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Current Mesothelioma News and Events, Mesothelioma News Articles.
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Study examines association of asbestos exposure, mesothelioma in Eastern China
A new research letter published online by JAMA Oncology looks at asbestos exposure and malignant mesothelioma in Eastern China. (2016-12-01)

New study challenges assumption of asbestos' ability to move in soil
A new study led by Scripps Institution of Oceanography at the University of California San Diego scientist Jane Willenbring challenges the long-held belief that asbestos fibers cannot move through soil. The findings have important implications for current remediation strategies aimed at capping asbestos-laden soils to prevent human exposure of the cancer-causing material. (2016-08-19)

Mesothelioma surgery improves quality of life, study finds
Many mesothelioma patients avoid surgery for fear it will degrade their quality of life. But a study has found just the opposite: Patients who underwent an operation called pleurectomy and decortication (PD) generally reported their quality of life improved after surgery. (2016-06-08)

NYU's Perlmutter Cancer Center & the Technion launch global cancer research initiative
Drug-carrying 'nanoghosts' that battle melanoma and new treatments for malignant mesothelioma will be the focus of the first joint research projects led by NYU Langone Medical Center and the Technion-Israel Institute of Technology. (2016-04-21)

AACR: Targeting cancer with engineered T cells
Dr. Philip Greenberg, head of immunology and a member of the Clinical Research Division at Seattle's Fred Hutchinson Cancer Research Center and a leader in cancer immunology, will describe at AACR 2016 how he and colleagues are genetically engineering T cells to seek out cancer cells, penetrate their defenses and kill them. (2016-04-20)

Immunotherapy with live bacterium improves response rate in malignant pleural mesothelioma
Immunotherapy with a live bacterium combined with chemotherapy demonstrated more than 90% disease control and 59% response rate in patients with malignant pleural mesothelioma (MPM), according to the results of a phase Ib trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland. (2016-04-14)

UH Cancer Center and Jabsom researchers receive $3 million US Department Of Defense Awards
University of Hawai'i Cancer Center and John A. Burns School of Medicine researchers were awarded three out of only 45 United States Department of Defense grants for cancer research and career development. The awards to the University of Hawai'i are for malignant mesothelioma research and total more than $3 million. (2016-03-30)

New drug hope for mesothelioma
A new drug is showing promise as a treatment for mesothelioma -- one of the most lethal cancers of all. The drug, known as HRX9, works by preventing the cancer cells from avoiding apoptosis -- the natural process by which unhealthy and damaged cells close themselves down and die. (2016-03-14)

New genetic insights into mesothelioma
In a comprehensive genomic analysis using more than 200 mesothelioma tumors, investigators from Brigham and Women's Hospital have found previously unknown genetic alterations, including some that may be clinically actionable, as well as others that may improve diagnostics, screening and predictions about outcomes for patients. The team's results are published this week in Nature Genetics. (2016-02-29)

The test that reveals cancer sooner
MorNuCo Laboratories' clinical trial, recently published in Clinical Proteomics, demonstrated the ability of a serum test to detect the presence of mesothelioma 4-10 years in advance of clinical symptoms. The ONCOblot® Test detects ENOX2 proteins present in serum, and in this trial, ENOX2 proteins that are specific to mesothelioma. This is an exciting step forward in the continued development of tools for early cancer detection. (2016-02-04)

Study suggests improvements in how mesothelioma is staged
A new study suggests that significant improvements could be made in the scoring system physicians use to estimate the stage (severity) of mesothelioma, an aggressive and deadly cancer. (2016-02-02)

Mutation of BAP1 gene passed down over centuries
In the findings published in PLOS Genetics, through genetic and genealogical studies by Michele Carbone, M.D., Ph.D., director of the UH Cancer Center's Thoracic Oncology Program and colleagues, it was demonstrated that the family members were related and that they descended from a couple that immigrated to the US from Germany in the early 1700's. (2015-12-22)

BAP1 mutation passed down over centuries and is associated with high incidence of several cancers
Carbone and colleagues discovered that members of 4 families, apparently unrelated and living in different US States, shared the identical mutation of a gene called BAP1 that is associated with a higher incidence of mesothelioma, melanoma, renal carcinoma and other cancers. Through genetic and genealogical studies, it was demonstrated that the families were related, and that they descended from a couple that immigrated to the USA from Germany in the early 1700s. (2015-12-18)

Atezolizumab set to change refractory lung cancer treatment
Atezolizumab is set to substantially change treatment strategies for patients with refractory lung cancer, according to Dr. Martin Reck, Chief Oncology Physician in the Department of Thoracic Oncology, Hospital Grosshansdorf, Germany. Reck's comments came as the results from the POPLAR and BIRCH studies showing the first results of efficacy with atezolizumab across lines were presented at the European Cancer Congress 2015 (ECC 2015) in Vienna, Austria. (2015-09-27)

