Current Metformin News and Events

Current Metformin News and Events, Metformin News Articles.
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New data on COVID-19 patients with diabetes show that one in five die within
Updated results from the CORONADO study, analysing the outcomes of patients with diabetes admitted to hospital with COVID-19, shows that one in five patients die within 28 days while around half are discharged. The study is published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]). (2021-02-17)

The body produces new satiety factor during prolonged exercise
Researchers at the University of Copenhagen confirm that the hormone GDF15 is released in response to vigorous exercise, but likely not in sufficient quantity to affect behavior or appetite. These findings add nuance to a hormone that is currently under scrutiny for its potential as an anti-obesity medication. (2021-02-16)

Use of goldenseal may compromise glucose control in diabetics on metformin
Diabetic patients taking the natural product goldenseal while taking the prescription drug metformin may be unwittingly sabotaging their efforts to maintain healthy blood glucose levels. Metformin--the world's most-prescribed oral glucose-lowering medication--was included in a cocktail of selected drugs given to participants in a clinical study led by scientists at Washington State University. The study found that after six days of taking goldenseal, participants had about 25 percent less metformin in their bodies. (2021-02-08)

Oncotarget: The goal of geroscience is life extension
Dr. Mikhail V. Blagosklonny from The Roswell Park Cancer Institute said, ''Although we do not know everything about aging, we now know enough to start its pharmacologic suppression using clinically approved drugs.'' (2021-02-02)

Healthy lifespan analysis using nematodes
Researchers have developed an automated measurement system to assess healthy lifespan using nematodes. This system performs a mini-population analysis to classify specific populations of nematodes based on qualitative differences in lifespan. Since there are many similarities between the mechanisms that determine the lifespan of nematodes and humans, this system could make it easier to develop drugs and find foods that extend the healthy lifespan of humans. (2021-01-27)

Mouse study identifies novel compound that may help develop diabetes drugs
Research led by The Ohio State University Wexner Medical Center and College of Medicine identified a new compound that might serve as a basis for developing a new class of drugs for diabetes. Study findings are published online in the journal Nature Chemical Biology. (2021-01-26)

Fine tuning first-responder immune cells may reduce TBI damage
Immediately after a traumatic brain injury and as long as one year later, there are increased levels of immune cells called ILCs in the brain promoting inflammation, which can worsen brain damage, scientists report. They also report for the first time that the cell energy sensor AMPK is a brake that can stop what becomes a chronic state of destructive inflammation driven by these ILCs, or innate lymphoid cells. (2021-01-25)

Metformin use reduces risk of death for patients with COVID-19 and diabetes
Use of the diabetes drug metformin -- before a diagnosis of COVID-19 -- is associated with a threefold decrease in mortality in COVID-19 patients with Type 2 diabetes, according to a racially diverse study at the University of Alabama at Birmingham. Diabetes is a significant comorbidity for COVID-19. This beneficial effect remained, even after correcting for age, sex, race, obesity, and hypertension or chronic kidney disease and heart failure. (2021-01-14)

Potential preventative treatment demonstrated for Crohn's disease
A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease. (2020-12-21)

Study finds metformin reduced COVID-19 death risks in women
University of Minnesota Medical School and UnitedHealth Group researchers found that metformin was associated with significantly reduced COVID-19 death risks in women in one of the world's largest observational studies of COVID-19 patients. (2020-12-03)

A molecule from gut bacteria reduces effect of diabetes medication
The action of metformin, the classic drug used to treat diabetes by stabilizing blood sugar, can be blocked by a molecule from the bacteria in our intestines, a University of Gothenburg study shows. (2020-11-11)

Cell ageing can be slowed by oxidants
At high concentrations, reactive oxygen species - known as oxidants - are harmful to cells in all organisms and have been linked to ageing. But a study from Chalmers University of Technology, Sweden, has now shown that low levels of the oxidant hydrogen peroxide can stimulate an enzyme that helps slow down the ageing of yeast cells. (2020-11-09)

Combo-drug treatment for Type 2 diabetes remains effective after two years
Patients whose Type 2 diabetes is not controlled with metformin can benefit long-term from a two-drug combination treatment that also reduces weight. (2020-11-02)

