Current Malignant Melanoma News and Events

Current Malignant Melanoma News and Events, Malignant Melanoma News Articles.
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Targeted delivery of highly toxic anti-cancer drug to brain tumors
University of Houston biomedical researcher Sheeren Majd is reporting the development and testing of a new nano-carrier as a potential treatment to deliver highly toxic medicine to glioblastomas, the most common and aggressive form of primary brain tumors. (2021-02-23)

3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

An mRNA vaccine for cancer immunotherapy
Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer. Now, researchers reporting in ACS' Nano Letters have developed a hydrogel that, when injected into mice with melanoma, slowly released RNA nanovaccines that shrank tumors and kept them from metastasizing. (2021-02-17)

Cosmetic laser may boost effectiveness of certain anti-cancer therapies
In mice treated with cancer immunotherapy, shining a cosmetic laser on a tumor boosted the therapy's effectiveness. The strategy stimulated the immune system to attack nonmutated proteins on the tumor. The findings may help investigators make cancer immunotherapy effective against currently incurable cancers. (2021-02-17)

Neural network could help clinicians look for 'ugly duckling' pre-cancerous skin lesions
A neural network system that analyzes photographs can rank and distinguish suspicious, potentially precancerous skin lesions, which can turn into the deadly skin malignancy melanoma if not caught and removed early. (2021-02-17)

Identifying "ugly ducklings" to catch skin cancer earlier
Melanoma is by far the deadliest form of skin cancer, but very few people get a full skin exam by a dermatologist every year. Now, a new AI system designed by the Wyss Institute and MIT based on convolutional deep neural networks has successfully replicated dermatologists' ''ugly duckling'' process of evaluating multiple skin lesions with ~90% accuracy using smartphone images, allowing effective screening for melanoma at the population level and reducing deaths. (2021-02-16)

New immunotherapy target discovered for malignant brain tumors
Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body's immune system. The discovery, reported in the journal CELL, emerged from laboratory experiments and has no immediate implications for treating patients. (2021-02-15)

Zika vaccine candidate shows promise in phase I trial
The Zika virus candidate, Ad26.ZIKV.001, a replication-incompetent human adenovirus serotype 26 (ad26) vector showed promising safety and immunogenicity in a phase I clinical trial. Researchers say the vaccine warrants further development should the need reemerge. The findings are published in Annals of Internal Medicine. (2021-02-15)

Oncotarget: AKT isoforms have discrete expression in triple negative breast cancers
Oncotarget recently published ''AKT isoforms have discrete expression in triple negative breast cancers and roles in cisplatin sensitivity'' which reported that the authors investigated the expression and net effect of the individual isoforms in triple negative breast cancers and response to cisplatin treatment using cellular, mice models and clinical samples. (2021-02-15)

Melanoma patients respond to immunotherapy after changes to gut microbiome
Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients' gut microbiome led them to respond to a type of treatment capable of providing long-term benefit. (2021-02-14)

Algorithm that performs as accurately as dermatologists
A study has now been presented that boosts the evidence for using AI solutions in skin cancer diagnostics. With an algorithm they devised themselves, scientists at the University of Gothenburg show the capacity of technology to perform at the same level as dermatologists in assessing the severity of skin melanoma. (2021-02-12)

Gene-based blood test for melanoma spread evaluates treatment progress
A test that monitors blood levels of DNA fragments released by dying tumor cells may serve as an accurate early indicator of treatment success in people in late stages of one of the most aggressive forms of skin cancer, a new study finds. (2021-02-12)

Sinai team builds first model acute myeloid leukemia progression using CRISPR
A research team led by the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) has built the first cellular model to depict the evolution of acute myeloid leukemia (AML), from its early to late stages. By using gene editing technologies to alter genes that make cells malignant, the team was able to identify potential therapeutic targets for early disease stages. The study was reported in the journal Cell Stem Cell in February. (2021-02-10)

Brain tumor study reveals surprising gene deletion and method to overcome drug resistance
Experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance. (2021-02-10)

Samara Polytech scientists proved the anti-cancer properties of a number of plant extracts
The composition of some extracts obtained from plant raw materials was studied at Samara Polytech, and their anticarcinogenic and antioxidant properties were assessed. (2021-02-09)

Fecal transplant turns cancer immunotherapy non-responders into responders
A phase II clinical trial shows that changing the gut microbiome through fecal transplant can transform cancer patients who never responded to immunotherapy into patients who do. (2021-02-04)

Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy
For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines--known as the gut microbiome--through the use of stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests. Researchers at the NCI, part of the National Institutes of Health, conducted the study in collaboration with investigators from UPMC Hillman Cancer Center at the University of Pittsburgh. (2021-02-04)

BU researchers identify promising therapeutic agent against melanoma
There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease. A new study from Boston University School of Medicine (BUSM) has discovered that a drug (YK-4-279) that was previously created to target one specific type of protein has much broader use against a family of proteins that act to promote melanoma. (2021-02-01)

Nivolumab effective treatment for malignant mesothelioma
Nivolumab monotherapy is an effective treatment option for relapsed malignant mesothelioma (MM), according to research presented today at the International Association for the Study of Lung Cancer World Conference on Lung Cancer. (2021-01-30)

Genetic changes in tumours could help predict if patients will respond to immunotherapy
Researchers at the Francis Crick Institute, the UCL Cancer Institute, and the Cancer Research UK Lung Cancer Centre of Excellence have identified genetic changes in tumours which could be used to predict if immunotherapy drugs would be effective in individual patients. (2021-01-27)

