Current Macular Degeneration News and Events

Current Macular Degeneration News and Events, Macular Degeneration News Articles.
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ALS neuron damage reversed with new compound
Scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims. In ALS, movement-initiating nerve cells in the brain and muscle-controlling nerve cells in the spinal cord die. After administering the new compound,, the diseased brain neurons stopped degenerating so much that they became similar to healthy control neurons after 60 days of treatment. (2021-02-23)

Improved vectors for ocular gene therapy
Strategies based on the use of gene therapy to mitigate the effects of mutations that cause blindness are undergoing rapid development. Novel gene vectors now achieve widespread gene delivery and reduce the risks associated with these approaches. (2021-02-22)

New therapeutic approach may help treat age-related macular degeneration effectively
Runt-related transcription factor 1 (RUNX1) has been linked to retinal neovascularization and the development of abnormal blood vessels, which result in vision loss in diabetic retinopathy. Now, scientists have found that RUNX1 inhibition presents a new therapeutic approach in the treatment of age-related macular degeneration (AMD), which is the leading cause of blindness in the elderly worldwide. Their results are reported in The American Journal of Pathology, published by Elsevier. (2021-02-22)

Credit card-sized soft pumps power wearable artificial muscles
Robotic clothing that is entirely soft and could help people to move more easily is a step closer to reality thanks to the development of a new flexible and lightweight power system for soft robotics. (2021-02-17)

In-silico modelling helps with the integrated study of the intervertebral disc in health and disease
Published in the journal Bioinformatics and conducted entirely by members of the BCN MedTech Research Unit, with Laura Baumgartner as first author under the guidance of Jérôme Noailly. (2021-02-05)

New research sheds light on vision loss in Batten disease
Progressive vision loss, and eventually blindness, are the hallmarks of juvenile neuronal ceroid lipofuscinosis (JNCL) or CLN3-Batten disease. New research shows how the mutation associated with the disease could potentially lead to degeneration of light sensing photoreceptor cells in the retina, and subsequent vision loss. (2021-02-05)

Synthesized very-long-chain polyunsaturated fatty acids improved retinal function in mice
A University of Utah ophthalmologist is investigating how lipids known as VLC-PUFAs could be used to prevent eye disease thanks to a new way to synthesize them for research. (2021-02-04)

Researchers describe a molecular mechanism involved in the pathology's neurodegeneration
Protein alteration in the family of lamins causes several diseases, known as laminopathies, such as progeria or precocious ageing. A study in which UB researchers have taken part states that alterations in the levels of one of these proteins, lamin B1, contribute to the degeneration of neuronal populations in Huntington's disease. Caused by a mutation in the huntingtin gen, this pathology features involuntary movements, cognitive deficit and psychiatric disorders, and has no cure yet. (2021-02-01)

Common HIV drugs may prevent leading cause of vision loss, study finds
Scientists have identified a group of drugs that may help stop macular degeneration after making an unexpected discovery that overturns a fundamental belief about DNA. (2021-02-01)

Scientists identify locations of early prion protein deposition in retina
The earliest eye damage from prion disease takes place in the cone photoreceptor cells, specifically in the cilia and the ribbon synapses, according to a new study of prion protein accumulation in the eye by National Institutes of Health scientists. Prion diseases originate when normally harmless prion protein molecules become abnormal and gather in clusters and filaments in the human body and brain. (2021-01-29)

A compound that slows bone loss, and a resource for developing treatments to slow aging
A compound that extends lifespan in a tiny nematode worm slows bone loss in aging mice. That surprising result comes from a longitudinal and functional study of 700 aging mice at the Buck Institute, a project that provides a treasure trove of data for researchers aiming to develop therapeutics to slow aging and age-related diseases. The study is currently online in the Journal of Bone and Mineral Research Plus. (2021-01-26)

Aging-US: Nicotinamide mononucleotide in degenerative model of retinal detachment
'This Aging-US article concludes that NMN administration exerts neuroprotective effects on photoreceptors' (2021-01-25)

