Current Mechanism News and Events

Current Mechanism News and Events, Mechanism News Articles.
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Deep seabed mining must benefit all humankind
As investors set their sights on the mineral resources of the deep seabed, the International Seabed Authority (ISA) is developing regulations that will govern their future exploration and possible exploitation. A new IASS Policy Brief, published in cooperation with the Federal Environment Agency (UBA), presents three recommendations to ensure that future deep seabed mining would be to the common benefit all humankind, as required by international law. (2021-02-18)

Electron cryo-microscopy sheds light on how bioenergy makers are made in our body
Scientists uncover how the body's energy makers are made. A new paper published in Science by Alexey Amunts' laboratory with an international team of researchers reports the molecular mechanism of membrane-tethered protein synthesis in mitochondria. (2021-02-18)

Correspondence between representations in visual cortices and neural networks
A research group led by Nobuhiko Wagatsuma, Lecturer at Toho University, Akinori Hidaka, Associate Professor at Tokyo Denki University, and Hiroshi Tamura, Associate Professor at Osaka University, found that the neural network structure of attention prediction, based on deep learning used in the development of artificial intelligence, has similar characteristics to the cerebral mechanism of primates. (2021-02-08)

The proton conduction mechanism in protic ionic liquids
Researchers from Niigata University, Japan along with their collaborators from Tokyo University of Science, Japan, Yamagata University, Japan and University of Regensburg, Germany have reported a marked shift in the hydrogen ion hopping mechanism as a function of acid/alkali index in protic ionic liquids. The study holds immense potential to revolutionize the development of protonic conductors for fuel cells. These promising results are now published in The Journal of Physical Chemistry B. (2021-02-04)

The underestimated mutation potential of retrogenes
mRNA molecules from retrogenes are reverse transcribed to DNA and incorporated into the genome. (2021-02-02)

Researchers discover mechanism to overcome drug-resistance in leukemia
In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published online today in the Proceedings of the National Academy of Sciences. (2021-02-01)

New study: Malaria tricks the brain's defence system
Malaria is one of the most common causes of death in children in Africa. When the parasite builds up in the blood vessels of the brain, it develops into one of the most dangerous forms of the disease, cerebral malaria. Though it wasn't certain if the parasite was able to penetrate the brain tissue, now researchers from the University of Copenhagen have found parasites can do that and have mapped the mechanism they utilise. (2021-01-26)

Alcohols exhibit quantum effects
Skoltech scientists and their colleagues from the Russian Quantum Center revealed a significant role of nuclear quantum effects in the polarization of alcohol in an external electric field. The new research provides insight into the properties of liquid dielectrics. The core assumption of the model pertains to a novel understanding of dielectric polarization phenomena in polar liquids by means of nuclear quantum effects. (2021-01-19)

To understand periodontal disease, researchers examine the surprising behavior of T cells
In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone? In a paper published recently in Scientific Reports, researchers from the Forsyth Institute and the Universidad de Chile describe a mechanism that unlocks a piece of the puzzle. (2021-01-11)

Diseased cell fragments burst from pockets in immune cells to activate response
Researchers at the Francis Crick Institute have uncovered an important process in how our immune system detects signs of disease and activates a protective response. This understanding could improve efforts to find new and effective immunotherapy treatments for diseases like cancer. (2020-12-21)

How does pathogen sense environment? Scientists identify key proteins' structures
Recently, a team led by Prof. TAO Yuyong from the School of Life Sciences, University of Science and Technology of China of the Chinese Academy of Sciences, in cooperation with Hefei National Laboratory for Physics Sciences at the Microscale, revealed the signal transduction mystery inside S. aureus, using a comprehensive application of biochemical and structural biology research methods. The study was published online in PNAS. (2020-12-15)

Researchers identify the physical mechanism that can kill bacteria with gold nanoparticles
A multidisciplinary team of researchers have discovered that the mechanical deformation of bacteria is a toxic mechanism that can kill bacteria with gold nanoparticles. The results of this research are a breakthrough in researchers' understanding the antibacterial effects of nanoparticles and their efforts to find new materials with bactericide properties. (2020-12-10)

Gasdermin offers insight into coral necrotic death
A research team led by Professor SUN Li from the Institute of Oceanology of the Chinese Academy of Sciences (IOCAS), in collaboration with Professor ZHOU Zhi from Hainan University, has identified gasdermin E (GSDME) from the reef-building coral Orbicella faveolata and demonstrated that coral GSDME triggers pyroptosis and is involved in pathogen-induced coral death. (2020-12-04)

