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Current Micrornas News and Events, Micrornas News Articles.
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Cheap, quick test identifies pneumonia patients at risk of respiratory failure or sepsis
Spanish researchers in Valencia have identified specific fragments of genetic material that play a role in the development of respiratory failure and sepsis in pneumonia patients, according to research presented at the European Respiratory Society International Congress. The findings could enable doctors to test quickly for these biological markers when a patient is admitted to hospital with pneumonia, so that they could anticipate complications and provide more intensive support and monitoring. (2019-10-01)

New mechanisms that regulate pluripotency in embryonic stem cells are discovered
A study by researchers at the Center for Cell-Based Therapy, which is supported by FAPESP, identified microRNAs involved in pluripotency maintenance and cell differentiation. (2019-09-24)

To grow or to flower: Genes IDed in early land plant descendant also found in modern crops
Since they first arrived on land, plants have likely been using the same genetic tools to regulate whether they grow bigger or reproduce. The discovery was made using liverwort, one descendant of the first plants to move out of the ancient oceans and onto land. 'Liverworts have the maximum power with the least structure,' said Professor Yuichiro Watanabe from the University of Tokyo's Department of Life Sciences, an expert in plant molecular biology. (2019-09-19)

UTSW researchers identify new pathway that controls fat formation
In work suggesting new therapeutic targets to fight obesity, UT Southwestern researchers have identified a novel mechanism that regulates the creation of fat in mammals. (2019-09-17)

Methylation of microRNA may be a new powerful biomarker for cancer
Researchers from Osaka University found that levels of methylated microRNA were significantly higher in tissue and serum from cancer patients compared with that from normal controls. Specifically, methylation levels in serum samples distinguished patients with early pancreatic cancer from healthy controls with extremely high sensitivity and specificity. These findings provide a basis for new diagnostic strategies for early-stage cancer and represent a new perspective for understanding microRNA biology. (2019-09-02)

Tiny RNA provides big protection after a heart attack
Heart muscle can continue to die even after restoring blood following a heart attack, and scientists have new evidence that one way to help it live is by boosting levels of a tiny RNA that helped the heart form. (2019-08-26)

Rapid evolution: New findings on its molecular mechanisms
Evolutionary biologists from Konstanz analyze the role of microRNAs in the evolution of new species. (2019-08-14)

Slowing metabolic rate can prevent detrimental effects of genetic mutations
In a new Northwestern University study, researchers slowed mutant fruit flies' metabolic rates by 50%, and the expected detrimental effects of many mutations never manifested. After experimentally testing fruit flies' many different genetic mutations, the researchers found the same result each time. (2019-07-25)

TGen-led study finds link between gene and severe liver damage
Researchers have found that a gene known as AEBP1 may play a central role in the development, severity and potential treatment of liver disease, according to a study by Temple University, the Geisinger Obesity Institute and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope. One of the study's major findings is that AEBP1 regulates the expression of a network of at least nine genes related to fibrosis: AKR1B10, CCDC80, DPT, EFEMP1, ITGBL1, LAMC3, MOXD1, SPP1, and STMN2. (2019-07-18)

New insight into microRNA function can give gene therapy a boost
Scientists at the University of Eastern Finland and the University of Oxford have shown that small RNA molecules occurring naturally in cells, i.e. microRNAs, are also abundant in cell nuclei. Previously, microRNAs were mainly thought to be found in cytoplasm. The scientists also discovered that microRNA concentrations in cell nuclei change as a result of hypoxia. The findings strongly suggest that microRNAs play a role in the expression of genes in the cell nucleus. (2019-07-17)

Timing is everything for the mutualistic relationship between ants and acacias
Ant-acacia plants attract ants by offering specialized food and hollow thorns in which the ants live, while the ant colony in turn defends its acacia against herbivores. This mutualistic relationship only occurs in older plants. New findings from University of Pennsylvania plant biologists, identify the genetic pathway that appears to regulate the timing of the acacia's ant-sustaining arsenal. (2019-07-16)

Researchers unlock mysteries of complex microRNA oncogenes
A new collaborative study, led by researchers at McGill University's Goodman Cancer Research Centre (GCRC), and published in the journal Molecular Cell, uncovers novel functions for polycistronic microRNAs and showing how cancers such as lymphoma twist these functions to reorganize the information networks that control gene expression. (2019-06-27)

Overcoming PTSD: Study reveals memory disruption drug target
A new study suggests it may be possible to disarm the emotional memories of trauma that drive PTSD symptoms. (2019-06-19)

