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Current Multiple Sclerosis News and Events, Multiple Sclerosis News Articles.
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Identification of a new mechanism in the immune system provides knowledge about diseases
A recently identified mechanism in the immune system reveals a previously unknown protein that could provide an opening to a better understanding of infections and autoimmune diseases. This is shown by a new basic research study from Aarhus University, Denmark. (2020-08-04)

Stretches of repeating DNA predispose to systemic sclerosis
Researchers from the University of Tsukuba found that extended repeats of DNA in the gene FLI1 are associated with systemic sclerosis. By comparing the DNA of systemic sclerosis patients with healthy controls, they found that GA repeats over 22 are associated with the development of the disease as well as with a more severe outcome. These findings help us understand how FLI1 may contribute to the pathogenesis of systemic sclerosis. (2020-08-03)

Your brain parasite isn't making you sick -- here's why
The new discovery could have important implications for brain infections, neurodegenerative diseases and autoimmune disorders. (2020-07-30)

Stem cell 'therapy' injuries more widespread than we knew
Grotesque side effects from unproven 'stem cell' therapies are more common than we realized, reports a team of researchers led by UConn Health in Annals of Neurology on July 29. And despite the dangers, many neurologists feel ill-equipped to warn and educate their patients. (2020-07-29)

A safer cell therapy harnesses patient T cells to fight multiple myeloma
A treatment for multiple myeloma that harnesses the body's cancer-fighting T cells was safe in humans and showed preliminary signs of effectiveness, according to a clinical trial involving 23 patients with relapsed or treatment-resistant disease. (2020-07-29)

Mental fatigue of multiple sclerosis linked to inefficient recruitment of neural resources
Results of the pilot study were consistent with prior research into brain activity in response to mental fatigue, according to Dr. Genova. 'In the absence of effective treatment for the disabling fatigue of MS, it is essential to expand our understanding of these underlying brain mechanisms. Using fMRI allows us to determine how individuals with MS differ from their peers without MS in their cerebral responses to cognitive challenges, an important first step in the development of interventions to counter mental fatigue.' (2020-07-28)

New role for white blood cells in the developing brain
Whether white blood cells can be found in the brain has been controversial, and their role there a complete mystery. In a study published in Cell, an international team from the Babraham Institute, UK & VIB-KU Leuven, Belgium describe a population of specialised brain-resident immune cells discovered in the mouse and human brain, and show that the presence of white blood cells is essential for normal brain development in mice. (2020-07-22)

Restoring mobility by identifying the neurons that make it possible
Partial mobility can be restored in rodents with impaired spinal cords. Using AI, scientists can now determine the ¬cellular mechanisms responsible -- a technique that may be applicable to many biomedical problems. (2020-07-20)

Yale researchers discover potential treatment for rare degenerative disease
Yale pharmacology professor Barbara Ehrlich and her team have uncovered a mechanism driving a rare, lethal disease called Wolfram Syndrome and also a potential treatment. Their findings appear in the July 6 edition of Proceedings of the National Academy of Sciences (2020-07-16)

Simple blood test may predict concussion severity just as well as spinal tap
A blood biomarker in people who have had concussions may be just as accurate at predicting the severity of the injury and how long it will last as biomarkers that are obtained through more expensive and invasive tests, according to a study published in the July 8, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2020-07-08)

Study: Fever-associated seizures after vaccination do not affect development, behavior
Now a new study has found there is no difference in developmental and behavioral outcomes for children who have febrile seizures after vaccination, children who have febrile seizures not associated with vaccination and children who have never had a seizure. (2020-07-01)

Does deep brain stimulation for Parkinson's increase risk of dementia?
There's good news for people with Parkinson's disease. A new study shows that deep brain stimulation may not increase the risk of developing dementia. The study is published in the July 1, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2020-07-01)

Novel pathology could improve diagnosis and treatment of Huntington's and other diseases
Bristol scientists have discovered a novel pathology that occurs in several human neurodegenerative diseases, including Huntington's disease. The article, published in Brain Pathology, describes how SAFB1 expression occurs in both spinocerebellar ataxias and Huntington's disease and may be a common marker of these conditions, which have a similar genetic background. (2020-06-30)

Clinical characteristics, outcomes in patients with COVID-19, multiple sclerosis
The clinical characteristics and outcomes in patients with multiple sclerosis who contract COVID-19 are described in this observational study, which identifies factors associated with COVID-19 severity. (2020-06-26)

