Current Molecule News and Events

Current Molecule News and Events, Molecule News Articles.
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Tool encoded in coronaviruses provides a potential target for COVID-19
Coronaviruses exploit our cells so they can make copies of themselves inside us. (2021-02-23)

Improving stroke treatment with a modified therapeutic molecule
A research team from the Institut national de la recherche scientifique (INRS) has improved the protective effect of a molecule against ischemic stroke, which is caused by an interruption of blood flow to the brain. The results of the study, conducted in collaboration with a Spanish team, were published in the Communications Biology of Nature Research journal. (2021-02-18)

Investigating the wave properties of matter with vibrating molecules
The working group led by Prof. Stephan Schiller, Ph.D. from Heinrich Heine University Düsseldorf (HHU) has used a novel, high-precision laser spectroscopic experiment to measure the internal vibration of the simplest molecule. This allowed the researchers to investigate the wave character of the motion of atomic nuclei with unprecedented accuracy. They present their findings in the current edition of Nature Physics. (2021-02-18)

How inflammatory signalling molecules contribute to carcinogenesis
A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signalling molecule and one of the main oncogenes. The study has been published in the leading journal 'Molecular Cancer'. (2021-02-17)

Researchers measure temperature effect of plasmon in chemical reactions using organic "sensors"
The researchers of TPU together with their colleagues from Russian and foreign scientific centers have found a way to estimate the temperature of a chemical reaction activated by pseudo-particles - plasmons. Two organic molecules served as ultra-small sensors or thermometers. (2021-02-15)

Bacterial degradation of the MYC oncogene -- a new cancer treatment strategy?
Scientists at Lund University have discovered how E. coli bacteria target and degrade the well-known oncogene MYC, which is involved in many forms of cancer. The study is now published in Nature Biotechnology. (2021-02-12)

Combination of pine scent and ozone as super source of particulate emissions
Scientists have managed to figure out why conifer forests produce so many fine particles into the atmosphere. Aerosol particles are particularly abundant when ?-pinene, the molecule responsible for the characteristic pattern of pine trees reacts with atmospheric ozone. (2021-02-11)

New way to power up nanomaterials for electronic applications
UCLA materials scientists and colleagues have discovered that perovskites, a class of promising materials that could be used for low-cost, high-performance solar cells and LEDs, have a previously unutilized molecular component that can further tune the electronic property of perovskites. (2021-02-05)

New combination therapy offers chance of healing hepatitis B
Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. (2021-02-04)

A single-molecule guide to understanding chemical reactions better
Scientists at Tokyo Institute of Technology (Tokyo Tech) report measurement of electrical conductivity of single DNA molecules as a way of monitoring the formation of double-stranded DNA on a gold surface. In their latest paper, they investigate the time evolution of the reaction and report findings not observed previously, demonstrating the suitability of the single-molecule approach in elucidating reaction pathways and exploring novel chemical processes. (2021-02-04)

Molecule from nature provides fully recyclable polymers
Plastics are among the most successful materials of modern times. However, they also create a huge waste problem. Scientists from the University of Groningen and the East China University of Science and Technology (ECUST) in Shanghai produced different polymers from lipoic acid, a natural molecule. These polymers are easily depolymerized under mild conditions. Some 87 percent of the monomers can be recovered in their pure form and re-used to make new polymers of virgin quality. (2021-02-04)

Modern anti-cancer drugs work via tiny molecular motions
Modern immunotherapeutic anti-cancer drugs support a natural mechanism of the immune system to inhibit the growth of cancer cells. They dock onto a specific receptor of the killer cell and prevent it from being switched off by the cancer cells. In a molecular dynamics study scientists from MedUni Vienna and the University of Natural Resources and Applied Life Sciences (Boku) Vienna, have analysed this mechanism for the drugs nivolumab and pembrolizumab. (2021-02-03)

Subset of COVID-19 patients have increased bleeding risk
A new potential biomarker raises concerns over the current standard for treating COVID-19 induced blood clots with high dose blood thinners. (2021-02-01)