A rapid, easy-to-use DNA amplification method at 37°C
Scientists in Japan have developed a way of amplifying DNA on a scale suitable for use in the emerging fields of DNA-based computing and molecular robotics. By enabling highly sensitive nucleic acid detection, their method could improve disease diagnostics and accelerate the development of biosensors, for example, for food and environmental applications. (2019-06-14)

Using microRNA to detect early signs of type 2 diabetes in teens
Exosomes, tiny nanoparticles released from fat cells, may hold biochemical clues to the early development of type 2 diabetes, according to a new study of 55 teens with obesity (2019-06-08)

Potential novel biomarker for alcohol dependence
Specific molecules (small noncoding microRNAs or miRNAs) found in saliva may be able to predict alcohol dependence as biomarkers. This is the first study to examine changes in the miRNA expression in the saliva of people with alcohol dependence. Currently, no genetic markers exist to test for this condition. (2019-05-29)

Why lack of sleep is bad for your heart
People who sleep fewer than 7 hours per night have lower levels of gene-regulating molecules, or microRNAs, which help dampen down inflammation in cells and support vascular health. (2019-05-21)

Fingerprint of sleep habits as warning sign for heart disease
Chronic short sleep is associated with increased risk of clogged arteries, heart disease, and thus increased morbidity and mortality. New research in Experimental Physiology may have figured out why lack of sleep increases susceptibility to heart disease, and allowing doctors to identify the patients who might need to change their habits before they develop disease. (2019-05-02)

Protecting damaged hearts with microRNAs
Once the heart is formed, its muscle cells have very limited ability to regenerate. After a heart attack, these cells die off and scar tissue forms, potentially setting people up for heart failure. A new study advances the possibility of using microRNAs -- small molecules that regulate gene function -- to regenerate heart muscle. In mice, two microRNAs that are abundant in developing hearts, miR-19a and miR-19b, repaired heart muscle and improved cardiac function after heart attack. (2019-04-22)

Scientists home in on microRNA processing for novel cancer therapies
More than a decade of research on the mda-7/IL-24 gene has shown that it helps to suppress a majority of cancer types, and now scientists are focusing on how the gene drives this process by influencing microRNAs. Published this week in the journal Proceedings of the National Academy of Sciences, the findings could potentially have implications beyond cancer for a variety of cardiovascular and neurodegenerative diseases caused by the same microRNA-driven processes. (2019-03-25)

How the heart sends an SOS signal to bone marrow cells after a heart attack
Exosomes are key to the SOS signal that the heart muscle sends out after a heart attack. Exosomes in the bloodstream carry greatly increased amounts of heart-specific microRNAs -- as seen in both mice and humans. These exosomes preferentially go to progenitor cells in the bone marrow. Inside those cells, the microRNAs turn off a specific gene that allows the progenitor cells to leave the bone marrow and travel to the heart to attempt repairs. (2019-03-13)

Putting the break on our immune system's response
Researchers have discovered how a tiny molecule known as miR-132 acts as a 'handbrake' on our immune system -- helping us fight infection. (2019-03-04)

FASEB Journal: Study suggests novel biomarker for predicting AFib progression
A human study published in The FASEB Journal suggests a novel type of biomarker to predict the progression of atrial fibrillation (AF), the most common form of irregular heart rhythm. Despite inconsistent evidence to date, one idea that has surfaced is that AF may be regulated by alterations in circulating microRNAs (miRNAs), which regulate cell-to-cell communication. If this hypothesis were correct, by better understanding such alterations, scientists could potentially monitor the progression of heart disease. (2019-02-26)

Micro-control of liver metabolism
A new discovery has shed light on small RNAs called microRNAs in the liver that regulate fat and glucose metabolism. Research carried out by scientists in TIFR show that a molecular anticipation, during fast to re-feed transition, is essential for capping glucose production by the liver. This novel control enables a rapid switch in physiology following food consumption. Besides the therapeutic potential, the findings show that these mechanisms may be associated with metabolic diseases and aging. (2019-02-19)

The hitchhiker's guide to defeating glioblastoma
A team of investigators at Brigham and Women's Hospital and Harvard Medical School has begun looking at microRNAs in an entirely new way. Their approach has shown promising results in preclinical models, increasing survival in a murine model of glioblastoma by five-fold when combined with chemotherapy. The team's results are published in Nature Communications. (2019-01-25)

Killer blows? Knockout study of pair of mouse MicroRNA provides cancer insight
Tokyo Medical and Dental University (TMDU) researchers used knockout mouse models created by gene editing to reveal that the miRNA miR-146b, like miR-146a, is involved in the development of cancers, with them having similar but not identical effects. The knockout mice showed high rates of B-cell lymphoma and acute myeloid leukemia, which was associated with the absence of miRNA causing NF-κB overactivation. These insights should help in the fight against cancers involving miRNA dysregulation. (2019-01-17)

