Current Liver Transplant News and Events | Page 25

Current Liver Transplant News and Events, Liver Transplant News Articles.
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Growing evidence that probiotics are good for your liver
Increased awareness of the importance of the microbes that live in our gut has spurred a great deal of research on the microbiome and fueled a booming probiotics industry. A new study suggests probiotics can improve not only the health of our gut but liver health, as well. (2018-04-22)

New leads in the development and treatment of liver disease
A treatment gap remains for many conditions involving damage to the liver, the body's main organ for removing toxins, among other functions. The Experimental Biology 2018 meeting (EB 2018) will feature important research announcements related to the causes of liver degradation and possible treatments. (2018-04-21)

Bedside art therapy decreases pain and anxiety in patients with cancer
A brief bedside visual art intervention (BVAI) facilitated by art educators improved mood and reduced pain and anxiety in a study of inpatients with hematological cancers. (2018-04-19)

Unique protein is a vulnerability in the malaria parasite
The malaria parasite is highly dependent on a unique protein for infecting new mosquitoes. This protein could be a target for the development of new drugs. It was discovered recently by researchers from Radboud university medical center and colleagues from the Humboldt University of Berlin. The results were published in Cell Reports on April 18. (2018-04-18)

Many European countries are not ready to stop viral hepatitis
Many European countries lack a comprehensive policy to eliminate viral hepatitis as a major public health threat, according to a patient group-based survey implemented in 25 countries. The Hep-CORE study was coordinated by ISGlobal -- an institution supported by the 'la Caixa' Foundation -- and led by the European Liver Patient's Association. (2018-04-18)

Transplanted livers help body defend against organ rejection, Mayo Clinic study finds
When patients undergo a dual kidney-liver transplant, the liver has a protective effect on the kidney, the study found. (2018-04-18)

Updates on new therapies in development for rare liver diseases
Long-term data with sebelipase alfa for lysosomal acid lipase deficiency and preliminary data for investigational RNAi therapeutics for acute intermittent porphyria and alpha-1 antitrypsin deficiency add continued hope for the future management of metabolic and rare liver diseases. (2018-04-14)

Fecal microbiota transplantation produces sustained improvements in cognitive and clinical outcomes
Long-term results of a randomized study demonstrate sustained improvements in hepatic encephalopathy episodes, hospitalizations, and cognitive performance compared with standard-of-care. (2018-04-14)

Hepatitis C: Simplified curative treatments can drive global scale-up
According to a WHO progress report, an estimated 1.5 million people started direct-acting antiviral (DAA) treatment in 2016, compared to around 1 million in 2015.1 Behind the impressive scale-up seen in 2016, a diverse set of countries have been leading the action. (2018-04-14)

Phase 2 studies of two novel treatments for primary biliary cholangitis report encouraging results
Ongoing Phase 2 studies of tropifexor and seladelpar report promising preliminary efficacy, safety and tolerability results, paving the way for longer-term studies in patients with primary biliary cholangitis (2018-04-13)

NGM282 -- an engineered analogue of FGF19 -- shows promise in patients with primary sclerosing cholangitis
A Phase 2, randomized, double-blind, placebo-controlled study reports significant improvements in markers of disease activity and fibrosis with subcutaneous NGM282 in patients with primary sclerosing cholangitis. (2018-04-13)

Automated analysis of biopsy samples enables rapid and reproducible quantification of NASH disease activity
Automated analysis of biopsy samples enables rapid and reproducible quantification of NASH disease activity ILC 2018: New deep-learning approach to pattern recognition in liver biopsy samples enables automated scoring of ballooning and inflammation in a pre-clinical model of NASH. (2018-04-13)

Germany: compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
Compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. (2018-04-13)

HCV-related liver transplantation and post-transplant survival rates in Europe have improved rapidly in the era of direct-acting antiviral drugs
HCV-related liver transplantation and post-transplant survival rates in Europe have improved rapidly in the era of direct-acting antiviral drugs. (2018-04-13)