Double delight: New synthetic transmembrane ion channel can be activated in two ways
Scientists at Tokyo Institute of Technology (Tokyo Tech) and University of Tokyo, Japan, have, for the first time, synthesized a novel artificial transmembrane ion channel--modelled on a naturally found transmembrane channel involved in neuron signaling--that responds to both chemical and electrical stimuli. Given its overall properties, this artificial channel opens doors to novel fundamental research into cellular transport and signaling, new possibilities in drug development, and the potential for new types of biosensors. (2021-02-01)

Dalian coherent light source reveals the origin of interstellar medium S2 fragments
Researchers observed the C+S2 product channel from CS2 photodissociation for the first time using a home-made Time-Sliced Velocity Map Ion Imaging (TS-VMI) experimental setup, based on the Dalian Coherent Light Source (DCLS). (2021-01-28)

An efficient tool to link X-ray experiments and ab initio theory
The electronic structure of complex molecules and their chemical reactivity can be assessed by the method of resonant inelastic X-ray scattering (RIXS) at BESSY II. However, the evaluation of RIXS data has so far required very long computing times. A team at BESSY II has now developed a new simulation method that greatly accelerates this evaluation. The results can even be calculated during the experiment. Guest users could use the procedure like a black box. (2021-01-28)

Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA
Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome, called heterochromatin, that are densely packed. Fragile X syndrome, sickle cell anemia, beta-thalassemia and other diseases are the result of genetic defects in the heterochromatin. (2021-01-27)

Identification of Oligo-DNA that promotes skeletal muscle differentiation
Skeletal muscle is the largest tissue in the human body and is responsible not only for locomotion but for energy metabolism and heat production. Myoblasts play an important role in maintaining muscle homeostasis, but it has been reported that the differentiation ability of myoblasts decreases with age and disease and this will be one of the causes of muscle atrophy. To prevent muscle atrophy, researchers of Shinshu University studied molecules that promote myoblast differentiation. (2021-01-25)

Unlocking 'the shape of water' in mechanisms of antibiotic resistance
Researchers captured and comparted hi-res images of ribosome structures from sensitive and resistant bacteria and report that a water molecule needed for antibiotic binding was not present in the ribosomes from the drug-resistant bugs. (2021-01-19)

Synthesis of potent antibiotic follows unusual chemical pathway
Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic's synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine. (2021-01-18)

A massive advance in spectrometry
Kanazawa University scientists use computer simulations of charged molecules to help improve the accuracy of mass spectrometers. By understanding the collisions between ions that reduce excess charges, this work may lead to more sensitive radiocarbon dating and medical testing. (2021-01-18)

Researchers discover potential new therapy for chemotherapy-resistant breast cancer
Scientists have discovered a molecule that can selectively kill cells of a hard-to-treat subtype of breast cancer, which could lead to a new therapy. (2021-01-18)

Scientists modeled protein behavior of archaeal viruses to crack protein folding mystery
Scientists from the Pacific Quantum Center of Far Eastern Federal University (FEFU) figured out how the AFV3-109 protein with slipknot structure folds and unfolds depending on temperature. The protein is typical for the viruses of the oldest single-celled organisms that can survive in the extreme conditions of underwater volcanic sources - archaea. The research outcome appears in PLOS ONE. (2021-01-13)

Drug combination increases susceptibility to chemotherapy in cases of severe neuroblastoma
Researchers at the University of Gothenburg now suggest a possible cure for children with hard-to-treat forms of neuroblastoma using a new combination of drugs. In a new study in the journal Cancer Research, they describe how a two small molecule-based drug combination likely inhibit the tumor's growth. (2021-01-07)

Electrons hop to it on twisted molecular wires
Osaka University scientists show how purposely introducing twists into molecular wires can improve their electrical conductivity. This work may lead to sophisticated and more ecofriendly smartphones and other electronic devices. (2020-12-29)

Regulatory RNAs promote breast cancer metastasis
A gene-regulating snippet of RNA may contribute to the spread of many breast cancers. A molecule designed to destroy that RNA prevented metastases in animal models. The same strategy could be used to develop a new breast cancer drug. (2020-12-22)

Chemists describe a new form of ice
Scientists from the United States, China, and Russia have described the structure and properties of a novel hydrogen clathrate hydrate that forms at room temperature and relatively low pressure. Hydrogen hydrates are a potential solution for hydrogen storage and transportation, the most environmentally friendly fuel. (2020-12-22)

