Current Melanoma News and Events

Current Melanoma News and Events, Melanoma News Articles.
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Oncotarget: Improved therapeutic efficacy of unmodified anti-tumor antibodies
The Oncotarget findings suggest that MEKi induced an increased expression of tumor-associated antigens, which in combination with anti-tumor antibodies, generated a robust adaptive anti-tumor response that was sustained by immune checkpoint inhibition therapy. (2021-01-25)

Vaccine produces long-lasting anti-tumor response in patients with melanoma
Patients treated with a vaccine tailored to mutated proteins on patients' own tumor cells, continue to have a strong immune response to the cancer four years after being vaccinated. Results demonstrate the ability of personalized cancer vaccines to provide long-term immunity against some cancers. (2021-01-21)

New humanized mouse model provides insight into immunotherapy resistance
Wistar scientists have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. (2021-01-12)

Texas A&M research explores how melanoma grows and spreads
The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact. (2021-01-12)

An epidemic of overdiagnosis: Melanoma diagnoses sky rocket
In a Sounding Board article, Welch and colleagues present evidence for why they believe that increased diagnostic scrutiny is the primary driver of the rapid rise in melanoma diagnoses. (2021-01-06)

Immunology study finds protein critical to T cell metabolism and anti-tumor immune response
Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumor immune response. (2021-01-04)

How cancers hurt themselves to hurt immune cells more
A study of melanoma cells explains a puzzling response they exhibit to ward off T cell attacks. (2020-12-20)

For college students, skin cancer risk remains high in winter months
New research finds college students could be just as at risk for developing skin cancer in the dead of winter as they are in the middle of summer. (2020-12-17)

UV exposure, risk of melanoma in skin of color
The association between ultraviolet (UV) light exposure and the risk of melanoma in individuals with skin of color was examined with a review of the results of 13 studies. (2020-12-16)

New combination therapy could help fight difficult-to-treat cancers with common mutations
UCLA scientists describe a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. This combination of two small molecules has the potential to treat not only BRAF mutated melanoma but also additional aggressive subtypes of cancers, including melanoma, lung, pancreatic and colon cancers that harbor common mutations in cancer genes called RAS or NF1. (2020-12-14)

Phase 1 trial assesses whether fecal microbiota transplant impacts cancer patients resistant to immu
In one of the first in-human studies to investigate whether modifying the gut microbiome by a fecal microbiota transplant could make cancer immunotherapy more effective, researchers analyzing this in ten cancer patients with refractory melanoma suggest the treatment can improve patient outcomes. (2020-12-10)

Huntsman Cancer Institute researchers identify promising drug combination for melanoma
Researchers at Huntsman Cancer Institute at the University of Utah have identified a potential drug combination to treat uveal melanoma, a type of eye cancer. Lead author Amanda Truong, trainee in the McMahon Lab at HCI and student at the U of U, explains uveal melanoma patients frequently have changes in genes called GNAQ and GNA11, which are key targets for these drugs. This study was published in the journal Clinical Cancer Research. (2020-12-03)

Scientists discover roles for a cellular motor in cancer
Utah scientists have discovered new functions of a key cellular machine that regulates gene packaging and is mutated in 20% of human cancers. The study was published in print today in the journal Molecular Cell. (2020-11-19)

AI may predict response to immune checkpoint blockade in patients with metastatic melanoma
A computational method that combines clinicodemographic variables with deep learning of pre-treatment histology images could predict response to immune checkpoint blockade among patients with advanced melanoma. (2020-11-18)

Artificial intelligence program can pick best candidates for skin cancer treatment
Experts trained a computer to tell which skin cancer patients may benefit from drugs that keep tumors from shutting down the immune system's attack on them, a new study finds. (2020-11-18)

Immunotherapy for lung and other cancers may also be beneficial for rare skin cancer
New research from the University of North Carolina School of Medicine and the Lineberger Comprehensive Cancer Center found immunotherapies effective against lung cancer and melanoma may work against cutaneous angiosarcoma, a rare, highly aggressive skin tumor found primarily on the scalps of older White people. The researchers report tumor-infiltrating lymphocytes and the surface protein markers PD-1 and PD-L1 could help guide the choice of immunotherapy to fight cutaneous angiosarcomas. (2020-11-18)

UV light may be a greater risk for melanoma than suspected
Studies conducted in yeast show that exposure to ultraviolet light (UV) induces new types of DNA damage that may cause the deadliest form of skin cancer, malignant melanoma. While melanoma has been associated with UV light, this study directly links UV exposure to the atypical mutations known to spread the disease. The results also indicate that UV light can induce a more diverse spectrum of mutations than previously suspected. (2020-11-17)

Study identifies patients with lung cancer most likely to respond to immunotherapy
In a new study, researchers at UCLA found patients with a particular type of HLA, a protein scaffold involved in presenting pieces of proteins described as peptides to the immune system, were particularly likely to benefit from immunotherapy. (2020-11-16)

Researchers discover how to boost vaccine designed to prevent melanoma recurrence
A vaccine created to prevent the recurrence of the deadly skin cancer melanoma is about twice as effective when patients also receive two components that boost the number and effectiveness of immune system cells called dendritic cells, according to phase 2 clinical trial results published in Nature Cancer in November. (2020-11-16)

MD Anderson researchers present immunotherapy advances at Society for Immunotherapy of Cancer Annual Meeting
Promising clinical results with combination treatments for patients with melanoma and lung cancer highlight immunotherapy advances being presented by researchers from The University of Texas MD Anderson Cancer Center at The Society for Immunotherapy of Cancer (SITC) 35th Anniversary Annual Meeting & Pre-Conference Programs (SITC 2020) . (2020-11-11)