Cilia beat to an unexpected rhythm in male reproductive tract, study in mice reveals
Waves of undulating cilia drive several processes essential to life. They clear debris and mucus from the respiratory tract, move spinal fluid through the brain and transport embryos from the ovaries to the uterus for implantation. According to a new study in mice, however, cilia perform somewhat differently in the male reproductive tract. (2019-01-14)

A role for microRNAs in social behavior
Researchers have uncovered a microRNA cluster that regulates synaptic strength and is involved in the control of social behavior in mammals. The researchers presume that their discovery may point to new therapeutic strategies for the treatment of social deficits in neurodevelopmental disorders such as autism spectrum disorder or schizophrenia. The research is published today in EMBO Reports. (2018-12-14)

Protecting cell powerhouse paves way to better treatment of acute kidney injury
For the first time, scientists have described the body's natural mechanism for temporarily protecting the powerhouses of kidney cells when injury or disease means they aren't getting enough blood or oxygen. (2018-12-06)

New cancer immunotherapy approach turns human cells into tiny anti-tumor drug factories
In lab and mouse experiments, UC San Diego School of Medicine researchers developed a method to leverage B cells to manufacture and secrete tumor-suppressing microRNAs. (2018-12-04)

Targeting sepsis, the leading cause of ICU deaths, with a nanocarrier-delivered microRNA
One obstacle to therapeutic use of microRNAs (miRNA), which are in clinical trial for a number of diseases, are ribonucleases, whose job it is to destroy them. Medical University of South Carolina researchers report in Inflammation that an miRNA (miR-126) protective against sepsis can be delivered effectively via a nanocarrier. Almost 67 percent of mice treated with one of the nanocarrier/miR-126 complexes were still alive at seven days vs. just 25 percent of controls. (2018-12-03)

The taming of the dog, cow, horse, pig and rabbit
Research at the Earlham Institute into one of the 'genetic orchestra conductors', microRNAs, sheds light on our selectively guided evolution of domestic pets and farmyard animals such as dogs and cows. (2018-11-20)

Decrease in specific gene 'silencing' molecules linked with pediatric brain tumors
Experimenting with lab-grown brain cancer cells, Johns Hopkins Medicine researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the development and growth of pediatric brain tumors known as low-grade gliomas. (2018-11-12)

Tracking down microRNA candidates that can contribute to disease
A novel computational tool called ADmiRE extensively annotates human microRNA variants to determine which ones are likely to contribute to or cause diseases. (2018-11-06)

New genetic cause of liver fat uncovered
New research has uncovered genetic variations that may contribute to the development of non-alcoholic fatty liver disease (NAFLD), the leading cause of liver disease. (2018-11-04)

UMass Medical School study safely delivers RNAi-based gene therapy for ALS in animal model
Promising new research by Christian Mueller, Ph.D., and Robert H. Brown Jr., D.Phil., M.D., at the University of Massachusetts Medical School, provides evidence that a therapy using synthetic microRNAs may safely treat patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. (2018-10-31)

Cancer's most deadly assassin exists in every cell
A kill code is embedded in every cell in the body whose function may be to cause the self-destruction of cells that become cancerous, reports a new study. As soon as the cell's inner bodyguards sense it is mutating into cancer, they punch in the kill code to extinguish the mutating cell. Cancer can't become resistant to it, the study shows, making it a potentially bulletproof treatment. The next step is to turn synthetically duplicate the code and turn it into therapy. (2018-10-29)

New way to prevent heart disease in type 1 diabetes
Research shows metformin, a commonly prescribed drug for type 2 diabetes prevents heart disease in patients with type 1 diabetes. (2018-10-19)

Loss of a microRNA molecule boosts rice production
Rice, one of the world's biggest staples, has fed humanity for thousands of years. A new study links the loss of a microRNA molecule to several of the yield-related traits associated with domestication of the indica variety of rice. In addition to providing insight into the origin of rice as we know it, this work suggests creative strategies to increase grain yield in an age when population growth is outpacing food production. (2018-10-16)

Nanopore technology with DNA computing easily detects microRNA patterns of lung cancer
Researchers at Tokyo University of Agriculture and Technology (TUAT) have developed a simple technique that allows detection of two independent microRNAs as an early diagnosis marker of Small Cell Lung Cancer (SCLC) , which is very aggressive. In this technique, they combined nanopore and DNA computing technologies as rapid and label-free detection. This method, therefore, could help to identify SCLC in the early stage. (2018-10-05)

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