Current Metabolite News and Events

Current Metabolite News and Events, Metabolite News Articles.
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Sewage study shows which countries like to party hard
The Netherlands, United States, Australia and New Zealand are consuming the highest amounts of designer 'party' drugs, according to wastewater samples taken from eight countries over the New Year period. (2021-02-21)

A novel gel electrophoresis technique for rapid biomarker diagnosis via mass spectrometry
Polyacrylamide gel electrophoresis enables high-resolution separation of proteins extracted from biological samples, but it requires more than one day of pretreatment to recover the separated proteins trapped inside the gel for detection by mass spectrometry. BAC-DROP, our novel electrophoresis technology, uses a dissolvable form of polyacrylamide gel, which allows sample pretreatment to be completed in about 5 hours. The developed technology will enable the rapid diagnosis of viruses and disease protein markers. (2021-02-18)

Gut microbiome implicated in healthy aging and longevity
The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. The work is set to be published in the journal Nature Metabolism(2021-02-18)

Metabolic response behind reduced cancer cell growth
Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells' metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment by EZH2 inhibition. The study has been published in the journal Cell Death & Disease. (2021-02-12)

Flowers of St. John's Wort serve as green catalyst
An interdisciplinary team of scientists from the School of Science at TU Dresden has for the first time used dried flowers of St. John's Wort (genus Hypericum) as an active catalyst in various photochemical reactions. This conceptually new and sustainable process was registered as a German patent and presented in the journal 'Green Chemistry'. (2021-02-12)

Harvard researchers use machine learning models to study health impacts of walnuts
Researchers, from the Harvard T.H. Chan School of Public Health in collaboration with investigators from Rovira i Virgili University and the University of Navarra, Spain, used machine learning models, a subset of artificial intelligence, to identify more precisely the components in walnuts that may be responsible for potentially reducing the risk of type 2 diabetes and cardiovascular diseases - two of the leading causes of death in the U.S. (2021-02-02)

Ludwig Cancer Research study reveals how certain gut bacteria compromise radiotherapy
A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients. (2021-01-26)

ACSL1 as a main catalyst of CoA conjugation of propionic acid-class NSAIDs in liver
Researchers from Kanazawa University have found that propionic acid-class nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, form ''conjugates'' with coenzyme A (CoA) by one of the acyl-CoA synthetases, ACSL1, in liver. These conjugates have the covalent binding ability to cellular proteins that may lead to liver injury, a rare severe side effect of NSAID treatment. This knowledge could help pharmaceutical companies to generate pain control options with fewer risks of severe side effects. (2021-01-22)

New antifungal compound from ant farms
Attine ants are farmers, and they grow fungus as food. Pseudonocardia and Streptomyces bacteria are their farmhands, producing metabolites that protect the crop from pathogens. Surprisingly, these metabolites lack common structural features across bacteria from different geographic locations, even though the ants share a common ancestor. Now, researchers report in ACS Central Science they have identified the first shared antifungal compound among many of these bacteria across Brazil. The compound could someday have medical applications. (2021-01-20)

On the trail of active ingredients from marine yeasts
Numerous natural products are awaiting discovery in all kinds of natural habitats. Especially microorganisms such as bacteria or fungi are able to produce diverse natural products with high biomedical application potential in particular as antibiotics and anticancer agents. Researchers from GEOMAR and Kiel University isolated red yeast of the species Rhodotorula mucilaginosa from a deep-sea sediment sample and analyzed for its genome and chemical constituents. The scientists succeeded in demonstrating its anticancer and antibacterial effects. (2021-01-20)

The regulatory network of sugar and organic acid in watermelon fruit is revealed
The innovation project watermelon and melon cultivation and physiology team of Zhengzhou Fruit Research Institute has made new progress in the metabolism regulation of sugar and organic acid in watermelon fruit. (2021-01-14)

Lipid biomarkers in urine can determine the type of asthma
In a new study, researchers at Karolinska Institutet in Sweden have used a urine test to identify and verify a patient's type of asthma. The study, which has been published in the American Journal of Respiratory and Critical Care Medicine, lays the foundation for a more personalized diagnosis and may result in improved treatment of severe asthma in the future. (2021-01-13)

Mothers of children with Autism found to have significantly different metabolite levels
Blood sample analysis showed that, two to five years after they gave birth, mothers of children with autism spectrum disorder (ASD) had several significantly different metabolite levels compared to mothers of typically developing children. That's according to new research recently published in BMC Pediatrics by a multidisciplinary team from Rensselaer Polytechnic Institute, Arizona State University, and the Mayo Clinic. (2021-01-13)

Texas A&M research explores how melanoma grows and spreads
The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact. (2021-01-12)

