Current Liver Failure News and Events | Page 25

Current Liver Failure News and Events, Liver Failure News Articles.
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Alcohol-related cirrhosis deaths skyrocket in young adults
Liver disease deaths jumped by 65 percent in the United States, from 1999-2016, disproportionately affecting adults ages 25-34. The increase in deaths among young adults was driven entirely by alcohol-related liver disease, according to a study by Michigan Medicine. (2018-07-18)

Death rates from heart failure higher for women than men
Death rates from heart failure are higher for women than men, and hospitalization rates have increased in women while declining in men, found a study from the University of Ottawa Heart Institute published in CMAJ (Canadian Medical Association Journal). (2018-07-16)

Genetic marker for drug risk in multiple sclerosis offers path toward precision medicine
A team of researchers has uncovered a specific gene variant associated with an adverse drug reaction resulting in liver injury in a people with multiple sclerosis (MS). It is the first time researchers have been able to establish a validated genetic marker for a drug-induced harm in people with MS. (2018-07-16)

Homology Medicines announces publication of in vivo gene editing data with nuclease-free technology
Homology Medicines, Inc., a genetic medicines company, announced today a peer-reviewed publication demonstrating that Homology's technology induces efficient and precise in vivo gene editing. The publication, by senior author Saswati Chatterjee, Ph.D., Department of Surgery, member of the Beckman Research Institute at City of Hope in California, and scientific co-founder of Homology, also highlights the platform's use of homologous recombination, the cells' natural DNA correction pathway, for nuclease-free gene editing. (2018-07-16)

Is surgery the best option for penetrating kidney trauma?
SLU surgeon Sameer A. Siddiqui, M.D., and his research team examined patient records to study the best approach for renal trauma injuries. (2018-07-13)

Why internal scars won't stop growing
A study has newly identified an immune trigger of some fibrotic diseases and an experimental compound to treat it. Fibrosis -- a progressive scarring and hardening of internal organs -- is estimated to cause 35 to 40 percent of deaths in the world. (2018-07-12)

Study highlights genetic risk of heart failure
Heart failure is known to be more common in certain families but whether this familial transition is caused by genetic or lifestyle factors. By studying adoptees in relation to both their biological parents and adoptive parents, a new population study in Sweden has found that genetic heritage is the dominant factor when it comes to heart failure in these families. (2018-07-12)

Hepatitis C vaccine could dramatically reduce transmission in people who inject drugs
Among the most serious consequences of the opioid epidemic is the spread of hepatitis C among injecting drug users. A study published in Science Translational Medicine shows that if a hepatitis C vaccine were successfully developed, it would dramatically reduce transmission of hepatitis C among drug users -- even though it's unlikely such a vaccine would provide complete immunity. (2018-07-11)

Pancreatic cancer: Mutable cancer cells are more dangerous
Pancreatic cancer often spreads, forming metastases in the liver or lungs. The prognosis is better for patients with metastases in the lungs. However, the organ that is more likely to be affected depends on the cancer cells' ability to alter their characteristics and shape -- as a research team at the Technical University of Munich (TUM) has discovered. (2018-07-09)

UAB researchers cure type 2 diabetes and obesity in mice using gene therapy
A single administration of a therapeutic vector in mouse models cures type 2 diabetes and obesity in the absence of long-term side effects. In healthy mice, the therapy prevents age-associated weight gain and insulin resistance and promotes healthy aging. The research constitutes the basis to support the future clinical translation of a gene therapy for these metabolic diseases in humans and is published today in EMBO Molecular Medicine. (2018-07-09)

New way to regenerate hearts after a heart attack
New research from the University of Oxford has revealed that an injection of a protein called VEGF-C can repair damaged hearts in mice, after a heart attack -- treated mice regained almost all of their heart function while untreated lost nearly half. (2018-07-09)

Simple test to predict rare cancers' likely spread
Circulating tumor cell clusters in the blood of head and neck patients with locally and regionally advanced cancer have been found to be strongly associated with distant metastases within six months. (2018-07-08)

In patients with heart failure, anxiety and depression linked to worse outcomes
Symptoms of depression and anxiety are present in about one-third of patients with heart failure - and these patients are at higher risk of progressive heart disease and other adverse outcomes, according to a review and update in the July/August issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer. (2018-07-06)