Statistical model may identify patients who can benefit from surgery for mesothelioma
A new statistical model may help predict which patients are most likely to receive life-extending benefits from surgical treatment for malignant pleural mesothelioma, according to an article in the September 2015 issue of the Annals of Thoracic Surgery. (2015-09-08)

Aspirin may delay growth of asbestos-related cancer
A University of Hawai'i Cancer Center study finds aspirin may help mesothelioma patients. (2015-07-06)

Braking mechanism identified for cell growth pathway linked to several cancers
Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role in controlling organ size, cell proliferation and cell death. (2015-06-26)

SPECTAlung providing patients with thoracic tumors efficient clinical trial access
Our understanding of tumor biology has improved and continues to expand at a rapid pace, and this has opened new opportunities for cancer clinical trials, particularly for thoracic tumors. The identification and molecular alterations in the cancer and the possibility to specifically and selectively target them, has dramatically improved the treatment efficacy in patients with lung cancer. (2015-06-23)

Trabectedin shows activity in ATREUS trial in patients with sarcomatoid malignant mesothelioma
PharmaMar today announced data from the Phase 2 ATREUS study in patients with sarcomatoid/biphasic malignant pleural mesothelioma showing that 41.2 percent of patients treated with the anticancer drug trabectedin in second line were alive and free of progression at 12 weeks. The median progression-free survival in these 17 evaluated patients was 8.3 weeks. The study will be presented at the 2015 ASCO Annual Meeting. (2015-06-01)

PharmaMar announces new advances in oncology at ASCO 2015 for compounds YONDELIS® and PM1183
PharmaMar announces new advances in oncology at ASCO 2015 for its compounds YONDELIS® and PM1183 highlighting data in small cell lung cancer, soft tissue sarcoma, and mesothelioma. (2015-05-14)

Investigational personalized cellular therapy tolerated well by patients
Genetically modified versions of patients' own immune cells successfully traveled to tumors they were designed to attack in an early-stage trial for mesothelioma and pancreatic and ovarian cancers at the Perelman School of Medicine at the University of Pennsylvania. The data adds to a growing body of research showing the promise of CAR T cell technology. The interim results will be presented at the American Association for Cancer Research Annual Meeting 2015, April 18-22. (2015-04-19)

Penn Medicine: Immunotherapy drug pembrolizumab shows promise for mesothelioma patients
The PD-1 inhibitor pembrolizumab, a cancer immunotherapy drug, shrank or halted growth of tumors in 76 percent of patients with pleural mesothelioma, a rare and deadly form of cancer that arises in the outer lining of the lungs and internal chest wall, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania. (2015-04-19)

Asbestos use in Asia poses serious health dangers
The use of asbestos continues to increase in Asia despite clear health hazards. A recent Respirology review notes that with approximately 4.3 billion people and a growing population, Asia will likely see a large crop of asbestos-related lung diseases in the next few decades. (2015-04-07)

A fatal cancer found among Southern Nevada residents likely caused by asbestos in nature
A highly fatal cancer is found in unusually higher proportions among women and younger residents in Southern Nevada, suggesting that the surrounding environment is a contributing source of the cancers, researchers at the University of Hawai'i Cancer Center have found. (2015-02-11)

Mesothelioma in southern Nevada likely result of asbestos in environment
Malignant mesothelioma has been found at higher than expected levels in women and in individuals younger than 55 years old in the southern Nevada counties of Clark and Nye, likewise in the same region carcinogenic mineral fibers including actinolite asbestos, erionite, winchite, magnesioriebeckite and richterite were discovered. These data suggest that these elevated numbers of malignant mesothelioma cases are linked to environmental exposure of carcinogenic mineral fibers. (2015-02-10)

EARTH Magazine: Asbestos found in Nevada and Arizona
The discoveries, in Clark County in southern Nevada and across the border in northwestern Arizona, suggest that asbestos may be more widespread than previously thought; they also raise questions about the potential health hazards of naturally occurring asbestos. (2015-01-30)

Targeted next-generation sequencing reveals a high number of genomic mutations in advanced malignant
Next generation sequencing in malignant pleural mesothelioma tumors shows a complex mutational setting with a high number of genetic alterations in genes involved in DNA repair, cell survival and cell proliferation pathways. Increased accumulation of mutations correlates with early progression of the tumor and decreased survival. (2014-12-17)

