Current Muscle News and Events

Current Muscle News and Events, Muscle News Articles.
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Identification of Oligo-DNA that promotes skeletal muscle differentiation
Skeletal muscle is the largest tissue in the human body and is responsible not only for locomotion but for energy metabolism and heat production. Myoblasts play an important role in maintaining muscle homeostasis, but it has been reported that the differentiation ability of myoblasts decreases with age and disease and this will be one of the causes of muscle atrophy. To prevent muscle atrophy, researchers of Shinshu University studied molecules that promote myoblast differentiation. (2021-01-25)

Exercising muscle combats chronic inflammation on its own
Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors. (2021-01-22)

Mechanism that produces rapid acceleration in clicking beetles identified
Snap-through unbending movement of the body is the main reason for the clicking beetle's fast acceleration. (2021-01-21)

NAD+ can restore age-related muscle deterioration
Scientists at EPFL have discovered that Alzheimer's-like protein aggregates underly the muscle deterioration seen in aging. But the aggregates can be reversed by boosting the levels of nicotinamide adenine dinucleotide (NAD+), which turns on the defense systems of mitochondria in cells and restores muscle function. (2021-01-19)

Well-built muscles underlie athletic performance in birds
Muscle structure and body size predict the athletic performance of Olympic athletes, such as sprinters. The same, it appears, is true of wild seabirds that can commute hundreds of kilometres a day to find food, according to a recent paper by scientists from McGill and Colgate universities published in the Journal of Experimental Biology. (2021-01-19)

How the brain paralyzes you while you sleep
Researchers from the University of Tsukuba have discovered a group of neurons in the mouse brainstem that control muscle tone. Inhibiting these neuronal cells caused mice to move during REM sleep, reminiscent of REM sleep behavior disorders. These neurons were also responsible for episodes of cataplexy in a mouse model of narcolepsy; inhibiting them reduced the number of cataplexic bouts. These circuits could thus be a new target for treating these sleep disorders. (2021-01-14)

How insects activate muscles to adapt to limbs removed
Adaptability explains why insects spread so widely and why they are the most abundant animal group on earth. Insects exhibit resilient and flexible locomotion, even with drastic changes in their body structure such as losing a limb. (2021-01-14)

Research breaks new ground in understanding how a molecular motor generates force
A team of biophysicists set out to tackle the long-standing question about the nature of force generation by myosin, the molecular motor responsible for muscle contraction. The key question they addressed - one of the most controversial topics in the field - was: how does myosin convert chemical energy, in the form of ATP, into mechanical work? The answer revealed new details into how myosin, the engine of muscle and related motor proteins, transduces energy. (2021-01-14)

Researchers identify promising model for studying human aging
The research team plans to study how the changes observed in animal models mimic the deterioration of muscle function in aging humans. (2021-01-13)

New technology reveals fast and slow twitch muscle fibers respond differently to exercise
Scientists at the University of Copenhagen have performed the most in-depth analysis of fast and slow twitch muscle fibers and the different ways they respond to exercise. Their novel approach uses large scale protein analysis of freeze-dried muscle samples, which opens the door for new analyses of muscle samples that are located in freezers around the world. (2021-01-12)

Enhanced oral uptake of exosomes opens cell therapy alternative
Cell-derived exosomes are effective in treating disease when mixed with the dominant protein in breast milk and given orally, a new Smidt Heart Institute study of laboratory mice shows. The findings, published in the peer-reviewed Journal of Extracellular Vesicles, could help develop new oral medications for treating patients with muscular dystrophy and heart failure. (2021-01-12)

Cardiac MRI shows lower degrees of myocarditis in athletes recovered from COVID-19
In a letter published in the December issue of the American Heart Association's medical journal Circulation a group of researchers at Vanderbilt University Medical Center (VUMC) dispute the most recent findings of the incidence of myocarditis in athletes with a history of COVID-19. (2021-01-08)

New strategy to fight botulinum toxin - expert available
Published research shows a new ''Trojan horse'' approach that produces strong antidotal efficacy in treating lethal botulism. (2021-01-06)

Not just a guys' club: Resistance training benefits older women just as much as older men
Sure, everything might come down to sex - but not when strength training is concerned. (2021-01-06)

