Current Macrophages News and Events

Current Macrophages News and Events, Macrophages News Articles.
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Scientists identify potential contributor to hyper immune responses in patients with severe COVID-19
Researchers have pinpointed a helper T cell population in the lungs of patients with severe COVID-19 that may be central to the development of hyperinflammation, lung injury, and subsequent acute respiratory distress syndrome (ARDS) during disease (2021-02-23)

Yale neurologists identify consistent neuroinflammatory response in ICH patients
Understanding how the immune system responds to acute brain hemorrhage could open doors to identifying treatments for this devastating disease. However, up until now, there has been limited information on inflammation in the brain from human patients, especially during the first days after a hemorrhagic stroke. This led a team of researchers to partner with a large clinical trial of minimally-invasive surgery to tackle defining the human neuroinflammatory response in living patients. (2021-02-22)

Improving immunotherapies for blood cancers: real-time exploration in the tumor
Monoclonal antibodies are part of the therapeutic arsenal for eliminating cancer cells. Some make use of the immune system to act and belong to a class of treatment called ''immunotherapies.'' But how do these antibodies function within the tumor? And how can we hope to improve their efficacy? Using innovative in vivo imaging approaches, scientists from the Institut Pasteur and Inserm visualized in real time how anti-CD20 antibodies, used to treat B-cell lymphoma, guide the immune system to attack tumor cells. (2021-02-21)

3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

Antibody response may drive COVID-19 outcomes
Researchers at the Ragon Institute of MGH, MIT and Harvard and Massachusetts General Hospital show that levels of specific antibodies developed in the immune response may influence COVID-19 outcomes in both children and adults. (2021-02-18)

Oncotarget: Cancer stem cells and macrophages against cancer
The aim of this Oncotarget review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies (2021-02-15)

Antitumoral effects of LXR activation
Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defences: these become, thus, the tumor-associated macrophages (TAMs). (2021-02-12)

Sweet coating for sour bones
Scientists invent a bioactive coating to improve the function of titanium implants in osteoporotic bones. This coating, comprising a chemically-modified glycan, can sequentially turn on and off inflammation on titanium surface upon implantation. This modulation stimulates the body's immune system to promote bone healing in an effective and safe way, without addition of bone-forming genes or drugs, according to the data from a rat osteoporotic model. (2021-02-12)

Aggressive brain tumor mapped in genetic, molecular detail
A new study led by Washington University School of Medicine in St. Louis has revealed a detailed map of the genes, proteins, infiltrating cells and signaling pathways that play key roles in driving glioblastoma. The study, of 99 tumors from patients, is the largest and most detailed schematic of this deadly brain tumor. (2021-02-11)

Novel protein could reverse severe muscle wasting in disease, aging and trauma
Muscle stem cells drive the tissue's growth and repair after such injuries. But growing these cells in the lab and using them to therapeutically replace damaged muscle has been frustratingly difficult. Australian researchers have discovered a factor that triggers these muscle stem cells to proliferate and heal. In a mouse model of severe muscle damage, injections of this naturally occurring protein led to the complete regeneration of muscle and the return of normal movement after severe muscle trauma. (2021-02-10)

Scientists switch on tissue repair in inflammatory bowel disease
Researchers have developed a method that instructs immune system cells to help repair damaged tissue in the intestine. The finding opens the way for more effective treatment of inflammatory bowel disease. (2021-02-08)

Study identifies noncoding RNA involved in immune response and sepsis
When the body's immune response to an infection gets out of control, the result can be sepsis, a life-threatening condition in which an overwhelming inflammatory response can lead rapidly to failure of multiple organs and death. In a new study, researchers at UC Santa Cruz have identified a long noncoding RNA (lncRNA) molecule that regulates the expression of pro-inflammatory genes in immune system cells called macrophages and affects the susceptibility of mice to septic shock. (2021-02-01)