Insights on a mechanism to stop COVID-19 replication
Stopping the replication of SARS-CoV-2 is likely possible thanks to a compound called EBSELEN: a group of researchers from the Politecnico di Milano has communicated aspects relevant to the blocking of replication mechanism in the New Journal of Chemistry. (2020-11-19)

Existing antidepressant helps to inhibit growth of cancer cells in lab animals
New research has shown that the antidepressant sertraline helps to inhibit the growth of cancer cells. The substance acts on a metabolic addiction that allows different types of cancer to grow. This is shown by a study on cell cultures and lab animals by researchers at KU Leuven. (2020-11-17)

Researchers show how to target a shape-shifting protein in Alzheimer's disease
A new study suggests that it is possible to design drugs that can target a type of shape-shifting protein involved in Alzheimer's disease, which was previously thought to be undruggable. (2020-11-04)

Researchers discover mechanism that allows SINEUPs to amplify protein production
Scientists from an international group led by the RIKEN Center for Integrative Medical Sciences and Yokohama City University have discovered that a pair of proteins play a key role in allowing an important type of functional non-coding RNA, known as SINEUPs, to act to promote their target messenger RNA. (2020-11-01)

Changes in subcellular traffic increase invasiveness of radioresistant cancer cells
Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy. (2020-10-29)

How do snakes 'see' in the dark? Researchers have an answer
Certain species of snake -- think pit vipers, boa constrictors and pythons, among others -- are able to find and capture prey with uncanny accuracy, even in total darkness. Now scientists have discovered how these creatures are able to convert the heat from organisms that are warmer than their ambient surroundings into electrical signals, allowing them to 'see' in the dark. (2020-10-21)

The line of succession
An unusual mechanism of robustness in charge of brain mRNAs (2020-10-19)

Reelin-Nrp1 interaction regulates neocortical dendrite development
Reelin exhibits a context-dependent function during brain development; however, its underlying mechanism is not well understood. Here, we found that neuropilin-1 specifically binds to the C-terminal region of Reelin and acts as a co-receptor for canonical Reelin-receptor. The Reelin-Nrp1 interaction is essential for proper dendritic development in superficial-layer neurons. This study provides evidence of the context-specific function of Reelin regulated by the C-terminal residues. (2020-10-15)

Severe COVID-19 infection linked to overactive immune cells
Samples from the lungs of patients show a runaway immune system reaction could be one mechanism behind severe COVID-19 cases. (2020-10-08)

Chinese researchers uncover link between phase separation and human developmental disorders
Researchers from the Shanghai Institute of Organic Chemistry (SIOC) of the Chinese Academy of Sciences have uncovered the mechanism that underlies the pathogenesis of Noonan syndrome and Noonan syndrome with multiple lentigines. (2020-09-30)

NUS researchers solve decades-old problem of how to uniformly switch memristors
An international team, led by the scientists from the National University of Singapore, has developed a solution to uniformly switch memristors. This innovation addresses a long-standing problem in the field of organic and molecular electronics. (2020-09-29)

Human acid-sensing ion channel 1a inhibition by snake toxin Mambalgin1
USTC initially resolved the hASIC1a and freeze electron structure of the compound of hASCI1a and Mambalgin1 through freeze electron microscopic technology. (2020-09-27)

Mystery of giant proton pump solved
Mitochondria are the powerhouses of our cells, generating energy that supports life. A giant molecular proton pump, called complex I, is crucial: It sets in motion a chain of reactions, creating a proton gradient that powers the generation of ATP, the cell's fuel. Leonid Sazanov and his group at the Institute of Science and Technology Austria (IST Austria) have solved the mystery of how complex I works: Conformational changes in the protein combined with electrostatic waves move protons into the mitochondrial matrix. (2020-09-24)

Tracking structural regeneration of catalysts for electrochemical CO2 reduction
Electrocatalytic reduction of CO2 to fuels and chemicals is one of the most attractive routes for CO2 utilization. Unveiling active sites of catalysts under realistic operating conditions is crucial for the design of efficient electrocatalysts for CO2 electroreduction. Scientists from East China University of Science and Technology employed Operando structural measurements at multiscale levels to identify the catalytically active components and uncover the working mechanism under realistic electrochemical CO2 reduction conditions. (2020-09-10)

