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Current Melanoma News and Events, Melanoma News Articles.
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Next generation BRAF inhibitor cancer drug shows promise in early patient trial
A new drug designed to work on cancers with an altered BRAF gene has shown promise in an early patient trial presented at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (2020-10-25)

Response to adjuvant bevacizumab among patients with resected melanoma may vary by age
Younger patients with resected melanoma had some benefit from adjuvant treatment with the anti-VEGF therapeutic bevacizumab (Avastin) while older patients with resected melanoma did not. (2020-10-23)

Cholesterol medications linked to lower cancer-related deaths in women
Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology. (2020-10-21)

Aggressive melanoma cells at edge of tumours are key to cancer spread
Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumours at secondary sites around the body. (2020-10-20)

CNIO team finds how melanoma 'deceives' the immune system, increasing resistance to immunotherapy
* The CNIO researchers have identified how melanoma redirects the immune system, preventing it from attacking the tumour and transforming it into an ally in cancer development * A key element in this 'deception' is MIDKINE, a protein that modifies the function of several components of the immune system. By blocking MIDKINE, the researchers managed to rewire immune cells to resume the attack against the tumour * This finding can lead to the development of optimised immunotherapy, which is only partly effective in some tumours today (2020-10-19)

A promising new tool in the fight against melanoma
An Edith Cowan University (ECU) study has revealed that a key blood marker of cancer could be used to select the most effective treatment for melanoma. (2020-10-16)

ctDNA may predict outcomes with first-line, but not second-line immunotherapy for melanoma
Baseline levels of circulating tumor DNA (ctDNA) predicted responses to first-line, but not second-line, immune checkpoint inhibition in patients with melanoma. (2020-10-16)

Virus-mimicking drug helps immune system target cunning cancer cells
UCLA researchers found that a drug that activates the body's natural defenses by behaving like a virus may also make certain stealthy melanoma tumors visible to the immune system, allowing them to be better targeted by immunotherapy. (2020-10-14)

Scientists show jet lag conditions impair immune response in mice
International researchers publishing in Science Advances reveal in a mouse study that chronic jet lag alters the microenvironment surrounding tumor cells, making it more favorable for tumor growth, and also hinders the body's natural immune defenses. (2020-10-14)

UCI study points to how skin cells cooperate to thwart cancer
Melanoma is a life-threatening skin cancer that spreads quickly to other organs if not treated early. A new discovery by University of California, Irvine biologists shatters traditional beliefs about how melanomas develop, providing new insights into fighting the disease. The scientists' research appears in eLife. (2020-10-13)

Risk of deadly skin cancer may be gauged by accumulated DNA damage
Risk for melanoma, the most deadly skin cancer, can be estimated long before detection of any suspicious moles, according to a UC San Francisco scientist who led a new study to detect DNA mutations in individual skin cells. (2020-10-07)

Cancer's hidden vulnerabilities
To fight cancer more effectively, a Caltech researcher probes its inner workings for metabolic weaknesses. (2020-09-28)

Scientists kill cancer cells by 'shutting the door' to the nucleus
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes--large channels that control the flow of materials in and out of the cell nucleus--shrank aggressive tumors in mice while leaving healthy cells unharmed. The study, published in Cancer Discovery, a journal of the American Association for Cancer Research, reveals a new Achilles heel for cancer that may lead to better treatments for deadly tumors such as melanoma, leukemia and colorectal cancer. (2020-09-28)

Pale melanomas masked by albino gene
People with pale coloured melanomas are more likely to have a gene mutation associated with albinism, University of Queensland research has found. (2020-09-23)

Increasing the effectiveness of immunotherapy against skin cancer
Researchers at the University of Bern have discovered a mechanism in the body's own immune system which is responsible for the maturation and activation of immune cells. In the fight against skin cancer, the results have the potential to help immunotherapies succeed, even in patients for whom they have so far been ineffective. (2020-09-18)

