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Current Lung Function News and Events, Lung Function News Articles.
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New guidelines issued for diagnosis and care of LAM, a rare lung disease
The American Thoracic Society (ATS) and the Japanese Respiratory Society (JRS) have published additional clinical practice guidelines regarding four specific questions related to the diagnosis of lymphangioleiomyomatosis (LAM) and management of pneumothoraces in patients with LAM. (2017-11-15)

Molecular pathway offers treatment targets for pulmonary fibrosis, related conditions
A study led by investigators at Massachusetts General Hospital and University Health Network in Toronto has identified a molecular pathway that appears to be critical to the development of fibrosis -- scarring and excessive tissue deposition that result from abnormal healing responses and can compromise the function of vital organs. (2017-11-15)

Study: Process used to select lung transplant patients may need to be changed
New research from the University of Maryland School of Medicine suggests that the system for choosing transplant recipients in chronic obstructive pulmonary disease (COPD) may underestimate how long a person might survive without a lung transplant and therefore, may mislead clinicians. (2017-11-14)

Did prolonged breastfeeding reduce risk of asthma, atopic eczema in adolescents?
A breastfeeding program appeared to reduce the development of atopic eczema (an allergic skin response) but not asthma and lung function among children at age 16. (2017-11-13)

UK study shows cell signaling interaction may prevent key step in lung cancer progression
New findings from University of Kentucky faculty published in Scientific Reports reveals a novel cell signaling interaction that may prevent a key step in lung cancer progression. (2017-11-09)

Older donor lungs should be considered for transplantation
With a scarcity of lungs available for transplantation, the use of lungs from donors older than age 60 has been shown to achieve reasonable outcomes and should be considered as a viable option, according to research published online today in The Annals of Thoracic Surgery. (2017-11-09)

Chronic stress hormones may promote resistance to EGFR inhibitors in lung cancer patients
Elevated levels of chronic stress hormones, such as those produced by psychological distress, may promote resistance to drugs commonly used to treat lung cancer patients with EGFR mutations, according to new research from The University of Texas MD Anderson Cancer Center. Retrospective analysis of clinical patient data suggests that beta blocker drugs may slow or prevent the development of resistance to EGFR inhibitors. (2017-11-08)

Is anticoagulant warfarin associated with lower risk of cancer incidence?
Bottom Line: Use of the blood thinner warfarin was associated with a lower risk of new cancers in people over 50. (2017-11-06)

Biomarkers may provide early warning of lung problems in 9/11 firefighters
Blood biomarkers appear to be an early-warning signal for the accelerated loss of lung function and airway obstruction in firefighters who responded to the World Trade Center disaster, according to new research published online in the Annals of the American Thoracic Society. (2017-11-03)

Air pollution is associated with cancer mortality beyond lung cancer
A large scale epidemiological study associates some air pollutants with kidney, bladder and colorectal cancer death. (2017-10-31)

Drexel researchers identify 'master regulator' involved in infant lung damage
Blocking the micro-RNA miR-34a significantly reduced bronchopulmonary dysplasia (BPD) in mice. (2017-10-27)

Using networks to understand tissue-specific gene regulation
Researchers at Brigham and Women's Hospital have discerned that different tissue functions arise from a core biological machinery that is largely shared across tissues, rather than from their own individual regulators. (2017-10-27)

More early stage lung cancer patients survive the disease
With the advancement of surgical and radiation therapy strategies for stage 1 non-small-cell lung cancer (NSCLC), more patients are being treated, resulting in higher survival rates, according to a study published online today in The Annals of Thoracic Surgery. (2017-10-26)

American College of Chest Physicians unveils new lung cancer screening guidelines at CHEST 2017
Each year, more people die of lung cancer than of colon, breast and prostate cancers combined, and low-dose CT (LDCT) screening for lung cancer has become a standard practice mostly due to the results of the National Lung Cancer Screening Trial. Evidence continues to evolve, in turn informing the benefits and risks of LDCT in clinical practice. (2017-10-26)

Three new lung cancer genetic biomarkers are identified in Dartmouth study
SNPs (single-nucleotide polymorphisms) are variations in our DNA that determine our susceptibility to developing some diseases. Using the largest genome-wide SNP-smoking interaction analysis reported for lung cancer, a research team led by Dartmouth's Norris Cotton Cancer Center's Yafang Li, PhD, has identified three novel SNPs. The results from their study reinforce that gene-smoking interactions play important roles in the etiology of lung cancer and account for part of the missing heritability of this disease. (2017-10-26)

