Current Lung Function News and Events

Current Lung Function News and Events, Lung Function News Articles.
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Potential combined drug therapy for lung cancer
Researchers at Kanazawa University report in Clinical Cancer Research that in the most common type of lung cancer, certain secondary mutations occurring with another gene alteration known as ALK make the efficacy of alectinib, an otherwise commonly used drug for treating lung cancer, become unfavorable. Combining alectinib with another kind of drug can overcome this adverse effect, however. (2021-01-22)

New study on the role of monocytes in sarcoidosis
The cause of the inflammatory lung disease sarcoidosis is unknown. In a new study, researchers at Karolinska Institutet in Sweden have investigated whether a type of immune cell called a monocyte could be a key player in sarcoidosis pathogenesis and explain why some patients develop more severe and chronic disease than others. The study, which is published in The European Respiratory Journal, opens new possibilities for future diagnostic and therapeutic methods. (2021-01-21)

Study defines small-cell lung cancer subtypes and distinct therapeutic vulnerabilities for each type
Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell. (2021-01-21)

New combination of immunotherapies shows great promise for treating lung cancer
McMaster University researchers have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer. (2021-01-21)

Scientists discover link between nicotine and breast cancer metastasis
Scientists at Wake Forest School of Medicine have found that nicotine promotes the spread of breast cancer cells into the lungs. (2021-01-20)

Cancer-related suicide declined in the US during the past two decades
Despite increases in overall suicide rates in the United States during the past two decades, cancer-related suicides declined by 2.8% per year, according to a new study by the American Cancer Society. (2021-01-19)

Routine thoracic surgery safe during COVID-19 pandemic
A study in the Journal of Thoracic Oncology (JTO) comparing surgeries performed at one Chinese hospital in 2019 with a similar date range during the COVID-19 pandemic found that routine thoracic surgery and invasive examinations were performed safely. The JTO is the official journal of the International Association for the Study of Lung Cancer. (2021-01-19)

E-cigarettes stress lungs, impair protein function
E-cigarette exposure stresses and inflames the lungs of rats, compromising important quality control proteins, according to new research. (2021-01-18)

Record drop in cancer mortality for second straight year due to improved lung cancer treatment
Overall cancer death rates in the United States dropped continuously from 1991 through 2018 for a total decrease of 31%, including a 2.4% decline from 2017 to 2018. (2021-01-12)

A CNIO study links severe COVID-19 disease to short telomeres
The data show that telomeres are shorter in patients suffering more severe COVID-19 pathologies. The researchers propose that one of the consequences of the viral infection is shortening of the telomeres, which, in turn, hampers the regeneration of lung tissue and causes prolonged sequelae in some patients. The study, published in the journal 'Aging', suggests the usefulness of a possible therapy for patients with post-COVID pulmonary injury based on activation of the enzyme telomerase. (2021-01-11)

Why COVID-19 pneumonia lasts longer, causes more damage than typical pneumonia
COVID pneumonia is significantly different from pneumonia caused by other causes, reports a new study in Nature. It shows how hijacks the lungs' own immune cells and uses them to spread across the lung over weeks. The infection leaves damage in its wake and fuels the fever, low blood pressure and damage to the kidneys, brain, heart and other organs in patients with COVID-19. Scientists discovered a target for treating COVID pneumonia and a clinical trial is underway at Northwestern. (2021-01-11)

Initial severity of COVID-19 not associated with later respiratory complications
A new study published online in the Annals of the American Thoracic Society examines the recovery of lung function and overall wellness in individuals who had varying degrees of COVID-19 severity. Little is known about lung health following infection with SARS-CoV-2, the virus that causes COVID-19, and whether later respiratory problems, fatigue and ill health are associated with the disease's initial severity. (2021-01-08)

Immune cells discovered in the lungs improve virus defense
A research team at the University of Basel has discovered immune cells resident in the lungs that persist long after a bout of flu. Experiments with mice have shown that these helper cells improve the immune response to reinfection by a different strain of the flu virus. The discovery could yield approaches to developing longer-lasting vaccinations against quickly-mutating viruses. (2021-01-08)

The Lancet: Most patients hospitalised with COVID-19 have at least one symptom six months after falling ill, Wuhan follow-up study suggests
More than three quarters of COVID-19 patients have at least one ongoing symptom six months after initially becoming unwell, according to research published in The Lancet. (2021-01-08)