New cancer drugs saved over 1.2 million people in the US over 16 years, new study shows
More than 1.2 million people in the US prevented facing death following a cancer diagnosis, between the year 2000 and 2016, thanks to ever improving treatment options -- a large new national study shows. (2020-11-09)

New method developed by Lithuanian scientists can reach 90% accuracy in detecting melanoma
A team of researchers from Kaunas University of Technology and Lithuanian University of Health Sciences proposed a non-invasive method for detection of melanoma. A patented computer-aided diagnostic system developed by Lithuanian scientists proved to be more than 90% accurate in detecting malignancy in diagnostic images of skin lesions acquired from 100 patients. (2020-11-09)

A better test for the tumor-targeting of CAR-T therapies
Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies, in which the immune system's T cells are extracted from a patient, engineered to target a specific tumor-associated molecule and then grown and reinfused for cancer treatment. (2020-11-06)

Boosting treatments for metastatic melanoma
University of Cincinnati clinician-scientist Soma Sengupta, MD, PhD, says that new findings from her and Daniel Pomeranz Krummel's, PhD, team might have identified a treatment-boosting drug to enhance effectiveness of therapies for metastatic cancer and make them less toxic, giving patients a fighting chance at survival and improved quality of life. (2020-11-05)

Age is a primary determinant of melanoma treatment resistance, two studies find
Age may cause identical cancer cells with the same mutations to behave differently. In animal and laboratory models of melanoma cells, age was a primary factor in treatment response. (2020-11-02)

Vitamin B3 protects skin cells from the effects of UV exposure, new research finds
Research presented today at EADV's 29th Congress, EADV Virtual, shows hope that a form of vitamin B3 could protect skin cells from the effects of ultraviolet (UV) exposure: the main risk factor for non-melanoma skin cancers. (2020-10-31)

Scientists engineer new cancer immunotherapy to train immune system in cancer fight
A groundbreaking new type of cancer immunotherapy developed at the Icahn School of Medicine at Mount Sinai trains the innate immune system to help it eliminate tumor cells through the use of nanobiologics, tiny materials bioengineered from natural molecules that are paired with a therapeutic component, according to a study published in Cell in October. (2020-10-29)

Groundbreaking study on trained immunity to fight cancer
An extensive international collaboration led by Prof. Willem Mulder Eindhoven University of Technology has developed a groundbreaking approach based on trained immunity of the innate immune system to help in the elimination of tumorous cells. The immunotherapy approach uses nanobiologics to help produce trained immunity cells from bone marrow. (2020-10-29)

Next generation BRAF inhibitor cancer drug shows promise in early patient trial
A new drug designed to work on cancers with an altered BRAF gene has shown promise in an early patient trial presented at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (2020-10-25)

Response to adjuvant bevacizumab among patients with resected melanoma may vary by age
Younger patients with resected melanoma had some benefit from adjuvant treatment with the anti-VEGF therapeutic bevacizumab (Avastin) while older patients with resected melanoma did not. (2020-10-23)

Cholesterol medications linked to lower cancer-related deaths in women
Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology. (2020-10-21)

Aggressive melanoma cells at edge of tumours are key to cancer spread
Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumours at secondary sites around the body. (2020-10-20)

CNIO team finds how melanoma 'deceives' the immune system, increasing resistance to immunotherapy
* The CNIO researchers have identified how melanoma redirects the immune system, preventing it from attacking the tumour and transforming it into an ally in cancer development * A key element in this 'deception' is MIDKINE, a protein that modifies the function of several components of the immune system. By blocking MIDKINE, the researchers managed to rewire immune cells to resume the attack against the tumour * This finding can lead to the development of optimised immunotherapy, which is only partly effective in some tumours today (2020-10-19)

A promising new tool in the fight against melanoma
An Edith Cowan University (ECU) study has revealed that a key blood marker of cancer could be used to select the most effective treatment for melanoma. (2020-10-16)

ctDNA may predict outcomes with first-line, but not second-line immunotherapy for melanoma
Baseline levels of circulating tumor DNA (ctDNA) predicted responses to first-line, but not second-line, immune checkpoint inhibition in patients with melanoma. (2020-10-16)

Virus-mimicking drug helps immune system target cunning cancer cells
UCLA researchers found that a drug that activates the body's natural defenses by behaving like a virus may also make certain stealthy melanoma tumors visible to the immune system, allowing them to be better targeted by immunotherapy. (2020-10-14)

Scientists show jet lag conditions impair immune response in mice
International researchers publishing in Science Advances reveal in a mouse study that chronic jet lag alters the microenvironment surrounding tumor cells, making it more favorable for tumor growth, and also hinders the body's natural immune defenses. (2020-10-14)

UCI study points to how skin cells cooperate to thwart cancer
Melanoma is a life-threatening skin cancer that spreads quickly to other organs if not treated early. A new discovery by University of California, Irvine biologists shatters traditional beliefs about how melanomas develop, providing new insights into fighting the disease. The scientists' research appears in eLife. (2020-10-13)

Risk of deadly skin cancer may be gauged by accumulated DNA damage
Risk for melanoma, the most deadly skin cancer, can be estimated long before detection of any suspicious moles, according to a UC San Francisco scientist who led a new study to detect DNA mutations in individual skin cells. (2020-10-07)

Cancer's hidden vulnerabilities
To fight cancer more effectively, a Caltech researcher probes its inner workings for metabolic weaknesses. (2020-09-28)

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