Current Medulloblastoma News and Events

Current Medulloblastoma News and Events, Medulloblastoma News Articles.
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Discovery of a new approach to inhibiting a highly treatment-refractory liver cancer
Blocking placental growth factor (PlGF), a member of the vascular endothelial growth factor family, inhibits the progression of intrahepatic cholangiocarcinoma (ICC) and enhances the efficacy of chemotherapy in mouse models. This novel approach to targeting the connective tissue microenvironment of ICC, a rare but notoriously treatment-resistant form of liver cancer, could pave the way for combination therapies, including chemotherapy and immune checkpoint blockade. (2021-01-12)

Breakthrough in childhood brain cancer will save lives
A scientific breakthrough has enabled experts to predict relapse in a common childhood cancer and means doctors can tailor treatment for each individual child and improve prognosis. (2020-11-17)

Personalized drug screens could guide treatment for children with brain cancer
Scientists at Sanford Burnham Prebys Medical Discovery Institute, University of California San Diego School of Medicine and Hopp Children's Cancer Center Heidelberg (KiTZ) have demonstrated that personalized drug screens can be used to identify new therapeutic candidates for medulloblastoma. The approach measures the effectiveness of therapeutics using tumor cells obtained from a biopsy and can be performed in a few days--making it one of the quickest sources of information used in clinical decision-making. (2020-11-12)

Cerebrospinal fluid as liquid biopsy for characterizing & policing of medulloblastoma
Building on previous research led by Joan Seoane, Director of Translational Research at the Vall d'Hebron Institute of Oncology (VHIO) and ICREA Research Professor, latest findings from a proof-of-concept study published in Nature Communications, show that the analysis of cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA), allows for the more precise characterization, molecular diagnosis (including subtyping and risk stratification), and real time tracking of medulloblastoma (MB) - the most prevalent malignant brain tumor in childhood. (2020-10-27)

Researchers find potential to make brain cancers in children respond better to treatment
Research has identified a small molecule compound that can activate the Wnt pathway in non-Wnt subtypes of medulloblastoma, making these aggressive forms of cancer more responsive to therapies. The work also found the Wnt pathway, which has historically been considered cancer-promoting, to function as a cancer inhibitor in certain contexts. (2020-08-28)

Leukemia drug shows the potential to treat aggressive pediatric brain câncer
When tested in vitro, arsenic trioxide killed tumor cells and prevented the formation of new colonies. This leukemia drug also boosted the effect of radiation therapy on medulloblastoma, a type of central nervous system tumor most common in children. (2020-07-21)

St. Jude creates resource for pediatric brain tumor research
Researchers worldwide can access orthotopic patient-derived xenograft models to speed discovery and test novel therapies for childhood brain tumors. (2020-06-23)

Scientists identify promising immunotherapy combination for pediatric brain cancer
Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. The discovery, published in Nature Neuroscience, is expected to lead to a clinical trial to test the benefits of the treatment in patients. The findings also hold implications for other cancers that do not respond to immunotherapy. (2020-05-18)

A promising new treatment for recurrent pediatric brain cancer
Researchers developed a novel approach that delivers appropriately-targeted chimeric antigen receptor (CAR) T cell therapy directly into the cerebrospinal fluid that surrounds recurrent pediatric brain tumors. (2020-04-27)

Understanding brain tumors in children
The causes of 40% of all cases of certain medulloblastomas -- dangerous brain tumors affecting children -- are hereditary. These are the findings of a recent genetic analysis carried out by scientists from the European Molecular Biology Laboratory (EMBL) and numerous colleagues around the world. A genetic defect that occurs in 15% of these children plays a key role by destabilizing the production of proteins. The researchers suspect that protein metabolism defects could be a previously underestimated cause of other types of cancer. (2020-04-01)

Inherited mutation can predispose children to a type of brain tumor
Collaboration co-led by researchers at St. Jude Children's Research Hospital discovers a novel predisposition gene in pediatric medulloblastoma. (2020-04-01)

Brain tumors in children: Hereditary genetic defect destabilizes protein regulation
The causes of 40 percent of all cases of certain medulloblastoma - dangerous brain tumors affecting children - are hereditary. These are the findings of a recent genetic analysis carried out by scientists from the Hopp Children's Cancer Center (KiTZ), the European Molecular Biology Laboratory (EMBL) and numerous colleagues around the world, which have just been published in the scientific journal Nature. (2020-04-01)

