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Current Mitochondria News and Events, Mitochondria News Articles.
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Disease-aggravating mutation found in a mouse model of neonatal mitochondrial disease
The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. (2020-01-29)
Biophysicists find 'extra' component in molecular motor
Researchers discovered an additional component in ATP synthase, a molecular machine that produces the energy-conserving compound. (2020-01-29)
Consequences of Zika virus attack on glial cells
Few studies have identified the effects of zika virus infection on astrocytes, as well as their association with developmental alterations, including brain malformations and microcephaly. (2020-01-27)
A new blood component revealed
Does the blood we thought to know so well contain elements that had been undetectable until now? (2020-01-23)
Immune cell health discovery could optimise cancer therapies
Scientists at UCL have discovered how immune cells, essential for tackling life-threatening infections and cancers, are able to 'recycle' material within themselves in order to stay healthy and function, a breakthrough finding which could lead to more effective immunotherapies. (2020-01-21)
Zebrafish teach researchers more about atrial fibrillation
Genetic research in zebrafish at the University of Copenhagen has surprised the researchers behind the study. (2020-01-21)
Experimental therapy may offer hope for rare genetic disorders
Researchers at Massachusetts General Hospital (MGH) have developed a new way to alleviate problems caused by dysfunctional mitochondria, which are the ''powerhouses'' that produce energy in cells (2020-01-13)
Protein associated with ovarian cancer exacerbates neurodegeneration in Alzheimer's
Houston Methodist scientists identified a protein found in ovarian cancer that may contribute to declining brain function and Alzheimer's disease, by combining computational methods and lab research. (2020-01-12)
Neurons' energy organelle protected from damage linked to ALS, Alzheimer's
Mitochondrial damage is increasingly recognized as a key factor underlying neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS. (2020-01-08)
MDI biological scientists identify pathways that extend lifespan by 500%
Scientists at the MDI Biological Laboratory, in collaboration with scientists from the Buck Institute for Research on Aging in Novato, Calif., and Nanjing University in China, have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. (2020-01-08)
Researchers suggest a pathway to reverse the genetic defect of Friedreich's ataxia
Scientists have identified a molecular mechanism that could reverse the genetic defect responsible for Friedreich's ataxia, a neurodegenerative disease that leaves its victims with difficulty walking, a loss of sensation in the arms and legs and impaired speech. (2020-01-06)
New insights into the earliest events of seed germination
Plant seeds can store their energy in a dry state for years, only to suddenly release it and germinate. (2019-12-27)
Evolution: Revelatory relationship
A new study of the ecology of an enigmatic group of novel unicellular organisms by scientists from Ludwig-Maximilians-Universitaet (LMU) in Munich supports the idea hydrogen played an important role in the evolution of Eukaryota, the first nucleated cells. (2019-12-27)
A step closer to understanding evolution -- mitochondrial division conserved across species
A group of scientists at Tokyo University of Science showed for the first time that in red algae, an enzyme that is usually involved in cell division also plays a role in replication of mitochondria -- a crucial cell organelle. (2019-12-20)
Mitochondria are the 'canary in the coal mine' for cellular stress
Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. (2019-12-13)
Study finds differences in energy use by immune cells in ME/CFS
New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions in the way they produce energy. (2019-12-12)
Muscle weakness after sepsis linked to mitochondrial dysfunction
Damage to energy-producing mitochondria may underlie prolonged muscle weakness following a sepsis-like condition in mice, according to a new study published today in eLife. (2019-12-10)
Alzheimer's drug candidates reverse broader aging, study shows
In mouse models of Alzheimer's disease, the investigational drug candidates known as CMS121 and J147 improve memory and slow the degeneration of brain cells. (2019-12-10)
Increasing food intake by swapping mitochondrial genomes
To uncover the relationship between variation in genes and phenotypic diversity, geneticists use a set of fully sequenced fruit-fly genomes. (2019-12-09)
Eating more ketones may fight against Alzheimer's disease
A ketone-supplemented diet may protect neurons from death during the progression of Alzheimer's disease, according to research in mice recently published in JNeurosci. (2019-12-09)
