Current Microbiota News and Events

Current Microbiota News and Events, Microbiota News Articles.
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Melanoma patients respond to immunotherapy after changes to gut microbiome
Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients' gut microbiome led them to respond to a type of treatment capable of providing long-term benefit. (2021-02-14)

Smectite promotes probiotic biofilm formation in gut for cancer immunotherapy
Orally administrating probiotics is ineffective due to the poor inhabitation of exogenous bacteria in host intestines. Chinese scientists report that smectite, a type of mineral clay and classical anti-diarrhoea drug, can promote the expansion of probiotics in the murine gut that subsequently elicits anti-tumor immune responses. Their findings suggest a novel approach to specifically enrich probiotics in the body, with high translational potential for cancer immunotherapy. (2021-02-10)

Pooping out miracles: scientists reveal mechanism behind fecal microbiota transplantation
In a study published in Gastroenterology - Researchers at Osaka City University and The Institute for Medical Science, The University of Tokyo, in collaboration with Brigham and Women's Hospital in Boston, report the intestinal bacterial and viral metagenome information from the fecal samples of patients with recurrent Clostridioides difficile infection (rCDI). This comprehensive analysis reveals the bacteria and phages involved in pathogenesis in rCDI, and their remarkable pathways important for the recovery of intestinal flora function. (2021-02-10)

Researchers explore how to protect gut integrity to improve outcomes in blood cancers
MUSC Hollings Cancer Center researchers found that a single strain of bacteria may be able to reduce the severity of graft-versus-host disease. (2021-02-10)

Microbiota transfer therapy for autism: Multi-omic approaches and lessons learned
Recent studies in mice and humans have revealed intriguing links between the composition of gut microbiota and Autism Spectrum Disorder (ASD), a disease believed to affect one in 54 children, according to the Centers for Disease Control. Dr. Krajmalnik-Brown's lecture will propose linkages between gut bacteria and ASD, highlighting encouraging results of a microbiome-targeted, ASD open-label clinical trial. (2021-02-08)

Nehandertals' gut microbiota and the bacteria helping our health
Through the study of ancient DNA from 50,000-year-old Neanderthal faecal sediments, an international research group isolated a group of micro-organisms whose characteristics are similar to those of modern Sapiens: such findings can be instrumental to the protection of our gut microbiota (2021-02-05)

Probiotics or prebiotics? Exploring the complex world of 'gut' health
Elena Goun at the University of Missouri and an international team of scientists have developed a noninvasive diagnostic imaging tool to measure the levels of a naturally occurring enzyme -- bile salt hydrolase -- inside the body's entire gastrointestinal tract. This research could lead to better precision medicine treatments by providing a way for scientists to better understand how a person's individual gut health is connected to various human pathologies, or the origin and nature of human diseases. (2021-02-04)

Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy
For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines--known as the gut microbiome--through the use of stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests. Researchers at the NCI, part of the National Institutes of Health, conducted the study in collaboration with investigators from UPMC Hillman Cancer Center at the University of Pittsburgh. (2021-02-04)

Lactobacillus manipulates bile acids to create favorable gut environment
Probiotic Lactobacillus bacteria use enzymes situationally to manipulate bile acids and promote their own survival in the gut. (2021-02-01)

Specific bacteria in the gut prompt mother mice to neglect their pups
As scientists learn more about the microorganisms that colonize the body--collectively called the microbiota--one area of intense interest is the effect that these microbes can have on the brain. A new study led by Salk Institute scientists has identified a strain of E. coli bacteria that, when living in the guts of female mice, causes them to neglect their offspring. The findings were published January 29, 2021, in the journal Science Advances. (2021-01-29)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

Inflamed environment is C. diff paradise
A new study shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive. (2021-01-19)

Study in twins identifies fecal microbiome differences in food allergies
A new study out of the University of Chicago and Stanford University on pairs of twins with and without food allergies has identified potential microbial players in this condition. (2021-01-19)

