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Tips from the American Journal of Pathology
The following highlights summarize research articles that are published in the March issue of The American Journal of Pathology. (2009-02-23)
Study in mice identifies molecular target for treatment of West Nile encephalitis
In animal studies, researchers at Cedars-Sinai Medical Center and Yale University have identified molecular interactions that govern the immune system's ability to defend the brain against West Nile virus, offering the possibility that drug therapies could be developed to improve success in treating West Nile and other viral forms of encephalitis. (2009-02-05)
Stat3 signaling tips the balance of immunity in favor of cancer
New research reveals how a cancer-associated protein enables tumor cells to evade the immune system by both suppressing anti-tumor influences and promoting tumor-enhancing conditions, in essence turning the immune system to the dark side of the force. (2009-02-02)
Comparative genomics reveals molecular evolution of Q fever pathogen
In the year of the 200th anniversary of the birth of Darwin, researchers have uncovered genetic clues about why some strains of the pathogen that causes Q fever, Coxiella burnetii, are more virulent than others. (2009-02-02)
Helicobacter pylori can multiply in autophagic vesicles
Some Taiwanese clinical isolates of Helicobacter pylori are found to replicate in some macrophage cell lines. (2009-01-27)
Novel drugs selectively target pathway important in rheumatoid arthritis
Methotrexate, a folate antagonist that blocks folic acid activity, is the most widely used disease-modifying anti-rheumatic drug for rheumatoid arthritis. (2009-01-13)
Findings turn events in early TB infection on their head, may lead to new therapy
Masses of immune cells that form as a hallmark of tuberculosis have long been thought to be the body's way of trying to protect itself by literally walling off the bacteria. (2009-01-08)
Lung cancer cells activate inflammation to induce metastasis
A research team from the University of California, San Diego School of Medicine, has identified a protein produced by cancerous lung epithelial cells that enhances metastasis by stimulating the activity of inflammatory cells. (2008-12-31)
Prostaglandin receptor key to atherosclerosis development
Atherosclerosis -- a disease that includes the buildup of fatty, cholesterol-laden lumps of cells inside the artery wall -- is the underlying cause of heart attacks and strokes. (2008-12-15)
JCI online early table of contents: Dec. 8, 2008
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Dec. (2008-12-08)
Cold Spring Harbor Protocols features tissue culture methods for immune cells and neurons
This month's issue of Cold Spring Harbor Protocols features two articles detailing experimental culture methods for cells from the immune system and the nervous system. (2008-12-02)
Proteomics study yields clues as to how tuberculosis might be thwarting the immune system
A link between the immune system and the self-cleaning system by which biological cells rid themselves of obsolete or toxic parts may one day yield new weapons in the fight against tuberculosis and other deadly infectious diseases. (2008-11-05)
New therapeutic target identified for rheumatoid arthritis
Researchers at Hospital for Special Surgery have identified a potential new therapeutic target that could be used to treat inflammatory disorders, such as rheumatoid arthritis. (2008-11-04)
Parasites that live inside cells use loophole to thwart immune system
St. Jude Children's Research Hospital scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body's key chemical weapons against them: nitric oxide. (2008-11-03)
Persistent bacterial infection exploits killing machinery of immune cells
A new study reveals an important and newly discovered pathway used by disease-causing bacteria to evade the host immune system and survive and grow within the very cells meant to destroy them. (2008-11-02)
How did glycine significantly decrease liver injury?