Alzheimer's disease: regulating copper in the brain stops memory loss among mice
Alzheimer's disease is characterized by the presence of amyloid plaques1 in the patient's brain. These plaques sequester copper, and contain approximately five times as much as a healthy brain. Two CNRS scientists from the Coordination Chemistry Laboratory recently developed, with their colleagues from the Guangdong University of Technology and Shenzhen University (China), a molecule that regulates the circulation of copper in the brain. (2020-12-17)

Cancer researchers identify potential new class of drugs to treat blood and bone marrow cancers
CLEVELAND - A new study by researchers in Cleveland Clinic's Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia. The results first appeared online in Blood Cancer Discovery. (2020-12-15)

Molecule holds promise to reprogram white blood cells for better cancer treatment
Cancer immunotherapy using ''designer'' immune cells has revolutionized cancer treatment. In this type of therapy, T cells, a type of white blood cell, are collected from a patient's blood and genetically engineered to produce T cells carrying a synthetic molecule termed chimeric antigen receptor (CAR) that enables T cells to recognize and destroy cancer cells. Then these genetically modified CAR T cells are expanded and infused back to the patient. (2020-12-14)

A molecule like a nanobattery
How do molecular catalysts function, and what effects do they have? A team of chemical scientists at the University of Oldenburg has come closer to the answers using a model molecule that functions like a molecular nanobattery. It consists of several titanium centres linked to each other by a single layer of interconnected carbon and nitrogen atoms. The researchers' recently published findings combine the results of three multi-year PhD research projects. (2020-12-08)

Key building block for organic molecules discovered in meteorites
Scientists from Japan and the USA have confirmed the presence in meteorites of a key organic molecule which may have been used to build other organic molecules, including some used by life. The discovery validates theories of the formation of organic compounds in extraterrestrial environments. (2020-12-07)

Better diabetes treatment: New insulin molecule can self-regulate blood sugar
Researchers from the University of Copenhagen and biotech firm Gubra have developed a new insulin molecule that will make blood sugar regulation both easier and safer for those with type 1 diabetes. (2020-12-03)

Visualisation reveals how a protein 'hunkers down' to conserve energy
A visualisation made from nearly 100,000 electron microscope images has revealed the ingenious way a protein involved in muscle activity shuts itself down to conserve energy. The protein is called myosin and it is known as a molecular motor because of the way it interacts with other proteins and energy molecules to generate force and movement. It is found inside muscle fibres where it forms long myosin filaments made up of hundreds of individual myosin molecules. (2020-12-02)

Curtin collision models impact the future of energy
A new Curtin University-created database of electron-molecule reactions is a major step forward in making nuclear fusion power a reality, by allowing researchers to accurately model plasmas containing molecular hydrogen. (2020-12-01)

SLC25A51 regulates the transport of the coenzyme NAD into the mitochondria
Scientists at CeMM have now discovered that the previously uncharacterized protein SLC25A51 acts as a transporter into the mitochondria for the coenzyme NAD. This molecule has already been associated with processes such as aging, neurological diseases and the metabolism of cancer cells. Therefore, the results of this study not only open up new possibilities to study the biological role of NAD but also potentially provide the basis for new therapeutic approaches. (2020-12-01)

New immunotherapeutic approach takes aim at cancer's enzyme shield
A Brigham team observed that in a range of mouse models, inhibiting the protein SerpinB9 with a small molecule reduced tumor growth both by weakening the tumor's defense mechanisms and by triggering cell death in the tumors themselves. (2020-12-01)

Potential treatment against antibiotic-resistant bacteria causing gonorrhea and meningitis
A team from the Institut national de la recherche scientifique (INRS) has demonstrated the effectiveness of an inexpensive molecule to fight antibiotic-resistant strains of the bacteria responsible for gonorrhea and meningococcal meningitis. These two infections affect millions of people worldwide. The results of this research, led by Professor Frédéric Veyrier and Professor Annie Castonguay, have just been published online in the Antimicrobial Agents and Chemotherapy journal. (2020-11-24)

Guiding the way to improved solar cell performance
Small molecules could hold the key to enhancing the efficiency of organic solar cells. (2020-11-24)

Treatment shows reduction in heart failure after myocardial infarction
Researchers at Baylor College of Medicine identified potential preventative therapies for heart failure after a significant heart attack. (2020-11-24)

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