Precision genomics point the way to mutations associated with accelerated aging
Mayo Clinic researchers are using precision genomics to search for undiscovered, inheritable genetic mutations that cause accelerated aging. In a study recently published in Mayo Clinic Proceedings, researchers conducted a study assessing 17 patients with short telomere syndromes -- rare conditions that result in premature DNA and cellular deterioration. The ability to pinpoint the genetic abnormalities associated with short telomere syndromes is key to finding better ways to screen, diagnose and treat patients. (2018-07-05)

Economic burden of fatty liver disease in US is $32 billion annually, new study finds
Nonalcoholic fatty liver disease, or NAFLD, which affects roughly 100 million Americans, costs the United States healthcare system $32 billion annually, according to a first-of-its-kind study by Intermountain Healthcare researchers on the economic impact of the disease. (2018-07-03)

New clues to sepsis may speed diagnosis
Researchers at Columbia University Irving Medical Center have found a clue in understanding how an infection can spiral into sepsis by blunting the body's immune response. This research may also help doctors identify the patients who may need immediate intensive treatment to save their lives. (2018-07-03)

Stem cells restore function in primate heart-failure study
Human stem cells have been successfully used to restore heart function in monkeys with heart failure. The findings suggest that the technique would be effective in heart-failure patients. The cells form new muscle that integrates into the heart so that it pumps vigorously again. (2018-07-02)

$20 blood test could help diagnose hepatitis B patients across Africa
A simple $20 blood test could help diagnose thousands of patients with hepatitis B in need of treatment in some of Africa's poorest regions. (2018-07-01)

UCalgary researchers discover antidepressant could be a promising treatment for PBC
A team of scientists at the University of Calgary's Cumming School of Medicine (CSM) discovered what could be a new option for these hard to treat patients. A drug usually prescribed for depression appears to effectively stop progression of Primary Biliary Cholangitis (PBC). (2018-06-27)

Lipid species offer insights into metabolic health
Two new Morgridge Institute for Research studies suggest the current tests, which measure the abundance of lipid classes, are insufficient. Rather, lipids identified and studied at the individual species level -- instead of grouped in classes -- may be better signatures of metabolic health. (2018-06-27)

Genetically humanized mice could boost fight against aggressive hepatitis
In research that could lead to treatments for an aggressive type of liver disease, scientists describe a genetically humanized mouse that can be persistently infected with hepatitis delta virus. (2018-06-27)

In search of biomarkers to detect patients with latent 'Plasmodium vivax' infection
Proteins derived from the latent liver stage of Plasmodium vivax can be detected in small extracellular vesicles that circulate in blood, according to a study led by ISGlobal, an institution supported by 'la Caixa' Foundation. The results pave the way for identifying patients with asymptomatic infections, an essential requirement to stop parasite transmission. (2018-06-26)

Progress toward improved Wilson's disease drug
Researchers at CSHL, working in collaboration with DepYmed Inc., a CSHL spinout company, today report that they have conducted promising preclinical experiments on a compound that could be used to treat Wilson's disease and possibly other disorders -- including certain types of cancer -- in which levels of copper in the body are elevated, causing or contributing to pathology. (2018-06-26)

Gut bacteria markers could be a 'smoking gun' for liver disease
Chemical compounds produced by the bacteria in our gut could be used to spot the early stages of liver disease, according to new research. (2018-06-25)

Sex, drugs, and heart failure
Heart failure is almost as common in women as men, but its characteristics vary by sex. A new review summarizes the current state of sex-sensitive issues related to heart failure drugs included in treatment guidelines, and suggests future directions for improved care. (2018-06-22)

TGen-led study identifies gene expression patterns associated with fatty liver disease
In an effort towards discovering a drug target, scientists at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, for the first time have identified significant gene expression patterns associated with obesity-related NASH inflammation and fibrosis. The study, which was done in collaboration with the Geisinger Obesity Institute and Temple University, was published June 5 in the Journal of the Endocrine Society. (2018-06-22)

Potential to replace race as a risk factor for kidney-transplant failure
Marva Moxey-Mims, M.D., FASN, says APOLLO study researchers hope that clarifying the role of the APOL1 gene in kidney-transplant failure could lead to fewer discarded kidneys, which could boost the number of available kidneys for patients awaiting transplants. (2018-06-20)

Researchers find a promising new approach for treating liver cirrhosis
In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis. (2018-06-18)

New radiological procedure for the diagnosis of liver disease
Researchers from Charité -- Universitätsmedizin Berlin have successfully tested a new technology for use in the assessment of overweight adolescents with liver disease. Known as 'time-harmonic elastography' (THE), the technology enables physicians to determine the disease's severity without having to resort to invasive liver biopsies. The results of this research have been published in Radiology*. (2018-06-18)

