Current Microrna News and Events

Current Microrna News and Events, Microrna News Articles.
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A new study identifies possible biomarkers of severe malaria in African children
The analysis identified a series of small molecules called microRNAs that are released as a result of organ damage and are associated with disease severity (2021-01-13)

Protecting lungs from ventilator-induced injury
An unfortunate truth about using mechanical ventilation to save lives is that the pressure can cause further lung damage. Scientists have identified a helpful molecule produced by immune cells during ventilation and are working to boost that natural process in pursuit of a therapy that could lower the chances for lung damage in patients on vents. (2021-01-12)

Novel RNA factors may help cancer cells thrive
Recent work by researchers at Brigham and Women's Hospital pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. The team identified primary actors circ2082, a circular RNA, and RBM3, an RNA-binding protein, which form a complex with DICER to trap it in the nucleus of glioblastoma cells, therefore disrupting the cytoplasmic microRNAome. (2021-01-08)

New clues to prostate cancer
Australian research has identified a new mechanism in which prostate cancer cells can 'switch' character and become resistant to therapy. These findings, just published in Cell Reports, are an important development in unravelling how an aggressive subtype of prostate cancer, neuroendocrine prostate cancer (NEPC), develops after hormonal therapies. (2021-01-05)

Study can orient use of melatonin in the treatment of breast cancer
In an article published in the Journal of Pineal Research, researchers at São Paulo State University and collaborators describe a set of genes potentially regulated by the ''sleep hormone'' in some types of tumor (2020-12-08)

Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases
Experiments with mice and humans showed that exercise training increased the expression in adipose tissue of a key enzyme for the organism's metabolic health, combating the harmful effects of aging and obesity (2020-12-07)

Penn researchers develop approach to prevent toxicity tied to neurological gene therapy
Penn Medicine researchers have developed a new targeted approach to prevent a toxicity seen in the sensory neurons of dorsal root ganglia after gene therapy to treat neurological disorders. It's an important hurdle to clear, as the field works toward more safe and effective gene therapies for patients with disorders like spinal muscular atrophy. (2020-11-11)

Nothing but the truth in the fight against cancer
Researchers from Tokyo Medical and Dental University (TMDU) have found that TruB1, a protein known to be involved in RNA modification, can directly bind to and promote the maturation of the microRNA let-7. This novel function of TruB1 can also reduce rates of cell proliferation. This unique anti-cancer role of this protein is crucial information that will assist with the development of novel cancer therapeutics. (2020-11-09)

Study confirms spit testing may help doctors diagnose concussions
Doctors may soon be able to more accurately diagnose concussions by measuring the number of certain molecules in a person's saliva, according to Penn State College of Medicine researchers. The results of a recent clinical study confirmed that a patient's spit may be used to aid concussion diagnosis in a non-invasive, non-biased fashion. (2020-11-09)

UArizona Health Sciences researchers find biomarker that can appear before stomach cancer
A microRNA that can be found in a blood sample may make it easier to detect gastric cancer and could lead to improved treatment for the disease and others like it that are resistant to common immunotherapies. (2020-10-20)

Secure nano-carrier delivers medications directly to cells
Medications often have unwanted side-effects. One reason is that they reach not only the unhealthy cells for which they are intended, but also reach and have an impact on healthy cells. Researchers at the Technical University of Munich (TUM), working together with the KTH Royal Institute of Technology in Stockholm, have developed a stable nano-carrier for medications. A special mechanism makes sure the drugs are only released in diseased cells. (2020-09-25)

New insight into how muscles and fat cells work together to make you more fit
Scientists in Denmark and Brazil find evidence of muscle and adipose cross-talk and gain new insight into the importance of adipose DICER in the adaptive response of muscle to exercise training (2020-09-14)

Decreased MIR2911 absorption in human with SIDT1 polymorphism fails to inhibit SARS-CoV-2
In a new study in Cell Discovery, Liang Li and Chen-Yu Zhang's group at Nanjing University and two other groups report that SIDT1 polymorphism remarkably decreases HD-MIR2911 absorption in human. Exosome isolated from volunteers that carry SIDT1 polymorphism has lower level of HD-MIR2911 and fails to inhibit of SARS-CoV-2 replication. (2020-09-11)

Blood marker may reduce cancer burden
Researchers at Flinders University are expanding work on a promising blood test model to help predict or diagnose head and neck cancer, a difficult cancer to pick up early and treat. With cancer accounting for almost 10 million a year, the Global Burden of Disease report (2017) attributed more than 380,000 deaths to head and neck cancer. (2020-09-01)