Cancer from asbestos caused by more than one cell mutation
It has been a long held belief that tumors arising from exposure to asbestos are caused by mutations in one cell, which then produces multiple clones. This hypothesis is challenged by new research published in the open-access Journal of Translational Medicine, which suggests it is caused by mutations in multiple cells. (2014-12-03)

Studies report new findings on treatment options for mesothelioma
Treating patients with high-dose radiotherapy after chemotherapy and surgery for malignant pleural mesothelioma does not achieve improvements in local relapse and overall survival, according to data from a prospective randomized phase II trial presented at ESMO 2014 Congress in Madrid. (2014-09-29)

Modest acute changes in cardiac biomarkers and electrocardiogram findings following thoracic radiation therapy
There were only modest acute changes in cardiac biomarkers and electrocardiograms and there were no clinically significant cardiac events in patients with high-dose radiation exposure to the heart following thoracic radiation therapy and short-term follow-up. (2014-09-24)

Curcumin, special peptides boost cancer-blocking PIAS3 to neutralize STAT3 in mesothelioma
A common Asian spice and cancer-hampering molecules show promise in slowing the progression of mesothelioma, a cancer of the lung's lining often linked to asbestos. Scientists from Case Western Reserve University and the Georg-Speyer-Haus in Frankfurt, Germany, demonstrate that application of curcumin, a derivative of the spice turmeric, and cancer-inhibiting peptides increase levels of a protein inhibitor known to combat the progression of this cancer. Their findings appear in Clinical Cancer Research. (2014-09-18)

Idiopathic pulmonary fibrosis cases linked with asbestos exposure
A proportion of idiopathic pulmonary fibrosis (IPF) cases may be linked with asbestos exposure, according to the results of a new study. If confirmed, the findings would mean that current treatment strategies need to be altered as people with a history of asbestos exposure are not currently able to access new treatments for IPF. (2014-09-09)

Penn mesothelioma program receives $8 million NCI grant
Researchers at the Perelman School of Medicine at the University of Pennsylvania in collaboration with the Roswell Park Cancer Institute have received an $8 million grant from the National Cancer Institute to study the effects of photodynamic light therapy in patients with malignant pleural mesothelioma. (2014-07-09)

Finding the Achilles' Heel of ovarian tumor growth
A team of scientists, led by principal investigator David D. Schlaepfer, PhD, professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine report that small molecule inhibitors to a protein called focal adhesion kinase selectively prevent the growth of ovarian cancer cells as tumor spheroids. (2014-06-19)

Penn receives $10 million award to study asbestos adverse health effects, remediation
Researchers at the Center of Excellence in Environmental Toxicology, Perelman School of Medicine at the University of Pennsylvania, have been awarded a $10 million grant from the National Institute for Environmental Health Sciences over the next four years to study asbestos exposure pathways that lead to mesothelioma, the bioremediation of this hazardous material, and mechanisms that lead to asbestos-related diseases. (2014-06-09)

Biomarkers accurately distinguish mesothelioma from non-cancerous tissue
Scientists have identified four biomarkers that may help resolve the difficult differential diagnosis between malignant pleural mesothelioma (MPM) and non-cancerous pleural tissue with reactive mesothelial proliferations. This is a frequent differential diagnostic problem in pleural biopsy samples taken from patients with clinical suspicion of MPM. The ability to make more accurate diagnoses earlier may facilitate improved patient outcomes. This new study appears in the Journal of Molecular Diagnostics. (2014-06-06)

20 years of data shows treatment technique improvement for advanced abdominal cancer
Wake Forest Baptist has the largest reported, single-center experience with cytoreductive surgery and HIPEC and analysis of 20 years' worth of patient data shows that outcomes have clearly improved for patients undergoing this treatment technique. (2014-04-17)

Media alert: European Lung Cancer Conference abstracts online
Latest results and state-of-the art treatment options will be discussed at the 4th European Lung Cancer Conference, which has become the reference event in Europe for professionals treating lung cancers. (2014-03-17)

Novel cancer vaccine holds promise against ovarian cancer, mesothelioma
A novel approach to cancer immunotherapy may provide a new and cost-effective weapon against some of the most deadly tumors, including ovarian cancer and mesothelioma. Massachusetts General Hospital investigators report that a protein engineered to combine a molecule targeting a tumor-cell-surface antigen with another protein that stimulates several immune functions prolonged survival in animal models of both tumors. (2014-03-05)

Radiation before surgery more than doubles mesothelioma survival: UHN study
Results of clinical research that treated mesothelioma with radiation before surgery show the three-year survival rate more than doubled for study participants afflicted with this deadly disease, compared to treating with surgery first. (2014-01-20)

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