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Current Leukemia Cells News and Events, Leukemia Cells News Articles.
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AACR: Breast cancer stem cells radicalize normal neighbors for purpose of metastasis
A University of Colorado Cancer Center study presented at the American Association for Cancer Research Annual Meeting 2016 shows that stem-like breast cancer cells secrete molecules that allow neighboring, otherwise anchored cells to metastasize. (2016-04-18)

St. Jude Children's Research Hospital research at AACR Annual Meeting
The American Association for Cancer Research annual meeting features the work of St. Jude researchers. (2016-04-15)

Spotting DNA repair genes gone awry
Researchers led by Ludwig Cancer Research scientist Richard Kolodner have developed a new technique for sussing out the genes responsible for helping repair DNA damage that, if left unchecked, can lead to certain cancers. (2016-04-13)

Discovered a protein that spreads cancer
Aggressive cancer cells spread from a tumor to another part of the body through the blood vessel. To be able get in and out of the blood vessel, the cancer cell needs to penetrate tissue. Researchers from The University of Bergen have discovered a protein that the cancer cell uses like scissors to cut up tissue, so it can spread from a tumor to a new organ. (2016-04-13)

New public repository of patient-derived cancer models aims to improve drug testing
Testing experimental cancer drugs in mouse models with patient-derived tumors could reduce the high failure rate of drugs in early clinical trials, according to a report from Dana-Farber Cancer Institute scientists. (2016-04-11)

Improving models of chronic lymphocytic leukemia
In this issue of JCI Insight, Nicholas Chiorazzi and colleagues at the Feinstein Institute for Medical Research sought to understand a model of chronic lymphocytic leukemia in which patient cancer cells are transplanted into immunocompromised mice. (2016-04-07)

New study implicates unusual class of circular RNAs in cancer
Cancer cells are notorious for their genomes gone haywire, often yielding fusion proteins -- mash-ups of two disparate genes that, once united, assume new and harmful capabilities. Exactly how such genome scrambling impacts RNA, particularly the vast and mysterious world of non-coding RNA, has been largely unexplored. (2016-03-31)

CHOP oncologist receives $1 million Hyundai Quantum Grant to improve leukemia treatment
A physician-researcher at The Children's Hospital of Philadelphia has received a $1 million Hyundai Quantum Grant from Hyundai Hope on Wheels to advance treatment for a high-risk form of childhood leukemia. The research focuses on immunotherapy -- an approach that utilizes a patient's immune system to better fight off cancer. (2016-03-30)

New mouse model for acute myeloid leukemia opens door to research, possible treatments
A novel mouse model of a highly lethal form of acute myeloid leukemia (AML) offers a new tool for scientists working to better understand this disease and research new therapeutic targets. (2016-03-30)

Children's Hospital Los Angeles initiates clinical trial for treatment-resistant leukemia
The Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles is one of the first sites in the world to offer a promising new investigational therapy to treat pediatric acute lymphoblastic leukemia (ALL). The most common cancer diagnosed in children, ALL accounts for 25 percent of pediatric malignancy. Although the cure rate is high for pediatric ALL, the disease remains a leading cause of cancer related mortality in children. (2016-03-29)

New hope for a type 2 diabetes cure
A research team, led by Professor Jang Hyun Choi (School of Life Sciences) of UNIST discovered Gleevec, which is used in leukemia medications, holds promise for a dramatically more effective treatment of type 2 diabetes. (2016-03-27)

Most individuals harbor B cells sensitive to HIV-fighting immunogen
Researchers have identified a relatively potent immunogen that could be harnessed to induce the immune system to target HIV. (2016-03-24)

Prooxidants may fix metabolic defect in arthritis-driving T cells
Researchers have uncovered a metabolic defect that spurs T cells to go rogue in rheumatoid arthritis patients. (2016-03-23)

Lymphoma overrides a key protein's quadruple locks
Protein chemists at Johns Hopkins report they are closer to explaining why certain blood cancers are able to crack a molecular security system and run rampant. (2016-03-22)

