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Current Liver News and Events, Liver News Articles.
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Incarceration linked to excess burden of cancer, new study finds
People who spend time in jails and prisons are more likely to develop certain types of cancer than the general population in Ontario, according to a study published today in the open-access journal PLOS ONE. They were also more than 50 percent more likely to die from cancer than the general population in Ontario, the study found. (2017-02-22)

Dying patients who received palliative care visited the ER less
WASHINGTON -- Community-based palliative care -- care delivered at home, not the hospital - was associated with a 50 percent reduction in emergency department visits for patients in their last year of life. The results of an Australian study were published online February 3rd in Annals of Emergency Medicine ('The Association of Community-Based Palliative Care with Reduced Emergency Department Visits in the Last Year of Life Varies by Patient Factors'). (2017-02-21)

Pizza, burgers and the like: A single high-fat meal can damage the metabolism
The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats. Scientists have found that even the one-off consumption of a greater amount of palm oil reduces the body's sensitivity to insulin and causes increased fat deposits as well as changes in the energy metabolism of the liver. (2017-02-16)

Signals from fat may aid diagnostics and treatments
Scientists at Joslin Diabetes Center now have identified a route by which fat also can deliver a form of small RNAs called microRNAs that helps to regulate other organs. This mechanism may offer the potential to develop an entirely new therapeutic approach. (2017-02-15)

Fructose consumption linked to the increase of liver disease among adolescents and children
Recent research suggests that dietary fructose intake may increase serum uric acid concentrations and that both uric acid concentration and fructose consumption may be increased in individuals with non-alcoholic fatty liver disease (NAFLD). Investigators have now established that both dietary fructose consumption and serum uric acid concentrations are independently associated with non-alcoholic steatohepatitis (NASH). Their conclusions are published in the Journal of Hepatology. (2017-02-14)

Two months left to register for The International Liver CongressTM 2017
With just over two months to go until The International Liver Congress™ (ILC) 2017, it's time to register for your seat! (2017-02-14)

Inducing an identity crisis in liver cells may help diabetics
It is now possible to reprogram cells from the liver into the precursor cells that give rise to the pancreas by altering the activity of a single gene. A team of researchers at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) has now accomplished this feat in mice. Their results should make it feasible to help diabetic patients through cell therapy. (2017-02-13)

Critically ill children can still undergo liver transplantation and survive
Advancements in critical care make it possible for even the sickest children to successfully undergo liver transplantation. According to a new study published online as an 'article in press' in the Journal of the American College of Surgeons (JACS), children who are sick enough to require mechanical ventilation or dialysis before transplantation achieve the same survival benefit as children who are stable prior to the surgical procedure. (2017-02-07)

Toxic liver effects of fifteen drugs predicted using computational approach
A team of researchers has used a computational modeling approach to analyze and compare the toxic effects of fifteen different drugs on the liver, according to a study in PLOS Computational Biology. (2017-02-02)

Risk of liver cancer is low in patients with cirrhosis
Although one of the most serious complications of cirrhosis is liver cancer, or hepatocellular carcinoma (HCC), an analysis of health records revealed that the 10-year incidence of HCC in UK patients with cirrhosis is 4 percent or lower. (2017-02-01)

SLU researchers receive $416,000 to further work toward hepatitis B cure
Saint Louis University scientists aim to advance our understanding of how the hepatitis B virus replicates in order to develop a new drug that could cure the viral infection. (2017-02-01)

Paracetamol study could open door for way to treat liver damage
Scientists have shed light on how paracetamol can damage the liver, by harming vital structural connections between adjacent cells in the organ. (2017-01-31)

A single episode of high fat intake injures liver metabolism
In a study published this week in the JCI, Michael Roden's lab at the German Diabetes Center found that one instance of fat intake, equivalent to the amount in a rich meal, led to immediate increases in fat accumulation and alterations in liver metabolism. (2017-01-23)

A new index for the diagnosis of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease has become a global epidemic. There is not only a great interest worldwide to understand the causes and consequences of fatty liver disease, but also to diagnose fatty liver disease at an early stage. Under the direction of Professor Norbert Stefan researchers of the German Center for Diabetes Research (DZD) generated a new index from clinical data which can predict the presence of fatty liver disease with high accuracy. (2017-01-23)