New targets for melanoma treatment
A collaborative study led by Monash University's Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute (ONJCRI) has uncovered new markers (HLA-associated peptides) that are uniquely present on melanoma tumours and could pave the way for therapeutic vaccines to be developed in the fight against melanoma. (2020-09-16)

UCLA study shows how interferon-gamma guides response to cancer immunotherapy
UCLA researchers shed light on how interferon-gamma (IFN-y) guides the treatment response in people with advanced melanoma who are treated with one of the leading immunotherapies -- immune checkpoint blockade. (2020-09-10)

DNA-based nanotechnology stimulates potent antitumor immune responses
Combining their expertise in protein engineering and synthetic DNA technology, Wistar scientists successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models. (2020-09-10)

New nanosystem from Tel Aviv university enhances treatment for melanoma in animal models
Researchers at Tel Aviv University, led by Prof. Ronit Satchi-Fainaro of TAU's Department of Physiology and Pharmacology at the Sackler School of Medicine, have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma. (2020-09-08)

Moffitt researchers identify metastasis driver in BRAF inhibitor resistant melanoma
In a new article published in the Journal of Investigative Dermatology, Moffitt researchers identify erythropoietin-producing hepatocellular receptor A2 (EphA2) as a driver of metastasis and BRAF-MEK inhibitor resistance in melanoma. (2020-09-02)

Effective cancer immunotherapy further linked to regulating a cell 'suicide' gene
Johns Hopkins Medicine researchers have added to evidence that a gene responsible for turning off a cell's natural ''suicide'' signals may also be the culprit in making breast cancer and melanoma cells resistant to therapies that use the immune system to fight cancer. A summary of the research, conducted with mice and human cells, appeared Aug. 25 in Cell Reports. (2020-09-01)

Finding a way to STING tumor growth
The immune protein STING has long been noted for helping protect against viruses and tumors by signaling a well-known immune molecule. Now, UT Southwestern scientists have revealed that STING also activates a separate pathway, one that directly kills tumor-fighting immune cells. (2020-08-24)

New, pharmacologically available STING agonists promote antitumor immunity in mice
In a pair of studies, researchers report the discovery and molecular pharmacology of stable, synthetic STING (stimulator of interferon genes) agonists that induce anticancer immune responses in mice. (2020-08-20)

Unleashing the immune system's 'STING' against cancer
Scientists at Scripps Research have discovered a molecule that can activate a natural immune-boosting protein called STING. The findings mark a key advance in the field of oncology, as the STING protein is known for its strong antitumor properties. (2020-08-20)

The secret of lymph: How lymph nodes help cancer cells spread
For decades, physicians have known that many kinds of cancer cells often spread first to lymph nodes before traveling to distant organs through the bloodstream. New research from Children's Medical Center Research Institute at UT Southwestern (CRI) provides insight into why this occurs, opening up new targets for treatments that could inhibit the spread of cancer. (2020-08-19)

Study finds cancer mapping may solve puzzle of regional disease links
New statistical analysis finds cancer mapping may help question regional disease links. (2020-08-13)

UCalgary researchers discover the microbiome's role in attacking cancerous tumours
University of Calgary researchers have discovered which gut bacteria help our immune system battle cancerous tumours and how they do it. The discovery may provide a new understanding of why immunotherapy, a treatment for cancer that helps amplify immune response, works in some cases, but not others. The findings, published in Science, show combining immunotherapy with specific microbial therapy helps the immune system to recognize and attack cancer cells in three forms of cancer. (2020-08-13)

Molecules in urine allow doctors to monitor skin cancer
What if you could simply provide a urine sample rather than undergo a painful surgical procedure to find out if your cancer was responding to treatment? It may seem too good to be true, but researchers at Pavol Jozef Šafárik University in Košice, Slovakia, have identified fluorescent molecules in urine that may allow patients with malignant melanoma to do just that. (2020-08-11)

