Current Liver Disease News and Events

Current Liver Disease News and Events, Liver Disease News Articles.
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Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases. (2021-01-27)

A stem cell based cell culture model for nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a widespread condition in the Western World. In order to improve our understanding of the basic mechanisms underlying the etiology of NAFLD, Dr. Nina Graffmann, Prof. James Adjaye and the team of the Institute for Stem Cell research and Regenerative Medicine, University Hospital Duesseldorf, differentiated induced pluripotent stem cells (iPSCs) derived from healthy donors and NAFLD patients into hepatocyte-like cells (HLCs). (2021-01-25)

The liver processes coconut oil differently than rapeseed oil
Coconut oil has increasingly found its way into German kitchens in recent years, although its alleged health benefits are controversial. Scientists at the University of Bonn have now been able to show how it is metabolized in the liver. Their findings could also have implications for the treatment of certain diarrheal diseases. The results are published in the journal Molecular Metabolism. (2021-01-25)

ACSL1 as a main catalyst of CoA conjugation of propionic acid-class NSAIDs in liver
Researchers from Kanazawa University have found that propionic acid-class nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, form ''conjugates'' with coenzyme A (CoA) by one of the acyl-CoA synthetases, ACSL1, in liver. These conjugates have the covalent binding ability to cellular proteins that may lead to liver injury, a rare severe side effect of NSAID treatment. This knowledge could help pharmaceutical companies to generate pain control options with fewer risks of severe side effects. (2021-01-22)

CT identifies patients with high-risk nonalcoholic fatty liver disease (NAFLD)
According to ARRS' American Journal of Roentgenology, Fibrosis-4 and multiple CT findings can identify patients with high-risk nonalcoholic fatty liver disease--advanced fibrosis or cirrhosis, that is--though the presence of nonalcoholic steatohepatitis remains elusive on CT. (2021-01-22)

Researchers study what happens to your body during tailgating
Football watch parties are synonymous with eating fatty foods and drinking alcohol. Have you ever wondered what all of that eating and drinking does to your body? Researchers from the University of Missouri School of Medicine simulated a tailgating situation with a small group of overweight but healthy men and examined the impact of the eating and drinking on their livers using blood tests and a liver scan. (2021-01-20)

Green med diet cuts non-alcoholic fatty liver disease by half - Ben-Gurion U. study
Overall, the green MED diet produced dramatic reductions in fatty liver. NAFLD prevalence dropped from 62% at baseline to 31.5% in the green Mediterranean group, down to 47.9% in the Mediterranean group and 54.8% in the healthy dietary regimen group. Addressing this common liver disease by targeted lifestyle intervention might promote a more effective nutritional strategy. This Ben-Gurion University of the Negev clinical trial demonstrates an effective nutritional tool for NAFLD beyond weight loss (2021-01-18)

Armouring anti-cancer T cells against immunosuppressants
New 'armoured' T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection. (2021-01-18)

Scoring system to redefine how U.S. patients prioritized for liver transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (2021-01-13)

Discovery of a new approach to inhibiting a highly treatment-refractory liver cancer
Blocking placental growth factor (PlGF), a member of the vascular endothelial growth factor family, inhibits the progression of intrahepatic cholangiocarcinoma (ICC) and enhances the efficacy of chemotherapy in mouse models. This novel approach to targeting the connective tissue microenvironment of ICC, a rare but notoriously treatment-resistant form of liver cancer, could pave the way for combination therapies, including chemotherapy and immune checkpoint blockade. (2021-01-12)

Non-Hispanic Black patients are disproportionately left off liver transplant waitlists
A new study of liver transplant centers confirms that non-Hispanic white patients get placed on liver transplant waitlists at disproportionately higher rates than non-Hispanic Black patients. (2021-01-11)

How the circadian clock regulates liver genes in time and space
EPFL scientists have carried out the first comprehensive study of how genes in the liver perform their metabolic functions in both space and time of day. Monitoring almost 5000 genes at the level of the individual cell across a 24-hour period, the researchers have modelled how the circadian clock and liver functions crosstalk throughout the day in sync with the feeding-fasting cycle. (2021-01-11)

Liver cancer cells manipulate stromal cells involved in fibrosis to promote tumor growth
Researchers led by Osaka University have found that liver cancer cells induce autophagy in hepatic stellate cells, causing them to produce a growth factor called GDF15 that promotes tumor growth. GDF15 was more highly expressed in tumor tissue than normal liver tissue, and patients with higher levels of GDF15 had a poorer prognosis. New therapies targeting GDF15 may help prevent the development and proliferation of hepatocellular carcinoma. (2021-01-06)