Pillar-like molecules as biosensors for metabolites
Researchers at Kanazawa University report in Communications Chemistry that a molecule known as pillar[6]arene can form a host-guest compound with a cancer-associated metabolite. The phenomenon can be used to efficiently detect the metabolite in crude biological samples, which is important for preventing and treating metabolic syndrome and associated pathologies. (2021-01-11)

Faulty metabolism of Parkinson's medication in the brain linked to severe side effects
Until now, the reason why the drug levodopa (L-Dopa), which reduces the motor symptoms of Parkinson's disease, declines in efficacy after a few years' use has been unknown. A side effect that then often occur is involuntary movements. A Swedish-French collaboration, led from Uppsala University, has now been able to connect the problems with defective metabolism of L-Dopa in the brain. The study is published in Science Advances. (2021-01-07)

How to identify heat-stressed corals
Researchers have found a novel way to identify heat-stressed corals, which could help scientists pinpoint the coral species that need protection from warming ocean waters linked to climate change, according to a Rutgers-led study. (2021-01-04)

Light flips genetic switch in bacteria inside transparent worms
Researchers from Rice University and Baylor College of Medicine have shown that colored light can both activate and deactivate genes of gut bacteria in the intestines of worms. The research shows how optogenetic technology can be used to investigate the health impacts of gut bacteria. (2020-12-22)

Lipid identified in human breast milk may play important role in early childhood weight
A lipid metabolite called 12,13-diHOME is in human breast milk. The authors of the study propose that 12,13-diHOME, as well as linked pathway metabolites from breast milk, have a protective effect against obesity development in offspring. They also suggest that a single bout of maternal exercise may boost levels of the metabolite in breast milk and that may translate into benefits for offspring in terms of healthy growth and development. (2020-12-16)

Melatonin: finally, a supplement that actually boosts memory
Researchers at Tokyo Medical and Dental University (TMDU) showed that melatonin's metabolite AMK can enhance the formation of long-term memories in mice. Memory of objects were tested after treatment with melatonin or two of its metabolites. Older mice that normally performed poorly on the memory task showed improvements as dosage increased. The metabolite AMK was found to be the most important as melatonin failed to improve memory if it was blocked from metabolizing into AMK. (2020-12-10)

Gut microbes: a key to normal sleep
Researchers at the University of Tsukuba used a cocktail of antibiotics to deplete gut microbes in mice. They found that metabolites in the gut differed in these mice compared with controls. In particular, metabolic pathways involved in making important neurotransmitters like serotonin were affected. Additionally, these mice showed abnormal day-night distribution in sleep/wake patterns, particularly the amount of REM sleep, and frequent transitions between REM and non-REM sleep episodes. (2020-11-30)

Identifying compound classes through machine learning
Bioinformaticians at Friedrich Schiller University Jena, Germany together with colleagues from Finland and the USA, have now developed a unique method with which all metabolites in a sample can be taken into account, thus considerably increasing the knowledge gained from examining such molecules. The team reports on its successful research in the scientific journal Nature Biotechnology. (2020-11-23)

Gut microbiome link to deadly lung disease
Research led by the Centenary Institute, the University of Technology Sydney and the University of Queensland has shown for the first time a link between chronic obstructive pulmonary disease (COPD), an often fatal lung condition, and the gut microbiome. (2020-11-19)

Bursts of exercise can lead to significant improvements in indicators of metabolic health
Short bursts of physical exercise induce changes in the body's levels of metabolites that correlate to, and may help gauge, an individual's cardiometabolic, cardiovascular and long-term health, a study by Massachusetts General Hospital has found. Approximately 12 minutes of acute cardiopulmonary exercise impacted more than 80% of circulating metabolites, including pathways linked to a range of favorable health outcomes, thus identifying potential mechanisms that could contribute to a better understanding of cardiometabolic benefits of exercise. (2020-11-16)

Managing the microbiome raises new hope for autism
Analysis of 619 plasma metabolites in a new study show a distinctive metabolic profile in autistic children prior to microbial transfer therapy The procedure helps modify gut microbiota, improving symptoms gastrointestinal and behavioral symptoms of the disease. Careful investigation of metabolites in blood and feces, as opposed to simply tabulating microbial species in the gut, is crucial when trying to tease out the complex bacterial interactions, which can form both collaborative and competing networks, depending on the particulars of their environment. (2020-11-13)

Biomarkers could be used in a quick, inexpensive COVID-19 blood screening tool
A new study suggests that COVID-19 affects the human body's blood concentration levels of specific metabolites - small molecules broken down in the human body through the process of metabolism. Three specific metabolites identified in this study could act as biomarkers and one day be measured through an inexpensive blood test to quickly screen patients for the disease and predict which patients will become most critically ill. (2020-10-27)

Bacterial metabolism of dietary soy may lower risk factor for dementia
A metabolite produced following consumption of dietary soy may decrease a key risk factor for dementia - with the help of the right bacteria, according to a new discovery led by researchers at the University of Pittsburgh Graduate School of Public Health. (2020-10-22)