Survey: Alternative medicine is widespread among people with MS
A new survey of more than 1,000 people with multiple sclerosis finds that an overwhelming majority use complementary and alternative medicine, with many using cannabis. In a sign of broader societal acceptance of treatments beyond conventional medications, the survey found that patients are nine times more likely to talk with their neurologist about the use of alternative therapies than patients in a similar survey conducted in 2001. (2020-06-25)

Hookworm trial offers new hope to MS patients
Parasitic worms could offer a new treatment hope for patients suffering from the autoimmune disease multiple sclerosis, according to experts from the University of Nottingham. (2020-06-18)

Evidence lacking for drug treatment of multiple sclerosis-related cognitive impairment
There was insufficient evidence for cognitive efficacy across the spectrum of pharmacologic agents used in multiple sclerosis. 'Given the impact of cognitive dysfunction on individuals with MS, it is prudent to explore the potential for cognitive efficacy of available pharmaceuticals,'' explained Dr. Genova. ''The design of future studies, especially of DMTs, must focus on cognitive outcomes and follow standardized criteria. Randomized, controlled studies with cognition as the primary outcomes will provide clinicians with the information they need to choose optimal treatments for patients.' (2020-06-17)

Experts analyze options for treating multiple sclerosis-related cognitive impairment
'Evidence suggests that cognitive rehabilitation is effective in MS-related cognitive dysfunction, and may confer long-lasting effects,' said Dr. DeLuca. 'Access to cognitive rehabilitation therapy is likely to increase as remote options for delivery become more widely accepted, such as programs for home computers and telerehabilitation services.' Exercise training also shows promise for enhancing cognitive function. 'As studies continue to evolve, clinical applications of exercise recommendations are likely to be implemented within the next ten years.' (2020-06-16)

Treating relapsing multiple sclerosis with hookworm infection
This randomized clinical trial assessed the effect of treating patients with relapsing multiple sclerosis with a therapeutic hookworm infection compared with placebo. Some studies have suggested that gut worms induce immune responses that can protect against multiple sclerosis. (2020-06-15)

Improved gut microbiota with cholesterol-lowering medication
There is a clear link between improved gut microbiota and one of our most common cholesterol-lowering drug groups: statins. This is evident from a European study involving researchers from the University of Gothenburg. (2020-06-15)

Case series: Teriflunomide therapy in COVID-19 patients with MS
Co-authors present the cases of five multiple sclerosis patients who developed COVID-19 infection while taking the oral disease-modifying therapy teriflunomide and continued taking the medication. All five patients had favorable outcomes, with their COVID-19 taking a mild course and without experiencing relapse of their MS. (2020-06-12)

Experts clarify subtypes of multiple sclerosis to improve care and clinical trials
An international committee has clarified previously published descriptors of courses of MS and disease activity. MS subtypes are consensus definitions rather than pathologically defined phenotypes, and easily misconstrued. The clarification was prompted in part by differences in specified indications for MS therapies recently approved by the FDA and EMA. The goal is to improve care and refine the selection of clinical trial participants so that trial outcomes can better inform clinical care. (2020-06-11)

People make irrational trust decisions precisely
Online health information is deemed doubly less trustworthy if the text includes both ''shouting'' and spelling errors together, according to a new study at Brighton and Sussex Medical School (BSMS). (2020-06-10)

Fecal transplants show promise as treatment for non-alcoholic fatty liver disease
A new study from Lawson Health Research Institute and Western University suggests that fecal transplants could be used as a treatment for non-alcoholic fatty liver disease (NAFLD). The randomized controlled trial published in The American Journal of Gastroenterology found that fecal transplants in patients with NAFLD result in a reduction in how easily pathogens and other unwanted molecules pass through the human gut and into circulation, known as intestinal permeability. (2020-06-09)

Birmingham scientists 're-train' immune system to prevent attack of healthy cells
The body's immune system can be re-wired to prevent it from recognising its own proteins which, when attacked by the body, can cause autoimmune diseases like multiple sclerosis, a significant new study by UK scientists has found. (2020-06-09)

