Current Microscopy News and Events

Current Microscopy News and Events, Microscopy News Articles.
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3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

A new piece of the HIV infection puzzle explored
Researchers from the European Molecular Biology Laboratory and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics. (2021-02-18)

A 'twisted elevator' could be key to understanding neurological diseases
For the first time, researchers have found one of the most important molecular machines in our cells uses a 'twisting elevator' mechanism, solving a mystery of how it transports crucial chemical signals from one cell to another. (2021-02-17)

3D microscopy clarifies understanding of body's immune response to obesity
Researchers who focus on fat know that some adipose tissue is more prone to inflammation-related comorbidities than others, but the reasons why are not well understood. Thanks to a new analytical technique, scientists are getting a clearer view of the microenvironments found within adipose tissue associated with obesity. This advance may illuminate why some adipose tissues are more prone to inflammation - leading to diseases like type 2 diabetes, cancer and cardiovascular disorders - and help direct future drug therapies to treat obesity. (2021-02-17)

New microscopy analysis allows discovery of central adhesion complex
Researchers at University of Münster and the Max Planck Institute of Biochemistry have developed a method for determining the arrangement and density of individual proteins in cells. In this way, they were able to prove the existence of an adhesion complex consisting of three proteins. (2021-02-15)

Vibrating 2D materials
Two-dimensional materials hold out hope for many technical applications. An international research team now has determined for the first time how strongly 2D materials vibrate when electronically excited with light. (2021-02-11)

Metabolism: Researchers first to shed light on structure of huge enzyme complex
A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published their findings in the journal Cell Reports. They investigated a multi-enzyme complex that plays an essential role in metabolism and have discovered that it functions differently than previously thought. This will help scientists better understand certain diseases. (2021-02-10)

New microscopy concept enters into force
The first demonstration of an approach that inverts the standard paradigm of scanning probe microscopy raises the prospect of force sensing at the fundamental limit. (2021-02-05)

SARS-CoV-2 under the helium ion microscope for the first time
Scientists at Bielefeld University's Faculty of Physics have succeeded for the first time in imaging the SARS-CoV-2 coronavirus with a helium ion microscope. In contrast to the more conventional electron microscopy, the samples do not need a thin metal coating in helium ion microscopy. This allows interactions between the coronaviruses and their host cell to be observed particularly clearly. The findings have been published in the Beilstein Journal of Nanotechnology. (2021-02-04)

Skoltech imaging resources used in international experiment with new photocatalysts
Skoltech researchers helped their colleagues from Japan, Germany, the United States, and China study the crystal structure and optical properties of a new class of two-dimensional compounds, which can be used as effective visible-light-responsive photocatalysts for energy and chemical conversion. They used the Advanced Imaging Core Facility equipment for imaging and structural analysis. (2021-02-01)

High-speed holographic fluorescence microscopy system with submicron resolution
The National Institute of Information and Communications Technology (NICT), Tohoku University, Toin University of Yokohama, and Japan Science and Technology Agency (JST) have succeeded in developing a scanless high-speed holographic fluorescence microscopy system with submicron resolution for a 3D space. The system is based on digital holography. The developed microscopy system has an algorithm to acquire 3D information of fluorescent objects toward scanless 3D measurement in less than 1 millisecond. (2021-01-29)

Singles or pairs in cancer cells
An important receptor on the surface of cancer and immune cells prefers to remain noncommittal; sometimes it is present as a single, sometimes as a pair. This was first shown by an MDC team in the journal PNAS, and will decisively advance the development of new medications. (2021-01-29)

A vacuum-ultraviolet laser with submicrometer spot for spatially resolved photoemission spectroscopy
If vacuum ultraviolet lasers can be focused into a small beam spot, it will allow investigation of mesoscopic materials and structures and enable the manufacture of nano-objects with excellent precision. Towards this goal, Scientist in China invented a 177 nm VUV laser system that can achieve a sub-micron focal spot at a long focal length. This system can be re-equipped for usage in low-cost ARPES and might benefit condensed matter physics. (2021-01-27)

Focusing on field analysis
One potential approach to developing a low-cost portable microscopy system is to use transparent microspheres in combination with affordable low-magnification objective lenses to increase image resolution and sensitivity. (2021-01-27)

Electrons caught in the act
Tsukuba University scientists create movies of the ultrafast motion of electrons traveling through an organic semiconductor with atomic-level resolution. This work may lead to more powerful and miniaturized smart devices. (2021-01-21)

Adaptive optics with cascading corrective elements
As reported in Advanced Photonics, researchers from the University of Freiburg, Germany, have made a significant advance in AO microscopy through the demonstration of a new AO module comprising two deformable phase plates (DPPs). (2021-01-21)

Researchers resolve controversy over energy gap of Van der Waals material
Scanning tunneling microscopy and spectroscopy measurements revealed that the energy gap of chromium tribromide is around 0.3 electron volt (eV), which is much smaller than optical measurements, which ranged from 1.68 to 2.1 eV. (2021-01-15)

GridTape: An automated electron microscopy platform
Scientists have developed an automated, faster, and more rapid electron microscopy technique, called GridTape, that enables them to label and read the location of every neuron in a tissue sample. The team used GridTape to map the circuity of the spinal cord nerve of the fruit fly. The technique not only provides a comprehensive map of neuronal circuits; it can also be used to study nerve circuitry in larger animal systems. (2021-01-11)

Singapore and US scientists uncover the structure of Wnt, Wntless proteins
Preventing Wnt from hitching a ride may offer new avenue for novel treatments for cancer and fibrosis. (2021-01-11)

High-speed atomic force microscopy visualizes cell protein factories
Factor-pooling by ribosomes caught on video using state-of-art high-speed atomic force microscopy technology. (2021-01-08)