New USC study on circadian clock shows "junk DNA" plays a key role in regulating rhythms
Researchers have been trying to figure out what regulates molecular circadian clocks, in search of new insights into diseases like Alzheimer's, cancer and diabetes. Until now, that research has focused on what is known as clock genes. But new research reveals the discovery of a new cog in the circadian clock - a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as micro RNAS (miRNAs). (2021-01-04)

New research may explain severe virus attacks on the lungs
In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet in Sweden describe how different kinds of immune cells, called macrophages, develop in the lungs and which of them may be behind severe lung diseases. The study, which was published in Immunity, may contribute to future treatments for COVID-19, among other diseases. (2020-12-30)

Promising clinical data for fenofibrate's ability to prevent lung damage in COVID patients
In what has the potential to significantly change how Corona patients are being treated and the severity of the disease, research spearheaded at Jerusalem's Hebrew University gathered early clinical evidence demonstrating the efficacy of an existing drug in treating COVID-19. (2020-12-22)

Pneumolysis: High altitude specialists explain lung destruction caused by COVID-19
According to the scientific paper, COVID-19's hypoxemia (low oxygen tension in the blood) can hardly be handled by ventilators and should not be considered as pneumonia or treated as a SARS (severe acute respiratory syndrome). (2020-12-21)

Impaired blood vessel and kidney function underlie heart disease risk in people with HIV
People living with human immunodeficiency virus (HIV) have impaired blood vessel function, which increases risk of heart and blood vessel-disease. The increased heart disease risk is especially pronounced in people with HIV who also have kidney disease. The increased heart disease risk remains regardless of HIV severity or use of antiretroviral therapy. (2020-12-17)

Study: the pandemic's impact on lung cancer
A recent study led by University of Cincinnati Cancer Center researchers shows the impact the pandemic had on lung cancer screening, which experts say could be bad for both screening programs in general and for the overall well-being of patients. The article appears on the website of the Journal of the American College of Surgeons in advance of print. (2020-12-17)

Study reports drop in lung cancer screening, rise in malignancy during COVID-19 surge
Reporting on how deferred care worsened outcomes for lung cancer patients when the COVID-19 pandemic first surged in the spring of 2020, researchers from the University of Cincinnati explained that they have identified a framework that could help people with serious health conditions keep up their appointments during the current surge. The study has been selected for the 2020 Southern Surgical Association Program. (2020-12-17)

Finding a personalized approach to treating chronic rejection after lung transplantation
By studying the roles of an inflammatory protein and antibodies in chronic rejection after lung transplantation, researchers discover possibilities for new treatments. (2020-12-17)

Antifungal drug improves key cystic fibrosis biomarkers in clinical study
A drug widely used to treat fungal infections improved key biomarkers in lung tissue cultures as well as in the noses of patients with cystic fibrosis, a clinical study by researchers at the University of Illinois Urbana-Champaign and the University of Iowa found. (2020-12-17)

Research strongly suggests COVID-19 virus enters the brain
The SARS-CoV-2 virus, like many viruses before it, is bad news for the brain. In a study published Dec. 16, 2020 in Nature Neuroscience, researchers found that the spike protein, often depicted as the red arms of the virus, can cross the blood-brain barrier in mice. The spike proteins alone can cause brain fog. Since the spike protein enters the brain, the virus also is likely to cross into the brain. (2020-12-17)

Protein linked to progressive lung scarring in scleroderma patients
Osteopontin is discovered as the culprit behind systemic sclerosis patients' main cause of death: lung fibrosis. However, a repurposed immunosuppressive drug may combat the pro-inflammatory protein. (2020-12-17)

Study uncovers two phases of infection in patients with severe COVID-19 pneumonia
To analyze SARS-CoV-2 at the tissue level, scientists examined lung specimens from 24 patients who succumbed to COVID-19. The analyses revealed two phases of infection in the patients: an early phase defined by high levels of virus in the lungs, and a later phase in which the virus is no longer present, but the damage to the lungs is too severe for recovery. (2020-12-16)