Study explains why patients with cancer spread to the liver have worse outcomes
A new study finds that tumors in the liver siphon off critical immune cells, rendering immunotherapy ineffective. But coupling immunotherapy with radiotherapy to the liver in mice restored the immune cell function and led to better outcomes. (2021-01-04)

Frailty is a factor in higher mortality for women awaiting liver transplants
Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this gender gap. (2020-12-30)

New study: available drugs can prevent rejection and tissue injury after transplantation
Controlling inflammation after transplantation of organs, cells, or tissues is critical for graft survival; however, it can be difficult. Continuing injuries due to chronic rejection can be particularly problematic. Now, a team of researchers from Albert Einstein College of Medicine report that neutralizing the cell signaling molecule, tumor necrosis factor (TNF), can prevent cascades of injurious molecules and signals after cell transplantation in The American Journal of Pathology, published by Elsevier. (2020-12-21)

Protecting against atherosclerosis at the molecular level
Researchers from the University of Tsukuba identified a novel mechanism by which CREB3L3 protects against atherosclerosis. By studying the absence or overexpression of the protein in mice prone to develop atherosclerosis, the researchers demonstrated that the absence of CREB3L3 exacerbates the formation of atherosclerosis, whereby the overexpression protects against atherosclerosis. At the molecular level, CREB3L3 exhibited its protective effects by inhibiting SREBP. This study could help develop a novel molecular target against atherosclerosis. (2020-12-20)

In liver, a stressed cell can be bad news for its neighbors
When a stressed liver cell starts communicating with its neighbors, it can send stress signals to neighboring cells, causing significant problems that can lead to fatty liver disease and metabolic disease. (2020-12-18)

Gene biomarkers indicate liver toxicity quickly and accurately
When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval. This testing usually involves lengthy and expensive animal studies. A research team at University of Illinois has developed a gene biomarker identification technique that cuts the testing process down to a few days while maintaining a high level of accuracy. (2020-12-18)

UMD paves the way for growing human organs for transplantation with new proof-of-concept
With the number of people who suffer from organ failures and the growing need for available organs for transplant, finding a new way to provide organs and therapeutic options to transplant patients is a critical need. In a new paper, University of Maryland researchers show for the first time that newly established stem cells from pigs could provide a solution, laying the groundwork for growing transplantable human organs. (2020-12-17)

Patients with COVID-19 and obesity have poor outcomes not driven by inflammation
Obesity is associated with poor COVID-19 outcomes but a new study suggests this is not due to increased inflammation, but instead may be driven by respiratory issues or other factors. (2020-12-16)

A first-in-human clinical trial shows microbubbles augments radiation in liver cancer patients
Bursting gas-filled microbubbles using ultrasound waves sensitizes tumors to targeted radiation, reducing tumor growth and improving overall survival after treatment. (2020-12-15)

Novel MRI contrast agent sidesteps toxic effects of current products
Researchers are developing an alternative MRI contrast agent based on manganese, an essential element in human nutrition, that is easily processed and eliminated by the body. Manganese has magnetic properties similar to those of gadolinium, but without gadolinium's toxicity. (2020-12-15)

Effects of organohalogen pollution are coded in gene expression profiles of Baltic salmon
Researchers of Ehime University and the University of Helsinki measured hepatic organohalogen (OHC) concentrations and gene expression profiles in Atlantic salmon collected from three areas in the Baltic Sea. The results showed that OHCs and gene expression profiles were individually grouped in three areas and the covariation of the two datasets provided by a multivariate method was significantly similar. This suggests that the gene expression profiles in salmon are affected by OHC contamination. (2020-12-15)

Screening for endocrine disruption in artificial zebrafish for long-term risk assessment
the Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Young Jun Kim, leader of environmental safety at KIST Europe, and Professor Hyunjoon Kong from the University of Illinois at Urbana-Champaign tried to develop the long-term toxicity and risks by cultivating organoids that mimic the liver of zebrafish. (2020-12-11)

Beta-blockers display anti-inflammatory effects in advanced liver disease
Beta-blockers are used to prevent internal bleeding in patients with liver cirrhosis and portal hypertension. Researchers from MedUni Vienna have now shown that Beta-blockers also have beneficial effects on systemic inflammation and this translates into improved clinical outcomes. (2020-12-10)