Raising plants to withstand climate change
Success with improving a model plant's response to harsh conditions is leading plant molecular researchers to move to food crops including wheat, barley, rice and chickpeas. (2019-12-03)
TU Dresden biologists examine sperm quality on the basis of their metabolism
Every tenth couple worldwide is affected by infertility. The reasons for this are manifold, but mostly well researched. (2019-11-28)
The molecule that can AUTAC bad proteins
Tohoku University researchers have developed a strategy that could help cells get rid of disease-related debris. (2019-11-27)
Gene discovery in fruit flies could help search for new treatments for mitochondrial disease
Scientists have identified a protein in fruit flies that can be targeted to reverse the effects of disease-causing mutations in mitochondrial genes. (2019-11-27)
Mapping the pathway to gut health in HIV and SIV infections
A UC Davis study found that Lactobacillus plantarum bacteria rapidly repaired damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus. (2019-11-19)
Master regulator in mitochondria is critical for muscle function and repair
New study identifies how loss of mitochondrial protein MICU1 disrupts calcium balance and causes muscle atrophy and weakness. (2019-11-14)
Research points to possible target to treat idiopathic pulmonary fibrosis, or IPF
In a study of idiopathic pulmonary fibrosis, or IPF, recruited monocyte-derived macrophages with increased flux in their mevalonate pathway were able induce lung fibrosis in a mouse model without prior lung injury. (2019-11-12)
Oxygen deficiency rewires mitochondria
Researchers slow the growth of pancreatic tumor cells. (2019-11-11)
The pathway to Parkinson's takes a surprising twist
A new study finds that neurons affected in Parkinson's disease can shut down without fully dying, allowing them to also switch off neighboring cells. (2019-11-11)
Salmonella -- how the body fights back
New research shows how our immune system fights back against Salmonella infection. (2019-11-11)
Self-cannibalizing mitochondria may set the stage for ALS development
Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration that is seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking.  The discovery was so novel, the scientists needed to coin a new term to describe it: mitoautophagy, a collection of self-destructive mitochondria in diseased upper motor neurons of the brain that begin to disintegrate from within at a very early age. (2019-11-07)
SDHI pesticides are toxic for human cells
French scientists led by a CNRS researcher have just revealed that eight succinate dehydrogenase inhibitor pesticide molecules do not just inhibit the SDH activity of fungi, but can also block that of earthworms, bees, and human cells in varying proportions. (2019-11-07)
'Big data' for life sciences
Scientists have produced a co-regulation map of the human proteome, which was able to capture relationships between proteins that do not physically interact or co-localize. (2019-11-05)
New research tool for studying mitochondrial disorders and aging
Researchers at Karolinska Institutet in Sweden have developed a new research tool for studying how mitochondrial protein synthesis is affected by disease, pharmaceuticals, ageing and different physiological situations such as exercise and diet. (2019-11-05)
Molecular gatekeepers that regulate calcium ions key to muscle function
Controlled entry of calcium ions into the mitochondria, the cell's energy powerhouses, makes the difference between whether muscles grow strong or easily tire and perish from injury, according to research published in Cell Reports. (2019-10-31)
Cocktail proves toxic to leukemia cells
Rice bioscientists find a way to predict the sensitivity of acute myeloid leukemia to mitochondria-damaging molecules and develop cocktails to fight the cancer. (2019-10-31)
Mitochondrial activity in lung tumors predicts response to drug inhibitor
Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new biomarker using a noninvasive imaging method that tracks mitochondrial activity in lung tumors. (2019-10-30)
Mysterious microproteins have major implications for human disease
As the tools to study biology improve, researchers are beginning to uncover details into microproteins, small components that appear to be key to some cellular processes. (2019-10-25)
Health in old age is a lifelong affair
Reduced food intake in old mice can no longer improve health. (2019-10-23)
Newly discovered protein is the permit to the powerhouse of cells
Medical University of South Carolina (MUSC) researchers report in Science Advances the discovery of a protein, P17/PERMIT, that is key to recycling aging and damaged mitochondria. (2019-10-23)
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