Current Lupus News and Events

Current Lupus News and Events, Lupus News Articles.
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New improved dog reference genome will aid a new generation of investigation
Researchers at Uppsala University and the Swedish University of Agricultural Sciences have used new methods for DNA sequencing and annotation to build a new, and more complete, dog reference genome. This tool will serve as the foundation for a new era of research, helping scientists to better understand the link between DNA and disease, in dogs and in their human friends. The research is presented in the journal Communications Biology. (2021-02-10)

When hyperactive proteins trigger illnesses
Autoimmune diseases, in which the body's own immune system attacks healthy tissue, can be life-threatening and can impact all organs. A research team at the Technical University of Munich (TUM) has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells. The research opens the door to new therapeutic possibilities. (2021-02-02)

Study pins down number of Americans with most common form of lupus
Just over 200,000 Americans suffer from systemic lupus erythematosus, or SLE, a condition in which the body's immune system mistakenly attacks its own healthy tissues, especially joints and skin, a new study shows. (2021-01-21)

Study finds especially high rates of lupus in certain racial/ethnic groups
The US prevalence of the autoimmune disease lupus is 72.8 cases per 100,000 individuals, according to an analysis of population-based registries. The analysis, which is published in Arthritis & Rheumatology, found that the rate is 9 times higher for females than males (128.7 vs. 14.6 per 100,000), and it's highest among American Indians/Alaska Natives and Black females. (2021-01-21)

Study reveals new insights into the link between sunlight exposure and kidney damage
A new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington and published in the Proceedings of the National Academy of Sciences (PNAS), reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus. (2021-01-21)

Autoimmune diseases: similar molecular signatures in target tissues
A study conducted by Professor Decio L. Eizirik's group - ULB Center for Diabetes Research - and published in Sciences Advances shows that autoimmune diseases, including type 1 diabetes, must be studied in their entirety, taking into account not only the immune system but also the target tissues. Indeed, the key mechanisms induced by inflammation, potentially shared between type 1 diabetes, systemic lupus erythematosus, multiple sclerosis and rheumatoid arthritis, could generate similar molecular signatures at the target tissue level. (2021-01-07)

Hydroxychloroquine blood levels predict clotting risk in patients with lupus
A new study in Arthritis & Rheumatology shows that monitoring patients' blood levels of hydroxychloroquine can predict their clotting risk. (2021-01-06)

New research finds ginger counters certain autoimmune diseases in mice
The main bioactive compound of ginger root lowers autoantibody production and helps halt disease progression in mice with antiphospholipid syndrome and lupus. (2021-01-06)

A new approach to study autoimmune diseases
A team of researchers led by the Indiana Biosciences Research Institute Diabetes Center's Scientific Director Decio L. Eizirik, MD, PhD, has found that identifying new treatments for autoimmune diseases requires studying together the immune system AND target tissues. This study, ''Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis and rheumatoid arthritis,'' is featured in the Jan. 6, 2021, edition of Science Advances. (2021-01-06)

Developing new classification criteria for improving antiphospholipid syndrome research
An international team of more than 80 collaborators led by Hospital for Special Surgery (HSS) investigators is developing new classification criteria for clinical research of antiphospholipid syndrome (APS), a life-threatening autoimmune clotting disorder. In a paper published online in Arthritis Care & Research, the investigators reported on the first two of four phases of criteria development. (2020-12-17)

Two thirds of people with lupus would take COVID-19 vaccine, shows LRA survey
Two out of three people with lupus (64%) are willing to take a COVID-19 vaccine if it is free and determined safe by scientists according to results of a survey conducted by the Lupus Research Alliance (LRA). (2020-12-16)

People with rare autoimmune diseases at increased risk of dying during COVID-19 pandemic
A new study, led by experts from the University of Nottingham, has shown that people with rare autoimmune rheumatic diseases are at a greater risk of dying at a younger age during the COVID-19 pandemic. (2020-12-03)

HCQ has no significant impact on heart rhythm in lupus patients, even those with CKD
New research shows that adults with lupus who take the antimalarial drug, hydroxychloroquine, do not have any differences in their corrected QT (QTc) intervals, an electrocardiogram (EKG) measurement of the heart's electrical signals, even if they have chronic kidney disease (CKD), a complication of lupus that can be associated with increased levels of the medication. (2020-11-06)

Black patients with lupus have three times higher risk of stroke
New research reveals that, in the U.S., Black patients with lupus have a threefold higher risk of stroke and a 24-fold higher risk of ischemic heart disease. The study also found several lupus-specific symptoms that predict stroke and IHD in these patients. Details of the study was presented at ACR Convergence, the American College Rheumatology's annual meeting. (2020-11-06)

