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Current Liver Failure News and Events, Liver Failure News Articles.
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New study: available drugs can prevent rejection and tissue injury after transplantation
Controlling inflammation after transplantation of organs, cells, or tissues is critical for graft survival; however, it can be difficult. Continuing injuries due to chronic rejection can be particularly problematic. Now, a team of researchers from Albert Einstein College of Medicine report that neutralizing the cell signaling molecule, tumor necrosis factor (TNF), can prevent cascades of injurious molecules and signals after cell transplantation in The American Journal of Pathology, published by Elsevier. (2020-12-21)

Protecting against atherosclerosis at the molecular level
Researchers from the University of Tsukuba identified a novel mechanism by which CREB3L3 protects against atherosclerosis. By studying the absence or overexpression of the protein in mice prone to develop atherosclerosis, the researchers demonstrated that the absence of CREB3L3 exacerbates the formation of atherosclerosis, whereby the overexpression protects against atherosclerosis. At the molecular level, CREB3L3 exhibited its protective effects by inhibiting SREBP. This study could help develop a novel molecular target against atherosclerosis. (2020-12-20)

In liver, a stressed cell can be bad news for its neighbors
When a stressed liver cell starts communicating with its neighbors, it can send stress signals to neighboring cells, causing significant problems that can lead to fatty liver disease and metabolic disease. (2020-12-18)

Gene biomarkers indicate liver toxicity quickly and accurately
When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval. This testing usually involves lengthy and expensive animal studies. A research team at University of Illinois has developed a gene biomarker identification technique that cuts the testing process down to a few days while maintaining a high level of accuracy. (2020-12-18)

Childhood intervention can prevent 'deaths of despair'
Mortality rates among young adults are rising in the US due in part to 'deaths of despair' -- preventable deaths from suicide, drug overdoses and alcohol-related liver disease. An intensive childhood intervention program called Fast Track could help reduce these deaths by reducing risky behaviors in adolescence and young adulthood, finds new research from Duke University and the Conduct Problems Prevention Research Group. (2020-12-17)

UMD paves the way for growing human organs for transplantation with new proof-of-concept
With the number of people who suffer from organ failures and the growing need for available organs for transplant, finding a new way to provide organs and therapeutic options to transplant patients is a critical need. In a new paper, University of Maryland researchers show for the first time that newly established stem cells from pigs could provide a solution, laying the groundwork for growing transplantable human organs. (2020-12-17)

Novel biomarkers predict the development of incident heart failure
Researchers at the University of Eastern Finland and Kuopio University Hospital have discovered several new biomarkers that are associated with incident heart failure. In a new study, several inflammatory biomarkers and cell energy metabolites were linked to an increased risk of incident heart failure. (2020-12-16)

A first-in-human clinical trial shows microbubbles augments radiation in liver cancer patients
Bursting gas-filled microbubbles using ultrasound waves sensitizes tumors to targeted radiation, reducing tumor growth and improving overall survival after treatment. (2020-12-15)

Effects of organohalogen pollution are coded in gene expression profiles of Baltic salmon
Researchers of Ehime University and the University of Helsinki measured hepatic organohalogen (OHC) concentrations and gene expression profiles in Atlantic salmon collected from three areas in the Baltic Sea. The results showed that OHCs and gene expression profiles were individually grouped in three areas and the covariation of the two datasets provided by a multivariate method was significantly similar. This suggests that the gene expression profiles in salmon are affected by OHC contamination. (2020-12-15)

Screening for endocrine disruption in artificial zebrafish for long-term risk assessment
the Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Young Jun Kim, leader of environmental safety at KIST Europe, and Professor Hyunjoon Kong from the University of Illinois at Urbana-Champaign tried to develop the long-term toxicity and risks by cultivating organoids that mimic the liver of zebrafish. (2020-12-11)

Predicting heart disease from the skin
Jefferson researchers find that the genetic underpinnings of a skin disorder at birth indicate future heart problems. (2020-12-10)

Beta-blockers display anti-inflammatory effects in advanced liver disease
Beta-blockers are used to prevent internal bleeding in patients with liver cirrhosis and portal hypertension. Researchers from MedUni Vienna have now shown that Beta-blockers also have beneficial effects on systemic inflammation and this translates into improved clinical outcomes. (2020-12-10)

