Current Lymphedema News and Events

Current Lymphedema News and Events, Lymphedema News Articles.
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Phase I clinical trial shows promise of adipose-derived stem cells in treating lymphedema
Results of a phase I clinical trial released in STEM CELLS Translational Medicine shows there is a strong possibility that stem cells may alleviate lymphedema, a chronic debilitating condition affecting up to one in three women treated for breast cancer. (2021-02-17)

How blood and lymph vessels remain separated after development
Researchers in Japan have clarified the mechanism by which blood and lymphatic vessels remain separated after development. The characteristics and structures of these two vessel types are very similar, and how they maintain separation has remained unexplained for many years. In this study, researchers found that the molecule Folliculin (FLCN) in vascular endothelial cells acts as a gatekeeper to maintain separation between the two. (2021-02-04)

Non-hereditary mutation acts as natural gene therapy in patient with rare disease
Scientists at a research center supported by FAPESP identified a non-inherited mutation in blood cells from a patient with GATA2 deficiency that may have prevented bone marrow failure and other clinical manifestations. (2020-11-17)

Missing rehab due to COVID-19 increased distress in women with breast cancer
Beyond the tragic surges in hospitalizations and deaths, the first months of the COVID-19 pandemic disrupted healthcare for people with a wide range of medical conditions - including cancer. For women recovering after breast cancer treatment, COVID-19-related interruptions in rehabilitation care led to emotional distress and other effects on health and well-being, reports a study in the October issue of Rehabilitation Oncology, official journal of the APTA Oncology, an Academy of the American Physical Therapy Association. (2020-09-28)

Photoacoustic microscopy for identifying sentinel lymph nodes of breast cancer
Tumor metastatic sentinel lymph nodes is difficult to distinguish from normal or inflamed lymph nodes (Inf-LN). Researchers designed a dual-targeting nanoparticle 5K-HA-HPPS for fluorescent/photoacoustic imaging of sentinel LN. Photoacoustic imaging showed a distinct spatial distribution of 5K-HA-HPPS among different LN statuses, which the signals were mainly distributed at the centre of T-MLN but at the periphery of normal and Inf-LNs. This ability to distinguish T-MLN has potential application value for surgeons in tumor surgery. (2020-09-22)

Researchers discovered a novel gene involved in primary lymphedema
Reseachers have made an important discovery how mutations in a novel gene, ANGPT2, cause a lymphatic disease called primary lymphedema. Discovery is essential for the proper diagnosis of patients suffering from primary lymphedema. (2020-09-10)

App detects harsh side effect of breast cancer treatment
Many breast cancer survivors suffer from lymph collection known as lymphedema. It causes arms to swell, and sufferers often become severely depressed. A new app detects it early, and its makers hope it will help spread awareness of the disease. (2020-03-16)

Researchers use genomics to discover potential new treatment for parasite disease
Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine (UMSOM) Institute for Genome Sciences identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat. The potential new therapy is an experimental cancer drug called JQ1 and targets proteins found prominently in the worm's genome; it appears to effectively kill the adult worms in a laboratory setting, according to the study. (2019-12-03)

Sentinel lymph node biopsy has no benefits for stage zero breast cancer
Older women with a very early, non-invasive breast cancer known as ductal carcinoma in situ (DCIS) gain no long-term benefit from undergoing a sentinel lymph node biopsy to see if the cancer has spread, new research by the Yale School of Public Health has found. (2019-10-24)

New international exercise guidelines for cancer survivors
For the rising number of cancer survivors worldwide, there's growing evidence that exercise is an important part of recovery. But how much, and what type of exercise, is needed? (2019-10-16)

A PoEM on breast cancer metastasis
When breast cancer cells spread through the body, they do so mainly through the lymph system that normally removes excess fluid and waste products from our tissues. Now, scientists from the group of Professor Massimiliano Mazzone (VIB-KU Leuven Center for Cancer Biology) identified a novel subset of immune cells, called Podoplanin-expressing macrophages (PoEMs), that change the tissues near a tumor in a way that promotes the spreading of cancer cells. (2019-08-28)

Study finds cellular processes controlling the formation of lymphatic valves
A mouse model study led by the University of South Florida Health (USF Health) Morsani College of Medicine has identified new cellular processes controlling development of the small valves inside lymphatic vessels, which prevent lymph fluid from flowing the wrong way back into tissues. The new findings suggest that targeting signaling pathways involved in creating and maintaining lymphatic valves may be a viable therapy for patients coping with lymphedema. (2019-08-27)