Air pollution linked to higher risk of sight loss from AMD
Air pollution is linked to a heightened risk of progressive and irreversible sight loss, known as age related macular degeneration (AMD), reveals a large long term study led by UCL researchers, published in the British Journal of Ophthalmology. (2021-01-25)

Medicated drops may help close macular holes, helping some patients avoid surgery
Medicated drops may help close small macular holes over a two- to eight-week period, allowing some people to avoid surgery to fix the vision problem, a new study suggests. (2021-01-21)

Target discovered that halts osteoarthritis-type knee cartilage degeneration
In a mouse study, researchers used nanotechnology and previous knowledge of a protein pathway to significantly reduce knee cartilage degeneration and pain (2021-01-15)

Retinal cell transplant clears experimental hurdle toward treating blindness
Retinal cells derived from adult human eye stem cells survived when transplanted into the eyes of monkeys, an important early step in the validation of this approach for treating blindness, according to a study by Liu, et al recently published in Stem Cell Reports. The retinal pigment epithelium (RPE), a layer of pigmented cells in the retina, is essential for sustaining normal vision. Blindness due to RPE dysfunction, such as macular degeneration, affects about 200 million people worldwide. (2021-01-14)

Scientists take important step toward using retinal cell transplants to treat blindness
Latest discovery is promising step in use of cell therapy to treat retinal diseases (2021-01-14)

New molecular structures associated with ALS
Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of the disease, as well as to propose new solutions to curb it. (2021-01-13)

Shriners Hospitals for Children study reveals new link to arthritis
A new study by investigators at the Shriners Hospital for Children -- St. Louis suggests the damaging effects of obesity are not due to body weight but rather come from something much smaller - biochemical signals released by fat cells. (2021-01-08)

AI-supported test predicts eye disease three years before symptoms
A pioneering new eye test, developed by scientists at UCL in collaboration with the Western Eye Hospital, London, may predict wet AMD, a leading cause of severe sight loss, three years before symptoms develop, finds a new study in Expert Review of Molecular Diagnostics. (2020-12-18)

Development of the first biohybrid artificial retina built with silk fibroin and retinal cells.
An international research led by the Complutense University of Madrid has taken a further step to solve Age-related Macular Degeneration (AMD)-derived blidness problem with the development of the first biohybrid artificial retina built with silk fibroin and retinal cells. (2020-12-11)

Oregon researchers find that like adults, children by age 3 prefer seeing fractal patterns
By the time children are 3 years old they already have an adult-like preference for visual fractal patterns commonly seen in nature, according to University of Oregon researchers. (2020-12-11)

New insights about age-related macular degeneration could spur better treatments
Experiments in a mouse model have uncovered mechanisms involved in abnormal blood vessel formation in ''wet'' age-related macular degeneration. Certain inflammatory pathways and proteins may be attractive therapeutic targets for the disease. (2020-12-11)

New pathway in Alzheimer's disease provides earlier target for potential therapies
A novel Alzheimer's disease marker--coming early in progression of the condition--could open significant new fronts of research into possible therapies (2020-12-04)

Reconstruction of eye tissue gives new insight into outer retina
Researchers used a newly developed imaging technique called serial block face scanning electron microscopy, to produce a digital reconstruction of eye tissues from the outer retina, at very high resolution. This is the first time this technology has been used to fully reconstruct cells from the retina and could provide new insights into the causes of irreversible blinding diseases. (2020-12-02)

LSU Health New Orleans discovers drug development target for retinal dystrophies
A team of LSU Health New Orleans researchers reports for the first time that deleting one of the inhibitors of the RPE65 gene in a mouse model that carries a human disease mutation prevents degeneration of cone photoreceptors that are used for daytime high-resolution color vision. (2020-12-01)

Targets for avoidable sight loss 'not being met': 30-year study finds
A new global study has found no significant reduction in the number of people with treatable sight loss since 2010. (2020-12-01)