Protein influences regeneration of vascular cells
Through their basic research, physicians at the Heart Center of the University Hospital Bonn have discovered how the communication between individual cells can be influenced with the help of a specific protein. These findings are an important approach to improving the treatment of diseases such as arteriosclerosis (calcified blood vessels), which causes heart attacks. The study was published online in advance in the ''Journal of Extracellular Vesicles'', the printed version will be published shortly. (2020-08-19)

Stomach SIDT1 mediates dietary microRNA absorption: ending of the 10-year debate
In a new study published in Cell Research, Chen-Yu Zhang's group at Nanjing University School of Life Sciences, China, reports that SIDT1 in the mammalian stomach mediates host uptake of dietary and orally administered microRNAs (miRNAs), thus exerting biological functions in the host. (2020-08-17)

Exercise induces secretion of biomarkers into sweat
The aim was to reveal the potential of microRNAs in sweat extracellular vesicles in monitoring exercise performance. (2020-08-12)

Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication
In a new study in Cell Discovery, Chen-Yu Zhang's group at Nanjing University and two other groups from Wuhan Institute of Virology and the Second Hospital of Nanjing present a novel finding that absorbed miRNA MIR2911 in honeysuckle decoction (HD) can directly target SARS-CoV-2 genes and inhibit viral replication. Drinking of HD accelerate the negative conversion of COVID-19 patients. (2020-08-05)

Researchers find therapeutic targets to fight SARS-CoV-2
Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE journal. (2020-07-29)

A practicable and reliable therapeutic strategy to treat SARS-CoV-2 infection
In a new study in Cell Discovery, Chen-Yu Zhang's group at Nanjing University and two other groups from Wuhan Institute of Virology and the Second Hospital of Nanjing present a novel finding that absorbed miRNA MIR2911 in honeysuckle decoction (HD) can directly target SARS-CoV-2 genes and inhibit viral replication. Drinking of HD accelerate the negative conversion of COVID-19 patients. (2020-07-28)

Silver-plated gold nanostars detect early cancer biomarkers
Biomedical engineers at Duke University have engineered a method for simultaneously detecting the presence of multiple specific microRNAs in RNA extracted from tissue samples without the need for labeling or target amplification. The technique could be used to identify early biomarkers of cancer and other diseases without the need for the elaborate, time-consuming, expensive processes and special laboratory equipment required by current technologies. (2020-07-21)

Study: Single drop of blood could help rapidly detect radiation sickness
A new proof-of-concept study reports evidence that a new testing method has the potential to rapidly identify radiation sickness based on biomarkers measured through a single drop of blood. Scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute say the test could help save lives through early and real-time identification of the condition to enable timely clinical interventions. (2020-07-15)

Moffitt researchers identify protein that causes epithelial cancers to spread
In a new article published in the July issue of Cancer Research, Elsa Flores, Ph.D., and her team discovered a key protein that oscillates its expression through microRNA regulation to facilitate cancer spread to distant organs. This protein is deltaNp63, a member of the p53 family of tumor suppressor genes. (2020-07-06)

CNIO team develop a technology to improve effectiveness of stem cells in regenerative medicine
Stem cells have been holding great promise for regenerative medicine for years. However, one of the main limitations in the application of these therapies is the quality of the stem cells that can be generated in the laboratory. Now, a team from the Spanish National Cancer Research Centre (CNIO) has developed a new, simple and fast technology that enhances in vitro and in vivo the potential of stem cells to differentiate into adult cells. (2020-07-02)

Maternal obesity increases the chance of liver cancer in offspring for generations
Scientists recognize the connection between maternal obesity and liver cancer in the offspring of obese mothers, however, the mechanism is not well understood. In a novel study, appearing in the Journal of Hepatology, published by Elsevier, investigators have identified a microRNA in obese mouse mothers that appears to pass on liver cancer susceptibility, increasing the odds of liver cancer developing in their offspring and throughout future generations. (2020-06-25)

New biomaterial has potential to repair damaged bone with lower risk of inflammation
Scientists at RCSI University of Medicine and Health Sciences have developed a new biomaterial that has the potential to accelerate bone regeneration by promoting an immune response that encourages repair and lowers the risk of inflammation. (2020-06-12)

Oncotarget: Anticancer effect of physical activity is mediated
Volume 11, Issue 22 of Oncotarget reported that the goal of this study was to explore the involvement of mi RNAs in beneficial effects exerted by physical activity in breast cancer prevention. (2020-06-03)