Binge drinking may quickly lead to liver damage
Alcohol consumed during just seven weeks of intermittent binge drinking harms the liver in ways that more moderate daily drinking does not, according to researchers at UC San Francisco. (2017-01-19)

Save the date; 3 months to go until The International Liver CongressTM 2017
With just over three months to go until The International Liver Congress 2017, we invite you to attend the 52nd Annual Congress of The European Association for the Study of the Liver to be held April 19-23, at the RAI Congress Centre, Amsterdam, The Netherlands. (2017-01-19)

Atherosclerosis: Endogenous peptide lowers cholesterol
Cells of the innate immune system that play an important role in development of atherosclerosis contain a protein that reduces levels of cholesterol in mice -- and thus helps to inhibit or mitigate the disease. (2017-01-19)

Mount Sinai researchers involved in successful phase 3 trial of drug for liver cancer
An international phase 3 trial has found that the drug regorafenib improved survival in patients with advanced hepatocellular carcinoma, a form of liver cancer, giving people who previously had no other options a better chance at survival. Results from the study, which included researchers at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, were recently published in The Lancet. The trial, funded by Bayer, included 152 sites in 21 countries. (2017-01-18)

Protein involved in blood clotting stimulates liver repair
A team of Michigan State University researchers, led by James Luyendyk in the College of Veterinary Medicine, has uncovered a new pathway in the body that stimulates liver repair. Using an experimental model of high-dosage acetaminophen, the team found that liver injury activated blood clotting, which then stimulated liver repair. The study is published online in the Journal of Hepatology. (2017-01-18)

Diabetes in Chinese adults linked to 9 years' loss of life
Among adults in China, those with diabetes diagnosed in middle age lose, on average, nine years of life compared with those without diabetes, according to new research published in the Jan. 17 issue of JAMA. (2017-01-17)

Not just small adults: Pediatric liver transplant recipients need special care
A new review discusses important consideration when caring for children who have received liver transplants. (2017-01-17)

Discovery of a protein that protects against fatty liver
A team co-headed by scientists at the Institute for Research in Biomedicine and the IDIBAPS Biomedical Research Institute (part of the Hospital Clínic de Barcelona) has revealed the capacity of the CPEB4 protein to prevent fatty liver disease. (2017-01-17)

Unveiling the biology behind nonalcoholic fatty liver disease
EPFL scientists have discovered a new biological mechanism behind nonalcoholic fatty liver disease. (2017-01-17)

Funding for development of new strategies to treat and prevent hepatitis C virus
Current drug treatments for hepatitis C virus are prohibitively expensive and have limiting side effects and achieve sustained clearance of the virus in only 50-60 percent of patients. In a project funded by the Medical Research Council scientists from the Nuffield Department of Medicine at the University of Oxford and the School of Biomedical and Healthcare Sciences at the University of Plymouth take a new look at this problem by using a recently developed model system. (2017-01-13)

Antioxidant may protect offspring of obese mothers from fatty liver disease
In new research published online in The FASEB Journal, scientists show that the antioxidant pyrroloquinoline quinone (PQQ) may prevent the development of nonalcoholic fatty liver disease in offspring. (2017-01-10)

Epigenetic changes promote development of fatty liver in mouse and man
Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver. Such changes in DNA methylation are also detectable in humans with fatty liver and suggest a similar causal chain. (2017-01-09)

Tamed malaria parasite vaccine passes early trial
Results from a first-in-human phase 1 study reveal a weakened form of the malaria parasite safely activated strong immune responses in 10 healthy volunteers, whose antibodies completely protected mice from malaria infection. (2017-01-04)

Common antioxidant may guard against liver disease, says CU Anschutz researcher
A common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD) in the offspring of obese mice, according to researchers at the University of Colorado Anschutz Medical Campus. (2017-01-03)