Cancer: Tumor driver promoting EMT, metastasis and resistance to therapy
Publication in Nature: researchers at the Université libre de Bruxelles (ULB) identify, for the first time, the functions of FAT1, one of the most frequently mutated cancer gene drivers. They uncover that FAT1 mutations promotes invasive features, metastasis and resistance to commonly used anti-cancer drugs, and discover new therapy for FAT1 mutated cancers. (2020-12-16)

The un-appeal of banana: liquid e-cigarette flavorings measurably injure lungs
UC San Diego researchers report chemicals used for flavor in e-cigarette liquid negatively affect specialized proteins that support immune system. (2020-12-14)

Study shows endothelial cell targeting could help fight Covid-19 symptoms
For Covid-19 patients with serious lung disease, targeting endothelial cells -cells that comprise the blood vessel wall which regulate oxygen exchange between airways and the bloodstream- may be a novel approach restoring normal lung function. (2020-12-14)

Inhaled vaccine induces fast, strong immune response in mice and non-human primates
Researchers demonstrate in a study publishing December 10 in the journal Med that a phage-based inhalation delivery system for vaccines generates potent antibody responses in mice and non-human primates, without causing lung damage. The findings suggest that a safe and effective lung delivery system could one day be used for vaccines and therapeutics against respiratory diseases. (2020-12-10)

Lung ultrasounds could help determine COVID-19 outcome
Researchers have developed a method using ultrasound imaging to score a patient's lung health, which may help predict if a patient with COVID-19 will worsen. Using 14 points in the lungs, they looked for abnormalities and assigned each spot a score out of 3 based on its severity. Adding up all the points, the researchers found the total lung ultrasound score was higher for those who had a worsening outcome of COVID-19. (2020-12-10)

How blood and wealth can predict future disability
Research shows that blood tests for biomarkers such as cholesterol and inflammation can predict disability in five years. Researchers studied blood biomarkers of 5,286 participants involved in the UK Household Longitudinal Study - and found that biological health can predict disability and healthcare demand in five years' time. They also found that people on higher-incomes were more likely to seek GP appointments and outpatient treatments for their medical problems. (2020-12-09)

New guidelines for treating the complications of brain tumours
Experts from the leading oncology societies ESMO (European Society for Medical Oncology) and EANO (European Association of Neuro-Oncology) hav now compiled international guidelines and standards for the treatment of complications of brain tumours (2020-12-09)

Study connects diabetes, air pollution to interstitial lung disease
People with pre-diabetes or diabetes who live in ozone-polluted areas may have an increased risk for an irreversible disease with a high mortality rate. These findings are especially important today in the midst of the COVID-19 pandemic, where there is a heightened concern for the convergence of health effects from air pollution and SARS-CoV-2 in susceptible populations. (2020-12-09)

Large US study confirms COVID-19 complications: lung, kidney and cardiovascular issues
A large study of patients in the United States who contracted coronavirus disease 2019 (COVID-19) confirms many complications of the disease, according to new research in CMAJ (Canadian Medical Association Journal). (2020-12-08)

Scientists shed new light on how lung bacteria defend against pneumonia
New insight on how bacteria in the lungs protect against invading pathogens has been published today in the open-access eLife journal. (2020-12-08)

Johns Hopkins develops potential antibiotic for drug-resistant pathogen
Scientists from Johns Hopkins University and Medicine have developed a possible new antibiotic for a pathogen that is notoriously resistant to medications and frequently lethal for people with cystic fibrosis and other lung ailments. (2020-12-08)

Lung tissue from COVID-19 patients and others reveals promising target to treat lung fibrosis
An analysis of lung tissues from patients with different types of pulmonary fibrosis - including cases triggered by COVID-19 - has revealed a promising molecular target to ameliorate the chronic and irreversible disease. Experiments in mouse models of lung fibrosis showed that administering blockers of (2020-12-04)

Medicine-carriers made from human cells can cure lung infections
Scientists used human white blood cell membranes to carry two drugs, an antibiotic and an anti-inflammatory, directly to infected lungs in mice. The nano-sized drug delivery method successfully treated both the bacterial growth and inflammation in the mice's lungs. The study shows a potential new strategy for treating infectious diseases, including COVID-19. (2020-12-03)

Geisinger researchers explore safety of ventilator sharing to mitigate equipment shortages
Using a single ventilator to support two patients could be feasible in crisis situations involving a ventilator shortage, researchers have found. (2020-12-03)

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