Current Microscopy Techniques News and Events

Current Microscopy Techniques News and Events, Microscopy Techniques News Articles.
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3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

A new piece of the HIV infection puzzle explored
Researchers from the European Molecular Biology Laboratory and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics. (2021-02-18)

Capturing the contours of live cells with novel nanoimaging technique using graphene
Researchers from DGIST have now found a way to keep living, wet cells viable in an ultra-high-vacuum environment, using graphene, allowing--like never before--accurate high-resolution visualization of the undistorted molecular structure and distribution of lipids in cell membranes. This could enhance our bioimaging abilities considerably, improving our understanding of mechanisms underlying complex diseases such as cancers and Alzheimer's. (2021-02-17)

A 'twisted elevator' could be key to understanding neurological diseases
For the first time, researchers have found one of the most important molecular machines in our cells uses a 'twisting elevator' mechanism, solving a mystery of how it transports crucial chemical signals from one cell to another. (2021-02-17)

Upending complex crystal formation
PNNL researchers discover a new route to forming complex crystals. (2021-02-17)

3D microscopy clarifies understanding of body's immune response to obesity
Researchers who focus on fat know that some adipose tissue is more prone to inflammation-related comorbidities than others, but the reasons why are not well understood. Thanks to a new analytical technique, scientists are getting a clearer view of the microenvironments found within adipose tissue associated with obesity. This advance may illuminate why some adipose tissues are more prone to inflammation - leading to diseases like type 2 diabetes, cancer and cardiovascular disorders - and help direct future drug therapies to treat obesity. (2021-02-17)

New microscopy analysis allows discovery of central adhesion complex
Researchers at University of Münster and the Max Planck Institute of Biochemistry have developed a method for determining the arrangement and density of individual proteins in cells. In this way, they were able to prove the existence of an adhesion complex consisting of three proteins. (2021-02-15)

Vibrating 2D materials
Two-dimensional materials hold out hope for many technical applications. An international research team now has determined for the first time how strongly 2D materials vibrate when electronically excited with light. (2021-02-11)

Metabolism: Researchers first to shed light on structure of huge enzyme complex
A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published their findings in the journal Cell Reports. They investigated a multi-enzyme complex that plays an essential role in metabolism and have discovered that it functions differently than previously thought. This will help scientists better understand certain diseases. (2021-02-10)

Study reveals platinum's role in clean fuel conversion
Scientists at the US Department of Energy's Brookhaven National Laboratory, Stony Brook University (SBU), and other collaborating institutions have uncovered dynamic, atomic-level details of how an important platinum-based catalyst works in the water gas shift reaction. The experiments provide definitive evidence that only certain platinum atoms play an important role in the chemical conversion, and could therefore guide the design of catalysts that use less of this precious metal. (2021-02-10)

New microscopy concept enters into force
The first demonstration of an approach that inverts the standard paradigm of scanning probe microscopy raises the prospect of force sensing at the fundamental limit. (2021-02-05)

Innovation from Vienna: Ultrasound in the treatment of brain diseases
Ultrasound is not only used as an imaging technique but targeted pulses of ultrasound can be used as a highly accurate treatment for a range of brain diseases. A review jointly written by MedUni Vienna and the University of Toronto shows that the new treatments are already on the brink of broad clinical application. (2021-02-04)

SARS-CoV-2 under the helium ion microscope for the first time
Scientists at Bielefeld University's Faculty of Physics have succeeded for the first time in imaging the SARS-CoV-2 coronavirus with a helium ion microscope. In contrast to the more conventional electron microscopy, the samples do not need a thin metal coating in helium ion microscopy. This allows interactions between the coronaviruses and their host cell to be observed particularly clearly. The findings have been published in the Beilstein Journal of Nanotechnology. (2021-02-04)

Surface effect of electrodes revealed by operando surface science methodology
Super-dense anions together with cations intercalation into the surface region of graphite electrode has been visualized by applying operando surface science methodology over an Al/HOPG planar model device. The observed unusual electrochemical behavior in surface region can be described as the intercalation pseudocapacitor in contrast with the battery process in the bulk. Guided by this distinct surface effect, the capacity can be doubled by using surface-dominant nano-thick graphite electrode. (2021-02-04)

