Current Mice News and Events

Current Mice News and Events, Mice News Articles.
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Mouse study shows bacteriophage therapy could fight drug-resistant Klebsiella pneumoniae
Using viruses instead of antibiotics to tame troublesome drug-resistant bacteria is a promising strategy, known as bacteriophage or ''phage therapy.'' Scientists at the National Institutes of Health have used two different bacteriophage viruses individually and then together to successfully treat research mice infected with multidrug-resistant Klebsiella pneumoniae sequence type 258 (ST258). (2021-02-23)

Fat cells may influence how the body reacts to heart failure, study shows
University of Alberta researchers have found that limiting the amount of fat the body releases into the bloodstream from fat cells when in heart failure could help improve outcomes for patients. (2021-02-23)

Oil spill has long-term immunological effects in dolphins
A study published in Environmental Toxicology and Chemistry has found long-term impacts of the 2010 Deepwater Horizon oil spill in the northern Gulf of Mexico on bottlenose dolphins' immune function. (2021-02-18)

Store fat or burn it? Targeting a single protein flips the switch
As obesity becomes a growing issue worldwide - nearly tripling over the last-half century - scientists are trying to gain a better understanding of the condition at the molecular level. Now, new research led by UC San Francisco scientists suggests that a single protein could play an outsize role in weight gain. (2021-02-18)

Mimicking a chronic immune response changes the brain
Abnormal production of Inflammatory cytokines by the immune system is responsible for a host of autoimmune disorders. One important cytokine is IL-17A, which is also involved in neurological diseases. Researchers at Tsukuba University in Japan made a mouse model of chronically high IL-17A and to study its effect on the brain. They show that it leads to reduced activity and density of microglia in the brain's hippocampus, but no obvious memory deficits. (2021-02-17)

Columbia researchers uncover altered brain connectivity after prolonged anesthesia
A body of evidence supports the association between prolonged anesthesia and cognitive impairment, but the Columbia study is first to address the effect of the procedure on neural connections. (2021-02-17)

Protein linked to Alzheimer's, strokes cleared from brain blood vessels
Amyloid deposits in the brain increase the risk of dementia and strokes. Researchers at Washington University School of Medicine in St. Louis have identified an antibody that clears amyloid deposits from the brain without raising the risk of brain bleeds. (2021-02-17)

Understanding cellular clock synchronization
In humans, the disruption of circadian clocks is the cause of many metabolic diseases. Thanks to an observation tool based on bioluminescence, a research (UNIGE) were able to demonstrate that cells that compose a particular organ can be in-phase, even in the absence of the central brain clock. Indeed, the scientists managed to restore circadian function in the liver in completely arrhythmic mice, demonstrating that neurons are not unique in their ability to coordinate. (2021-02-17)

The body produces new satiety factor during prolonged exercise
Researchers at the University of Copenhagen confirm that the hormone GDF15 is released in response to vigorous exercise, but likely not in sufficient quantity to affect behavior or appetite. These findings add nuance to a hormone that is currently under scrutiny for its potential as an anti-obesity medication. (2021-02-16)

Metabolic response behind reduced cancer cell growth
Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells' metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment by EZH2 inhibition. The study has been published in the journal Cell Death & Disease. (2021-02-12)

Study suggests sounds influence the developing brain earlier than previously thought
In experiments in newborn mice, scientists at Johns Hopkins report that sounds appear to change ''wiring'' patterns in areas of the brain that process sound earlier than scientists assumed and even before the ear canal opens. (2021-02-12)

Compounds from apples may boost brain function
Natural compounds found in apples and other fruits may help stimulate the production of new brain cells, which may have implications for learning and memory, according to a new study in mice published in Stem Cell Reports. (2021-02-11)

Meet the Smurfs: A bone metabolism family
Researchers from Osaka University and Ehime University have found that protein Smurf2 can regulate a cellular pathway that affects bone metabolism. Smurf2 can mark certain messenger proteins--specifically those that are part of the bone morphogenetic protein signaling pathway--for destruction to prevent the signals from going out of control. The BMP-induced bone in mice without Smurf2 had higher mass and formation rates. These findings improve our understanding of various bone defects. (2021-02-08)

Auditory brainstem pathways do not develop properly without microglia
Auditory pathways in the brainstem do not fully mature without microglia clearing away extra cell connections. This crucial function occurs even when pruning by microglia is delayed, according to new research published in eNeuro. (2021-02-08)

Study finds childhood diet has lifelong impact
Eating too much fat and sugar as a child can alter your microbiome for life, even if you later learn to eat healthier, a new UC Riverside study in mice suggests. (2021-02-03)

Iron release may contribute to cell death in heart failure
A process that releases iron in response to stress may contribute to heart failure, and blocking this process could be a way of protecting the heart, suggests a study in mice published today in eLife. (2021-02-02)

Childhood trauma could affect development, treatment of multiple sclerosis
Childhood trauma could affect the trajectory of multiple sclerosis development and response to treatment in adulthood, a new study in mice found. Mice that had experienced stress when young were more likely to develop the autoimmune disorder and less likely to respond to a common treatment, researchers at the University of Illinois Urbana-Champaign found. However, treatment that activated an immune-cell receptor mitigated the effects of childhood stress in the mice. (2021-01-29)

Immune cells found in the brain are behind the depression experienced in inflammation
Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. This is the conclusion of a study using mice carried out by researchers at Linköping University, Sweden. The results have been published in the scientific journal Immunity, and suggest that microglial cells contribute to the negative mood experienced during several neurological diseases, and maybe also depression. (2021-01-25)