Targeting mitochondria in pulmonary hypertension
Investigators at the University of Alberta and the Imperial College of Medicine have shown that the generic drug, Dichloroacetate (DCA), can decrease the blood pressure in the lungs of pulmonary arterial hypertension patients and improve their ability to walk, without significant side effects at the doses tested. (2017-10-25)

Some people with cystic fibrosis might live longer because of genetic mutations
Research suggests that genetic mutations to an 'epithelial sodium pathway' could protect against cystic fibrosis and its debilitating effects on the lungs. (2017-10-25)

Sexual function concerns not always reflected in prostate cancer treatment choices
A study led by UNC Lineberger Comprehensive Cancer Center researchers found that preference for preserving sexual function was not strongly reflected in the treatment choices of men with low-risk prostate cancer. (2017-10-25)

Study indicates arsenic can cause cancer decades after exposure ends
A new paper published in the Journal of the National Cancer Institute shows that arsenic in drinking water may have one of the longest dormancy periods of any carcinogen. By tracking the mortality rates of people exposed to arsenic-contaminated drinking water in a region in Chile, the researchers provide evidence of increases in lung, bladder, and kidney cancer even 40 years after high arsenic exposures ended. (2017-10-24)

Tarloxitinib puts tumor-seeking tail on anti-EGFR drug to precisely target lung cancer
University of Colorado Cancer Center study being presented Oct. 28 at the AACR-NCI-EORTC International Conference on Molecular Targets: By pairing an anti-EGFR drug with a 'tail' that only activates the drug when it is very near tumor cells, tarloxitinib brings the drug to tumors while keeping concentrations safe in surrounding tissues. (2017-10-24)

Vapor from glo™ had little or no biological impact on cells in laboratory tests
Unlike smoke, vapor from tobacco heating product -- gloTM -- is not toxic, does not cause oxidative stress, gene mutations or the promotion of tumors in cells in laboratory tests. gloTM, a tobacco heating device, heats rather than burns tobacco. It is well established that it is the toxicants produced by burning tobacco that are responsible for causing most smoking-related diseases. The numbers and levels of toxicants in gloTM emissions are significantly lower than in cigarette smoke, meaning it has the potential to be reduced risk. (2017-10-24)

Scientists identify 'first responders' to bacterial invasion
When bacteria enter our body, they kick-start a powerful immune response. But this chain of reactions doesn't fully account for our immediate responses. Researchers at KU Leuven, Belgium, show that so-called ion channels play a key role as 'first responders'. (2017-10-23)

Scientists discover new gene associated with debilitating lung disease
Finding of lung fibrosis gene highlights a potential new avenue for treatment. (2017-10-23)

Virus-like particle vaccine protects against RSV vaccine-enhanced respiratory disease, study finds
Researchers have discovered that a virus-like particle vaccine can prime the body's immune response and prevent the severe respiratory disease that results when patients given an early form of a vaccine for respiratory syncytial virus (RSV) are exposed to RSV, according to a study led by Georgia State University. (2017-10-23)

Lung cancer driver ALK-fusion found in melanoma
A University of Colorado Cancer Center study published today in the journal Molecular Cancer Therapeutics finds a genetic change called ALK-fusion in a patient sample of a melanoma subtype called mucosal melanoma. When researchers treated a tumor grown from this sample with the drugs crizotinib and ceritinib - both FDA approved to treat ALK-positive lung cancer - the tumor responded dramatically. (2017-10-23)

Two studies explore gender, language, and treatment setting as barriers in screening and patient care in lung cancer
More people die of lung cancer than any other type of cancer, and two new studies from CHEST 2017 reveal disparities in lung cancer screening and care that may impact detection, as well as mortality and survival rates in the disease. (2017-10-23)

New asthma biomarkers identified from lung bacteria
New research from the University of Illinois at Chicago suggests that the lung microbiome plays a significant role in asthma severity and response to treatment. (2017-10-23)

Yoga can be an effective supportive therapy for people with lung cancer and their caregivers
In a feasibility trial of people with advanced lung cancer receiving radiation therapy, and their caregivers, yoga was beneficial to both parties. (2017-10-23)