Rates of skin cancer have increased dramatically over recent decades
Incidence rates of skin cancer (cutaneous malignant melanoma) have increased more than 550% in males and 250% in females since the early 1980s in England - according to a new study by Brighton and Sussex Medical School (BSMS). (2021-01-26)

Oncotarget: Improved therapeutic efficacy of unmodified anti-tumor antibodies
The Oncotarget findings suggest that MEKi induced an increased expression of tumor-associated antigens, which in combination with anti-tumor antibodies, generated a robust adaptive anti-tumor response that was sustained by immune checkpoint inhibition therapy. (2021-01-25)

Aging-US: Growth factor beta type 1 and hypoxia-inducible factor 1 transcription complex
''The Aging-US authors report for the first time that in human breast cancer, AML and embryonic cells, HIF-1 and AP-1 upregulate the expression of TGF-β'' (2021-01-25)

Vaccine produces long-lasting anti-tumor response in patients with melanoma
Patients treated with a vaccine tailored to mutated proteins on patients' own tumor cells, continue to have a strong immune response to the cancer four years after being vaccinated. Results demonstrate the ability of personalized cancer vaccines to provide long-term immunity against some cancers. (2021-01-21)

Researchers develop a new approach to detect pancreatic cancer
A protein found commonly in human blood might help with the detection of hard-to-diagnose pancreatic tumours. Researchers at Martin Luther University Halle-Wittenberg (MLU), the Alfried Krupp Hospital in Essen and the University of Witten/Herdecke have developed approach using the protein's structure and its function as a proxy for this. In a first study in ACS Pharmacology & Translational Science, the team shows how its method can also be used to differentiate between benign and malignant tumours. (2021-01-20)

Moffitt researchers identify how cancer cells adapt to survive harsh tumor microenvironments
To better understand the conditions that select for the Warburg Effect and the mechanisms where cells can express this metabolic adaptation, Moffitt researchers subjected nonmalignant cells to the harsh tumor microenvironment that is present during early carcinogenesis, known as ductal carcinoma in situ. In a new research article published in the Proceedings of the National Academy of Sciences, the Moffitt team shows that these conditions select for cells to express a Warburg Effect. (2021-01-19)

New suspicious lesions on breast MRI in neoadjuvant therapy
According to ARRS' American Journal of Roentgenology (AJR), new suspicious findings occurred in 5.5% of breast MRI examinations performed to monitor response to neoadjuvant therapy; none of these new lesions were malignant. (2021-01-14)

Raman spectroscopy shows promise for diagnosing oral cancer
In a new study, researchers show that a light-based analytical technique known as Raman spectroscopy could aid in early detection of oral squamous cell carcinoma (OSCC). (2021-01-13)

New humanized mouse model provides insight into immunotherapy resistance
Wistar scientists have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. (2021-01-12)

Texas A&M research explores how melanoma grows and spreads
The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact. (2021-01-12)

A potent weapon against lymphomas
MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults. (2021-01-11)

An epidemic of overdiagnosis: Melanoma diagnoses sky rocket
In a Sounding Board article, Welch and colleagues present evidence for why they believe that increased diagnostic scrutiny is the primary driver of the rapid rise in melanoma diagnoses. (2021-01-06)

Immunology study finds protein critical to T cell metabolism and anti-tumor immune response
Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumor immune response. (2021-01-04)

How cancers hurt themselves to hurt immune cells more
A study of melanoma cells explains a puzzling response they exhibit to ward off T cell attacks. (2020-12-20)

For college students, skin cancer risk remains high in winter months
New research finds college students could be just as at risk for developing skin cancer in the dead of winter as they are in the middle of summer. (2020-12-17)

UV exposure, risk of melanoma in skin of color
The association between ultraviolet (UV) light exposure and the risk of melanoma in individuals with skin of color was examined with a review of the results of 13 studies. (2020-12-16)

Accurate neural network computer vision without the 'black box'
New research by a team at Duke University offers clues to what goes on inside the minds of machines as they learn to see. Instead of attempting to account for a neural network's decision-making on a post hoc basis, their method shows how the network learns along the way, by revealing how much the network calls to mind different concepts to help decipher what it sees as the image travels through successive layers. (2020-12-15)

New combination therapy could help fight difficult-to-treat cancers with common mutations
UCLA scientists describe a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. This combination of two small molecules has the potential to treat not only BRAF mutated melanoma but also additional aggressive subtypes of cancers, including melanoma, lung, pancreatic and colon cancers that harbor common mutations in cancer genes called RAS or NF1. (2020-12-14)

The immunomodulatory activity of a drug would improve the efficacy of immunotherapy in breast cancer
* The team of Eva González-Suarez, from the CNIO and IDIBELL, and the team of Christos Sotiriou, from the Jules Bordet Institute, demonstrate that a drug already used to treat osteoporosis promotes the infiltration of immune cells in breast tumours * These findings propose a new target to increase the antitumor immune response and make breast cancer more sensitive to immunotherapy (2020-12-10)

Phase 1 trial assesses whether fecal microbiota transplant impacts cancer patients resistant to immu
In one of the first in-human studies to investigate whether modifying the gut microbiome by a fecal microbiota transplant could make cancer immunotherapy more effective, researchers analyzing this in ten cancer patients with refractory melanoma suggest the treatment can improve patient outcomes. (2020-12-10)

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