Targeting a transporter to treat SHH medulloblastoma
Scientists at St. Jude Children's Research Hospital have identified a novel target for a type of pediatric brain tumor. (2020-03-31)

Researchers identify novel potential combination therapy for childhood brain tumors
Brazilian researchers working in collaboration with Canadian scientists demonstrated that all medulloblastoma tumor subtypes express two stem cell markers: BMI1 and CD133. When they induced DNA chromatin relaxation, tumor cell viability was reduced with down-regulation of BMI1 and CD133. These anti-tumor effects could be potentiated by concurrent inhibition of MAPK/ERK signaling. (2020-02-20)

Organoids (in vitro brains) to study pediatric brain tumors
Hundreds of miniature brains were grown in the laboratories of the University of Trento to study the genetic mechanisms responsible for the most common brain cancer affecting children. The results of a collaborative research effort, coordinated by the University of Trento and carried out with Sapienza University and Ospedale pediatrico Bambino Gesù in Rome and Irccs Neuromed, were published today in Nature Communications. (2020-01-29)

Nanoparticles deliver 'suicide gene' therapy to pediatric brain tumors growing in mice
Johns Hopkins researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a ''suicide gene'' to pediatric brain tumor cells implanted in the brains of mice. The poly(beta-amino ester) nanoparticles, known as PBAEs, were part of a treatment that also used a drug to kill the cells and prolong the test animals' survival. (2020-01-08)

Researchers identify possible approach to block medulloblastoma growth
University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified a potential approach to stop the growth of the most common type of brain tumor in children. (2019-10-24)

Compound extends survival in mice with certain pediatric brain tumors
Versions of an antibiotic drug called DON first isolated from soil bacteria more than 60 years ago have shown promising signs of extending survival in mice models of especially lethal pediatric brain tumors marked by the high expression of a cancer-causing gene known as the MYC oncogene, according to results of two studies from researchers at the Johns Hopkins Kimmel Cancer Center. (2019-09-23)

Leukemia drug shows promise for treating a childhood brain cancer
Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego researchers describe new use of leukemia drug, nilotinib, to treat subtype of medulloblastoma, a deadly pediatric brain cancer. (2019-09-20)

Two studies show promise, safety of proton therapy in the brain in children with cancer
From improving outcomes in children with brain cancer to lowering the risk of damage to the brainstem in children with central nervous system tumors, a pair of new studies published today add to the growing body of research showing the potential benefits of proton therapy. (2019-09-12)

Researchers move beyond sequencing and create a 3D genome
St. Jude Children's Research Hospital scientists have taken whole genome sequencing to the next level by creating a 3D map of the genome to better understand development and disease. (2019-09-04)

Cracking the code of a brain cancer that keeps coming back
Researchers used a powerful new computer-assisted technology called single-cell transcriptomics that measures thousands of individual cells simultaneously to map cell types and molecular cascades that drive the growth of SHH-medulloblastoma. In a study published Aug. 29, 2019 by the journal Cancer Cell, the scientists report they discovered new treatment strategies for the disease that may help patients fight a recurrent cancer. (2019-08-29)

Inherited BRCA2 mutations linked to increased risk of childhood lymphoma
A report from St. Jude Children's Research Hospital links inherited mutations in the BRCA2 gene with an increased risk of developing non-Hodgkin lymphoma in children and adolescents. The work appears as an advance online publication today in JAMA Oncology. (2019-07-25)

To understand a childhood brain tumor, researchers turn to single-cell analysis
Investigators at St. Jude Children's Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor. The work also has implications for how medulloblastoma is classified, which may eventually shape clinical care. The work appears as an advance online publication today in Nature. (2019-07-24)

Hearing loss weakens skills that young cancer survivors need to master reading
Researchers have identified factors that explain why severe hearing loss sets up pediatric brain tumor survivors for reading difficulties with far-reaching consequences. The findings lay the foundation for developing interventions to help survivors become better readers. The findings suggest that interventions should focus on improving neurocognitive and language-based skills like processing speed and phonemics before tackling more complex tasks like reading comprehension. (2019-05-02)

