Current Liver News and Events

Current Liver News and Events, Liver News Articles.
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Lab-grown 'mini-bile ducts' used to repair human livers in regenerative medicine first
Scientists at the University of Cambridge have used a technique to grow bile duct organoids - often referred to as 'mini-organs' - in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. (2021-02-18)

Organoids grown from bile duct cells repair human livers; may aid liver transplant processes
Organoids grown from bile duct epithelial cells can be used to repair damaged bile ducts in transplanted human livers, researchers report. (2021-02-18)

Understanding cellular clock synchronization
In humans, the disruption of circadian clocks is the cause of many metabolic diseases. Thanks to an observation tool based on bioluminescence, a research (UNIGE) were able to demonstrate that cells that compose a particular organ can be in-phase, even in the absence of the central brain clock. Indeed, the scientists managed to restore circadian function in the liver in completely arrhythmic mice, demonstrating that neurons are not unique in their ability to coordinate. (2021-02-17)

Cytoglobin: key player in preventing liver disease
Researchers have discovered that the use of Cytoglobin (CYGB) as an intravenous drug could delay liver fibrosis progression in mice. CYGB, discovered in 2001 by Professor Norifumi Kawada, is present in hepatic stellate cells, the cells that produce fibrotic molecules such as collagens when the liver has acute or chronic inflammation induced by different etiologies. The enhancement of CYGB on these cells or the injection of recombinant CYGB has the effect of suppressing liver damage and cirrhosis. (2021-02-16)

Going the distance--insights into how cancer cells spread
In a study published in Nature Communications, cancer researchers at Kanazawa University identify mechanisms by which malignant tumor cells extend their toxicity to distinct cell types and in turn help them spread. (2021-02-12)

Ionic liquid uniformly delivers chemotherapy to tumors while destroying cancerous tissue
A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab. This discovery could solve a problem that has long plagued drug delivery to tumors. (2021-02-11)

Routine blood tests could be key to stopping the silent killer of liver disease
New research has shown that results of blood tests routinely performed by GPs everywhere contain a hidden fingerprint that can identify people silently developing potentially fatal liver cirrhosis. The researchers have developed an algorithm to detect this fingerprint that could be freely installed on any clinical computer, making this a low-cost way for GPs to carry out large scale screening using patient data they already hold. (2021-02-11)

Type 2 diabetes: drugs initially increase glucose production
Although SGLT-2 inhibitors are central to the treatment of diabetes, their exact mode of action was hitherto unknown. A study shows that there is a direct correlation between the elimination of glucose via the kidneys and new glucose production in the liver. (2021-02-08)

Drug 'breakthrough' gives longest-ever survival in nonresectable liver cancer patients
New follow-up data from a landmark study of liver cancer patients treated with a combination of an immunotherapy drug (atezolizumab) and a monoclonal antibody (bevacizumab) has shown the longest-ever survival time in a frontline phase 3 trial of systemic therapy in advanced hepatocellular carcinoma (HCC), demonstrating a 'major breakthrough' in the field. (2021-02-05)

Cancer leading cause of death among people with diabetes
Cancer is the leading cause of death among people with diabetes in England. (2021-02-04)

New combination therapy offers chance of healing hepatitis B
Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. (2021-02-04)

Engineering immunity
University of New Mexico researchers study the use of virus-like particles to create a stable and effective malaria vaccine. (2021-02-03)

Liver cancer 'signature' in gut holds clues to cancer risk
People with non-alcohol-related liver cancer have a unique gut microbiome profile which could help predict disease risk, a new UNSW Sydney study has found. (2021-02-03)

Combining PD-1inhibitor with VEGF inhibitor in chemotherapy of cholangiocarcinoma patient
Cholangiocarcinoma is the second most frequent liver cancer. Many patients miss the opportunity of having a surgery performed on them and its control has always been considered difficult. Here, doctors from The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China, present a case of stage 4 cholangiocarcinoma. (2021-02-02)

