Current Morphine News and Events

Current Morphine News and Events, Morphine News Articles.
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Experimental vaccine blunts the deadliest of synthetic opioids
As the opioid epidemic raged on with an even greater force during COVID-19, the Scripps Research laboratory of chemist Kim Janda, PhD, has been working on new therapeutic interventions that may be able to prevent the bulk of deaths from opioid overdose. Janda and his team have developed experimental vaccines that have shown in rodents to blunt the deadly effects of fentanyl as well as its even more fatal cousin, carfentanil. (2021-02-04)

Legal cannabis stores linked to fewer opioid deaths in the United States
Access to legal cannabis stores is associated with a reduction in opioid related deaths in the United States, particularly those linked to synthetic opioids such as fentanyl, finds a study published by The BMJ today. (2021-01-27)

RUDN University chemist created a catalyst from orange peel for organic compounds production
N-heterocycles are organic substances used in the chemical industry and medicine. To produce them, expensive catalysts made from noble metals are used. A chemist from RUDN University developed a nanocatalyst for N-heterocycles that consists of zinc oxide and niobium and can be obtained using orange peel without any additional chemical agents. The catalyst makes the reaction almost 100% effective, thus increasing the efficiency and reducing the cost of N-heterocycles production. (2020-10-23)

Ketamine, a painkiller used by the army, does not impair tolerance to blood loss
A low dose of ketamine, administered intravenously, does not alter a healthy human's tolerance to blood loss. In other words, if someone was given ketamine to kill pain associated with a battlefield injury, they would be able to tolerate blood loss just as well as someone who did not received this pain killer. (2020-10-21)

Heroin-addicted individuals have unique brain disturbances resembling those of Alzheimer's
Herion-addicted individuals have alterations in the expression a gene called FYN - a gene known to regulate the production of Tau, a protein that is highly elevated and implicated in neurocognitive disorders like Alzheimer's disease. The study emphasizes that opioid use can affect the brain in a way that might increase vulnerability of neural systems that trigger neurodegeneration later in life; however, since these changes are epigenetic (alterations in gene function that are influenced by environmental factors and not alterations of the DNA itself), they are reversible and medications that have already been developed to target FYN for neurodegenerative disorders may be studied as a novel treatment for opioid addiction. (2020-09-14)

Opioid prescriptions for knee surgery vary widely from state to state
New research from Texas A&M University and the University of Pennsylvania on opioid prescribing practices across the country after outpatient knee surgeries found that prescription strength and number of tablets is prescribed highest in Oklahoma and lowest in Vermont. (2020-09-08)

Opioid prescription rates for knee surgery vary, but higher strength dosage common
Examining insurance data, Penn researchers found 36% of patients received an opioid prescription that was stronger than the CDC-recommended dose. (2020-08-25)

Study points out opioid risks for patients transitioning to skilled nursing facilities
Hospital patients discharged to skilled nursing facilities often bring a high-dose painkiller prescription with them, suggesting more attention should be paid to opioid safety for those patients. (2020-08-11)

Opium linked with more deaths after bypass surgery
The largest study on opium use and outcomes after bypass surgery has found that - in contrast to widely held beliefs - it is linked with more deaths and heart attacks. The research is published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC). The United Nations Office on Drugs and Crime estimates that in 2015, 17.7 million people used opiates (opium, heroin, and morphine) illicitly worldwide. (2020-07-16)

More than medicine: Pain-relief drug delivers choices for mothers in labor
Choice and control are important factors for ensuring a positive childbirth experience, yet until recently, little was known about the impact of alternative administrations of fentanyl -- one of the pain relief drugs used during labour- on both mother and baby. (2020-06-30)

Molecular simulations show how drugs block key receptors
Many pharmaceuticals work by targeting what are known as ''G-protein-coupled receptors''. In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used in new immunotherapy against cancer bind to these receptors. The researchers' calculation methods, presented in the journal Angewandte Chemie are a vital contribution to future structure-based drug design. (2020-06-24)

10 percent of patients continue to use opioids three to six months after heart surgery
Nearly 10 percent of patients who are prescribed opioid medications following heart surgery will continue to use opioids more than 90 days after the procedure, according to a new study led by researchers at Penn Medicine. The study also revealed a direct link between the dosage of opioids first prescribed following discharge and the likelihood of persistent opioid use 90 to 180 days after the procedure. (2020-06-17)

