-versus-host disease in stem cell transplants discovered
With more than $1.5 million in funding from the National Cancer Institute, MUSC Hollings Cancer Center researchers discovered a new biomarker, plasmacytoid dendritic cells expressing the ICOS ligand, whose activity can be blocked by the dual-acting drug candidate ALPN-101 to prevent graft-versus-host disease following hematopoietic stem cell transplantation. (2020-10-07)

Temple researchers discover drug resistance mechanism in leukemia, ID treatment strategy
In a new study, published online October 6 in the journal Cell Reports, scientists at the Lewis Katz School of Medicine at Temple University and researchers at multiple institutions in the United States and abroad, are the first to show that resistance to PARP inhibitors in leukemia can be overcome by combining PARP inhibition with blockade of TGFßR kinase activation. (2020-10-06)

Effects of acute and chronic graft-versus-myelodysplastic syndrome on long-term outcomes following a
A research group led by Assistant Professor Takaaki Konuma in the Department of Hematology/Oncology, the Hospital of the Institute of Medical Science, the University of Tokyo (IMSUT Hospital) has demonstrated a graft-versus-tumor (GVT) effect of a previously unknown/novel allogeneic hematopoietic cell transplantation in MDS patients. In addition, they succeeded in identifying a category of patients for whom the GVT effect was identified. (2020-10-06)

Latent lineage potential in neural stem cells enables spinal cord repair in mice
Spinal stem cells in mice can be reprogrammed to generate protective oligodendrocytes after spinal cord injury, enhancing neural repair, according to a new study. (2020-10-01)

New mechanism of cell survival in chronic lymphocytic leukemia
Researchers at The Wistar Institute unraveled a mechanism employed by chronic lymphocytic leukemia (CLL) cells for their survival. (2020-09-30)

Oncotarget: NRXN1 as a novel potential target for small cell lung cancer
The cover for issue 39 of Oncotarget features Figure 4, ''Apoptosis assay of NRXN1-targeted ADC at IC50 dose calculated by growth inhibition curves,'' by Yotsumoto, et al. which reported that the authors identified transmembrane proteins overexpressed specifically in SCLC with little or no expression in normal tissues and decided to focus on the cell adhesion molecule neurexin-1. (2020-09-30)

Scientists kill cancer cells by 'shutting the door' to the nucleus
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes--large channels that control the flow of materials in and out of the cell nucleus--shrank aggressive tumors in mice while leaving healthy cells unharmed. The study, published in Cancer Discovery, a journal of the American Association for Cancer Research, reveals a new Achilles heel for cancer that may lead to better treatments for deadly tumors such as melanoma, leukemia and colorectal cancer. (2020-09-28)

Unconventional T cell subset enriched in airways of some patients with severe COVID-19
Unconventional T cells called mucosa-associated invariant T (MAIT) cells are recruited to the airways and strongly activated in some patients with severe COVID-19, a new study has found, suggesting the cells' possible involvement in the development of disease. (2020-09-28)

New way to halt leukemia relapse shown promising in mice
Drugs tackling chronic myelogenous leukemia have completely transformed prognoses of patients over the last couple of decades, with most cases going into remission. But drug resistance can occur, leading to relapses. Targeting the lipids involved in regulating part of a leukemia stem cell's life span offers a potential second route to defeat the disease--and solid tumorous cancers as well. (2020-09-18)

Super-potent blood stem cells discovered in human embryos
In research recently published in Stem Cell Reports, Andrejs Ivanovs, Alexander Medvinsky (a.medvinsky@ed.ac.uk) and colleagues from the University of Edinburgh discovered that HSCs from early human embryos, when HSCs are just starting to form, are more robust at expanding than those from the cord blood. (2020-09-17)

New study estimates nearly 90,000 cancer cases diagnosed in adolescents and young adults
A new report examining cancer in adolescents and young adults (AYAs), defined as diagnoses occurring during ages 15 to 39, provides updated estimates of the contemporary cancer burden in this age group, predicting that 89,500 cases and 9,270 deaths will occur in 2020 in the United States. (2020-09-17)

A 'cell-less' therapy may regenerate heart tissue without cell transplant risks
Ling Gao and colleagues have developed a strategy that uses exosomes - tiny membrane-bound sacs secreted by cells - to mimic the heart-regenerating effects of cardiac cell transplants, while potentially avoiding risks associated with whole-cell transplants. (2020-09-16)

The Josep Carreras Institute identifies a marker of poor evolution in Hodgkin's lymphoma
Dr. Manel Esteller, director of the Josep Carreras Leukemia Research Institute, published today in Blood journal, the discovery of a marker that allows predicting which patient with Hodgkin's lymphoma will present the aggressive clinical course, and will therefore be a case of special risk. (2020-09-15)

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