Scientists found genes that help cancer cells to penetrate the brain
An international team of scientists, including a researcher from Sechenov University, reviewed scientific articles on proteins (and genes encoding them) that help cancer cells enter the brain. An understanding of the processes that facilitate the formation of metastases in the brain will allow scientists to create new methods for cancer diagnosis and treatment. Details of the study can be found in the journal Trends in Cancer. (2020-08-11)

How tumor cells evade the immune defense
Scientists are increasingly trying to use the body's own immune system to fight cancer. A new study by the University of Bonn and research institutions in Australia and Switzerland now shows the strategies tumor cells use to evade this attack. The method developed for this work contributes to a better understanding of the ''arms race'' between immune defense and disease. The results could help to improve modern therapeutic approaches. They have been published in ''Immunity''. (2020-08-05)

HDAC6 can control tumor growth and halt metastasis in triple-negative breast cancer
Genetic modifier HDAC6 was found to control tumor growth and halt metastasis in triple-negative breast cancer in vivo, according to a new study published in the journal Cancer Research by investigators at the GW Cancer Center. (2020-08-05)

Researchers outline need for evaluation of gene expression profiling in melanoma
A consensus statement published today in JAMA Dermatology cautions against routine use of currently available GEP tests for patients with cutaneous melanoma. (2020-07-29)

A helping hand for cancer immunotherapy
Scientists at Sanford Burnham Prebys Medical Discovery Institute have demonstrated the therapeutic potential of PRMT5 inhibitors to sensitize unresponsive melanoma to immune checkpoint therapy. PRMT5 inhibitors are currently in clinical trials in oncology, and this research provides a strong rationale for evaluating the drugs in tumors that are not responsive to immune checkpoint therapy. The study was published in Science Translational Medicine. (2020-07-08)

A 3D biofabricated cutaneous squamous cell carcinoma tissue model
The cover for issue 27 of Oncotarget features Figure 4, ''(A) Bimodal imaging examples of control and treated tumors (red) before and after the treatment period,'' by Browning, et al. and reported that the authors developed a 3-dimensional bioprinted skin model of cutaneous squamous cell carcinoma (cSCC) tumors together with a microscopy assay to test chemotherapeutic effects in tissue. (2020-07-07)

Protein derived from tick saliva proves effective in the treatment of equine skin cancer
Experiments were conducted by scientists affiliated with the Center of Excellence in New Target Discovery, a research center supported by FAPESP, involving five animals with spontaneous skin tumors. (2020-06-29)

Study reveals key finding about microbiome of anticancer compound-producing marine invertebrate
Could the cure for melanoma - the most dangerous type of skin cancer -- be a compound derived from a marine invertebrate that lives at the bottom of the ocean? A group of scientists led by Alison Murray, Ph.D. of the Desert Research Institute (DRI) in Reno think so, and are looking to the microbiome of an Antarctic ascidian called Synoicum adareanum to better understand the possibilities for development of a melanoma-specific drug. (2020-06-25)

Oncotarget: Mutation profile of primary subungual melanomas in Caucasians
Volume 11 Issue 25 of @Oncotarget reported that this study aimed to define the mutation profile of SUM in Caucasians. (2020-06-23)

Patient-personalized sequencing pipeline steps up sensitivity of tumor DNA monitoring
A sequencing pipeline that integrates a patient's specific tumor genetic data boosts the sensitivity of tests that detect cancer cell DNA circulating in the blood, according to a newly published study. (2020-06-17)

Wearable patch may provide new treatment option for skin cancer
Purdue University innovators have created a novel wearable patch to provide an improved treatment experience for people with melanoma. The researchers developed a novel wearable patch with fully miniaturized needles, enabling unobtrusive drug delivery through the skin for the management of skin cancers. (2020-06-16)

Photodynamic therapy used to treat ovarian cancer
Photodynamic therapy (PDT) is one of the most promising methods of treating localized tumors. PDT can be used for treatment in almost all major locations as an independent method or in combination with traditional types of treatment (surgery, radiation, and chemotherapy). (2020-06-08)

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