Scientists uncover secret of material for promising thermal imagers
Russian researchers have discovered what makes vanadium dioxide films conduct electricity. Published in Physical Review B, their findings will enable thermal imaging devices with a sensitivity and reaction rate superior to those of the currently existing analogues. (2020-09-07)

High blood pressure and salt, anti-aging factor Klotho key
The mechanism behind salt-intake and hypertension has been elucidated for the first time, through vascular non-canonical Wnt5a/RhoA under Klotho deficiency. (2020-08-19)

Researchers discover novel molecular mechanism that enables conifers to adapt to winter
Unlike broadleaf trees, conifers are evergreen and retain their photosynthesis structure throughout the year. Especially in late winter, the combination of freezing temperatures and high light intensity exposes the needles to oxidative damage that could lead to the destruction of molecules and cell structures that contribute to photosynthesis. Researchers from the University of Turku have discovered a previously unknown mechanism that enables spruce trees to adapt to winter. (2020-08-18)

Organic chemistry -- a brilliant tool
An international team led by the chemist Heinz Langhals of LMU Munich succeeded in molecular deflection of light radiation by means of Diamantane. Novel applications such as efficient light collectors or broadband light absorbers are promising. (2020-08-14)

Identification of a new mechanism in the immune system provides knowledge about diseases
A recently identified mechanism in the immune system reveals a previously unknown protein that could provide an opening to a better understanding of infections and autoimmune diseases. This is shown by a new basic research study from Aarhus University, Denmark. (2020-08-04)

How Venus flytraps snap
Venus flytraps catch spiders and insects by snapping their trap leaves. This mechanism is activated when unsuspecting prey touch highly sensitive trigger hairs twice within 30 seconds. A study led by researchers at the University of Zurich has now shown that a single slow touch also triggers trap closure - probably to catch slow-moving larvae and snails. (2020-07-10)

How are misfolded membrane proteins cleared from cells by "reubiquitinase"?
Chinese researchers recently discovered a protein quality control mechanism called ''reubiquitination'', which could promote the elimination of misfolded membrane proteins, minimize their dwell time in cells, and thereby reduce their probability to form toxic aggregates in human body. (2020-07-08)

Norovirus has two alternative capsid structures which change before infection
Researchers from the National Institute for Physiological Sciences have discovered that mouse noroviruses have two alternative capsid structures and change from one to the other before infection. The two capsid structures were also identified in human norovirus VLP. The result will accelerate the development of therapeutic drugs and vaccines. (2020-07-03)

Is not helping a bad person good or bad?
A research team led by Hitoshi Yamamoto from Rissho University has analyzed how the social norm of indirect reciprocity is adopted in human society and revealed results that contradicted previous theoretical predictions. The study was carried out in collaboration with colleagues Takahisa Suzuki (Tsuda University) and Ryohei Umetani (Rissho University), and its results were published in the open-access journal PLOS ONE on June 30, 2020. (2020-07-01)

Understanding of relaxor ferroelectric properties could lead to many advances
A new fundamental understanding of polymeric relaxor ferroelectric behavior could lead to advances in flexible electronics, actuators and transducers, energy storage, piezoelectric sensors and electrocaloric cooling, according to a team of researchers at Penn State and North Carolina State. (2020-06-29)

The balancing act between plant growth and defense
Kumamoto University researchers have pinpointed the mechanism that regulates the balance between plant growth and defense. Excessive accumulation of hormones that protect against pathogen infection significantly hinders plant growth. Researchers found that the DEL1 gene plays a role in balancing growth and defense of plants infected with nematodes. This finding is expected to contribute to the improvement of agricultural crop varieties and the identification of infection mechanisms of various pathogens. (2020-06-16)

New insights into epigenetic modifications
Scientists at the European Molecular Biology Laboratory in Rome, in collaboration with Tim Bestor at Columbia University in New York and John Edwards at Washington University in St. Louis, Missouri, show for the first time how DNA methylation instructs cells to repress parts of their genome by inducing the assembly of a silencing complex. Their work was published in Proceedings of the National Academy of Sciences. (2020-06-11)

Scientists reveal relationship between Dek and Intron retention during muscle stem cells quiescence
Adult stem cells are essential for tissue regeneration. However, the mechanisms underlying the activation of quiescent adult stem cells remain elusive. Recently, a team of HKUST scientists revealed that intron detention (IR) is a key to the mechanism; when stem cell enters quiescence exit, Dek releases conserved introns, which allow the cell to be activated. (2020-06-10)

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