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Current Leukemia News and Events, Leukemia News Articles.
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Key gene in leukemia discovered
Acute myeloid leukemia (AML) is one of the most common forms of blood cancer among adults and is associated with a low survival rate, and leads to the inhibition of normal blood formation. (2020-06-03)
Discovery in human acute myeloid leukemia could provide novel pathway to new treatments
Researchers at Mount Sinai have discovered that human acute myeloid leukemia (AML) stem cells are dependent on a transcription factor known as RUNX1, potentially providing a new therapeutic target to achieve lasting remissions or even cures for a disease in which medical advances have been limited. (2020-06-02)
Combination therapy well-tolerated and highly effective for patients with IDH1-mutated AML
A combination therapy of ivosenidib (IVO) plus venetoclax (VEN) with or without azacitidine (AZA) was found to be effective against a specific genetic subtype of acute myeloid leukemia (AML) in a Phase Ib/II trial led by researchers at The University of Texas MD Anderson Cancer Center. (2020-05-28)
At the crossroads
In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. (2020-05-20)
Assassin cells armed with anticancer drugs kill cancer masses
POSTECH Professor Won Jong Kim's team uses immunological synapse formation of natural killer cells to treat cancer. (2020-05-13)
More selective elimination of leukemia stem cells and blood stem cells
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. (2020-05-08)
E1912 trial leads to FDA approval of ibrutinib-rituximab combo for untreated CLL
Patients aged 70 or younger with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma have a new treatment option -- a combination of the targeted agent ibrutinib with the immunologic agent rituximab. (2020-04-29)
Drug prevents severe cardiac events in children undergoing chemotherapy for AML
The cardioprotective drug dexrazoxane preserved cardiac function in pediatric patients undergoing chemotherapy for acute myeloid leukemia (AML) without compromising overall patient survival and potentially improving it, according to a new study by researchers at Children's Hospital of Philadelphia (CHOP). (2020-04-28)
Discovered the physiological mechanisms underlying the most common pediatric Leukemia
Researchers from the Josep Carreras Leukaemia Research Institute unveil the mechanisms that lead to hyperdiploid Acute Lymphoblastic Leukemia, Hyper D-ALL, the most common pediatric B-cell Leukaemia. (2020-04-23)
Finding leukemia's weakness using genome-wide CRISPR technology
Researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia. (2020-04-20)
What's old is new again
Drug resistance is a major obstacle in cancer treatment--leading to relapse for many patients. (2020-04-20)
Impact of donor lymphocyte infusion and intensified conditioning for relapsed/refractory leukemia
Leukemia relapse is still a major problem that impedes the success of hematopoietic cell transplant (HCT). (2020-04-15)
Cancer mutation in dual role
Researchers show that an oncogenic mutation in leukemia cells also promotes inflammations in the body (2020-04-08)
Scientists modify CAR-T cells to target multiple sites on leukemia cells
In a preclinical study, scientists engineer new CAR-T cells to attack three sites on leukemia cells, instead of one. (2020-03-31)
Oncotarget Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment
Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest. (2020-03-26)
Engineers model mutations causing drug resistance
Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and 'second generation' approaches are needed. (2020-03-24)
3D genetic structure in blood cancer important beyond DNA code changes
Children with aggressive blood cancers have differences -- not just in the DNA code of their blood cells -- but also in the heavily twisted protein superstructure that controls access to genes. (2020-03-23)
Oncotarget Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity
Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors. (2020-03-20)
Oncotarget Acute promyelocytic leukemia (APL): a review of the literature
Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem. (2020-03-20)
St. Jude finds cancer drug resistance genes and possibly how to limit their effects
Drug resistance is a leading cause of cancer death in children and adults with leukemia. (2020-03-09)
New genetic signatures in childhood leukemia create paths for precision medicine
Researchers with Nemours Children's Health System utilized Next Generation Sequencing (NGS) to more precisely identify genomic characteristics of leukemias in children, the most common childhood cancer. (2020-03-05)
Cancer survival rates improve for young adults
A new study in the Journal of the National Cancer Institute finds improvements in five-year survival rates for all cancers in young adults. (2020-03-03)
Five-year survival improves for certain cancers in adolescent and young adults
The five-year survival rate for adolescents and young adults with cancer has significantly improved from 1975 to 2005 in the United States overall, but this was not the case for all cancers, according to a report in the Journal of the National Cancer Institute. (2020-03-03)
Study reveals properties of cells fated to relapse in acute lymphoblastic leukemia
Researchers have found that genetically defined subpopulations of leukemia cells present at diagnosis have distinct characteristics that lead to relapse. (2020-03-03)
A randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared...