Soil bacteria hormone discovery provides fertile ground for new antibiotics
The discovery of how hormone-like molecules turn on antibiotic production in soil bacteria could unlock the untapped opportunities for medicines that are under our very feet. An international team of scientists working at the University of Warwick, UK, and Monash University, Australia, have determined the molecular basis of a biological mechanism that could enable more efficient and cost-effective production of existing antibiotics, and also allow scientists to uncover new antibiotics in soil bacteria. (2021-02-03)

Skoltech imaging resources used in international experiment with new photocatalysts
Skoltech researchers helped their colleagues from Japan, Germany, the United States, and China study the crystal structure and optical properties of a new class of two-dimensional compounds, which can be used as effective visible-light-responsive photocatalysts for energy and chemical conversion. They used the Advanced Imaging Core Facility equipment for imaging and structural analysis. (2021-02-01)

High-speed holographic fluorescence microscopy system with submicron resolution
The National Institute of Information and Communications Technology (NICT), Tohoku University, Toin University of Yokohama, and Japan Science and Technology Agency (JST) have succeeded in developing a scanless high-speed holographic fluorescence microscopy system with submicron resolution for a 3D space. The system is based on digital holography. The developed microscopy system has an algorithm to acquire 3D information of fluorescent objects toward scanless 3D measurement in less than 1 millisecond. (2021-01-29)

Singles or pairs in cancer cells
An important receptor on the surface of cancer and immune cells prefers to remain noncommittal; sometimes it is present as a single, sometimes as a pair. This was first shown by an MDC team in the journal PNAS, and will decisively advance the development of new medications. (2021-01-29)

A vacuum-ultraviolet laser with submicrometer spot for spatially resolved photoemission spectroscopy
If vacuum ultraviolet lasers can be focused into a small beam spot, it will allow investigation of mesoscopic materials and structures and enable the manufacture of nano-objects with excellent precision. Towards this goal, Scientist in China invented a 177 nm VUV laser system that can achieve a sub-micron focal spot at a long focal length. This system can be re-equipped for usage in low-cost ARPES and might benefit condensed matter physics. (2021-01-27)

VCU technology could upend DNA sequencing for diagnosing certain DNA mutations
Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities. However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy. (2021-01-27)

Focusing on field analysis
One potential approach to developing a low-cost portable microscopy system is to use transparent microspheres in combination with affordable low-magnification objective lenses to increase image resolution and sensitivity. (2021-01-27)

A research team from Denmark discovers new control mechanism in the innate immune system
Although the protein ITIH4 is found in large amounts in the blood, its function has so far been unknown. By combining many different techniques, researchers from Aarhus University have discovered that ITIH4 inhibits proteases in the innate immune system via an unknown mechanism. The research results have just been published in the prestigious scientific journal Science Advances. (2021-01-26)

Smart algorithm cleans up images by searching for clues buried in noise
In a new study published in Nature Machine Intelligence, researchers at Texas A&M University have unveiled a machine learning-based algorithm that can reduce graininess in low-resolution images and reveal new details that were otherwise buried within the noise. (2021-01-26)

New variety of paintbrush lily developed by a novel plant tissue culture technique
Scientists at Hokkaido University and Chiba University have developed simultaneous triploid and hexaploid varieties of Haemanthus albiflos by the application of endosperm culture, thus extending the use of this technique. (2021-01-22)

Crystal close up
Two novel techniques, atomic-resolution real-time video and conical carbon nanotube confinement, allow researchers to view never-before-seen details about crystal formation. The observations confirm theoretical predictions about how salt crystals form and could inform general theories about the way in which crystal formation produces different ordered structures from an otherwise disordered chemical mixture. (2021-01-21)

Electrons caught in the act
Tsukuba University scientists create movies of the ultrafast motion of electrons traveling through an organic semiconductor with atomic-level resolution. This work may lead to more powerful and miniaturized smart devices. (2021-01-21)