Helping infants survive brain cancer
Choroid plexus carcinoma (CPC) is a particularly challenging type of brain cancer: The tumor most commonly arises in infants under the age of one. Progress in developing effective therapies has been hindered by the lack of models that could help researchers better understand the cancer. Now, scientists from SBP have developed a novel mouse model of CPC and have used it to identify multiple potential drug compounds. The study was published in Cancer Research. (2019-03-27)

Super-enhancers: novel target for pancreatic ductal adenocarcinoma
Among many pathways of cancer progression that PDAC relies on, anomalous activation of the sonic hedgehog pathway has shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. (2019-02-26)

FSU team breaks new ground in study of malignant pediatric brain tumor
FSU researchers identified a series of cancer-causing driver gene mutations and discovered that medulloblastoma is perhaps an even more dynamic and variable tumor than expected. (2019-01-30)

Targeted treatment shrinks deadly pediatric brain tumors
For children--whose tiny bodies are still growing--chemotherapy and radiation treatments can cause lifelong damage. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have reported that a targeted therapy that blocks a protein called LSD1 was able to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers. The study was published in Nature Communications. (2019-01-23)

Engineered immune cells target broad range of pediatric solid tumors in mice
Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study from the Stanford University School of Medicine. (2019-01-17)

Tiny molecule has big effect in childhood brain tumor studies
A very small molecule under study at UT Health San Antonio is able to kill a childhood brain cancer, and the lead researcher said it may be possible to reduce by 90 percent the amount of chemotherapy and radiation required to kill such tumors. (2018-11-07)

Breakthrough in childhood brain cancer
Scientists led by Newcastle University have been able to identify the group of children needing more intensive, aggressive chemotherapy treatment for the most common form of brain cancer. (2018-11-01)

Study holds promise for new pediatric brain tumor treatment
New research published in Nature Communications from scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U), in collaboration with the Stanford University School of Medicine, shows a specific protein regulates both the initiation of cancer spreading and the self-renewal of cancer cells in medulloblastoma, a type of pediatric brain cancer. (2018-10-11)

Cells in 'little brain' have distinctive metabolic needs
'Knocking out' an enzyme that regulates the flow of fuel into mitochondria specifically blocks the development of the mouse cerebellum more than the rest of the brain. (2018-10-10)

Discovery of a cancer promoter offers pathway to overcome drug resistance
Geneticists at St. Jude Children's Research Hospital have discovered a previously unknown cell growth mechanism that makes a wide range of cancers resistant to rapamycin and related drugs. The finding offers the promise of new drug therapies that can overcome that resistance to treat cancers including leukemia and tumors in the brain and other organs. (2018-09-12)

Stem cells show promise as drug delivery tool for childhood brain cancer
UNC Lineberger Comprehensive Cancer Center researchers showed they could shrink tumors in laboratory models of medulloblastoma, and extend life. The study, published in PLOS ONE, is a necessary step toward developing clinical trials that would see if the approach works for children. (2018-08-29)

Reviving the protector: new tactic against medulloblastoma
Scientists have a new tactic with potential for fighting medulloblastoma, the most common and most aggressive form of brain tumor in children. (2018-06-11)

International 'A' team debuts brain cancer atlas
It takes an 'A' team to make headway against glioblastoma, a highly aggressive type of brain cancer. Glioblastoma is the most common type of malignant brain tumor in adults. In addition to the caliber of the researchers involved, in this case 'A' also stands for atlas. A key member of the team, Jill S. Barnholtz-Sloan, PhD, and approximately 80 other internationally renowned neurologists, bioinformaticians, and pathologists from the US and India recently published details of the Ivy Glioblastoma Atlas in Science. (2018-06-06)

St. Jude trial identifies a medulloblastoma subset that requires less aggressive therapy
St. Jude Children's Research Hospital researchers have identified a subtype of the brain tumor medulloblastoma that is associated with improved survival of infants treated with less aggressive, risk-adapted therapy. (2018-05-16)

Genetic analysis for certain childhood brain tumors soon a standard-of-care?
An international team of researchers from the Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), the European Molecular Biology Laboratory (EMBL) and the German Cancer Consortium (DKTK) together with colleagues at the St. Jude Children's Research Hospital in Memphis and the Hospital for Sick Children in Toronto has summarized hereditary gene defects which can trigger the development of certain malignant brain tumors (medulloblastoma). From their findings, the team has derived recommendations for routine genetic screening in medulloblastoma patients. (2018-05-11)

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