E-cigarettes may trigger unique and potentially damaging immune responses
E-cigarettes appear to trigger unique immune responses as well as the same ones that cigarettes trigger that can lead to lung disease, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. (2017-10-20)

The microbial anatomy of an organ
University of California San Diego researchers have developed the first 3-D spatial visualization tool for mapping 'omics' data onto whole organs. The tool helps researchers and clinicians understand the effects of chemicals, such as microbial metabolites and medications, on a diseased organ in the context of microbes that also inhabit the region. The work could advance targeted drug delivery for cystic fibrosis and other conditions where medications are unable to penetrate. (2017-10-19)

New gene editing approach for alpha-1 antitrypsin deficiency shows promise in UMMS study
A study published in the journal Molecular Therapy by Christian Mueller, PhD, shows that using nuclease-free gene editing to correct cells with the mutation that causes alpha-1 antitrypsin deficiency leads to repopulation of a diseased liver with healthy cells. It has the potential to prevent liver and lung damage from forming in very young alpha-1 patients. (2017-10-19)

Terry Fox research team's model for detecting lung cancer saves lives, is a world leader
A pan-Canadian team of cancer researchers has developed a predictive model for detecting early-stage lung cancer in high-risk individuals with significantly greater accuracy than other leading models. This Terry Fox Research Institute study suggests the team's innovative approach could be considered for use in lung cancer screening programs both in Canada and around the world. (2017-10-18)

Exercise interventions in advanced lung cancer patients led to increased functionality
Physical exercise and psycho-social interventions in patients with advanced stage lung cancer improved functional capacity, which may be linked to quality of life benefits. Dr. Quist of the University of Copenhagen in Denmark presented these findings today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan. (2017-10-17)

Community engagement interventions may reduce disparities in lung cancer outcomes among minorities
Community-based interventions implemented in minority community sites resulted in changes in participants' knowledge, attitudes and beliefs about cancer, as well as perceived benefits and self-efficacy measures regarding lung cancer screening. Dr. Lovoria Williams of Augusta University in the United States presented these findings today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan. (2017-10-17)

Study cites race and socioeconomic factors as influential in NSCLC patient survival rates
New research found race and specific socioeconomic factors to have a significant influence on disparities in the survival rates of non-small cell lung cancer (NSCLC) patients. Dr. Yanyan Lou of the Mayo Clinic in the United States presented these findings today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan. (2017-10-16)

Integration of smoking cessation within CT lung cancer screenings shows life-saving results
A study that integrated robust smoking cessation programs into an organized low-dose CT (LDCT) lung cancer screening program found that the inclusion of both interventions has the potential to decrease mortality rates while being relatively cost-effective. Dr. William Evans of McMaster University in Canada presented these findings today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan. (2017-10-16)

Early palliative care provides no quality of life benefits for recently diagnosed MPM patients
Early specialist palliative care for patients that were recently diagnosed with malignant pleural mesothelioma (MPM) does not impact quality of life (QOL) measures, according to research presented by Prof. Fraser Brims of Curtin University in Australia, at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan. (2017-10-16)

Biopsy specimen found to be reliable for evaluating DLL3 expression in small cell lung cancer
Small cell lung cancer (SCLC) biopsy specimen was found to be reliable material for evaluating DLL3 expression; high levels of DLL3 in SCLC are correlated with poor survival trends. Dr. Li-Xu Yan of Guangdong General Hospital and Guangdong Academy of Medical Sciences in China presented her findings from this study today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan. (2017-10-16)

Treatment based On BRCA1 level does not increase survival of stage II/III NSCLC N+ resected patients
Research shows that treating stage II and III non-small cell lung cancer (NSCLC) N+ resected patients with customized chemotherapy treatment based on their specific BRCA1 expression levels, as opposed to providing the standard treatment, did not increase overall survival rates among those patients who received individualized CT treatment. Dr. Bartomeu Massuti of Alicante University Hospital in Spain presented his findings today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan. (2017-10-16)

Researchers confirm IASLC characterization of uncertain R status with prognosis between R0 and R1
The findings of a recent study confirm the International Association for the Study of Lung Cancer (IASLC)'s proposed criteria for uncertain resection margin status, R(un), in residual tumor (R) classification. Dr. John Edwards of the University of Sheffield in the United Kingdom presented his team's findings today at the IASLC 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan. (2017-10-16)

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