Why failing hearts love hard workouts
High-intensity interval training strengthens the heart even more than moderate exercise does. Now researchers have found several answers to what makes hard workouts so effective. (2020-12-10)

Human egg cells are imperfect surprisingly often
More than 7% of human oocytes contain at least one exchangeless chromosome pair, demonstrating a remarkably high level of meiotic recombination failure, finds a study appearing December 10 in the American Journal of Human Genetics. The findings suggest that right from the get-go of human egg cell development, a striking proportion of oocytes are predestined to be chromosomally abnormal. But the frequency of exchangeless chromosomes is not affected by maternal age. (2020-12-10)

Large US study confirms COVID-19 complications: lung, kidney and cardiovascular issues
A large study of patients in the United States who contracted coronavirus disease 2019 (COVID-19) confirms many complications of the disease, according to new research in CMAJ (Canadian Medical Association Journal). (2020-12-08)

Researchers discover treatment that suppresses liver cancer
Researchers from the University of Missouri School of Medicine have discovered a treatment combination that significantly reduces tumor growth and extends the life span of mice with liver cancer. This discovery provides a potentially new therapeutic approach to treating one of the leading causes of cancer-related death worldwide. (2020-12-08)

A library of mice to look up the best liver cancer treatment
Researchers from Osaka University have developed a mouse model that reproduces the real-world variety of genetic drivers of liver cancer, and used this model to discover that tumors driven by the gene FGF19 are especially vulnerable to treatment with the drug lenvatinib. They also found a serum biomarker that may help indicate which patients have this specific type of cancer, potentially leading to improved treatment selection and outcomes. (2020-12-07)

Synthetic biology and machine learning speed the creation of lab-grown livers
Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine learning algorithm to create human liver organoids with blood and bile handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life. (2020-12-07)

Fracking sites may increase heart failure hospitalizations across large regions
Heart failure patients who live in communities affected by fracking are at increased risk for hospitalization, according to a study published in the Journal of the American College of Cardiology today. The study looked at the environmental exposure risk of thousands of heart failure patients across Pennsylvania. (2020-12-07)

Amino acid connected to NAFLD could provide treatment clues
Basic science research explores the effects of impaired glycine metabolism in nonalcoholic fatty liver disease - and how to potentially use glycine-based treatment to help people with NAFLD. (2020-12-03)

Sensor can detect scarred or fatty liver tissue
MIT engineers have now developed a diagnostic tool, based on nuclear magnetic resonance (NMR), that could be used to detect both fatty liver disease and liver fibrosis. (2020-12-02)

COVID-19 can impact young children's hearts
A 2-month-old infant diagnosed with COVID-19 experienced reversible myocardial injury and heart failure, similar to COVID-19 related heart issues seen in adults, according to a case published in JACC: Case Reports. The infant recovered with normal heart function and was discharged with no heart failure medications. (2020-12-02)

Women found to be at higher risk for heart failure and heart attack death than men
Researchers found women face a 20% increased risk of developing heart failure or dying within five years after their first severe heart attack compared with men. In addition, women were more likely than men to be older and have a more complicated medical history at the time of their heart attacks. (2020-11-30)

Liver cirrhosis: Disease progression
Patients with liver cirrhosis display a wide range of clinical symptoms. A prospective study conducted by MedUni Vienna has now shown that blood levels of biomarkers for systemic inflammation increase over the various stages of the disease and can predict the development of complications, even in previously asymptomatic patients. (2020-11-30)

Plant-based diet ramps up metabolism, according to new study
A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine. (2020-11-30)

Engineered "stealth bomber" virus could be new weapon against metastatic cancer
Researchers at Emory and Case Western Reserve have re-engineered an oncolytic adenovirus. The resulting virus is not easily caught by parts of the innate immune system, making systemic delivery possible without arousing a massive inflammatory reaction. (2020-11-25)

Less sedentary time reduces heart failure risk for older women
The more waking hours older women spend sitting or lying down, the more likely they are to require hospitalization for heart failure. The association between sedentary hours and heart failure was present in postmenopausal women with a variety of health conditions and strikingly, even among women who were active at guideline-recommended levels. (2020-11-24)

Study: gut hormones' regulation of fat production abnormal in obesity, fatty liver disease
Gut hormones play an important role in regulating fat production in the body. One key hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver, but this regulation is abnormal in obesity, researchers at the University of Illinois Urbana-Champaign found in a new study. (2020-11-24)