Gene therapy for liver disease advancing with the help of adeno-associated viral vectors
Liver-directed gene therapy delivered using adeno-associated viral (AAV) vectors to treat diseases such as hemophilia have advanced into human testing. The potential for continued technological improvements to expand the therapeutic applications of gene therapy to treat liver disorders and the remaining clinical challenges are examined in a comprehensive review article published in Human Gene Therapy. (2016-12-30)

Mechanisms in reversible infantile liver failure illuminated
Researchers in Japan have used a novel murine model to show that a deficiency of the mitochondrial enzyme MTU1 has strong effects on the liver and on embryonic development in general. (2016-12-26)

One more piece in the puzzle of liver cancer identified
Manuela Baccarini and her team at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and Medical University of Vienna are one step closer to unraveling the mechanisms behind liver cancer. The researchers discovered that RAF1, a protein known as an oncogene in other systems, unexpectedly acts as a tumor suppressor in hepatocellular carcinoma. The study is published in the renowned journal Nature Communications. (2016-12-21)

Food withdrawal results in stabilization of important tumor suppressor
Tumor suppressors stop healthy cells from becoming cancerous. Researchers from Charité - Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam-Rehbruecke have found that p53, one of the most important tumor suppressors, accumulates in liver after food withdrawal. Results of this study have been published in The FASEB Journal. (2016-12-21)

Vitamin D improves gut flora and metabolic syndrome
A high fat diet alone is not enough to cause metabolic syndrome, a group of symptoms that pose as risk factors for diabetes and heart disease. This recent study shows it is needed in combination with vitamin D deficiency. Accordingly, vitamin D supplementation improves metabolic syndrome in mice. The next step would be to validate the results in humans. (2016-12-21)

Why some people may not respond to the malaria vaccine
Generating protective immunity against the early liver stage of malaria infection is feasible but has been difficult to achieve in regions with high rates of malaria infection. UW Researchers reveal one potential reason for this difficulty in Cell Reports.Their study demonstrates that exposure to the latter blood stage of malaria infection inhibits the formation of the protective immune cells (and their antibodies) that can prevent the early liver stage infection. (2016-12-20)

Researchers identify new suppressor effects of the NOX4 protein in liver cancer
Researchers of IDIBELL and King's College London, have unveiled the role of NADPH oxidase NOX4 as an inhibitor of the epithelial-amoeboid transition, a process that contributes to the migration and invasion of tumor cells. (2016-12-20)

Mayo Clinic researchers identify how liver fat stores provide energy source during fasting
In a recent Science Advances article, Mayo Clinic researchers show how hungry human liver cells find energy. This study, done in rat and human liver cells, reports on the role of a small regulatory protein that acts like a beacon to help cells locate lipids and provides new information to support the development of therapies for fatty liver disease. (2016-12-19)

Genetic study of primary sclerosing cholangitis reveals potential drug target
Primary sclerosing cholangitis is a debilitating rare disease of the liver with no effective treatment. Reported in Nature Genetics researchers from the Wellcome Trust Sanger Institute, Mayo Clinic and their collaborators identify four regions of the genome associated with the disease, one of which is a potential drug target. (2016-12-19)

SLU research: Silencing fat protein improves obesity and blood sugar
SLU scientist Angel Baldan, Ph.D., reports that turning off a protein found in liver and adipose tissue significantly improves blood sugar levels and reduces body fat in an animal model. (2016-12-15)

New approach to liver transplantation: Using a damaged liver to replace a dying liver
There's new hope for patients with liver disease who are waiting for a donor liver to become available for transplantation. Doctors at Intermountain Medical Center in Salt Lake City have found a way to safely use a damaged liver to replace a dying liver, then cure the damaged liver of its disease. (2016-12-14)

Red cabbage microgreens lower 'bad' cholesterol in animal study
Microgreens are sprouting up everywhere from upscale restaurants to home gardens. They help spruce up old recipes with intense flavors and colors, and are packed with nutrients. Now testing has shown that for mice on a high-fat diet, red cabbage microgreens helped lower their risk factors for developing cardiovascular disease and reduce their weight gain. The report appears in ACS' Journal of Agricultural and Food Chemistry. (2016-12-14)

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