Researchers discover treatment that suppresses liver cancer
Researchers from the University of Missouri School of Medicine have discovered a treatment combination that significantly reduces tumor growth and extends the life span of mice with liver cancer. This discovery provides a potentially new therapeutic approach to treating one of the leading causes of cancer-related death worldwide. (2020-12-08)

A library of mice to look up the best liver cancer treatment
Researchers from Osaka University have developed a mouse model that reproduces the real-world variety of genetic drivers of liver cancer, and used this model to discover that tumors driven by the gene FGF19 are especially vulnerable to treatment with the drug lenvatinib. They also found a serum biomarker that may help indicate which patients have this specific type of cancer, potentially leading to improved treatment selection and outcomes. (2020-12-07)

Synthetic biology and machine learning speed the creation of lab-grown livers
Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine learning algorithm to create human liver organoids with blood and bile handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life. (2020-12-07)

Amino acid connected to NAFLD could provide treatment clues
Basic science research explores the effects of impaired glycine metabolism in nonalcoholic fatty liver disease - and how to potentially use glycine-based treatment to help people with NAFLD. (2020-12-03)

Sensor can detect scarred or fatty liver tissue
MIT engineers have now developed a diagnostic tool, based on nuclear magnetic resonance (NMR), that could be used to detect both fatty liver disease and liver fibrosis. (2020-12-02)

Liver cirrhosis: Disease progression
Patients with liver cirrhosis display a wide range of clinical symptoms. A prospective study conducted by MedUni Vienna has now shown that blood levels of biomarkers for systemic inflammation increase over the various stages of the disease and can predict the development of complications, even in previously asymptomatic patients. (2020-11-30)

Combination therapy might improve outcomes in treatment-resistant liver cancer
A combination cancer therapy that is effective against treatment-resistant hepatocellular carcinoma (HCC) by inhibiting tumor growth and increasing survival has been identified by researchers at Massachusetts General Hospital. The dual therapy -- which combines the multikinase inhibitor drug regorafenib to ''reprogram'' the tumor immune microenvironment, and programmed cell death 1 antibodies to stimulate anti-tumor immunity -- improved survival in mouse models of HCC beyond what each therapy could have achieved alone. (2020-11-30)

Plant-based diet ramps up metabolism, according to new study
A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine. (2020-11-30)

Liver cancer ten times more likely in men with common genetic disorder haemochromatosis
Men who have the Western world's most common genetic disorder, haemochromatosis, are ten times more likely to develop liver cancer, according to a major new study. (2020-11-24)

Study: gut hormones' regulation of fat production abnormal in obesity, fatty liver disease
Gut hormones play an important role in regulating fat production in the body. One key hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver, but this regulation is abnormal in obesity, researchers at the University of Illinois Urbana-Champaign found in a new study. (2020-11-24)

Breakthrough in studying the enzyme that ultimately produces fish odour syndrome
Fish odour syndrome (trimethylaminuria) is a debilitating disease, in which the liver cannot break down the smelly chemical trimethylamine which is produced by enzymes from bacteria residing in the gut leaving people with a fish like odour. Researchers from the University of Warwick are paving the way to prevent the syndrome after a breakthrough in studying the enzyme in the gut which produces trimethylamine. (2020-11-23)

Antimicrobial soap additive worsens fatty liver disease in mice
Triclosan, an antimicrobial found in many soaps and other household items, worsens fatty liver disease in mice fed a high-fat diet. (2020-11-23)

A gene mutation that protects against disease
Called PCSK9Q152H, the mutation of the PCSK9 gene was initially thought to protect against cardiovascular diseases. Recent studies reveal that it may protect against other human illnesses, mainly liver diseases. It may allow the PCSK9Q152H mutant subjects to stay in good health and live longer. (2020-11-19)

Maraxilibat reduces debilitating itching in children with Alagille syndrome
On behalf of Childhood Liver Disease Research Network (ChiLDReN), Texas Children's Hospital and Baylor College of Medicine researchers report that prolonged treatment with Maraxilibat resulted in clinically meaningful improvements in debilitating itching (pruritus) and related quality of life outcomes in children with Alagille syndrome. The novel pharmacological approach addresses a major unfulfilled therapeutic need to control severe and relentless itching in pediatric patients with Alagille syndrome. (2020-11-19)

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