Study provides new hope for children suffering from rare muscle diseases
Stephen Greenspan and Laura Zah were devastated when they learned their son Alexander had a rare genetic mutation, which causes a deadly neuromuscular disease with no known treatment or cure. But the results of an international study, led by researchers from Monash University in Australia, provides renewed hope for children suffering from the progressive and devastating muscle disease. (2020-10-13)

New research provides fresh hope for children suffering from rare muscle diseases
Results of an international study published today in Autophagy and led by researchers from Monash University, School of Biological Sciences, provides renewed hope for children suffering from a progressive and devastating muscle disease. (2020-10-09)

Metformin treatment linked to slowed cognitive decline
A six-year study of older Australians with type 2 diabetes has uncovered a link between metformin use, slower cognitive decline and lower dementia rates. (2020-09-23)

Three common medications lower risk and mortality for lung cancer
Combined use of aspirin, statins, and metformin is associated with decreased lung cancer incidence and mortality, according to a study published in the Journal of Thoracic Oncology (JTO). The JTO is the official journal of the International Association for the Study of Lung Cancer. (2020-09-17)

Metformin for type 2 diabetes patients or not? Researchers now have the answer
Metformin is the first-line drug that can lower blood sugar levels in type 2 diabetes patients. One third of patients do not respond to metformin treatment and 5 per cent experience serious side effects, which is the reason many choose to stop medicating. Researchers at Lund University in Sweden have now identified biomarkers that can show in advance how the patient will respond to metformin treatment via a simple blood test. (2020-09-17)

Common diabetes drug reverses inflammation in the liver
The diabetes drug metformin has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 diabetes. Now, researchers at the Salk Institute have shown the importance of specific enzymes in the body for metformin's function. In addition, the new work showed that the same proteins, regulated by metformin, controlled aspects of inflammation in mice, something the drug has not typically been prescribed for. (2020-09-09)

Scientists discover key regulator of neuron function and survival
Scientists studying neuronal energy metabolism found evidence the loss of an important energy regulator called AMPK in neural stem cells or glial cells called astrocytes causes neuronal death in laboratory rodents. Publishing their findings in Cell Reports, researchers also discovered AMPK loss in neural stem cells or neurons causes spontaneous brain seizures in the animals. The study provides evidence that a medication used to treat diabetes may help control epileptic seizures. (2020-09-01)

Immunotherapy safe for patients with COVID-19, cancer
Preliminary data from researchers at the University of Cincinnati Cancer Center show that immunotherapy doesn't necessarily worsen complications for patients with both COVID-19 and cancer. (2020-07-20)

'Excretion of sugar into stool'? New action of anti-diabetic drug discovered
A research team led by Kobe University Graduate School of Medicine's Professor OGAWA Wataru and Project Associate Professor NOGAMI Munenobu has discovered that metformin, the most widely prescribed anti-diabetic drug, causes sugar to be excreted in the stool. Taking advantage of the new bio-imaging apparatus PET-MRI, they revealed that metformin promotes the excretion of blood sugar from the large intestine into the stool. This is a completely new discovery that was not previously anticipated. (2020-06-03)

Adherence to oral diabetes drugs may improve survival in diabetics with colorectal cancer
Among patients with both colorectal cancer and diabetes in Korea, those who had a high adherence to their oral diabetes medication had a significantly reduced risk of overall mortality compared with those with lower adherence. (2020-06-01)

An exploratory study of metformin and rapamycin as maintenance therapy
Volume 11, Number 21 of @Oncotarget reported that eligible patients with stable or responding mPDA after 6 months on chemotherapy were randomized 1:1 to metformin alone or with rapamycin, stratified by prior treatment with FOLFIRINOX. Metformin +/ rapamycin maintenance for mPDA was well-tolerated and several patients achieved stable disease associated with exceptionally long survival. (2020-05-27)

Researchers discover a key to the survival of dormant breast cancer cells
Trying to understand why dormant breast cancer cells survive despite being starved of estrogen to prevent growth, researchers from Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center found that breakdown of fat to produce energy supports cancer cell survival. This type of fat metabolism is activated by metformin, an anti-diabetes drug being tested in clinical trials as an anti-cancer agent. Their findings suggest that metformin actually has context-dependent effects on cancer cells. (2020-04-22)