New understanding of RNA movements can be used to treat cancer
Research from Karolinska Institutet published today in Nature shows that an RNA molecule involved in preventing tumour formation can change its structure and thereby control protein production in the cell. The finding can have important clinical implications as it opens for new strategies to treat different types of cancer. (2020-05-27)

Releasing molecular 'brake' kick-starts immune cell function
The immune system's ability to marshal specialized cells to fight off infection relies in part on tiny molecules called microRNAs, which act as a release for the 'brakes' that keep cells dormant until needed, according to a new study published in the journal Cell Reports. (2020-05-18)

First screening test for detecting lymph node metastasis in pancreatic cancer patients
For years, surgeons have operated on pancreatic cancer patients to remove what they thought was a localized tumor only to discover that the disease had spread to other, inoperable parts of the body. Now, a City of Hope molecular scientist thinks he may have found a way to prevent ineffective surgeries and prolong the lives of these patients. Unlike breast, skin or prostate cancer, there is no standard-of-care screening test for pancreatic cancer. (2020-05-15)

University of Minnesota researchers study radiation resistance in brain cancer cells
In a vertical climb to avoid collision with a towering mountain, a plane ejects cargo to gain altitude. Investigators at the University of Minnesota showed that cancer cells perform similar feats in escaping the killing effects of radiation. (2020-05-14)

Tiny RNA that should attack coronavirus diminish with age, disease
A group of tiny RNA that should attack the virus causing COVID-19 when it tries to infect the body are diminished with age and chronic health problems, a decrease that likely helps explain why older individuals and those with preexisting medical conditions are vulnerable populations, investigators report. (2020-05-13)

A study by TalTech geneticists revealed new potential causes of female infertility
Over the last six years a group of Estonian geneticists led by Associate Professor Agne Velthut-Meikas and a PhD student Ilmatar Rooda from TalTech Department of Chemistry and Biotechnology have studied genes previously associated primarily with female hormone synthesis and ovarian follicle development. The findings suggest that these genes may play a far more complex role in oocyte maturation than previously assumed. (2020-05-06)

HKUST scientists discover how multiple RNA elements control MicroRNA biogenesis
Scientists from the Hong Kong University of Science and Technology (HKUST) have recently identified new details regarding the mechanism by which Microprocessor, an RNase III enzyme-based complex, cleaves primary microRNAs (pri-miRNAs), suggesting ways for restoring the abnormal levels of miRNAs (microRNAs), which are associated with numerous human diseases. (2020-04-22)

Taking a break helps drosophila germline cells reach their destination
Quiescence, or breaks during cell cycling, are common during germ cell development in many animals but the mechanisms regulating these periods are unclear. In a recent study from the University of Tsukuba, researchers identified a microRNA, miR-10404, and subsequently the entire pathway, governing the first of two quiescence periods in Drosophila germ-cell cycling. Understanding this mechanism furthers our understanding of the significance of quiescence in germline development. (2020-03-23)

Oncotarget: MicroRNA (miR) dysregulation during Helicobacter pylori-induced gastric
Oncotarget Volume 11, Issue 10 reported that dysregulation of noncoding micro RNA molecules has been associated with immune cell activation in the context of Helicobacter pylori-induced gastric inflammation as well as carcinogenesis, but also with downregulation of mismatch repair genes, and may interfere with immune checkpoint proteins that lead to the overexpression of antigens on gastric tumor cells. (2020-03-13)

Possible new treatment strategy for fatty liver disease
Researchers at Karolinska Institutet in Sweden have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies for treating the condition, which is a major health risk for people with obesity. The study is published in the scientific journal Science Translational Medicine. (2020-02-26)

MicroRNA regulates process vital to placenta growth in early pregnancy
A study by University of South Florida Health (USF Health) researchers discovered how a very large human non-protein coding gene regulates epithelial-to-mesenchymal transition (EMT) -- a process that contributes to placental implantation during early pregnancy, as well as cancer progression and spread. EMT plays a key role in proper placenta growth, critical to the health of the mother and her growing fetus. The USF Health team showed that robustly activating the chromosome 19 microRNA cluster using CRISPR technology inhibited EMT. (2020-02-25)

MicroRNA exhibit unexpected function in driving cancer
New research shows that both strands of microRNA cooperate to drive growth and aggressiveness across cancer types, suggesting that these molecules may be more central in deadly cancers than previously thought. (2020-02-20)

Mass General Hospital researchers identify new 'universal' target for antiviral treatment
Researchers at Massachusetts General Hospital have uncovered a novel potential antiviral drug target that could lead to treatments protecting against a host of infectious diseases. (2020-02-11)

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