Hydroxychloroquine not linked to longer heart rhythm intervals in RA or lupus patientsti
New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, discovers that use of hydroxychloroquine, a generic drug, does not cause any significant differences in QTc length or prolonged QTc, key measures of heart rate, in people with rheumatoid arthritis (RA) or systemic lupus erythematosus. (2020-11-06)

Patients reported international hydroxychloroquine shortages due to COVID-19
A new study shows that patients with rheumatic diseases across Africa, Southeast Asia, the Americas and Europe had trouble filling their prescriptions of antimalarial drugs, including hydroxychloroquine, during the 2020 global coronavirus pandemic, when antimalarials were touted as a possible COVID-19 treatment. Patients who could not access their antimalarial drugs faced worse physical and mental health outcomes as a result. (2020-11-06)

Many with lupus at high risk for adverse reactions to pneumocystis pneumonia drug
New research shows that adults with systemic lupus erythematosus, who receive trimethoprim-sulfamethoxazole (TMP-SMX), a prophylactic therapy to help prevent pneumocystis pneumonia, are at high risk for adverse reactions to the drug, particularly if they are also positive for anti-Smith (anti-Sm) antibodies. Details of the study was presented at ACR Convergence, the American College of Rheumatology's annual meeting. (2020-11-06)

Immune cell activation in severe COVID-19 resembles lupus
In severe cases of COVID-19, activation patterns of B cells resemble those seen in systemic lupus erythematosus, an autoimmune disease. Emory researchers want to see how far that resemblance extends. (2020-10-09)

Physical activity and sleep in adults with arthritis
A new study published in Arthritis Care & Research has examined patterns of 24-hour physical activity and sleep among patients with rheumatoid arthritis, lupus, and knee osteoarthritis. (2020-10-07)

Targeting the treatment of autoimmune diseases
A team of researchers from Charité - Universitätsmedizin Berlin and the Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, have successfully treated two patients with the autoimmune disease systemic lupus erythematosus. Using daratumumab, a monoclonal antibody which targets specific immune cells known as plasma cells, the researchers were able to modulate the abnormal immunological memory processes found in these patients. Treatment induced sustainable clinical responses and resulted in a reduction in systemic inflammation. (2020-09-22)

Improving the transition from pediatric to adult rheumatology care
As children with chronic rheumatic illnesses age, it's important that they experience a smooth transition from pediatric to adult care. A study published in Arthritis Care & Research has identified certain factors that are important during this time. (2020-09-10)

Most adults with lupus or common types of arthritis have similar risks of getting admitted to hospital as other COVID-19 patients
Most adults with systemic lupus erythematosus (SLE) are not at increased risk of hospitalization from COVID-19 due to medications used to dampen their altered immune system, the cause of their disease. (2020-08-25)

New study: Hydroxychloroquine ineffective as a preventive antiviral against COVID-19
Researchers at Case Western Reserve University have added to the growing body of understanding about how hydroxychloroquine (HCQ) is not a possible defense against COVID-19. Specifically, they found that HCQ is not effective in preventing COVID-19 in patients with lupus and rheumatoid arthritis (RA), suggesting a broader interpretation of HCQ as ineffective preventive medicine for the general population. Their findings were recently published in the Annals of the Rheumatic Diseases. (2020-08-17)

Assessment of lupus anticoagulant positivity in patients with COVID-19
How common lupus anticoagulant (LA) positivity is in patients with COVID-19 was assessed in this observational study, which also examined the association of LA positivity with patient outcomes. (2020-08-12)

CHOP-pioneered spatial mapping method pinpoints potential new therapeutic targets in lupus
A team of researchers from Children's Hospital of Philadelphia (CHOP) used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders. (2020-07-08)

The protein that stands between us and autoimmunity
Researchers from Osaka University identified the epigenetic proteins Tet2 and Tet3 as key regulators of B cell function. They showed that these proteins suppress B cell function and conversely, that Tet2/Tet3 knockout mice develop a mild form of systemic lupus erythematosus due to hyperactivation of T cells. These findings could help develop a novel treatment for autoimmune diseases. (2020-07-02)

Systemic lupus erythematosus (SLE)
If renal remission is achieved therapeutically in cases of lupus nephritis (LN), the 10-year survival rate increases significantly. Successful therapy is therefore of great importance. As a recent presentation at the ERA-EDTA Congress showed, this can be achieved by additional administration of belimumab. (2020-06-07)