Chronic cholestasic liver diseases lead to liver injury and ultimately progress to portal fibrosis, cirrhosis, and end-stage liver disease requiring liver transplantation. (2008-10-31)
Friend or foe? How the body's clot-busting system speeds up atherosclerosis
Scientists have been puzzled by the fact that high levels of plasmin in blood and high levels of urokinase in artery walls are linked to high risk for rapid progression of atherosclerosis and heart attacks. (2008-10-30)
Drug-embedded microparticles bolster heart function in animal studies
Tiny polymer beads embedded with anti-inflammatory drugs can reduce damage to the heart when injected into rats' hearts after a simulated heart attack. (2008-10-19)
LIAI launches new division to look at novel approaches to heart disease and inflammation
While cholesterol-lowering drugs and new technologies have significantly advanced the nation's battle against heart disease, it continues to rank as the No. (2008-09-30)
MS patients have higher spinal fluid levels of suspicious immune molecule
MS patients have higher spinal fluid levels of suspicious immune molecule. (2008-09-29)
TB bacterium uses its sugar coat to sweeten its chances of living in lungs
Common strains of tuberculosis-causing bacteria have hijacked the human body's immune response to play tricks on cells in the lungs, scientists say. (2008-09-29)
Cancer-causing gut bacteria exposed
Normal gut bacteria are thought to be involved in colon cancer but the exact mechanisms have remained unknown. (2008-09-21)
News tips from the Journal of Neuroscience
The following articles are featured in the Sept. 17 issue of the Journal of Neuroscience: (2008-09-16)
JCI online early table of contents: Sept. 11, 2008
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Sept. (2008-09-11)
Catching the blood cell bus gives fatal yeast infection a clean getaway
Yeast fungus cells that kill thousands of AIDS patients every year escape detection by our bodies' defenses by hiding inside our own defense cells, and hitch a ride through our systems before attacking and spreading, scientists heard today at the Society for General Microbiology's autumn meeting being held this week at Trinity College, Dublin. (2008-09-08)
Potential new drug target to fight tuberculosis identified
With antibiotic resistance on the rise, tuberculosis is emerging as a bigger global health threat than ever before. (2008-07-30)
Scientists figure out how the immune system and brain communicate to control disease
A new anatomical path through which the brain and the spleen communicate. (2008-07-21)
Tumor-inhibiting protein could be effective in treating leukemia
Angiocidin, a tumor-inhibiting novel protein, may also have a role as a new therapeutic application in treating leukemia by inducing a differentiation of monocytic leukemia cells into a normal, macrophage-like phenotype. (2008-07-15)
New therapeutic options for diabetes-related tissue injury
Diabetes mellitus is a metabolic disorder characterized by altered glucose tolerance and impaired lipid and carbohydrate metabolism, and is associated with a number of complications directly resulting from hyperglycemiainduced inflammation. (2008-07-04)
Nanotubes could help study retrovirus transmission between human cells
Naturally occurring nanotubes may serve as tunnels that protect retroviruses and bacteria as they infect healthy cells. (2008-06-25)
Yale researchers discover Legionnaire microbe's tricks
Yale University researchers have shed new light how bacteria like the ones that cause Legionnaires' disease and Q-fever raise such havoc in human patients. (2008-06-19)
New discoveries from Harvard and Baylor get to the heart of cardiovascular disease
Even if you eat right and exercise regularly, chances are high that you'll still die of a heart attack or stroke. (2008-06-18)
TB treatment for the elderly likely requires a boost to immune response
Manipulating the immune system in elderly people appears to be the most likely way to help older patients wage an effective battle against tuberculosis, a new study suggests. (2008-06-09)
HSPH researchers discover natural inflammation-fighting mechanism in body-fat cells
Reporting in the journal Cell Metabolism, researchers from the Harvard School of Public Health said they have shown for the first time that fat-storing cells, or adipocytes, contain a protective anti-inflammatory immune mechanism that prevents the cells from over-reacting to inflammation-causing stimuli, such as fatty acids in the diet. (2008-06-03)
Yale researchers clear up Alzheimer's plaques in mice
Blocking a common immune system response cleared up plaques associated with Alzheimer's Disease and enabled treated mice to recover some lost memory, Yale University researchers report Friday in the journal Nature Medicine. (2008-05-30)
Unexpected results from study in mice may open new strategy against Alzheimer's disease
Interrupting a signaling pathway in certain immune system cells in laboratory mice had the opposite effect researchers expected but opened the possibility of a new approach to treating Alzheimer's disease, according to an article in the journal Nature Medicine. (2008-05-30)
Scattered light reveals size and shape of the nucleus
A new technology based on the interpretation of light reflected off cells will make it faster and more efficient for researchers to document how the nucleus, which contains a cell's DNA and controls its actions, changes shape in response to its environment. (2008-05-29)
A common denominator of inflammations and fatty liver
Cancer researchers find key molecule for tumor cachexia. (2008-05-27)
Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to reproduce
A team of scientists at Cold Spring Harbor Laboratory has discovered new details about how a simian strain of the AIDS virus replicates. (2008-05-23)
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