BIDMC researchers develop decision-making tool to benefit patients with HCV
BIDMC researchers led a retrospective analysis of four randomized clinical trials focused on the effects of DAA therapies in patients with HCV-associated liver failure, and developed a new means of predicting improvement in liver function in response to DAA treatment. (2018-06-18)

Big data identifies lipids as signatures of health and disease
Scientists from EPFL and the University of Wisconsin-Madison have carried out one of the most extensive lipidomics studies to date, connecting almost 150 different lipid species to their respective genetic regulators, revealing signatures of metabolic health and disease. Published in two papers in Cell Systems, the study is a landmark for metabolic health science. (2018-06-13)

Video conferencing helps PCPs improve liver disease care, survival rates
Providing physicians with virtual access to specialists can be lifesaving to liver disease patients. A new study by University of Michigan gastroenterologists finds that it boosts survival rates by 54 percent. (2018-06-12)

Study points to possible treatment target for aggressive liver cancer in kids
A protein in the cell nucleus already targeted therapeutically for several types of cancer has now been linked to an aggressive form of pediatric liver cancer called hepatoblastoma (HBL), according to a study published in the Nature journal Communications Biology. Scientists at Cincinnati Children's Hospital Medical Center report that laboratory testing indicates the protein, PARP1, may be an effective treatment target for the cancer, but emphasize additional research is needed to verify this. (2018-06-11)

'Therepi' device attaches to heart
A team of researchers is hoping to halt the progression from heart attack to heart failure with a small device called 'Therepi.' The device contains a reservoir that attaches directly to the damaged heart tissue. A refill line connects the reservoir to a port on or under the patient's skin where therapies can be injected either by the patient or a healthcare professional. (2018-06-11)

Heart transplantation for adult CHD: Overview and special considerations
In the current issue of Cardiovascular Innovations and Applications (Volume 3, Number 1, 2018, pp. pp. 73-84(12); DOI: 10.15212/CVIA.2017.0043), Dipankar Gupta, Jana Reid, Diego Moguillansky, Renata Shih, Mark S. Bleiweis, Frederick J. Fricker and Biagio A. Pietra from the University of Florida, Gainesville, FL, US consider how with improvements in surgical and medical management, the number of patients with congenital heart disease (CHD) reaching adulthood has increased over the last decade. (2018-06-10)

The Fontan circulation
In the current issue of Cardiovascular Innovations and Applications (Volume3, Number 1, 2018, pp. pp. 107-122(X); DOI: 10.15212/CVIA.2017.0041), researchers Ahmed Kheiwa, Anushree Agarwal and Anitha John from University of California San Francisco, San Francisco, CA, US and George Washington University, Washington, DC, US provide a summary of the Fontan surgeries and resultant physiology, discuss long-term complications, and provide a contemporary review of the management strategies. (2018-06-10)

Half of hepatitis C patients with private insurance denied life-saving drugs
The number of insurance denials for life-saving hepatitis C drugs among patients with both private and public insurers remains high across the United States. Private insurers had the highest denial rates, with 52.4 percent of patients denied coverage, while Medicaid denied 34.5 percent of patients and Medicare denied 14.7 percent. (2018-06-07)

Insurance denials for new hepatitis C drugs remain high nationwide, study suggests
Highly effective drugs that can cure chronic hepatitis C infection in approximately 95 percent of patients first became available in the US in 2014. But both public and private insurers continue to deny coverage for these costly drugs at high rates nationwide, despite efforts to remove treatment restrictions, according to a new study published in Open Forum Infectious Diseases. (2018-06-07)

Antibody blocks inflammation, protects mice from hardened arteries and liver disease
Researchers at University of California San Diego School of Medicine discovered that they can block inflammation in mice with a naturally occurring antibody that binds oxidized phospholipids (OxPL), molecules on cell surfaces that get modified by inflammation. Even while on a high-fat diet, the antibody protected the mice from arterial plaque formation, hardening of the arteries and liver disease, and prolonged their lives. (2018-06-06)

Computer simulations identify chemical key to diabetes drug alternatives
Jeremy Smith, Governor's Chair for Molecular Biophysics at the University of Tennessee, Knoxville, and director of the Center for Molecular Biophysics at Oak Ridge National Laboratory, has worked with a research team from the UT Health Science Center to discover a chemical compound that could lower sugar levels as effectively as the diabetes drug metformin but with a lower dose. (2018-06-05)

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