Study documents the challenges of herbicide-resistant annual bluegrass in turf
In an study featured in the journal Weed Science, researchers in Australia examined 31 populations of annual bluegrass suspected to be herbicide resistant. All 31 were found to be resistant to multiple turf herbicides. Three populations had evolved resistance to herbicides with five different mechanisms of action. (2020-06-05)

New antibody technology for monitoring MS patients may have potential in COVID-19 testing
A new study by Queen Mary University of London has demonstrated the effectiveness of using a novel light technology to monitor anti-drug antibodies in the treatment of MS, which leads to drug resistance and treatment failure. The technology has also been applied to COVID-19 for potential use in antibody testing to determine whether someone has previously been infected with the virus. (2020-06-04)

When astrocytes attack: Stem cell model shows possible mechanism behind neurodegeneration
A new study published today in Neuron led by The New York Stem Cell Foundation (NYSCF) Research Institute's Valentina Fossati, Ph.D., creates astrocytes - an integral support cell in the brain -- from stem cells and shows that in disease-like environments, these normally helpful cells can turn into neuron-killers. (2020-06-01)

New gut-brain link: How gut mucus could help treat brain disorders
Gut bacterial imbalance is linked with many neurological disorders. Now researchers have identified a common thread: changes in gut mucus. It's a new gut-brain connection that opens fresh paths for scientists searching for ways to treat brain disorders by targeting our 'second brain' - the gut. (2020-05-29)

Researchers develop new method to map cholesterol metabolism in brain
A team of researchers led by Swansea University have developed new technology to monitor cholesterol in brain tissue which could uncover its relation to neurodegenerative disease and pave the way for the development of new treatments. (2020-05-29)

Colorado tool, My-DST, may pick best multiple myeloma treatment
Response of liquid biopsies to approved drugs can help show resistance, predict response. (2020-05-28)

Biomarkers may help us understand recovery time after concussion
A blood test may help researchers understand which people may take years to recover from concussion, according to a study published in the May 27, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2020-05-27)

MS risk 29% higher for people living in urban areas, new research reveals
The research, due to be presented at the European Academy of Neurology (EAN) Virtual Congress, detected a reduced risk for MS in individuals residing in rural areas that have lower levels of air pollutants known as particulate matter (PM). It showed that the MS risk, adjusted for urbanisation and deprivation, was 29% higher among those residing in more urbanised areas. (2020-05-22)

Mechanism behind upper motor degeneration revealed
Scientists have pinpointed the electrophysiological mechanism behind upper motor neuron disease, unlocking the door to potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, such as Hereditary Spastic Paraplegia and Primary Lateral Sclerosis. (2020-05-21)

Cutting edge two-photon microscopy system breaks new grounds in retinal imaging
In a recent breakthrough, a team of HKUST scientists developed an adaptive optics two-photon excitation fluorescence microscopy using direct wavefront sensing for high-resolution in vivo fluorescence imaging of mouse retina, which allow in vivo fundus imaging at an unprecedented resolution after full AO correction. (2020-05-20)

Blood test may help predict whose MS will get worse
A blood test may help predict which people with multiple sclerosis (MS) will get worse during the following year, according to a study published in the May 20, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2020-05-20)

Animal study shows human brain cells repair damage in multiple sclerosis
A new study shows that when specific human brain cells are transplanted into animal models of multiple sclerosis and other white matter diseases, the cells repair damage and restore function. The study provides one of the final pieces of scientific evidence necessary to advance this treatment strategy to clinical trials. (2020-05-19)

Mindfulness training shows promise for people with MS
New research suggests mindfulness training may help multiple sclerosis patients in two very different ways: regulating negative emotions and improving processing speed. People with MS who underwent the four-week mindfulness training not only improved more compared to those who did nothing - they also improved compared to those who tried another treatment, called adaptive cognitive training. (2020-05-18)

CU researchers publish study on nerve cell repair in Nature Neuroscience
Researchers from the University of Colorado School of Medicine have identified a new way that cells in the central nervous system regenerate and repair following damage. In an article published in the current issue of Nature Neuroscience, scientists from CU found that precisely-timed motor learning stimulates cellular processes to improve recovery after damage to oligodendrocytes, cells that are critical for healthy neurologic function throughout life. (2020-05-18)

Not all multiple sclerosis-like diseases are alike
Scientists say some myelin-damaging disorders have a distinctive pathology that groups them into a unique disease entity. (2020-05-18)

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