A healthy gut could help prevent deadly side effect of bone marrow transplant
Researchers found a metabolite in the gut microbiome that could improve outcomes after bone marrow transplant. Butyrate was significantly reduced in the intestinal tract of experimental mice that received bone marrow transplant. When the researchers increased butyrate in these mouse models, they saw a decrease in the incidence and severity of graft vs. host disease. (2016-03-21)

A quartet of genes controls growth of blood stem cells
An important element in getting blood stem cells to multiply outside the body is to understand which of the approximately 20,000 genes in the human body control their growth. A research team at Lund University in Sweden has studied close to 15,000 of these genes alongside each other. The researchers have succeeded in identifying four key genes which, together, govern the growth and multiplication of the stem cells. The study is now being published in the journal Cell Reports. (2016-03-21)

Drug makes stem cells become 'embryonic' again
If you want to harness the full power of stem cells, all you might need is an eraser -- in the form of a drug that can erase the tiny labels that tell cells where to start reading their DNA. In a surprising new finding, scientists have shown that mouse stem cells treated with the drug reverted to an 'embryonic' state. (2016-03-17)

CIRM grant to fund proposed stem cell trials for ALS
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine approved yesterday a $6.3 million grant to a research team from the University of California, San Diego School of Medicine and University of California, Davis to pursue a novel human embryonic stem cell-based therapy to rescue and restore neurons devastated by amyotrophic lateral sclerosis or ALS. (2016-03-17)

Identification of a novel tyrosine kinase inhibitor for acute myeloid leukemia
A new study in JCI Insight reports the development of a new drug that targets both resistant tumors and FLT3-independent acute myeloid leukemia. (2016-03-17)

Reprogramming bone tumors
There exist several oncogenes that drive cancer. In many cases, however, the oncogenes themselves are not sufficient and must be complemented with other mutations before cancer develops. Researchers at the Center for iPS Cell Research and Application, Kyoto University, use cell reprogramming technology to revert cancer cells to a stem cell state. The researchers show that dysfunctional differentiation in conjunction with a specific oncogene could explain the cause of certain bone cancers. (2016-03-17)

Using generic cancer drug could save many millions of dollars
With the expiration in January of the patent on Gleevec, the drug that 15 years ago changed chronic myeloid leukemia from a death sentence to a treatable illness, insurance companies and patients have the opportunity to realize huge cost savings, new Johns Hopkins Bloomberg School of Public Health research suggests. (2016-03-15)

Leukemia study reveals role of RNA binding protein in driving cancer
A study of gene expression in leukemia cells has identified an RNA binding protein that plays an important role in driving the development of cancer. The protein is normally active in fetal tissue and switched off in adults, but it is reactivated in some cancer cells. This expression pattern makes it an attractive target for cancer-fighting drugs, because blocking its activity is unlikely to cause serious side effects. (2016-03-14)

Cellular protein plays important role in aggressive childhood cancer
UCLA scientists have uncovered how a cellular protein contributes to an aggressive form of leukemia prevalent in young children. The discovery is an important step forward in the effort to better understand and treat aggressive childhood leukemia. (2016-03-14)

Timing the treatment of cancer cells
Timing may not be everything, but it could be important in understanding why an anticancer treatment like radiation produces different results against cancer cells, according to a new study by Sheng-hong Chen and colleagues. (2016-03-10)

Protein increases signals that protect cancer cells, Stanford study finds
Researchers have identified a link between the expression of a cancer-related gene and cell-surface molecules that protect tumors from the immune system. (2016-03-10)

New class of drugs specifically induces cell death in B cell blood cancers
New research from The Wistar Institute shows how one protein found on the endoplasmic reticulum can serve as a target for stimulating the immune system and a more direct target for cellular death in B cell malignancies. (2016-03-10)