International research network identifies triggers for severe course of liver cirrhosis
Acute-on-chronic liver failure (ACLF) is a common cause of death in patients with cirrhosis. In ACLF the progressive loss of function of the scarred liver can no longer be compensated (acute decompensation). As a result, other organs such as the kidney or brain fail. The triggers for acute decompensation of liver cirrhosis and an ACLF are most frequently bacterial infections, liver inflammation caused by alcohol, or a combination of both factors. (2021-02-02)

Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases. (2021-01-27)

A stem cell based cell culture model for nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a widespread condition in the Western World. In order to improve our understanding of the basic mechanisms underlying the etiology of NAFLD, Dr. Nina Graffmann, Prof. James Adjaye and the team of the Institute for Stem Cell research and Regenerative Medicine, University Hospital Duesseldorf, differentiated induced pluripotent stem cells (iPSCs) derived from healthy donors and NAFLD patients into hepatocyte-like cells (HLCs). (2021-01-25)

The liver processes coconut oil differently than rapeseed oil
Coconut oil has increasingly found its way into German kitchens in recent years, although its alleged health benefits are controversial. Scientists at the University of Bonn have now been able to show how it is metabolized in the liver. Their findings could also have implications for the treatment of certain diarrheal diseases. The results are published in the journal Molecular Metabolism. (2021-01-25)

ACSL1 as a main catalyst of CoA conjugation of propionic acid-class NSAIDs in liver
Researchers from Kanazawa University have found that propionic acid-class nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, form ''conjugates'' with coenzyme A (CoA) by one of the acyl-CoA synthetases, ACSL1, in liver. These conjugates have the covalent binding ability to cellular proteins that may lead to liver injury, a rare severe side effect of NSAID treatment. This knowledge could help pharmaceutical companies to generate pain control options with fewer risks of severe side effects. (2021-01-22)

CT identifies patients with high-risk nonalcoholic fatty liver disease (NAFLD)
According to ARRS' American Journal of Roentgenology, Fibrosis-4 and multiple CT findings can identify patients with high-risk nonalcoholic fatty liver disease--advanced fibrosis or cirrhosis, that is--though the presence of nonalcoholic steatohepatitis remains elusive on CT. (2021-01-22)

Researchers study what happens to your body during tailgating
Football watch parties are synonymous with eating fatty foods and drinking alcohol. Have you ever wondered what all of that eating and drinking does to your body? Researchers from the University of Missouri School of Medicine simulated a tailgating situation with a small group of overweight but healthy men and examined the impact of the eating and drinking on their livers using blood tests and a liver scan. (2021-01-20)

Armouring anti-cancer T cells against immunosuppressants
New 'armoured' T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection. (2021-01-18)

Scoring system to redefine how U.S. patients prioritized for liver transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (2021-01-13)

Non-Hispanic Black patients are disproportionately left off liver transplant waitlists
A new study of liver transplant centers confirms that non-Hispanic white patients get placed on liver transplant waitlists at disproportionately higher rates than non-Hispanic Black patients. (2021-01-11)

How the circadian clock regulates liver genes in time and space
EPFL scientists have carried out the first comprehensive study of how genes in the liver perform their metabolic functions in both space and time of day. Monitoring almost 5000 genes at the level of the individual cell across a 24-hour period, the researchers have modelled how the circadian clock and liver functions crosstalk throughout the day in sync with the feeding-fasting cycle. (2021-01-11)

Liver cancer cells manipulate stromal cells involved in fibrosis to promote tumor growth
Researchers led by Osaka University have found that liver cancer cells induce autophagy in hepatic stellate cells, causing them to produce a growth factor called GDF15 that promotes tumor growth. GDF15 was more highly expressed in tumor tissue than normal liver tissue, and patients with higher levels of GDF15 had a poorer prognosis. New therapies targeting GDF15 may help prevent the development and proliferation of hepatocellular carcinoma. (2021-01-06)

Study explains why patients with cancer spread to the liver have worse outcomes
A new study finds that tumors in the liver siphon off critical immune cells, rendering immunotherapy ineffective. But coupling immunotherapy with radiotherapy to the liver in mice restored the immune cell function and led to better outcomes. (2021-01-04)

Frailty is a factor in higher mortality for women awaiting liver transplants
Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this gender gap. (2020-12-30)