Impact of a health system's three-pronged strategy to address the opioid epidemic
In the past two decades more than 700,000 people have died from a drug overdose in the United States. In 2017, more than 68% of the drug overdose deaths involved an opioid. To help stem this epidemic, Highmark Inc. developed, implemented and evaluated a series of quality management-focused opioid interventions utilizing a three-pronged public health approach. (2020-05-27)

Heating poppy seeds, but not baking them in muffins, reduces opiate levels
You might have heard the advice to avoid eating a poppy seed bagel or muffin before a drug screen, lest you test positive for opiates. This urban legend is rooted in truth because the tiny black seeds contain small amounts of morphine and codeine that can show up in a drug test. Now, researchers reporting in ACS' Journal of Agricultural and Food Chemistry have studied how different treatments affect levels of opiates in poppy seeds. (2020-05-20)

University of Arizona researchers identify potential pathway to make opioids safer, more effective
Researchers from the UArizona College of Medicine -- Tucson Department of Pharmacology found that inhibiting heat shock protein 90 in the spinal cord enhanced the efficacy of morphine -- a finding that could be used decrease the adverse side effects of opioid therapy. (2020-05-05)

Spider venom key to pain relief without side-effects
Molecules in tarantula venom could be used as an alternative to opioid pain killers for people seeking chronic pain relief. (2020-04-13)

Opioids for chronic non-cancer pain doubled in quarter century
A review of 24 years of global research has shown opioid prescribing doubled between 1991-2015, with demand most common for chronic conditions such as chronic lower back pain, finds University of Sydney-led research. (2020-02-25)

Gluten- and casein-free diets found not to affect behavior of autistic children
The study, conducted by the Department of Psychiatry at the University of Granada, involved more than 50 children diagnosed with autism-spectrum disorders (2020-02-05)

Re-engineered plant compound treats opioid addiction in mice
The abuse of prescription and illegal opioids, such as morphine and heroin, is a major problem in the US, with devastating public health, economic and social consequences. That's why scientists are searching for new medicines to help break the cycle of addiction. Now, researchers reporting in ACS' Journal of Medicinal Chemistry have re-engineered the structure of vincamine, a plant-derived compound, so that it reduces morphine-seeking behaviors in mice.  (2020-02-05)

More than half of dental prescriptions for opioids exceed pain-management guidelines
A new study suggests that roughly half of the opioid prescriptions written by dentists in the United States exceed the 3-day supply recommended by federal dental pain-management guidelines. (2020-02-04)

New research shows more people knowingly use fentanyl
Fentanyl use by people who use drugs has doubled since 2015, and two-thirds of people are aware they've taken it, finds new research out of British Columbia, the Canadian province that has experienced the highest number of illicit drug toxicity deaths as a result of the opioid crisis. (2020-01-24)

A molecular map of the brain's decision-making area
Researchers at Karolinska Institutet have come one step closer toward understanding how the part of our brain that is central for decision-making and the development of addiction is organized on a molecular level. In mouse models and with methods used for mapping cell types and brain tissue, the researchers were able to visualize the organization of different opioid-islands in striatum. Their spatiomolecular map, published in Cell Reports, may further our understanding of the brain's reward-system. (2019-12-24)

Virtual reality illuminates the power of opioid-associated memories
The brain acts differently when remembering environments associated with drug use. (2019-12-08)

Chronic opioid treatment may raise risk of post-traumatic stress disorder, study finds
While opioids are often prescribed to treat people with trauma-related pain, a new UCLA-led study suggests doctors should use caution before prescribing the drug to those they believe may experience severe stress in the future, in order to reduce the risk the patient will develop PTSD. (2019-12-03)

Chronic opioid treatment may increase PTSD risk
Long-term (chronic) treatment with opioids, such as morphine, prior to trauma enhances fear learning in mice, according to a study published in Neuropsychopharmacology. The findings, which link chronic opioid treatment before a traumatic event with responses to subsequent stressful events, may suggest a possible mechanism underlying the frequent co-occurrence of post-traumatic stress disorder (PTSD) and opioid dependence. (2019-12-01)

Fighting opioids with an unlikely supplemental painkiller: Anti-itch medicine
West Virginia University researcher Shane Kaski is investigating whether an anti-itch medication that targets a specific part of our nerve cells can make morphine -- which targets a different part--more effective. His findings suggest it can. (2019-11-21)

Patients with advanced breast cancer are being denied access to life-prolonging drug
Survival for patients with the most common forms of advanced breast cancer could be substantially improved if both younger and older patients had access to a group of anti-cancer drugs called CDK4/6 inhibitors, according to experts at the Advanced Breast Cancer Fifth International Consensus Conference (ABC5) in Lisbon today (Saturday). (2019-11-18)

