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Current Muscle News and Events, Muscle News Articles.
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Arctic ground squirrels recycle nutrients to endure deep hibernation
By studying the body chemistry of hibernating Arctic ground squirrels, researchers have found that the animals are able to recycle their body's own nutrients to survive during a long, inactive winter. A University of Alaska Fairbanks-led study monitored ground squirrels in a laboratory environment for two years, measuring the almost undetectable flow of nutrients through their hibernating bodies. Researchers found that the animals were able to convert the free nitrogen they were creating into amino acids. (2020-12-07)

Healthy muscles are a carrot on a string for healthy lungs
Scientists show effectiveness of carrot-based Japanese herbal medicine called ''Ninjin'yoeito'' in improving muscle atrophy in the hind legs of mice exposed to cigarette smoke through an increased expression of PGC-1α, positioning the medicine as a potential treatment for sarcopenia frailty-related complications with chronic obstructive pulmonary disease (COPD). Their findings were published online in the international scientific journal ''International Journal of Chronic Obstructive Pulmonary Disease'' on November 27, 2020. (2020-12-02)

Visualisation reveals how a protein 'hunkers down' to conserve energy
A visualisation made from nearly 100,000 electron microscope images has revealed the ingenious way a protein involved in muscle activity shuts itself down to conserve energy. The protein is called myosin and it is known as a molecular motor because of the way it interacts with other proteins and energy molecules to generate force and movement. It is found inside muscle fibres where it forms long myosin filaments made up of hundreds of individual myosin molecules. (2020-12-02)

Molecule that regulates muscle adaptation to exercise is discovered
An article in Cell shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency. (2020-12-01)

How thyroid function affects stress-related heart problems
Chest pain, shortness of breath, heart flutter and palpitations: these symptoms are not only characteristic of a heart attack, but can also be caused by another, as yet little researched condition. So-called Takotsubo cardiomyopathy is a rare but life-threatening disease of the heart that can occur during extreme stress events. Heart and hormone research teams in Bochum and Mannheim have now shown that there is apparently a strong link between the occurrence of Takotsubo syndrome and impaired thyroid function in patients. (2020-12-01)

Plant-based diet ramps up metabolism, according to new study
A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine. (2020-11-30)

Getting a grip on better health
Men with muscles like a young Arnold Schwarzenegger look powerful but a handshake will give away whether they're a healthy specimen - or at risk of a chronic disease or premature ageing, experts say. Medical researchers in South Australia assessed more than 600 men aged over 40 to 88 years in the Men, Androgen, Inflammation, Lifestyle, Environment, and Stress (MAILES) study to measure the link between sleep apnea and muscle mass with grip strength. (2020-11-29)

Age not just a number: Causes of joint stiffness differ between older and younger adults
As people age, joints become less flexible, causing balance problems that lower quality of life. Dr. Kosuke Hirata, Mr. Ryosuke Yamadera, and Prof. Ryota Akagi from the Shibaura Institute of Technology revealed that among younger adults, muscle but not nerve stiffness is associated with the ankle's range of motion (ROM), whereas only nerve stiffness is linked to ankle ROM among older adults. In other words, non-muscle tissue becomes more important for joint flexibility with age. (2020-11-25)

Minimal waste production is a fundamental law for animal locomotion
Is there a unifying principle underpinning animal locomotion in its rich diversity? The thermodynamic analysis shows why and how waste minimization prevails on efficiency or power maximization when it comes to free locomotion irrespective of the available mode and gaits. (2020-11-25)

The epidemiology of muscle-strengthening exercise in Europe: A 28-country comparison
A 28-country comparison of 280,605 adults reveals that just 17% of adult Europeans perform specific muscle-strengthening exercises--e.g.: squats, situps, and pushups--twice or more a week, as recommended by the WHO. (2020-11-25)

Simple measurement could transform injury rehabilitation
Researchers from Edith Cowan University in Western Australia have found a simple way to analyse the effectiveness of exercise training that could one day be conducted easily at a local gym or physio. Using vertical jumps as a test activity, the researchers could predict detailed information regarding technique and muscle activation patterns just through a relatively simple analysis of forces produced against the ground during the jump. (2020-11-19)

A bypass route for the coronary vessels in the heart?
When the heart develops, some of its coronary blood vessels develop from cells lining the inner surface of the heart's ventricular chambers (endocardium). Novel findings suggest that new blood vessel growth in the heart can be stimulated with the VEGF-B growth factor from the same source after myocardial infarction to increase blood delivery to the damaged area. (2020-11-19)