The objective of this study was to compare the safety and antitumor activity of F14512 and etoposide phosphate in dogs with spontaneous non-Hodgkin lymphoma and to investigate the potential benefit of F14512 in P-glycoprotein overexpressing lymphomas. (2020-02-19)
Mutation's role in blood cancers revealed by ideal team-up
Researchers from CSHL and MSKCC have determined that a mutation affecting the important process of RNA splicing can manipulate the 'quality control' in your cell. (2020-01-31)
Single-cell sequencing of CLL therapy: Shared genetic program, patient-specific execution
Researchers at the CeMM Research Center for Molecular Medicine and partners in Budapest have studied the response to targeted leukemia therapy in unprecedented detail, using single-cell sequencing and epigenetic analysis. (2020-01-29)
Male fertility after chemotherapy: New questions raised
Professor Delbès, who specializes in reproductive toxicology, conducted a pilot study in collaboration with oncologists and fertility specialists from the McGill University Health Centre (MUHC) on a cohort of 13 patients, all survivors of pediatric leukemia and lymphoma. (2020-01-22)
Cheap drug may alleviate treatment-resistance in leukemia
A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), one of the most common forms of blood cancer. (2020-01-17)
Partnership with China prompts change in care for high-risk type of leukemia
Findings from a collaborative clinical trial have generated key insights into how targeted therapy should be used to treat leukemia driven by the Philadelphia chromosome. (2020-01-16)
Cancer study may accidentally help researchers create usable blood stem cells
University of Colorado Cancer Center study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort to make personalizable, durable blood stem cells. (2020-01-16)
Research collaboration reveals promising drug candidate for treatment of blood cancers
An international research collaboration between the United States and Australia has revealed a promising new drug which could treat high-risk leukemia. (2020-01-15)
Vitamin B6, leukemia's deadly addiction
Researchers from CSHL and Memorial Sloan Kettering Cancer Center have discovered how Acute Myeloid Leukemia is addicted to vitamin B6. (2020-01-13)
Closer to identifying leukemic stem cells
Researchers at the Josep Carreras Leukaemia Research Institute have developed innovative diagnostic trials to identify cells resistant to leukemia treatment. (2020-01-02)
Artificial intelligence tracks down leukemia
Artificial intelligence can detect one of the most common forms of blood cancer - acute myeloid leukemia -- with high reliability. (2019-12-20)
When cells cycle fast, cancer gets a jumpstart
Yale researchers have now identified another bit of cellular chicanery that jumpstarts cancer. (2019-12-18)
Acute leukemia patients treated with common therapy have increased risk for heart failure
Patients with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) who are treated with anthracyclines are at a heightened risk of heart failure -- most often within one year of exposure to the chemotherapy treatment, according to a new study led by researchers at Penn Medicine. (2019-12-17)
Promising new approach to treating some of the worst types of leukaemia
'New therapeutic approaches are desperately needed for MLL-r leukaemia,' said Professor Richard Lock, Head of the Blood Cancers Theme at Children's Cancer Institute, Australia. (2019-12-11)
Immunotherapy drug improves outcomes for some children with relapsed leukemia
New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia (B-ALL) that has relapsed. (2019-12-10)
Research revises classification of acute myeloid leukemia & myelodysplastic syndrome
Findings presented as a late-breaking abstract at the American Society of Hematology annual meeting by St. (2019-12-10)
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