Fingerprint test can distinguish between those who have taken or handled heroin
A state-of-the-art fingerprint detection technology can identify traces of heroin on human skin, even after someone has washed their hands -- and it is also smart enough to tell whether an individual has used the drug or shaken hands with someone who has handled it. (2019-11-11)

Opioids offer minor pain relief and function benefits, but no quality of life benefit
New research presented at the 2019 ACR/ARP Annual Meeting suggests that opioids contribute no measurable benefit to quality of life or depression for patients with osteoarthritis (OA). Researchers also found only small benefits on pain and function after two to 12 weeks of treatment, and interestingly, strong opioids had consistently worse pain relief benefits and a greater risk of any safety-related outcome than weak opioids in this meta-analysis. (2019-11-09)

Black, Hispanic women report more pain postpartum but receive less opioid medication
Non-Hispanic black and Hispanic women were significantly more likely to report higher pain scores compared to non-Hispanic white women during the postpartum period. But despite higher pain scores, black and Hispanic women received significantly fewer morphine milligram equivalents (a measurement of opioids) than white patients and were significantly less likely to receive a prescription for an opioid at postpartum discharge, a new study found. The study shows black and Hispanic women experience disparities in pain management in postpartum care. (2019-11-06)

Scientists identify what may be a key mechanism of opioid addiction
Scientists at Scripps Research have discovered a molecular process in brain cells that may be a major driver of drug addiction, and thus may become a target for future addiction treatments. (2019-10-22)

Mayo Clinic study: 20% of patients are prescribed opioids after cardiac device implantation surgery
One in five patients is prescribed opioids after having a pacemaker or similar device implanted, according to a large US study conducted at Mayo Clinic published in HeartRhythm. Eighty percent of patients who were prescribed opioids had never taken them before. Investigators stress the importance of improving postoperative pain management following cardiac device procedures to reduce use of prescription opioids. (2019-10-21)

Oxygen in hyperbaric chamber provides relief after radiotherapy
Hyperbaric oxygen therapy (HBOT) can relieve self-reported symptoms and side-effects of radiotherapy against cancer in the pelvic region, a study shows. After 30-40 sessions in a hyperbaric chamber, many patients experienced reductions in bleeding, urinary incontinence, and pain alike. (2019-10-16)

Opioid Rx dosages drop 22% in Penn Medicine's NJ practices following changes to state law
The total amount of opioids dispensed per new opioid prescription decreased by 22% in Penn Medicine outpatient practices in New Jersey after the state passed a law limiting prescriptions to a five-day supply for new opioid prescriptions. Penn Medicine implemented an electronic health record (EMR) alert, or 'nudge,' to notify clinicians if that limit had been reached. (2019-10-11)

A breath test for opioids
A test to detect opioid drugs in exhaled breath has been developed by engineers and physicians at UC Davis. A breath test could be useful in caring for chronic pain patients as well as for checking for illegal drug use. (2019-10-03)

Room for improvement in drug dosage timing in hospitals
Study of 500K doses of 12 drugs led by Cincinnati Children's shows that hospitals provide medications according to staffing schedules rather than the ideal dosing times for their patients. (2019-10-01)

Patients in the US and Canada are likely to receive opioids after surgery
Patients in the United States and Canada are seven times as likely as those in Sweden to receive a prescription for opioid medications after surgery, according to a new multi-institutional study led by researchers from Penn Medicine. Though the United States and Canada had similar prescription rates, patients in the U.S. were prescribed a much higher dosage - as measured by the total morphine milligram equivalents (MME). The findings were published today in JAMA Network Open. (2019-09-04)

Discovery of anti-opioid pathway offers new route to designing safer pain medications
'A study like this makes it clear that even though we may think we know everything there is to know about the opioid response, we're actually just scratching the surface.' -- Kirill Martemyanov, PhD, Scripps Research Neuroscience Co-Chair (2019-08-16)

In worms, researchers uncover protein that may one day make opioid use safer
Studying mutant worms has led to the discovery of a receptor that reduces sensitivity to opioid side effects in these organisms. (2019-08-15)

Tiny biodegradable circuits for releasing painkillers inside the body
EPFL researchers have developed biodegradable microresonators that can be heated locally with a wireless system. Doctors could soon be using them in implants to control the release of painkillers within tissue. (2019-08-07)

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