Legacy pollutants found in migratory terns in Great Lakes region
Chemicals that haven't been manufactured in the U.S. for years or even decades are still turning up in the bodies of migratory terns in the Great Lakes region, a new study finds. The research focused on three types of compounds: PBDEs, PCBs, and the breakdown products, called metabolites, of DDT. (2020-10-21)

Changes in blood metabolite profile are visible years before diagnosis of alcohol-related disease
A new study from the University of Eastern Finland is the first in the world to show that the serum metabolite profile can be used to identify individuals likely at risk of developing an alcohol-related disease in the future. The finding also opens up new avenues for preventing alcohol-related adverse effects. (2020-10-19)

Gut bacteria could be responsible for side effect of Parkinson's drug
Bacteria in the small intestine can deaminate levodopa, the main drug that is used to treat Parkinson's disease. Bacterial processing of the unabsorbed fractions of the drug results in a metabolite that reduces gut motility. These findings were described in the journal BMC Biology on 20 October by scientists from the University of Groningen. Since the disease is already associated with constipation, processing of the drug by gut bacteria may worsen gastrointestinal complications. (2020-10-19)

High fructose intake may drive aggressive behaviors, ADHD, bipolar
New research suggests that conditions such as attention deficit hyperactivity syndrome (ADHD), bipolar disorder, and even aggressive behaviors may be linked with sugar intake, and that it may have an evolutionary basis. (2020-10-16)

Cortex-wide variation of neuronal cellular energy levels depending on the sleep-wake states
The brain is assumed to exert homeostatic functions to always keep the cellular energy status constant, this has not been proven. Researchers at Tokyo Metropolitan Institute of Medical Science discovered that cortical neuronal intracellular concentrations of ATP, the major cellular energy metabolite, greatly decreased during REM sleep, despite a simultaneous increase in cerebral hemodynamics for energy supply, compared with waking in mice. These indicate that cerebral energy metabolism may not always meet neuronal energy demands. (2020-10-07)

Deep learning gives drug design a boost
A computational tool created at Rice University may help pharmaceutical companies expand their ability to investigate the safety of drugs. (2020-10-05)

Copycat plant booster improves on nature
A molecular mimic designed to promote plant growth and limit witchweed infestation shows promise in initial trials. (2020-09-28)

A better alternative to Phthalates?
In collaboration with the Medical University of South Carolina, researchers at the National Institute of Standards and Technology (NIST) analyzed urine samples from pregnant women to look for the presence of DINCH, which is short for di(isononyl)cyclohexane-1,2-dicarboxylate. They found concentrations of DINCH in most of the urine samples but no evidence of effects in lab assays on two hormones, progesterone and estrogen. (2020-09-25)

Time-restricted feeding improves health without altering the body's core clock
For the first time, scientists have studied the early effects of time-restricted feeding on the daily periodic oscillations of metabolites and genes in muscle, and metabolites in blood. The findings by scientists at the University of Copenhagen, the Australian Catholic University and Karolinska Institutet find that time-restricted feeding does not influence the muscle's core clock, and opens the door to more research on how these observed changes improve health. (2020-09-17)

Metabolite signature of COVID-19 reveals multi-organ effects
SARS-CoV-2, the virus responsible for COVID-19, can cause a wide range of symptoms, from none at all to severe respiratory stress, multi-organ failure and death. The virus notably targets the lungs, but many patients also experience non-respiratory symptoms. Now, researchers reporting in ACS' Journal of Proteome Research compared lipoproteins and metabolites in the blood of COVID-19 patients and healthy subjects, revealing signs of multi-organ damage in patients that could someday help diagnose and treat COVID-19. (2020-09-09)

New role of arginine metabolism in plant morphogenesis identified
A research team led by ExCELLS/NIBB found that arginine metabolism has a vital role in regulating gametophore shoot formation in the moss Physcomitrium patens. (2020-09-08)

A naturally-occurring metabolite ups lifespan and compresses late-life morbidity in mice
Middle-aged mice that had the naturally-occurring metabolite alpha-ketaglutarate (AKG) added to their chow had a better 'old age.' They were healthier as they aged and experienced a dramatically shorter time of disease and disability before they died, a first for research involving mammals. Results from the double-blinded study, done at the Buck Institute and published in Cell Metabolism, were based on clinically-relevant markers of healthspan. (2020-09-01)

Sweat science: Engineers detect health markers in thread-based, wearable sweat sensors
Engineers at Tufts University have created a first-of-its-kind, flexible electronic sensing patch that can be sewn into clothing to analyze sweat for multiple markers. The patch could be used to to diagnose and monitor acute and chronic health conditions or to monitor athletic performance. (2020-07-28)

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