Pioneering new technique could revolutionise super-resolution imaging systems
Scientists have developed a pioneering new technique that could revolutionise the accuracy, precision and clarity of super-resolution imaging systems. (2021-01-21)

Adaptive optics with cascading corrective elements
As reported in Advanced Photonics, researchers from the University of Freiburg, Germany, have made a significant advance in AO microscopy through the demonstration of a new AO module comprising two deformable phase plates (DPPs). (2021-01-21)

New sodium oxide paves the way for advanced sodium-ion batteries
Skoltech researchers and their collaborators from France, the US, Switzerland, and Australia were able to create and describe a mixed oxide Na(Li1/3Mn2/3)O2 that holds promise as a cathode material for sodium-ion batteries, which can take one day complement or even replace lithium-ion batteries. (2021-01-20)

Message in a bottle: Info-rich bubbles respond to antibiotics
In a new study, Luis H. Cisneros and his colleagues describe the effects of antibiotics on membrane vesicles, demonstrating that such drugs actively modify the properties of vesicle transport. Under the influence of antibiotics, MVs were produced and released by bacteria in greater abundance and traveled faster and further from their origin. The work sheds new light on these important information-carrying entities, implicated in many cellular communication processes, including antibiotic resistance. (2021-01-20)

Researchers resolve controversy over energy gap of Van der Waals material
Scanning tunneling microscopy and spectroscopy measurements revealed that the energy gap of chromium tribromide is around 0.3 electron volt (eV), which is much smaller than optical measurements, which ranged from 1.68 to 2.1 eV. (2021-01-15)

Physical virology shows the dynamics of virus reproduction
The reproductive cycle of viruses requires self-assembly, maturation of virus particles and, after infection, the release of genetic material into a host cell. New physics-based technologies allow scientists to study the dynamics of this cycle and may eventually lead to new treatments. (2021-01-14)

Ovarian cancer cells adapt to their surroundings to aid tumor growth
A description of how ovarian cancer cells adapt to survive and proliferate in the peritoneal cavity has been detailed by a new study. It shows structures inside the cells change as the disease progresses, to help the cells grow in an otherwise hostile environment of low oxygen and nutrients. Understanding how these cellular adaptations are regulated could herald new targeted treatment options against the fifth-leading cause of cancer-related deaths in women. (2021-01-13)

GridTape: An automated electron microscopy platform
Scientists have developed an automated, faster, and more rapid electron microscopy technique, called GridTape, that enables them to label and read the location of every neuron in a tissue sample. The team used GridTape to map the circuity of the spinal cord nerve of the fruit fly. The technique not only provides a comprehensive map of neuronal circuits; it can also be used to study nerve circuitry in larger animal systems. (2021-01-11)

Singapore and US scientists uncover the structure of Wnt, Wntless proteins
Preventing Wnt from hitching a ride may offer new avenue for novel treatments for cancer and fibrosis. (2021-01-11)

High-speed atomic force microscopy visualizes cell protein factories
Factor-pooling by ribosomes caught on video using state-of-art high-speed atomic force microscopy technology. (2021-01-08)

Engineers find antioxidants improve nanoscale visualization of polymers
Reactive molecules, such as free radicals, can be produced in the body after exposure to certain environments or substances and go on to cause cell damage. Antioxidants can minimize this damage by interacting with the radicals before they affect cells. (2021-01-08)

Tracking the formation of the early heart, cell by cell
Richard Tyser and colleagues have mapped the origins of the embryonic mouse heart at single-cell resolution, helping to define the cell types that make up the heart in the earliest days of development. (2021-01-07)

New imaging method reveals if antibiotics reach bacteria hiding in tissues
Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance. (2021-01-05)

Comb of a lifetime: a new method for fluorescence microscopy
Conventional fluorescence microscopy provides poor quantitative information of the sample because it only captures fluorescence intensity, which changes frequently and depends on external factors. Now, scientists from Japan have developed a new fluorescence microscopy technique to measure both fluorescence intensity and lifetime. Their method does not require mechanical scanning of a focal point; instead, it produces images from all points in the sample simultaneously, enabling a more quantitative study of dynamic biological and chemical processes. (2021-01-01)

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