NIH scientists identify nutrient that helps prevent bacterial infection
Scientists studying the body's natural defenses against bacterial infection have identified a nutrient--taurine--that helps the gut recall prior infections and kill invading bacteria, such as Klebsiella pneumoniae (Kpn). The finding, published in the journal Cell by scientists from five institutes of the National Institutes of Health, could aid efforts seeking alternatives to antibiotics. (2021-01-15)

The cancer microbiome reveals which bacteria live in tumors
Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA). With a clearer picture of the microbiota living in various organs in both healthy and cancerous states, researchers will now be able to find new biomarkers of disease and better understand how numerous cancers affect the human body. (2021-01-13)

Poor gut health connected to severe COVID-19, new review shows
In a review published this week in mBio, researchers examined emerging evidence suggesting that poor gut health adversely affects COVID-19 prognosis. (2021-01-12)

Response to infection therapy better understood thanks to a new technique
A sequencing-based solution can be utilised to determine infection clearance and microbiota recovery. Next, the researchers will apply the technique to investigate the coronavirus disease. (2021-01-07)

Link between dietary fiber and depression partially explained by gut-brain interactions
Fiber is a commonly recommended part of a healthy diet. That's because it's good for your health in so many ways--from weight management to reducing the risk of diabetes, heart disease, and some types of cancer. A new study also finds that it might be linked with a reduced risk of depression, especially in premenopausal women. Study results are published online in Menopause, the journal of The North American Menopause Society (NAMS). (2021-01-06)

Research shows a few beneficial organisms could play key role in treating type 2 diabetes
Researchers have found that a few organisms in the gut microbiome play a key role in type 2 diabetes, opening the door to possible probiotic treatments for a serious metabolic disease affecting roughly one in 10 Americans. (2021-01-04)

Potential preventative treatment demonstrated for Crohn's disease
A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease. (2020-12-21)

Living environment affects the microbiota and health of both dogs and their owners
In urban environments, allergic diseases are more common among dogs and their owners compared to those living in rural areas. Simultaneous allergic traits appear to be associated with the microbes found in the environment, but microbes relevant to health differ between dogs and humans. (2020-12-18)

An avocado a day keeps your gut microbes happy
Eating avocado as part of your daily diet can help improve gut health, a new study from University of Illinois shows. Avocados are a healthy food that is high in dietary fiber and monounsaturated fat. However, it was not clear how avocados impact the microbes in the gastrointestinal system or 'gut.' (2020-12-15)

Gut microbiota plays a role in brain function and mood regulation
Depression is a mental disorder that affects more than 264 million people of all ages worldwide. Understanding its mechanisms is vital for the development of effective therapeutic strategies. Scientists from the Institut Pasteur, Inserm and the CNRS recently conducted a study showing that an imbalance in the gut bacterial community can cause a reduction in some metabolites, resulting in depressive-like behaviors. These findings, which show that a healthy gut microbiota contributes to normal brain function, were published in Nature Communications on December 11, 2020. (2020-12-11)

Phase 1 trial assesses whether fecal microbiota transplant impacts cancer patients resistant to immu
In one of the first in-human studies to investigate whether modifying the gut microbiome by a fecal microbiota transplant could make cancer immunotherapy more effective, researchers analyzing this in ten cancer patients with refractory melanoma suggest the treatment can improve patient outcomes. (2020-12-10)

Alterations to oral microbiota reduce the cardiovascular benefits of sport
The researchers note that sports drinks containing sugar, anti-bacterial mouthwashes and the excessive consumption of carbohydrates have a negative effect on oral microbiota and, consequently, on the cardiovascular benefits of sport. (2020-12-09)

UBCO researchers suggest stool transplants can battle serious infections
Could number two be number one when it comes to combating recurrent Clostridium difficile (CDI) infections? Using genetic material analysis and machine learning, UBC researchers have pinpointed several key factors to ensure successful fecal microbiota transplants (FMT), which have proven successful in treating bacterial infections in the gut including illnesses like C. difficile, Crohn's Disease, Colitis and even obesity, explains lead author Negin Kazemian. (2020-12-09)

Science paper links root endodermis and microbiota in mineral balance
Valéria Custódio, ITQB NOVA PhD Student and GREEN-IT member, is a co-author of the paper, which offers new insight on the importance of the relationship between microbiota and root endodermis. (2020-12-09)