In preclinical models, antiviral better inhibits COVID-19 than Remdesivir; further studies warranted
Working in preclinical models, researchers report that plitidepsin, a drug with limited clinical approval for the treatment of multiple myeloma, is more potent against SARS-CoV-2 than remdesivir, an antiviral that received FDA emergency use authorization for the treatment of COVID-19 in 2020. (2021-01-25)

Researchers engineer antibody that acts against multiple SARS-like viruses
Researchers have engineered an antibody that neutralizes SARS-CoV-2 with a potency that 'rivals' current lead SARS-CoV-2 clinical neutralizing antibodies, and that also broadly neutralizes a range of clade 1 sarbecoviruses. (2021-01-25)

Immunology - Functionality of immune cells in early life
A study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers shows that putatively immature dendritic cells found in young children are able to induce robust immune responses. The results could lead to improved vaccination protocols. (2021-01-21)

Study finds COVID-19 attack on brain, not lungs, triggers severe disease in mice
Georgia State University biology researchers have found that infecting the nasal passages of mice with the virus that causes COVID-19 led to a rapid, escalating attack on the brain that triggered severe illness, even after the lungs were successfully clearing themselves of the virus. (2021-01-19)

Increased blood flow during sleep tied to critical brain function
Our brains experience significant changes in blood flow and neural activity during sleep, according to Penn State researchers. Such changes may help to clean out metabolic brain waste that builds up during the day. (2021-01-18)

Target discovered that halts osteoarthritis-type knee cartilage degeneration
In a mouse study, researchers used nanotechnology and previous knowledge of a protein pathway to significantly reduce knee cartilage degeneration and pain (2021-01-15)

Sperm-specific gene expression in organisms including mice, macaques and men
A large class of mammalian genes is not completely shared throughout sperm development and differentiation, according to a new study of sperm in organisms including mice, macaques and men. (2021-01-14)

The role of T cells in fighting cancer
Why do some hosts' immune systems reject tumors easily, while others have a harder time doing so? It depends on the types of the immune cells known as CD8 T cells and how a host's specific T cells match up with the neoantigens present in the tumor. (2021-01-14)

NYUAD study finds fragmented sleep patterns can predict vulnerability to chronic stress
New research from NYU Abu Dhabi's Laboratory of Neural Systems and Behavior for the first time used an animal model to demonstrate how abnormal sleep architecture can be a predictor of stress vulnerability. These important findings have the potential to inform the development of sleep tests that can help identify who may be susceptible -- or resilient -- to future stress. (2021-01-12)

Gut microbes may antagonize or assist in anorexia
Anorexia is a debilitating eating disorder, and was long thought to be purely psychological. New research is challenging this by revealing that gut microbes may have a significant role in anorexia. A recent review examines the evidence that gut microbes can contribute to anorexia and may provide a new method to treat it. (2021-01-12)

Strategy tested in mice protects against SARS-CoV-2 & coronaviruses that represent human threats
An immunization strategy tested in mice protects against infection from SARS-CoV-2, as well as from potentially emerging animal coronaviruses, researchers say. (2021-01-12)

Scientists reveal how gut microbes can influence bone strength in mice
Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass, says a new study published today in eLife. (2021-01-12)

Neuroscientists identify brain circuit that encodes timing of events
MIT neuroscientists shed new light on how the timing of a memory is encoded in the hippocampus, and suggest that time and space are encoded separately. (2021-01-11)

Treating an autoimmune disease in mice with an mRNA vaccine
Christina Krienke and colleagues have designed an mRNA vaccine that delayed the onset of and reduced the severity of multiple sclerosis-like disease in mice. (2021-01-07)

Social transmission of pain, fear has different targets in mouse brain
Social contact can transfer the feeling of pain or fear in several animal species, including humans, but the exact neural mechanisms for this transmission are still being studied. (2021-01-07)

Toxin chimeras slip therapeutics into neurons to treat botulism in animals
Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments. (2021-01-06)

Mouse study finds link between gut disease and brain injury in premature infants
Working with mice, researchers at Johns Hopkins Medicine and the University of Lausanne in Switzerland have identified an immune system cell that they say travels from the gut to the brain and attacks cells rather than protect them as it normally does. (2021-01-06)

Why do males have to wait for 'round 2'? The reason may be different from what we think
New study refutes dominant theory claiming the hormone prolactin induces the male post-ejaculatory refractory period. (2021-01-04)

Large transporter protein linked to schizophrenia
Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens. Now, Kazumitsu Ueda of Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and colleagues in Japan have provided evidence that mice with disrupted ABCA13 protein demonstrate a hallmark behaviour of schizophrenia. The team investigated ABCA13's functions and published their findings in the Journal of Biological Chemistry. (2020-12-29)

Discovery of aging mechanism for hematopoietic stem cells
By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. (2020-12-24)

Maternal Immune Activation Induces Sustained Changes in Fetal Microglia Motility
Researchers at the Kobe University Graduate School of Medicine have revealed that alterations in fetal microglia resulting from maternal inflammation could contribute towards the onset of developmental and psychiatric disorders. These results can help clarify how changes in microglial process motility affect the development of the neural network, thus contributing towards the treatment of these disorders. (2020-12-22)

The Achilles' heel of cancer stem cells
Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body. (2020-12-21)

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