Treatment shows reduction in heart failure after myocardial infarction
Researchers at Baylor College of Medicine identified potential preventative therapies for heart failure after a significant heart attack. (2020-11-24)

Breakthrough in studying the enzyme that ultimately produces fish odour syndrome
Fish odour syndrome (trimethylaminuria) is a debilitating disease, in which the liver cannot break down the smelly chemical trimethylamine which is produced by enzymes from bacteria residing in the gut leaving people with a fish like odour. Researchers from the University of Warwick are paving the way to prevent the syndrome after a breakthrough in studying the enzyme in the gut which produces trimethylamine. (2020-11-23)

Antimicrobial soap additive worsens fatty liver disease in mice
Triclosan, an antimicrobial found in many soaps and other household items, worsens fatty liver disease in mice fed a high-fat diet. (2020-11-23)

A novel drug target for neonatal and infant heart failure
Researchers have identified a new druggable target for heart failure in neonates and infants. Approximately 60 percent of children born with congenital heart abnormalities will develop overt heart failure within the first year of life. The progression of heart failure in these infants is often rapid, with a high frequency of fatalities. Stimulation of this target significantly increased the cardiac contractility of newborns and infants in mice with few side effects. (2020-11-19)

A gene mutation that protects against disease
Called PCSK9Q152H, the mutation of the PCSK9 gene was initially thought to protect against cardiovascular diseases. Recent studies reveal that it may protect against other human illnesses, mainly liver diseases. It may allow the PCSK9Q152H mutant subjects to stay in good health and live longer. (2020-11-19)

Maraxilibat reduces debilitating itching in children with Alagille syndrome
On behalf of Childhood Liver Disease Research Network (ChiLDReN), Texas Children's Hospital and Baylor College of Medicine researchers report that prolonged treatment with Maraxilibat resulted in clinically meaningful improvements in debilitating itching (pruritus) and related quality of life outcomes in children with Alagille syndrome. The novel pharmacological approach addresses a major unfulfilled therapeutic need to control severe and relentless itching in pediatric patients with Alagille syndrome. (2020-11-19)

A case of pediatric heart failure caused by anomalous origin of the left coronary artery from the pulmonary artery
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0585, Lei Zhang, Tiewei Lv, Xiaoyan Liu, Chuan Feng, Min Zheng, Jie Tian and Huichao Sun from the Children's Hospital of Chongqing Medical University, Chongqing, China and the Chongqing Key Laboratory of Pediatrics, Chongqing, China consider a case of pediatric heart failure caused by anomalous origin of the left coronary artery from the pulmonary artery. (2020-11-19)

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy. (2020-11-18)

Normothermic Machine Perfusion (NMP) in rat livers extended from 6 to 24 hours
In a paper published in TECHNOLOGY, a team of researchers from Massachusetts General Hospital (MGH) have demonstrated 24-hour rat liver viability in a normothermic machine perfusion (NMP) system. Rat liver perfusion is an efficient and cost-effective method to study how various pharmacologic agents impact liver parenchyma. (2020-11-17)

Healthy sleep habits help lower risk of heart failure
Healthy sleep habits are associated with a lower risk of heart failure. Adults with the healthiest sleep patterns (morning risers, sleeping 7-8 hours a day and no frequent insomnia, snoring or excessive daytime sleepiness) experienced a 42% reduction in the risk of heart failure compared to those with unhealthy sleep patterns. (2020-11-16)

Liver condition identified in patients using urine samples: new research
Fifty fragments of proteins, termed peptides, have been identified in the urine of liver fibrosis patients in a new study that could pave the way for a potential diagnostic urine test for the condition if further validated. (2020-11-16)

Bursts of exercise can lead to significant improvements in indicators of metabolic health
Short bursts of physical exercise induce changes in the body's levels of metabolites that correlate to, and may help gauge, an individual's cardiometabolic, cardiovascular and long-term health, a study by Massachusetts General Hospital has found. Approximately 12 minutes of acute cardiopulmonary exercise impacted more than 80% of circulating metabolites, including pathways linked to a range of favorable health outcomes, thus identifying potential mechanisms that could contribute to a better understanding of cardiometabolic benefits of exercise. (2020-11-16)

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