How a little-known glycoprotein blocks a cancer cell's immune response
Researchers uncovered how stanniocalcin-1, or STC1, works inside a tumor cell to block a cellular ''eat-me'' signal that typically triggers the immune system to produce T cells to fight the tumor. The findings provide a potential target to improve immune responses to cancer. (2021-01-28)

Melatonin produced in the lungs prevents infection by novel coronavirus
The hormone acts as a barrier against SARS-CoV-2, blocking the expression of genes that encode proteins in cells serving as viral entry points, according to a study by researchers at the University of São Paulo. (2021-01-27)

Stanford study reveals immune driver of brain aging
Stanford scientists have identified a key factor in mental aging and shown that it might be prevented or reversed by fixing a glitch in the immune system's frontline soldiers. (2021-01-20)

New insights into the control of inflammation
Wistar scientists discovered that EGR1inhibits expression of pro-inflammatory genes in macrophages. The discovery expands the understanding of how macrophages are set off and deactivated in the inflammatory process, which is critical in many normal and pathological conditions. (2021-01-13)

Immune system killer cells controlled by circadian rhythms
An exhaustive dataset drawn from mammalian macrophage cells establishes that macrophage activity is controlled by circadian timing, and - with a substantial mismatch between oscillating proteins and mRNA - hints at unexpected calibration of that timing. (2021-01-12)

Turbo boosters for the immune system
Immunologist Prof. Dr. Olaf Groß of the Medical Center - University of Freiburg receives a Proof of Concept Grant from the European Research Council (ERC) for his project IMMUNOSTIM. (2021-01-11)

New research may explain severe virus attacks on the lungs
In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet in Sweden describe how different kinds of immune cells, called macrophages, develop in the lungs and which of them may be behind severe lung diseases. The study, which was published in Immunity, may contribute to future treatments for COVID-19, among other diseases. (2020-12-30)

Breast cancer study uncovers how macrophages may contribute to a therapeutic weak spot
Clinical trials have investigated pairing PARP inhibitor therapy with immunotherapy. Researchers are already looking ahead for ways to get even more benefit from PARP inhibitors plus checkpoint inhibitors in breast cancer patients. Investigators found macrophage-mediated immune suppression to be the weak spot of PARP inhibition treatment. Findings are published in Nature Cancer. (2020-12-18)

Mission to MAARS: Long non-coding RNA may play a key role in cardiovascular disease
Through utilization of genetically modified high-risk atherosclerotic mice, a research team from Brigham and Women's Hospital identified and characterized Macrophage-Associated Atherosclerosis lncRNA Sequence (MAARS), which is expressed specifically in macrophages in atherosclerotic plaques and contributes to the progression of the disease. (2020-12-17)

Molecules derived from omega-3 can regenerate inflamed periodontal tissue
An in vitro study by a Brazilian researcher shows that maresin and resolvin synthesized from fatty acid stimulate periodontal ligament stem cells even in the presence of inflammation (2020-12-16)

Immune cell that drives breast cancer could be effective target in novel immunotherapies
VCU Massey Cancer Center researcher Paula Bos, Ph.D., identified a type of immune cells that acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses. This new knowledge could be utilized for the development of novel immunotherapeutic approaches to treat the disease. (2020-12-15)

The un-appeal of banana: liquid e-cigarette flavorings measurably injure lungs
UC San Diego researchers report chemicals used for flavor in e-cigarette liquid negatively affect specialized proteins that support immune system. (2020-12-14)

Lung tissue from COVID-19 patients and others reveals promising target to treat lung fibrosis
An analysis of lung tissues from patients with different types of pulmonary fibrosis - including cases triggered by COVID-19 - has revealed a promising molecular target to ameliorate the chronic and irreversible disease. Experiments in mouse models of lung fibrosis showed that administering blockers of (2020-12-04)

Lung-on-chip provides new insight on body's response to early tuberculosis infection
Scientists have developed a lung-on-chip model to study how the body responds to early tuberculosis (TB) infection, according to findings published today in eLife. (2020-11-24)