First do no harm -- researchers urge halt in prescribing hydroxycholoroquine for COVID-19
Researchers urge a moratorium on prescribing chloroquine or hydroxychloroquine, with or without azithromycin, to treat or prevent COVID-19, and caution that the reassuring safety profile of hydroxychloroquine may be more apparent than real. Safety data derive from decades of prescriptions by clinicians, primarily for their patients with lupus and rheumatoid arthritis, both of which are of greater prevalence in younger and middle age women, who are at very low risk of fatal heart outcomes due to hydroxychloroquine. (2020-06-03)

New test method can offer safer dosages of hydroxychloroquine
Researchers at Uppsala University and Uppsala University Hospital have developed a new method to measure levels of the medication hydroxychloroquine in patients with the rheumatic disease systemic lupus erythematosus (SLE). The analysis method may also be useful in other areas, such as in the treatment of COVID-19. The study is being published in Arthritis Research and Therapy. (2020-06-01)

Study finds surge in hydroxychloroquine/chloroquine prescriptions during COVID-19
A new study by investigators from Brigham and Women's Hospital examines changes in prescription patterns in the United States during the COVID-19 pandemic. (2020-05-28)

Complement genes add to sex-based vulnerability in lupus and schizophrenia
Variants in a gene of the human immune system cause men and women to have different vulnerabilities to the autoimmune diseases lupus and Sjögren's syndrome, according to findings published in the journal Nature. This extends recent work that showed the gene variants could increase risk for schizophrenia. The gene variants are a member of the complement system, a cascade of proteins that help as an infection defense that promotes inflammation and attacks pathogens. (2020-05-18)

Sex, genes and vulnerability
Study offers molecular explanation for long-standing observation that certain diseases occur more often or more severely in different sexes. Complement component 4 (C4) genes protect against the autoimmune disorders lupus and Sjögren's syndrome while raising risk of severe schizophrenia. (2020-05-11)

Race-specific lupus nephritis biomarkers
A University of Houston biomedical researcher has discovered a difference in urinary biomarker proteins of lupus nephritis in patients according to race. The findings have implications for early diagnosis and new treatments. (2020-05-05)

New clinical review casts doubt on use of chloroquine and hydroxychloroquine for COVID-19
In its May issue, The FASEB Journal is publishing a comprehensive review on the science and clinical experiences with the drugs chloroquine and hydroxychloroquine, first introduced as effective weapons against malaria, rheumatoid arthritis, and the autoimmune disease lupus. Recent anecdotal reports suggested these drugs might be effective against the SARS-CoV-2 virus, the cause of the COVID-19 pandemic. This new review describes the growing skepticism regarding adoption of chloroquine and hydroxychloroquine for the respiratory infection caused by this virus. (2020-04-30)

Potential harms of chloroquine, hydroxychloroquine and azithromycin for treating COVID-19
Chloroquine, hydroxychloroquine and azithromycin are being used to treat and prevent COVID-19 despite weak evidence for effectiveness, and physicians and patients should be aware of the drugs' potentially serious adverse events, states a review in CMAJ (Canadian Medical Association Journal). (2020-04-08)

Drug shows promise in reversing kidney damage caused by lupus
A drug used for cancer therapy has shown promise in reversing kidney damage caused by systemic lupus erythematosus (SLE, or lupus), according to a Yale-led study published April 8 in the journal Science Translational Medicine. (2020-04-08)

But you don't look sick? How broad categories like autoimmune impact patient experience
Patients with autoimmune diseases often have an illness experience riddled with symptom ambiguities and shifting diagnoses. A new Drexel University study found that one way patients and physicians can work through the difficulty and frustration of communicating about these conditions is to use both broad diagnostic terms, like 'autoimmune disease,' as well as narrow ones, such as 'lupus or MS.' (2020-03-24)

Study finds molecule in lymphatic system implicated in autoimmune diseases
A study by investigators at Hospital for Special Surgery (HSS) has discovered a molecule in the lymphatic system that has the potential to play a role in autoimmune disease. (2020-03-20)

ACR releases reproductive health guideline for patients with rheumatic diseases
Today, the American College of Rheumatology (ACR) published the 2020 Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. This is the first, evidence-based, clinical practice guideline related to the management of reproductive health issues for all patients with rheumatic diseases. With 131 recommendations, the guideline offers general precepts that provide a foundation for its recommendations and good practice statements. (2020-02-24)

Research pinpoints rogue cells at root of autoimmune disease
Breakthrough cellular genomics technology has allowed Garvan and UNSW Sydney researchers to reveal genetic mutations causing rogue behaviour in the cells that cause autoimmune disease. (2020-02-13)

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