New study: available drugs can prevent rejection and tissue injury after transplantation
Controlling inflammation after transplantation of organs, cells, or tissues is critical for graft survival; however, it can be difficult. Continuing injuries due to chronic rejection can be particularly problematic. Now, a team of researchers from Albert Einstein College of Medicine report that neutralizing the cell signaling molecule, tumor necrosis factor (TNF), can prevent cascades of injurious molecules and signals after cell transplantation in The American Journal of Pathology, published by Elsevier. (2020-12-21)

Protecting against atherosclerosis at the molecular level
Researchers from the University of Tsukuba identified a novel mechanism by which CREB3L3 protects against atherosclerosis. By studying the absence or overexpression of the protein in mice prone to develop atherosclerosis, the researchers demonstrated that the absence of CREB3L3 exacerbates the formation of atherosclerosis, whereby the overexpression protects against atherosclerosis. At the molecular level, CREB3L3 exhibited its protective effects by inhibiting SREBP. This study could help develop a novel molecular target against atherosclerosis. (2020-12-20)

In liver, a stressed cell can be bad news for its neighbors
When a stressed liver cell starts communicating with its neighbors, it can send stress signals to neighboring cells, causing significant problems that can lead to fatty liver disease and metabolic disease. (2020-12-18)

Gene biomarkers indicate liver toxicity quickly and accurately
When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval. This testing usually involves lengthy and expensive animal studies. A research team at University of Illinois has developed a gene biomarker identification technique that cuts the testing process down to a few days while maintaining a high level of accuracy. (2020-12-18)

UMD paves the way for growing human organs for transplantation with new proof-of-concept
With the number of people who suffer from organ failures and the growing need for available organs for transplant, finding a new way to provide organs and therapeutic options to transplant patients is a critical need. In a new paper, University of Maryland researchers show for the first time that newly established stem cells from pigs could provide a solution, laying the groundwork for growing transplantable human organs. (2020-12-17)

A first-in-human clinical trial shows microbubbles augments radiation in liver cancer patients
Bursting gas-filled microbubbles using ultrasound waves sensitizes tumors to targeted radiation, reducing tumor growth and improving overall survival after treatment. (2020-12-15)

Effects of organohalogen pollution are coded in gene expression profiles of Baltic salmon
Researchers of Ehime University and the University of Helsinki measured hepatic organohalogen (OHC) concentrations and gene expression profiles in Atlantic salmon collected from three areas in the Baltic Sea. The results showed that OHCs and gene expression profiles were individually grouped in three areas and the covariation of the two datasets provided by a multivariate method was significantly similar. This suggests that the gene expression profiles in salmon are affected by OHC contamination. (2020-12-15)

Screening for endocrine disruption in artificial zebrafish for long-term risk assessment
the Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Young Jun Kim, leader of environmental safety at KIST Europe, and Professor Hyunjoon Kong from the University of Illinois at Urbana-Champaign tried to develop the long-term toxicity and risks by cultivating organoids that mimic the liver of zebrafish. (2020-12-11)

Beta-blockers display anti-inflammatory effects in advanced liver disease
Beta-blockers are used to prevent internal bleeding in patients with liver cirrhosis and portal hypertension. Researchers from MedUni Vienna have now shown that Beta-blockers also have beneficial effects on systemic inflammation and this translates into improved clinical outcomes. (2020-12-10)

Researchers discover treatment that suppresses liver cancer
Researchers from the University of Missouri School of Medicine have discovered a treatment combination that significantly reduces tumor growth and extends the life span of mice with liver cancer. This discovery provides a potentially new therapeutic approach to treating one of the leading causes of cancer-related death worldwide. (2020-12-08)

A library of mice to look up the best liver cancer treatment
Researchers from Osaka University have developed a mouse model that reproduces the real-world variety of genetic drivers of liver cancer, and used this model to discover that tumors driven by the gene FGF19 are especially vulnerable to treatment with the drug lenvatinib. They also found a serum biomarker that may help indicate which patients have this specific type of cancer, potentially leading to improved treatment selection and outcomes. (2020-12-07)

Synthetic biology and machine learning speed the creation of lab-grown livers
Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine learning algorithm to create human liver organoids with blood and bile handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life. (2020-12-07)

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