New type of immunotherapy may pave the way for better cancer treatments
Immunotherapy for cancer has made great advances and many patients can now receive effective treatments that were not available ten years ago. However, there are certain types of cancer that do not respond to existing immunotherapy. A study from Karolinska Institutet in Sweden published in Proceedings of the National Academy of Sciences (PNAS) reports on a new kind of immunotherapy that gives hope of more treatment options for cancer in the future. (2020-11-23)

Potential new target to combat inflammatory diseases
An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases - including COVID-19. WEHI's Associate Professor Seth Masters and his research team discovered the compound could prevent up-regulation of CD14, a key inflammatory protein. The discovery was recently published in EBioMedicine. (2020-11-19)

Potential therapeutic strategy for obesity
Together with researchers from Poland, Germany, Australia and Austria, a team of MedUni Vienna scientists has now discovered the signalling pathways responsible for the development of a valuable type of adipose tissue macrophage (ATM) in obesity, which prevents lipotoxicity. (2020-11-17)

Chronic inflammation causes a reduction in NAD+
NAD+, a metabolite central to metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has spawned the development of supplements aimed at restoring NAD+ to youthful levels. Researchers have identified chronic inflammation as a driver of NAD+ decline. They show an increasing burden of senescent cells causes NAD+ to degrade, via the activation of CD38, a protein found both inside and on the surface of many immune cells. (2020-11-16)

Study pinpoints target for managing inflammation, promoting tissue repair
Drugs that can manage the activity of a protein called BCAP could help the body repair IBD-related tissue damage caused by inflammation, according to experts at Cincinnati Children's. (2020-11-16)

Pharmacology - An unconventional ion channel
Scientists at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified the first mechanosensitive ion channel to be found in an intracellular vesicle system. It responds to concentration changes within the vesicle, and probably controls the initiation of immune reactions. (2020-11-13)

Uracil switch in SARS-CoV-2 genome alters innate immune responses
Our bodies could be inducing mutations in the COVID-19 virus that activate immune cells to increase the production of pro-inflammatory molecules. (2020-11-11)

Study sheds light on how MSCs suppress inflammation long after they leave the body
A new study released in STEM CELLS might just have solved the mystery behind why mesenchymal stem cells (MSCs) continue to suppress inflammation in the body long after the MSCs are cleared from the system. (2020-11-09)

Study points way to possible new treatment for ligament injuries
A new exosomes study released in STEM CELLS may lead to future treatment for ligament injuries. (2020-11-03)

Why are some COVID-19 infected people asymptomatic?
Immune cells in the lungs are important for the immune system's recognition and fight against viruses. However, the virus that produces COVID-19 is not recognised by these cells, as the virus may hide its genomic material, and as a result the cells' immune system against the virus is not activated. This may help explain why some people with COVID-19 are asymptomatic in the early stages of the disease. (2020-10-28)

New technology tracks role of macrophages in cancer spread
A Morgridge imaging study of macrophages -- immune cells that are important to human health, but paradoxically can help some cancers grow and spread -- is offering better ways to understand these cells and target them with immunotherapies. (2020-10-26)

Type 1 diabetes: Tannic acid encapsulation protects transplanted islets from rejection
One therapy for Type 1 diabetes is promising -- transplanting pancreatic islets from cadavers -- but a need for immunosuppression and a reactivated autoimmunity lead to low graft viability and function after five years. Now researchers show that a protective coating of alternating layers of two biopolymers delays allograft and autoimmune-mediated rejection in mouse models of T1D. (2020-10-22)

Researchers use gold nanorod scattering to identify immune system's 'killer and savior'
Researchers have utilized the scattering of gold nanorods to identify M1 and M2 macrophages. Further development of this technique will lead to a new point of care or a biopsy tool which can predict the stages of manifestation of diseases like cancer, atherosclerosis, and fibrosis just from the simple tissue fluids or blood samples. (2020-10-20)

Immune activation in the liver illuminated with new glycan-tagging strategy
A signaling system implicated in liver fibrosis and immune activation is better understood thanks to this creative chemical fishing lure. (2020-10-19)

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