People with type 2 diabetes and heart disease may benefit from newer therapies
Coronary artery disease among people with type 2 diabetes may need to be treated more aggressively than in people with coronary artery disease who do not have diabetes. A new American Heart Association scientific statement summarizes the simultaneous management of both diabetes and coronary artery disease and details medications, procedures and lifestyle modifications that may reduce the risk of heart attack and complications among people with both conditions. (2020-04-13)

Examining association of preoperative metformin, surgical outcomes in patients with diabetes
Metformin is the most commonly prescribed noninsulin medication for type 2 diabetes and this observational study examined postoperative death and hospital readmission among adults with type 2 diabetes who had a prescription for metformin before major surgery with those who didn't. (2020-04-08)

Diabetes drug reduces complications of long-term steroid therapy
A drug used to treat type 2 diabetes could offer a simple and cheap solution to reduce dangerous side effects of steroid treatment, new research from Queen Mary University of London suggests. (2020-02-25)

Can metformin reduce obesity in children and adolescents?
A new study has shown metformin -- a glucose-lowering drug commonly used to treat diabetes -- to be effective at lowering some measures of obesity in children and adolescents. (2020-02-18)

Human gut-in-a-dish model helps define 'leaky gut,' and outline a pathway to treatment
UC San Diego researchers use 3D human gut organoids to reveal the molecular system that keeps intestinal linings sealed, demonstrate how the system breaks down and how it can be strengthened with the diabetes drug metformin. (2020-02-10)

Statins may lower mortality in high-risk prostate cancer patients
Statin use alone or with metformin is associated with lower prostate cancer mortality from all causes, among high-risk patients. (2020-02-10)

Yale studies suggest new path for reversing type-2 diabetes and liver fibrosis
In a pair of related studies, a team of Yale researchers has found a way to reverse type-2 diabetes and liver fibrosis in mice, and has shown that the underlying processes are conserved in humans. (2020-02-04)

Elevated fasting blood sugar in pregnancy linked to harmful outcomes for mothers, babies
Women with gestational diabetes who have elevated blood sugar levels before eating are at higher risk for complications than those whose blood sugar is only elevated after meals -- even when their diabetes is treated, according to a new study from the University of Alberta. (2020-02-03)

Emerging organic contaminant levels greatly influenced by stream flows, seasons
Flow rates and time of year must be taken into account to better understand the potential risks posed by emerging organic contaminants in rivers and streams, according to Penn State researchers who studied contaminant concentrations and flow characteristics at six locations near drinking water intakes in the Susquehanna River basin. (2020-01-29)

Combination of chemo and diabetes drugs shows potential for treating Ewing sarcoma
Houston Methodist researchers propose a combination of two well-known drugs as a new treatment option for Ewing sarcoma -- one of them typically used to treat diabetes. (2019-12-16)

Secret behind diabetes drug's benefits revealed
Researchers went into this study with the idea that metformin might communicate with other tissues in the body by causing the secretion of a protein from the liver. They were totally surprised they we found out that metformin caused the secretion of GDF15, a protein which is known to suppress appetite. (2019-12-09)

Diabetes drug has unexpected, broad implications for healthy aging
Metformin is the most commonly prescribed type 2 diabetes drug, yet scientists still do not fully know how it works to control blood sugar levels. In a collaborative effort, researchers from the Salk Institute, The Scripps Research Institute and Weill Cornell Medical College have used a novel technology to investigate why it functions so well. The findings could also explain why metformin has been shown to extend health span and life span in recent studies. (2019-12-03)

Study shows metformin offers no strength training benefits for seniors
A clinical trial initiated by University of Kentucky researchers argues against the hypothesis that the diabetes drug metformin could help exercising seniors gain more muscle mass. The double-blind trial, conducted at the University of Kentucky and University of Alabama at Birmingham, found that older adults who took metformin while performing rigorous resistance exercise training had smaller gains in muscle mass than the placebo group. (2019-10-22)

Treatment of metabolic dysfunction could be a potential therapy for Alzheimer's disease
A team of researchers led by Yale-NUS College has found evidence that metabolic dysfunction is a primary cause of Alzheimer's disease. (2019-10-17)

Rapamycin for longevity -- Opinion article
The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today. (2019-10-16)

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