A change of heart -- new drug for HCM reduces heart mass
For the first time, a medication has impacted heart muscle thickness and function for patients with the most common inherited heart condition, hypertrophic cardiomyopathy, rather than simply addressing their symptoms. (2020-11-16)

A diet rich in ultra-processed fats and sugars increases the possibility of muscle pain
A research team from the Universitat Rovira i Virgili (Tarragona - Spain) has observed that following a diet rich in fats and sugars from ultra-processed foods (such as sweet rolls and pastries) for a six-week period increases the number of inflammatory molecules in the organism, which increases the excitability of the muscle nerves. This is known as musculoskeletal neurotransmission. (2020-11-13)

Atrophy can be combated by boosting expression of an enzyme produced in muscles
Study showed that targeted stimulation of PKA production promoted muscle growth and enhanced resistance to fatigue. (2020-11-06)

USask researchers find face masks don't hinder breathing during exercise
A new University of Saskatchewan (USask) study has found that exercise performance and blood and muscle oxygen levels are not affected for healthy individuals wearing a face mask during strenuous workouts. (2020-11-05)

Researchers study strength-training gender gap, possible solutions
Strength training is an important part of any exercise routine, but some women may not be getting the recommended hours. New Penn State research discovered some of the barriers preventing women from strength training, as well as some solutions to overcoming those obstacles. (2020-11-05)

Muscle pain and energy-rich blood: Cholesterol medicine affects the organs differently
Contrary to expectation, treatment with statins has a different effect on blood cells than on muscle cells, a new study from the University of Copenhagen reveals. Today, statins are mainly used in the treatment of elevated cholesterol, but the new results may help design drugs for a number of conditions. (2020-10-29)

A patch that could help heal broken hearts
According to the American Heart Association, heart disease is the leading cause of death worldwide in recent years. During a heart attack, or myocardial infarction (MI), a blocked artery and the resulting oxygen deprivation cause massive cardiac cell death, blood vessel impairment and inflammation. Now, researchers reporting in ACS Biomaterials Science & Engineering have developed a cardiac patch with tiny engineered blood vessels that improved recovery from MI in rats and pigs. (2020-10-28)

Brazilian researchers discover how muscle regenerates after exercise
Adaptation of muscle tissue to aerobic exercise alters the metabolism of muscle stem cells, helping them recover from injury. Findings may contribute to treatment of cachexia, sarcopenia and other conditions associated with lean mass loss. (2020-10-28)

Low quantity and quality of muscle predicts poor outcomes in colon cancer surgery
New study suggests interventions to help patients build muscle before surgery may improve their outcomes (2020-10-27)

Study reinforces drug's potential to treat hypertrophic cardiomyopathy
WSU research sheds new light on a molecule that may be used to treat heart conditions that can lead to stroke, heart attack and other forms of heart disease. (2020-10-27)

Identified a subgroup of stem cells that resists ageing and maintains muscle regeneration
For the first time the researchers have demonstrated in a study in mice that not all muscle stem cells age equally, and have identified a subgroup with greater regenerative capacity which is maintained until geriatric age. The finding provides a basis for mitigating the loss of muscle regenerative capacity in very elderly people. (2020-10-27)

Exercising one arm has twice the benefits
New research from Edith Cowan University (ECU) has revealed that training one arm can improve strength and decrease muscle loss in the other arm - without even moving it. The findings could help to address the muscle wastage and loss of strength often experienced in an immobilised arm, such as after injury, by using eccentric exercise on the opposing arm. (2020-10-22)

Scientists identify compound that stimulates muscle cells in mice
UCLA researchers have identified a compound that can reproduce the effect of exercise in muscle cells in mice. The findings are published in the journal Cell Reports Medicine. (2020-10-21)

New dimensions in the treatment of muscle spasticity after stroke and nervous system defects
Chronic muscle spasticity after nervous system defects like stroke, traumatic brain and spinal cord injury, multiple sclerosis and painful low back pain affect more than 10% of the population, with a socioeconomic cost of about 500 billion USD. Currently, there is no satisfying remedy to help these suffering people, which generates an immense medical need for a new generation antispastic drug. Drug candidate MPH-220 could mean new hope for millions of patients suffering from spasticity. (2020-10-16)

Research demonstrates a molecular dance that keeps your heart beating
New research demonstrates a molecular dance that keeps your heart beating. The findings could someday lead to improved diagnostics and medical treatments for serious and sometimes devastating hereditary heart conditions. (2020-10-14)