Technology better than tape measure for identifying lymphedema risk
Bioimpedance spectroscopy (BIS) is better than a tape measure for assessing a woman's risk for developing lymphedema, painful swelling in the arm after breast cancer surgery. (2019-05-07)

How does chronic edema impact health-related quality of life?
Final results of the large, international LIMPRINT study have provided new data on the prevalence of chronic swelling and the devastating impact it can have on health-related quality of life. (2019-04-26)

Breast cancer patients weigh in on addressing financial burdens
A qualitative study led by researchers at the Johns Hopkins Bloomberg School of Public Health yielded nine patient-driven recommendations across circumstances that include changes to insurance, supportive services and financial assistance to reduce long-term, breast cancer-related economic burden. (2019-03-06)

Axillary RT and lymph node surgery yielded comparable outcomes for patients with breast cancer
Patients with early-stage breast cancer who had cancer detected in a sentinel lymph node biopsy had comparable 10-year recurrence and survival rates following either axillary radiotherapy or axillary lymph node dissection, according to data from the randomized, phase III AMAROS clinical trial presented at the 2018 San Antonio Breast Cancer Symposium. (2018-12-06)

Anti-inflammatory drug effective for treating lymphedema symptoms
Two early-stage clinical trials led by Stanford researchers have shown that ketoprofen can improve skin damage in patients with lymphedema. (2018-10-18)

New findings cast light on lymphatic system, key player in human health
Defects in the lymphatic system have been linked to a wide range of health consequences, but new findings of how the system works could lead to future therapies. (2018-10-16)

The long-term financial toll of breast cancer
The financial fallout from breast cancer can last years after diagnosis, particularly for those with lymphedema, a common side effect from treatment, causing cumulative and cascading economic consequences for survivors, their families, and society, a study led by Johns Hopkins Bloomberg School of Public Health researchers suggests. (2018-08-22)

Machine learning helps detect lymphedema among breast cancer survivors
Machine learning using real-time symptom reports can accurately detect lymphedema, a distressing side effect of breast cancer treatment that is more easily treated when identified early, finds a new study led by NYU Rory Meyers College of Nursing and published in the journal mHealth. (2018-06-07)

Mass. General study reveals how MRSA infection compromises lymphatic function
Massachusetts General Hospital investigators find that MRSA infection impairs the ability of lymphatic vessels to pump lymphatic fluid to lymph nodes in mouse models, which may contribute to the frequent recurrences of MRSA infection experienced by patients. (2018-01-17)

Risk of non-infectious elephantiasis mapped in Cameroon
Both the etiology and demographics of podoconiosis, a non-infectious disease which causes massive swelling of the legs, are poorly understood. To help contribute to the global atlas of podoconiosis knowledge, researchers reporting in PLOS Neglected Tropical Diseases have now described the distribution of podoconiosis in Cameroon. (2018-01-11)

Lymphedema after cancer treatment -- special issue of Rehabilitation Oncology presents research update
Individuals who have been treated for cancer are at risk for a complication called lymphedema: swelling in the body region where lymph nodes were removed, causing pain and limited function. New research and insights on the management of cancer-related lymphedema are presented in the January special issue of Rehabilitation Oncology, official journal of the Oncology Section of the American Physical Therapy Association. The journal is published by Wolters Kluwer. (2018-01-04)

Researchers get first complete look at protein behind sense of touch
The findings point the way to targeting diseases where this protein is mutated. (2017-12-20)

Long-lasting blood vessel repair in animals via stem cells
An Emory/Yonsei team developed a new method for generating endothelial cells, which make up the lining of blood vessels, from human iPSCs.. When endothelial cells are surrounded by a supportive gel and implanted into mice with damaged blood vessels, they become part of the animals' blood vessels, surviving for more than 10 months. (2017-10-23)

Portable 3-D scanner assesses patients with elephantiasis
An estimated 120 million people worldwide are infected with lymphatic filariasis, a parasitic, mosquito-borne disease that can cause major swelling and deformity of the legs, a condition known as elephantiasis. Scientists at Washington University School of Medicine in St. Louis have shown that a portable scanning device can measure limb enlargement and disfigurement faster and more easily in patients with elephantiasis. The research tool makes it easy to obtain accurate measurements and determine whether treatments to reduce swelling are effective. (2017-10-16)

World's first super-microsurgery operation with 'robot hands'
Plastic surgeons at Maastricht University Medical Center have used a robotic device to surgically treat lymphedema in a patient. This is the world's first super-microsurgical intervention with 'robot hands'. The surgeons used the robotic device to suture vessels of 0.3 to 0.8 millimeter in the arm of the patient. The robotic device, created by Eindhoven company Microsure, enhances the surgeon's precision, making this type of procedure easier to perform. (2017-10-02)