Blood stem cells study could pave the way for new cancer therapy
People with leukaemia could be helped by new research that sheds light on how the body produces its blood supply. (2016-03-10)

Mount Sinai researchers report insights into blood stem cells from engineered stem cells
Building upon previous work, researchers at the Icahn School of Medicine at Mount Sinai have identified a precursor cell in the placenta and embryo of mice that can be matured in the lab to make hematopoietic stem/progenitor cells (2016-03-08)

Alliance for Cancer Gene Therapy announces three new grant awardees for cancer research
Alliance for Cancer Gene Therapy announces three new research grants into Leukemia/Lymphoma, Melanoma and Blood Cancers using cell, gene and immunotherapy. (2016-03-07)

New drug class offers potential new treatment for lethal bacteria
A new class of drugs has shown promise for treating the bacteria that cause legionnaires' disease, a potentially fatal lung infection. (2016-03-07)

Mechanism discovered for mosaic pattern of cells in the nasal cavity
Every cell in our bodies has its proper place, but how do they get there? A Japanese research group discovered the mechanism for a mosaic pattern formation of two different cell types. Their discovery has potentially broad applications as a common principle for determining pattern formation in different types of cell. The findings were published in 'The Journal of Cell Biology' on Feb. 29, 2016. (2016-03-02)

Ottawa researchers find Achilles' heel of a severe form of childhood leukemia
Researchers at The Ottawa Hospital and the University of Ottawa have found the Achilles' heel of one of the most aggressive forms of leukemia that affects both children and adults. They have also identified a possible new treatment that exploits this fatal weakness. (2016-03-02)

Study may widen patient pool that benefits from EPZ-5676 against acute myeloid leukemia
A University of Colorado Cancer Center study published today in the Journal of Clinical Investigation unpacks mechanism that gene MN1 uses to cause an aggressive AML subtype. Drugs targeting weak link in the chain of causation are in clinical trials for other subtypes. (2016-02-29)

Immune cell 'switch' discovery raises hopes in cancer fight
Walter and Eliza Hall Institute researchers have discovered the mechanism that drives specialised immune cells that detect and kill cancer cells in the body, offering scientists a new way to develop potential drug targets and cancer treatments. (2016-02-26)

Potential association between pre-labor cesarean delivery and childhood leukemia IDed
A potential correlation between pre-labor cesarean delivery (PLCD) and acute lymphoblastic leukemia (ALL) could offer new targets for cancer prevention research, according to new research from the Masonic Cancer Center, University of Minnesota. (2016-02-26)

Molecular 'brake' prevents excessive inflammation
Inflammation is a Catch-22: the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and sometimes leading to organ failure and death. Researchers at University of California, San Diego School of Medicine have discovered that a protein known as p62 acts as a molecular brake to keep inflammation in check and avoid collateral damage. (2016-02-25)

CAR trials drive leukemia and lymphoma treatment in new direction
Cancer immunology is based upon boosting the body's own immune system to vanquish malignancies. It is among the fastest growing areas of oncology research. Researchers at UC San Diego Moores Cancer Center have launched three clinical trials to test the safety and efficacy of a novel cellular-immunotherapy that uses modified T cells -- one of the immune system's primary weapons -- to treat three different types of blood cancer that often defy existing therapies. (2016-02-23)

DNA 'Trojan horse' smuggles drugs into resistant cancer cells
Drug-resistant leukemia cells absorb a drug and die, when the drug is hidden inside a capsule made of folded up DNA. (2016-02-23)

Researchers pinpoint potential enzyme for T-cell leukemia treatment
For the first time, researchers at Boston University have shown that T-cell leukemia cells use a particular cycle, called the TCA or Kreb cycle, to support their growth and survival. (2016-02-22)

Scientists discover secret to promising new cancer drug
Australian researchers have resolved a mystery about how a promising new class of anti-cancer drugs, called nutlins, work -- paving the way for improving the future of cancer treatment. (2016-02-19)

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