Study provides new hope for children suffering from rare muscle diseases
Stephen Greenspan and Laura Zah were devastated when they learned their son Alexander had a rare genetic mutation, which causes a deadly neuromuscular disease with no known treatment or cure. But the results of an international study, led by researchers from Monash University in Australia, provides renewed hope for children suffering from the progressive and devastating muscle disease. (2020-10-13)

Skeletal muscle development and regeneration mechanisms vary by gender
Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice. This was not observed in male mice that lacked the ERβ gene, suggesting that estrogen and its downstream signals may be a female-specific mechanism for muscle growth and regeneration. (2020-10-12)

Damaged muscles don't just die, they regenerate themselves
Researchers building a model of muscle damage in a cultured system found that components leaking from broken muscle fibers activate ''satellite cells,'' which are muscle stem cells. While attempting to identify the activating proteins, they found that metabolic enzymes, such as GAPDH, rapidly activated quiescent satellite cells and accelerated muscle injury regeneration. This is a highly rational and efficient regeneration mechanism, in which the damaged muscle itself activates satellite cells for regeneration. (2020-10-12)

New research provides fresh hope for children suffering from rare muscle diseases
Results of an international study published today in Autophagy and led by researchers from Monash University, School of Biological Sciences, provides renewed hope for children suffering from a progressive and devastating muscle disease. (2020-10-09)

Understanding the progress of viral infections
A team of researchers at the Institute for the Genetics of Heart Diseases at Münster University created a viral expression model that can be used to simulate and analyse a large number of viral infections - including the one with SARS-CoV-2. The results are published in the journal ''Scientific Reports''. (2020-10-08)

RTL1 gene a likely culprit behind temple and Kagami-Ogata syndromes
Researchers from Tokyo Medical and Dental University (TMDU) have found that Rtl1, which is a mouse ortholog of the human RTL1 gene, appears to be the major gene responsible for muscle and placental defects in models of Temple and Kagami-Ogata syndromes, which are serious genetic conditions. Theirs is the first study to demonstrate that a domesticated gene that is specific to placental mammals plays an important role in fetal and neonatal muscle development. (2020-10-06)

Cannabinoids associated with negative respiratory health effects in older adults with COPD
Cannabinoids, a class of prescription pills that contain synthetically-made chemicals found in marijuana, are associated with a 64 per cent increase in death among older adults with chronic obstructive pulmonary disease (COPD), according to the first published data on the impact of cannabinoids on the respiratory health of individuals with the lung disease. (2020-09-30)

Measuring muscle strength provides insights regarding weakness in older adults
Isokinetic dynamometry is a major tool in the measurement of muscle strength in the fields of sports medicine, orthopedic and neurological rehabilitation and exercise physiology. Its use in older individuals now extends far beyond orthopedics to such conditions as chronic obstructive pulmonary disease (COPD) and stroke. In a collection of articles published in Isokinetics and Exercise Science, experts address its validity, reliability and responsiveness in older adults. (2020-09-30)

Exosome treatment improves recovery from heart attacks in a preclinical study
Research in pigs shows that using the exosomes naturally produced from a mixture of heart muscle cells, endothelial cells and smooth muscle cells -- which were all derived from human induced pluripotent stem cells -- yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells. (2020-09-29)

Lockdown impact: Worsening symptoms for people with bone, joint and muscle pain
A new study reveals the impact of lockdown for people with bone, joint and muscle pain. It finds that the majority of people with musculoskeletal pain reported increased symptoms. And those who experienced most social isolation and loneliness were less likely to access healthcare. The findings are the result of a survey of more than 600 people across the UK to see how people with bone, joint and muscle pain coped in lockdown. (2020-09-25)

Blood vessel growth in muscle is reduced in women after menopause
A new study from the University of Copenhagen's Department of Nutrition, Exercise and Sports demonstrates that formation of small blood vessels is impaired in the muscle tissue of postmenopausal women. The study's findings highlight the importance of physical activity for women prior to and during menopause, as a means to prevent the development of disease later in life. (2020-09-22)

Exercise before menopause is important to optimise health in later years
The small blood vessels in muscles of women after menopause are less able to grow compared to young women, according to new research published today in the Journal of Physiology. This means exercising before menopause is all the more important for women in order to develop blood vessels in muscles, and thus the ability to develop muscle strength. (2020-09-22)

Shared protein fingerprint could simplify treatment of common inherited heart disease
University of Wisconsin-Madison scientists discovered that many different genetic mutations result in surprisingly similar changes to heart muscle proteins in patients with the most severe manifestations of hypertrophic cardiomyopathy. (2020-09-22)

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