Customized programming of human stem cells
Induced pluripotent stem cells (iPS) have the potential to convert into a wide variety of cell types and tissues. However, the ''recipes'' for this conversion are often complicated and difficult to implement. Researchers at TU Dresden, Harvard University (USA) and the University of Bonn have found a way to systematically extract hundreds of different cells quickly and easily from iPS using transcription factors. Researchers can use this transcription factor source through the non-profit organization Addgene. (2020-11-30)

UB study identifies new functions in the Machado-Joseph genetic disease
Ataxia is a minority disease with genetic origins, known for its neuromuscular alterations due to the selective loss of neurons in the cerebellum. University of Barcelona researchers have identified new functions in the ataxin 3 gene (ATXN3) -which causes Machado-Joseph disease, the most common type of ataxia- in the development of retina photoreceptors. These results are relevant also to understand other diseases, such as macular degenerations. (2020-11-25)

Stem cell-based screen identifies potential new treatments
In a recent study published in Stem Cell Reports, Seba Almedawar, PhD, and colleagues with the Center for Regenerative Therapies TU Dresden, Germany, used induced pluripotent stem cells (iPSCs) derived from the skin of healthy donors and of patients with retinitis pigmentosa to find drugs with the potential to enhance RPE phagocytosis. (2020-11-25)

Study: Early, late stages of degenerative diseases are distinct
Rice University biochemists have proposed that degenerative diseases as varied as Alzheimer's, Parkinson's and muscle atrophy occur in two distinct phases marked by protein signaling changes that could result in patients responding differently to the same treatment. (2020-11-23)

Racket sports may worsen knee arthritis
Racket sports like tennis and racquetball appear to accelerate knee joint degeneration in overweight people with osteoarthritis, according to a study being presented at the annual meeting of the Radiological Society of North America (RSNA). (2020-11-17)

An acebuchin-oil-enriched diet helps to reduce hypertension
The acebuche, also know as the wild olive tree, is a variety of tree widely found throughout Spain and covering almost nine million hectares in Andalusia. However, little data is available on the composition and therapeutic potential of acebuchin oil. The studies mainly focus on the composition and pharmacological effects of olive tree leaves and extra virgin olive oil. (2020-11-17)

Chronic inflammation causes a reduction in NAD+
NAD+, a metabolite central to metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has spawned the development of supplements aimed at restoring NAD+ to youthful levels. Researchers have identified chronic inflammation as a driver of NAD+ decline. They show an increasing burden of senescent cells causes NAD+ to degrade, via the activation of CD38, a protein found both inside and on the surface of many immune cells. (2020-11-16)

One step for fibrosis, one giant leap for scleroderma
At the Medical University of South Carolina, a team of researchers has demonstrated a ''moonlighting'' role for lysyl oxidase (LOX) in scleroderma. It was previously known that LOX crosslinked the connective tissue. However, this research showed that, independent of its crosslinking function, LOX plays multiple additional roles in promoting fibrosis in scleroderma, known as ''moonlighting.'' Furthermore, these researchers demonstrated that LOX could be a potential biomarker and target for antifibrotic therapy. (2020-11-16)

Novel deep learning method enables clinic-ready automated screening for diabetes-related eye disease
Researchers at Helmholtz Zentrum München together with LMU University Eye Hospital Munich and the Technical University of Munich (TUM) created a novel deep learning method that makes automated screenings for eye diseases such as diabetic retinopathy more efficient. (2020-11-12)

New strategy for treating common retinal diseases shows promise
Scientists at Scripps Research have uncovered a potential new strategy for treating eye diseases that affect millions of people around the world, often resulting in blindness. (2020-10-27)

Coronaviruses are masters of mimicry, new study finds
Coronaviruses are adept at imitating human immune proteins that have been implicated in severe COVID-19 disease, a study from researchers at Columbia University has found. (2020-10-27)

Common treatment for diabetic macular edema not effective in Black individuals
A medication frequently used to treat diabetic macular edema, which is the most common cause of blindness in people with diabetes, is less effective when used to treat the condition in Black patients, new study results show. (2020-10-22)

Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year. (2020-10-21)

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