3D-printed smart gel changes shape when exposed to light
Inspired by the color-changing skin of cuttlefish, octopuses and squids, Rutgers engineers have created a 3D-printed smart gel that changes shape when exposed to light, becomes ''artificial muscle'' and may lead to new military camouflage, soft robotics and flexible displays. The engineers also developed a 3D-printed stretchy material that can reveal colors when light changes, according to their study in the journal ACS Applied Materials & Interfaces. (2021-01-05)

Digging deep for differences in Duchenne muscular dystrophy
A UT Southwestern research team has catalogued gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic mutation that causes Duchene muscular dystrophy (DMD) in humans. The findings, published online recently in PNAS, could lead to new treatments for this devastating degenerative disease and insights into factors that affect muscle development. (2020-12-21)

Getting into shape pre-surgery to aid recovery for older patients - study
Older adults about to undergo elective surgery should undertake a sustained programme of targeted exercise beforehand to counteract the muscle-wasting effects of bedrest, new research suggests. (2020-12-20)

New mechanism of force transduction in muscle cells discovered
Researchers at the University of Münster (Germany) have now discovered how the muscle-specific adhesion molecule metavinculin modulates mechanical force transduction on the molecular level. The research results have just been published in the journal Nature Communications. (2020-12-18)

Resistance training paired with peanut protein affects muscle health in older adults
Researchers from Auburn University have found that when combined with resistance training, defatted peanut powder can be an effective plant-based protein option for positively affecting select markers of muscle growth and strength in untrained older adults. (2020-12-15)

Muscle cell secrets
A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are. The study, which has been published in Nature Communications, can help us better understand muscle diseases such as Duchenne muscular dystrophy. (2020-12-11)

Gene discovery could help prevent heart attacks
Doctors may be able to use the findings to identify people at high risk of coronary artery disease and to develop better treatments and preventative interventions. (2020-12-10)

Why failing hearts love hard workouts
High-intensity interval training strengthens the heart even more than moderate exercise does. Now researchers have found several answers to what makes hard workouts so effective. (2020-12-10)

Blocking protein restores strength, endurance in old mice, Stanford study finds
A single protein is a master regulator of mouse muscle function during aging, a Stanford study finds. Blocking this protein increased muscle strength and endurance in old animals. It may play a role in age-related muscle weakening in humans. (2020-12-10)

How poor oral hygiene may result in metabolic syndrome
Researchers from TMDU identified a novel mechanism by which periodontal disease may cause metabolic syndrome. By studying patients with metabolic syndrome, the researchers demonstrated high antibody titers against Porphyromonas gingivalis, the bacterium causing periodontal disease. In a mouse model, the researchers then showed that infection with this bacterium causes systemic insulin resistance and metabolic dysfunction in skeletal muscle by altering the gut microbiome. This study shows the effect periodontal disease can have on the entire body. (2020-12-08)

Grasping an object - model describes complete movement planning in the brain
Neurobiologists at the German Primate Center developed a model that for the first time can completely represent the neuronal processes from seeing to grasping an object. (2020-12-07)

Arctic ground squirrels recycle nutrients to endure deep hibernation
By studying the body chemistry of hibernating Arctic ground squirrels, researchers have found that the animals are able to recycle their body's own nutrients to survive during a long, inactive winter. A University of Alaska Fairbanks-led study monitored ground squirrels in a laboratory environment for two years, measuring the almost undetectable flow of nutrients through their hibernating bodies. Researchers found that the animals were able to convert the free nitrogen they were creating into amino acids. (2020-12-07)

Healthy muscles are a carrot on a string for healthy lungs
Scientists show effectiveness of carrot-based Japanese herbal medicine called ''Ninjin'yoeito'' in improving muscle atrophy in the hind legs of mice exposed to cigarette smoke through an increased expression of PGC-1α, positioning the medicine as a potential treatment for sarcopenia frailty-related complications with chronic obstructive pulmonary disease (COPD). Their findings were published online in the international scientific journal ''International Journal of Chronic Obstructive Pulmonary Disease'' on November 27, 2020. (2020-12-02)