Engineers find antioxidants improve nanoscale visualization of polymers
Reactive molecules, such as free radicals, can be produced in the body after exposure to certain environments or substances and go on to cause cell damage. Antioxidants can minimize this damage by interacting with the radicals before they affect cells. (2021-01-08)

Tracking the formation of the early heart, cell by cell
Richard Tyser and colleagues have mapped the origins of the embryonic mouse heart at single-cell resolution, helping to define the cell types that make up the heart in the earliest days of development. (2021-01-07)

New imaging method reveals if antibiotics reach bacteria hiding in tissues
Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance. (2021-01-05)

Comb of a lifetime: a new method for fluorescence microscopy
Conventional fluorescence microscopy provides poor quantitative information of the sample because it only captures fluorescence intensity, which changes frequently and depends on external factors. Now, scientists from Japan have developed a new fluorescence microscopy technique to measure both fluorescence intensity and lifetime. Their method does not require mechanical scanning of a focal point; instead, it produces images from all points in the sample simultaneously, enabling a more quantitative study of dynamic biological and chemical processes. (2021-01-01)

Sugars influence cell-to-surface adhesion
An international team of researchers examined how movement and adhesion in the green alga Chlamydomonas reinhardtii can be manipulated. To this end, the researchers altered the sugar modifications in proteins on the cell surface. As a result, the so-called adhesion force was also altered. The results have now been published in the open access scientific journal eLife. (2020-12-29)

High-speed atomic force microscopy takes on intrinsically disordered proteins
Kanazawa University's pioneering high-speed atomic force microscope technology has now shed light on the structure and dynamics of some of life's most ubiquitous and inscrutable molecules - intrinsically disordered proteins. The study is reported in Nature Nanotechnology. (2020-12-28)

Experiment takes 'snapshots' of light, stops light, uses light to change properties of matter
The team generated a movie of how light waves churn on their nanometer wavelength scale by imaging electrons that two light photons coming together cause to emit from the surface. (2020-12-23)

New electron microscopy technique offers first look at previously hidden processes
Northwestern researchers have developed a new microscopy method that allows scientists to see the building blocks of 'smart' materials being formed at the nanoscale. (2020-12-22)

Development of plaques in Alzheimer's disease resolved
In Alzheimer's disease patients, the protein amyloid-beta (Aβ) clumps up in the brain to form so-called fibrils. This has a toxic effect on the surrounding nerve cells. It is believed that immune cells compact the Aβ fibrils into what are known as plaques. It is now possible to track the development of these microscopically small structures in human using infrared microscopy. (2020-12-21)

CNIO and IRB Barcelona assemble the gamma-tubulin ring complex in vitro for the first time
This work paves the way for the in vitro study of the nucleation process that is essential for assembly and organization of the microtubule cytoskeleton. The paper is a collaboration between Jens Lüders' group at IRB Barcelona and Oscar Llorca's at CNIO. The results have been published in Science Advances. (2020-12-21)

Brain stem cells divide over months
For the first time, scientists at the University of Zurich have been able to observe the way stem cells in the adult brains of mice divide over the course of months to create new nerve cells. Their study shows that brain stem cells are active over a long period, and thus provides new insights that will feed into stem cell research. (2020-12-21)

Variety: Spice of life for bumble bees
The yield and quality of many crops benefit from pollination, but it isn't just honey bees that do this work: bumble bees also have a role. A team led by University of Göttingen used innovative molecular biological methods and traditional microscopy to investigate the pollen collecting behaviour of honey bees and bum-ble bees in agricultural landscapes. It turns out bumble bees take much more pollen from different plant species than honey bees to satisfy their need for protein. (2020-12-21)

New phase for synthetic aperture microscopy
Although SAM is undoubtedly a promising approach, current implementations lack in both spatial resolution and frame rate to be useful for emerging applications. To address these issues, a team of researchers led by Renjie Zhou from The Chinese University of Hong Kong recently developed a novel SAM method. (2020-12-21)

Flexible and powerful electronics
A team of researchers led by the University of Tsukuba has developed a method for optimizing the electrical properties of carbon-based conductors by turning them into an ionic gel. This work may open the way for cheap, highly efficient sensors that can be printed on flexible surfaces. (2020-12-16)

New approach reveals structure and function of individual synapses
An interdisciplinary team of scientists at the Max Planck Florida Institute for Neuroscience report the results of a novel approach that allowed them to achieve direct measurements of the activity of individual synapses, their size, and their neuron's output signal. Their work challenges predictions of the Hebbian model, demonstrating that synapse size is not correlated with response similarity and suggests neural response properties reflect the total number of active synapses, both weak and strong. (2020-12-16)

Record resolution in X-ray microscopy
Researchers at Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), the Paul Scherrer Institute in Switzerland and other institutions in Paris, Hamburg and Basel, have succeeded in setting a new record in X-ray microscopy. With improved diffractive lenses and more precise sample positioning, they were able to achieve spatial resolution in the single-digit nanometre scale. (2020-12-11)

Scientists invent a new type of microscope that can see through an intact skull
Researchers at IBS invented a new type of microscope called reflective matrix microscope, which uses adaptive optics techniques (2020-12-02)

Reconstruction of eye tissue gives new insight into outer retina
Researchers used a newly developed imaging technique called serial block face scanning electron microscopy, to produce a digital reconstruction of eye tissues from the outer retina, at very high resolution. This is the first time this technology has been used to fully reconstruct cells from the retina and could provide new insights into the causes of irreversible blinding diseases. (2020-12-02)

Cell membranes in super resolution
For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes. (2020-12-02)

Raman holography
Scientists from ICFO and University Rovira i Virgili report on a novel Raman holographic technique capable of tracking individual particles in 3D volumes from one single image. (2020-11-30)

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