Selective internal radiation therapy (SIRT) fails to extend survival in the SORAMIC study palliative cohort
ILC 2018: The addition of SIRT to sorafenib in patients with advanced hepatocellular carcinoma was associated with no overall survival benefits compared with sorafenib alone, but may offer benefits in some subgroups of patients (2018-04-13)

US study reports dramatic reduction in likelihood of liver transplantation in patients with hepatoce
ILC 2018: Although hepatocellular carcinoma is now the leading indication for liver transplantation in the USA, the probability of patients receiving a transplant has declined significantly in recent years. (2018-04-13)

Long-term obeticholic acid treatment leads to reversal or stabilization of fibrosis/cirrhosis in patients with PBC
After three years of treatment with obeticholic acid, 85 percent of patients with PBC and an incomplete response to UDCA experienced stabilization or regression of fibrosis/cirrhosis in the POISE biopsy sub-study. (2018-04-13)

Budesonide add-on therapy improves markers of disease activity but fails to improve histology in patients with primary biliary cholangitis
A randomized, placebo-controlled study reports that budesonide add-on therapy improves biochemical markers of disease activity but not histology in high-risk patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid. (2018-04-13)

Sustained virological response to oral hepatitis C virus treatment associated with reduced mortality in an Italian cohort
A large-scale, real-world data on the course of liver disease after clearance of HCV with direct-acting antiviral agents show reduced risk of death at all stages of disease. (2018-04-13)

A Web-based lifestyle intervention supports weight loss in patients with non-alcoholic fatty liver disease
A remote lifestyle modification intervention shown to be as effective as a face-to-face group program for weight loss and improved liver health. (2018-04-13)

Sensitive new assay detects hepatitis B infection in single liver cells and serum
Chronic hepatitis B virus (HBV) can progress to cirrhosis and hepatocellular carcinoma (HCC). A study published in The Journal of Molecular Diagnostics describes a new HBV assay that offers advantages over currently used methods because it has the capability to detect closed circular DNA (cccDNA) in serum, single cells, and preserved tissue samples. This assay can be used to diagnose HCC at an earlier stage to manage treatment more effectively. (2018-04-12)

First real-world studies report glecaprevir/pibrentasvir to be effective and well tolerated in chronic HCV infection
Studies conducted in Italy and Germany confirm the effectiveness and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus infection, with viral suppression rates similar to those observed in clinical trials. (2018-04-12)

HEPAHEALTH Project Report -- risk factors and the burden of liver disease in Europe and selected Central Asian countries
The HEPAHEALTH Project Report, which was presented today in a press conference at The International Liver Congress trade; 2018 in Paris, France, is the second overview commissioned by EASL on the burden of liver disease in Europe. (2018-04-12)

Mediterranean-style diet improves gut microbial diversity and reduces hospitalization
ILC 2018: Diets rich in vegetables, fermented milk products, tea, coffee and chocolate may improve outcomes in patients with liver cirrhosis. (2018-04-12)

Personalized T cell therapy shows signs of clinical effectiveness against HBV-related HCC
ILC 2018: HBV DNA integration profile of tumour cells used to guide T cell adoptive immunotherapy in a liver transplant patient with HBsAg-negative HCC metastases in the lungs. (2018-04-12)

Punjab, India: Mass treatment of a population with chronic hepatitis C infection produces high rates of cure
A program of decentralized public healthcare achieves high rates of cure regardless of genotype or the presence of cirrhosis: the Punjab Model. (2018-04-12)

Hepatitis E virus infections can be life threatening and transmitted through blood products
ILC 2018: Hepatitis E virus infections are associated with significant morbidity and mortality in both immunocompromised and immune-competent individuals - blood products are confirmed as an important source of infection. (2018-04-12)

Scotland: Direct-acting antiviral agent therapy reduces the burden of HCV-related decompensated cirrhosis
National surveillance data and cost-effectiveness modeling provide complementary evidence to support the scale-up of DAA therapy in Scotland. (2018-04-12)