Visualisation reveals how a protein 'hunkers down' to conserve energy
A visualisation made from nearly 100,000 electron microscope images has revealed the ingenious way a protein involved in muscle activity shuts itself down to conserve energy. The protein is called myosin and it is known as a molecular motor because of the way it interacts with other proteins and energy molecules to generate force and movement. It is found inside muscle fibres where it forms long myosin filaments made up of hundreds of individual myosin molecules. (2020-12-02)

Molecule that regulates muscle adaptation to exercise is discovered
An article in Cell shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency. (2020-12-01)

How thyroid function affects stress-related heart problems
Chest pain, shortness of breath, heart flutter and palpitations: these symptoms are not only characteristic of a heart attack, but can also be caused by another, as yet little researched condition. So-called Takotsubo cardiomyopathy is a rare but life-threatening disease of the heart that can occur during extreme stress events. Heart and hormone research teams in Bochum and Mannheim have now shown that there is apparently a strong link between the occurrence of Takotsubo syndrome and impaired thyroid function in patients. (2020-12-01)

Plant-based diet ramps up metabolism, according to new study
A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine. (2020-11-30)

Getting a grip on better health
Men with muscles like a young Arnold Schwarzenegger look powerful but a handshake will give away whether they're a healthy specimen - or at risk of a chronic disease or premature ageing, experts say. Medical researchers in South Australia assessed more than 600 men aged over 40 to 88 years in the Men, Androgen, Inflammation, Lifestyle, Environment, and Stress (MAILES) study to measure the link between sleep apnea and muscle mass with grip strength. (2020-11-29)

Age not just a number: Causes of joint stiffness differ between older and younger adults
As people age, joints become less flexible, causing balance problems that lower quality of life. Dr. Kosuke Hirata, Mr. Ryosuke Yamadera, and Prof. Ryota Akagi from the Shibaura Institute of Technology revealed that among younger adults, muscle but not nerve stiffness is associated with the ankle's range of motion (ROM), whereas only nerve stiffness is linked to ankle ROM among older adults. In other words, non-muscle tissue becomes more important for joint flexibility with age. (2020-11-25)

Minimal waste production is a fundamental law for animal locomotion
Is there a unifying principle underpinning animal locomotion in its rich diversity? The thermodynamic analysis shows why and how waste minimization prevails on efficiency or power maximization when it comes to free locomotion irrespective of the available mode and gaits. (2020-11-25)

The epidemiology of muscle-strengthening exercise in Europe: A 28-country comparison
A 28-country comparison of 280,605 adults reveals that just 17% of adult Europeans perform specific muscle-strengthening exercises--e.g.: squats, situps, and pushups--twice or more a week, as recommended by the WHO. (2020-11-25)

Simple measurement could transform injury rehabilitation
Researchers from Edith Cowan University in Western Australia have found a simple way to analyse the effectiveness of exercise training that could one day be conducted easily at a local gym or physio. Using vertical jumps as a test activity, the researchers could predict detailed information regarding technique and muscle activation patterns just through a relatively simple analysis of forces produced against the ground during the jump. (2020-11-19)

A bypass route for the coronary vessels in the heart?
When the heart develops, some of its coronary blood vessels develop from cells lining the inner surface of the heart's ventricular chambers (endocardium). Novel findings suggest that new blood vessel growth in the heart can be stimulated with the VEGF-B growth factor from the same source after myocardial infarction to increase blood delivery to the damaged area. (2020-11-19)

A change of heart -- new drug for HCM reduces heart mass
For the first time, a medication has impacted heart muscle thickness and function for patients with the most common inherited heart condition, hypertrophic cardiomyopathy, rather than simply addressing their symptoms. (2020-11-16)

A diet rich in ultra-processed fats and sugars increases the possibility of muscle pain
A research team from the Universitat Rovira i Virgili (Tarragona - Spain) has observed that following a diet rich in fats and sugars from ultra-processed foods (such as sweet rolls and pastries) for a six-week period increases the number of inflammatory molecules in the organism, which increases the excitability of the muscle nerves. This is known as musculoskeletal neurotransmission. (2020-11-13)

Atrophy can be combated by boosting expression of an enzyme produced in muscles
Study showed that targeted stimulation of PKA production promoted muscle growth and enhanced resistance to fatigue. (2020-11-06)

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