Hydrogen peroxide keeps gut bacteria away from the colon lining
An enzyme in the colon lining releases hydrogen peroxide - a known disinfecting compound- to protect the body from gut microbial communities. Findings from the UC Davis Health study points to the importance of considering a different approach to treating gut inflammation and bacterial imbalance in the colon. (2020-12-09)

Scientists shed new light on how lung bacteria defend against pneumonia
New insight on how bacteria in the lungs protect against invading pathogens has been published today in the open-access eLife journal. (2020-12-08)

Differences in immunity and blood vessels likely protect children from severe COVID-19
Differences in the immune systems and better blood vessel health were among the factors protecting children from severe COVID-19, according to a new review. (2020-12-02)

Gut microbes: a key to normal sleep
Researchers at the University of Tsukuba used a cocktail of antibiotics to deplete gut microbes in mice. They found that metabolites in the gut differed in these mice compared with controls. In particular, metabolic pathways involved in making important neurotransmitters like serotonin were affected. Additionally, these mice showed abnormal day-night distribution in sleep/wake patterns, particularly the amount of REM sleep, and frequent transitions between REM and non-REM sleep episodes. (2020-11-30)

MSK study is the first to link microbiota to dynamics of the human immune system
MSK researchers have uncovered an important finding about the relationship between the microbiota and the immune system, showing for the first time that the concentration of different types of immune cells in the blood changes in relation to the presence of different bacterial strains in the gut. (2020-11-30)

Glyphosate may affect human gut microbiota
More than half of bacterial species in the core of the human gut microbiome are potentially sensitive to glyphosate, shows new research. Researchers from the University of Turku Finland, introduced the first bioinformatics resource to determine and test the potential sensitivity of organisms to glyphosate. (2020-11-20)

The gut microbiota forms a molecule that can contribute to diabetes progression
It is the bacterial changes in the gut that increase the levels of imidazole propionate, the molecule that makes the body's cells resistant to insulin in type 2 diabetes. This result emerges from a European study, MetaCardis. (2020-11-18)

Antiviral defense from the gut
The study demonstrates how a subset of common gut bacteria renders mice resistant to viral infections. Experiments identify a specific bacterial population sharing a common molecule on their surface that is responsible for triggering natural antiviral immunity The work sets stage for development of preventive treatments that boost resistance to viruses in humans (2020-11-18)

Link between Alzheimer's disease and gut microbiota is confirmed
In recent years, the scientific community has suspected that the gut microbiota plays a role in the development of the disease. A team from the University and the Hospital of Geneva the National Research and, University and IRCCS SDN Research Center of Naples, confirm the correlation, in humans, between an imbalance in the gut microbiota and the development of amyloid plaques in the brain, which are at the origin of Alzheimer's disease. (2020-11-13)

Risk of childhood asthma by caesarean section is mediated through the early gut microbiome
New study highlights long-term perturbations of the early gut microbiome as a possible mechanism for the observed association between caesarean section and increased risk of developing asthma. (2020-11-12)

A molecule from gut bacteria reduces effect of diabetes medication
The action of metformin, the classic drug used to treat diabetes by stabilizing blood sugar, can be blocked by a molecule from the bacteria in our intestines, a University of Gothenburg study shows. (2020-11-11)

Dietary supplement may help in the treatment of fatty liver
A recent study by researchers at the University of Jyväskylä was successful in partially preventing fatty liver disease in rats. Rats with fatty liver disease were fed with a dietary supplement that is known to increase the growth of good bacteria in the gut. Simultaneous with the increased abundance of the bacteria, the liver fat content decreased significantly. In addition, preliminary results from a human study seem promising. (2020-11-04)

Study provides first evidence of a relationship between a bird's gut and its brain
A study of the relationships between cognition and the gut microbiome of captive zebra finches showed that their gut microbiome characteristics were related to performance on a cognitive assay where they learned a novel foraging technique. Researchers also identified potentially critical bacteria that were relatively more abundant in birds that performed better on this assay. This correlation provides some of the first evidence of a relationship between a bird's gut microbiome and its brain. (2020-11-03)

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