Study: Common surgical treatment for melanoma does not improve patients' overall survival
Patients who receive the standard surgical treatment for melanoma that has spread to one or more key lymph nodes do not live longer, a major new study shows. (2017-06-07)

NYU researchers study patients' genetic and susceptibility risk factors for lymphedema
Genetic variations may be one of the important factors that influence breast cancer survivors' responses to the inflammatory processes and vulnerability to lymphedema. (2017-02-08)

Actress Kathy Bates to be honored at Research!America's Advocacy Awards Dinner
Kathy Bates, award-winning actress and Lymphatic Education & Research Network (LE&RN) spokesperson, will receive Research!America's Isadore Rosenfeld Award for Impact on Public Opinion for raising the visibility of lymphedema and lymphatic diseases and advocating tirelessly on behalf of the patient community. The Rosenfeld Award is presented to individuals who have worked to effectively deliver medical or other health-related research advocacy messages to the public. (2017-01-18)

Fat fuels the road to cancer cell spread
Cancer cells spread to other sites in the body through promoting the growth of new 'roads' to travel on. In a study to be published on Dec. 26 in Nature, an international and multidisciplinary team of researchers, led by Prof. Dr. Peter Carmeliet (VIB-KU Leuven), discovered how a shift to increased fat utilization is required for the development and growth of these 'roads,' termed lymphatic vessels -- a special kind of blood vessels. (2016-12-26)

Researchers identify cause for lower-extremity overgrowths in obese patients
Morbidly obese individuals are prone to overgrowths in their lower extremities that can lead to infections and other health-threatening complications. Conventional treatment has involved surgical removal of these overgrowths. However, a new study published in the Journal of the American College of Surgeons has identified the underlying cause for these overgrowths, and the researchers recommend that weight loss be the preferred initial treatment for these patients. (2016-11-30)

Andrea Cheville, M.D., of Mayo Clinic elected to the National Academy of Medicine
Andrea Cheville, M.D., physical medicine and rehabilitation researcher and director of the Cancer Rehabilitation Program at Mayo Clinic, has been elected to the National Academy of Medicine. (2016-10-19)

New study links neuropilin 2 deficiency to inflammation-induced edema & lymphedema
Edema frequently occurs in chronic inflammatory diseases including psoriasis and eczema. Capillaries in the lymphatic system usually drain the excess fluid but their dysfunction can lead to another serious condition: lymphedema. A new study published in The American Journal of Pathology found that deficiency in neuropilin 2 (Nrp2) receptors in vascular endothelial cells results in excessive and prolonged fluid build-up after inflammation. This discovery may guide investigators toward new pharmacological therapies for edema and lymphedema. (2016-10-14)

Treating the inflammation in lymphedema
ETH researchers have discovered that certain cells in the immune system suppress the development of lymphedema. Anti-inflammatory therapies could therefore be the key to treating this previously incurable condition. (2016-10-11)

Mobile self-care apps for early identification & treatment of lymphedema
The development of TOLF was motivated by the request from breast cancer survivors in our prior research where nurse-patient-in-person delivery model was used and guided by the Model of Self-Care for Lymphedema Symptom Management based on our prior research in the figure above. TOLF focuses on building self-care skills based on research-based, innovative, safe, feasible and easily-integrated-into daily-routine self-care strategies to lessen lymphedema symptom burden. (2016-10-03)

Oklahoma researchers find that a biological 'good guy' has a dark side
A pair of Oklahoma Medical Research Foundation scientists have discovered that an enzyme previously thought only to be beneficial could, in fact, pose significant danger to developing embryos. The new research could have implications not only for prenatal development but also for treating lymphedema and liver damage resulting from acetaminophen overdose. (2016-05-04)

Scientists reveal new target for anti-lymphangiogenesis drugs
In an emerging field of research, a study in Nature Communications reveals a mechanism in the regulation of lymphangiogenesis. Scientists identified a new target for drug treatment to prevent conditions caused by lymphangiogenesis, which include some blinding eye diseases, organ transplant rejection, and cancer metastasis. (2016-04-12)

NYU study identifies method for detecting latent stage of lymphedema
NYU Nursing researchers examined the validity, sensitivity, and specificity of symptoms for detecting breast cancer-related related lymphedema. The study also determined the best clinical cutoff point for the count of symptoms that maximized the sum of sensitivity and specificity. (2015-12-18)

NYU nursing study examines obesity in relation to breast cancer related lymphedema
Lymphedema is a major health problem negatively affecting many breast cancer survivors survivors' quality of life. NYU researchers have shown this condition can be managed with early and appropriate treatment. (2015-12-17)

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