Screening for hepatocellular carcinoma in patients with hepatitis C-related cirrhosis achieving sustained virological response is likely to be cost effective
A Canadian study suggests that biannual or annual ultrasound screening for HCC is likely to be cost effective after a sustained virological response in those with hepatitis C-related cirrhosis, but not in those with advanced fibrosis without cirrhosis. (2018-04-12)

Linkage to care specialist facilitates access to hepatitis C treatment for people who inject drugs
A longitudinal study involving more than 1,000 individuals reports promising role for linkage to care specialists in expanding access to hepatitis C treatment for people who inject drugs. (2018-04-12)

A third of bacterial infections in patients with cirrhosis across the world are multi-drug resistant
An international study reports a high prevalence of multi-drug-resistant bacteria in hospitalized patients with cirrhosis and significant regional differences in risk. (2018-04-12)

Statins associated with reduced morbidity and mortality in patients with primary sclerosing cholangitischolangi
An award-winning register-based study reports a reduced risk of all-cause mortality, liver transplantation, liver cancer, and variceal bleeding in patients with primary sclerosing cholangitis exposed to statins. (2018-04-12)

Italy: Ongoing hepatitis A virus outbreak among men who have sex with men is linked to current outbreaks in Europe
ILC 2018: Phylogenetic analysis of circulating viruses in an ongoing acute hepatitis A outbreak in Lombardy, Italy links the majority of cases to two virus strains responsible for recent outbreaks in the UK and the Netherlands. (2018-04-12)

'Molecular microscope' system safer, more effective in heart and lung transplant biopsies
A transplant biopsy system that uses gene chips to read molecules is far safer and more effective than existing approaches used for heart transplant biopsies and is showing promising results for lung transplant biopsies, new University of Alberta-led research shows. (2018-04-12)

Alcoholic liver disease replaces hepatitis C infection as the leading cause of liver transplantation in patients without hepatocellular carcinoma in the USA
Two independent US studies confirm that, from 2016 onwards, alcoholic liver disease has led to more liver transplants than hepatitis C infection in patients without hepatocellular carcinoma (HCC). (2018-04-11)

Animated short created to raise public awareness about liver failure
An animated short-film produced by the ALIVER consortium titled 'Life After Liver Failure' premieres tomorrow morning at the BioTech Village in The International Liver Congress™ 2018. (2018-04-11)

Risk stages defined for children with chronic kidney disease
Experts in pediatric kidney disease have published a new staging system to help doctors better predict the length of time until a child with chronic kidney disease will need to undergo a kidney transplant or start receiving dialysis. Although this type of prognostic guide exists for adults, this is the first such tool specific to children. (2018-04-10)

How intestinal bacteria can affect your blood sugar and lipid levels
Intestinal bacteria have attracted recent attention since they were discovered to influence various physiological functions and diseases in humans. Japanese researchers analyzing the influence of changes in intestinal bacteria on sugar and lipid metabolism have found that secondary bile acids produced by intestinal bacteria can influence blood glucose and lipid concentrations as well as parts of their molecular mechanisms. (2018-04-10)

Fatty liver under stress
A poor diet and other risk factors can result in liver disease. This important metabolic organ can become fatty and inflamed. In the long term, this may result in irreversible and life-threatening organ damage (cirrhosis of the liver or 'shrunken liver'). Experts at the German Federal Institute for Risk Assessment (BfR) in Berlin have now analyzed liver cells in vitro to investigate how degenerative fattening and inflammation can impair the body's primary detoxification system. (2018-04-09)

20-year-old mystery of malaria vaccine target solved
The human piece of a malaria infection puzzle has been revealed for the first time, solving a long-standing mystery. A protein displayed on the surface of malaria parasites called 'TRAP' is a high-priority vaccine target, but how it interacts with human host cells has remained a puzzle. Wellcome Sanger Institute scientists have discovered a receptor protein on the surface of human cells that the TRAP protein interacts with as it navigates through the body. (2018-04-09)

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