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Current Muscle News and Events, Muscle News Articles.
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New method to grow and transplant muscle stem cells holds promise for treatment of MD
Satellite cells are stem cells found in skeletal muscles. While transplantation of such muscle stem cells can be a potent therapy for degenerative muscle diseases such as Duchenne muscular dystrophy, these cells tend to lose their transplantation efficiency when cultured in vitro. In a study in the current issue of the Journal of Neuromuscular Diseases, researchers treated these stem cells with leukemia inhibitory factor, which effectively maintained the undifferentiated state of the satellite cells and enhanced their transplantation efficiency. (2016-06-28)

Hypertrophic cardiomyopathy under-appreciated cause of sudden cardiac death in male minority athletes
Sudden deaths in young, seemingly healthy competitive athletes are tragic events. In a new study published in The American Journal of Medicine, investigators report that more than one-third of recorded cardiovascular deaths were caused by hypertrophic cardiomyopathy, the majority in young male minority athletes. Sudden deaths due to genetic and/or congenital heart diseases are uncommon in females, but relatively common in African-American and other minorities compared to whites. (2016-06-27)

Stem cell therapy as a potential treatment for severe burns patients
Scientists have discovered a new way to potentially treat muscle regeneration in patients with severe burns according to a study published today in The Journal of Physiology. (2016-06-27)

Intervening during scar process could help cardiac patients, reviewers say
Targeting non-muscle cells in the heart responsible for cardiac scarring could lead to new treatments for heart disease, international researchers say. (2016-06-24)

Longevity and human health may be linked to a muscle cell enzyme
Exercise and fasting do not change the location of a key enzyme involved in energy production, a study in Experimental Physiology found. (2016-06-23)

The absence of a single protein spurs muscle aging in mice
IRB Barcelona researchers discover that the loss of the protein Mitofusin 2 in the muscles of young mice speeds up aging and causes early sarcopenia, thus leading to the muscle quality of aged mice. Sarcopenia, which is muscle wastage and the accompanied loss of strength, is one of the most weakening conditions of old age and it has no treatment. The scientists propose that stimulating Mitofusin 2 activity would provide a good strategy through which to ameliorate sarcopenia. (2016-06-22)

Get a clue: Biochemist studies fruit fly to understand Parkinson's disease, muscle wasting
By studying the fruit fly, Kansas State University researchers have found a connection between a gene called clueless and genes that cause Parkinson's disease. (2016-06-22)

UTSW study finds new enzyme with structure that could explain how heart can beat optimally
The heart is the only muscle that contracts and relaxes continuously over a lifetime to pump oxygen-rich blood to the body's organs. Researchers at UT Southwestern Medical Center now have identified a previously unrecognized enzyme that could optimize contraction and lead to new strategies to treat heart failure. (2016-06-20)

Exercise may be the simple solution for rescuing seniors' lost and injured muscle
Exercise may have some surprising benefits for seniors who experience rapid muscle loss and muscle injury and loss as they age. Researchers at McMaster University have found that physical activity can help retain, even repair and regenerate damaged muscle in the elderly. The findings challenge what is generally seen as an inevitable fact of life: that muscle atrophy and damage cannot be completely repaired in old age and in some cases lost altogether. (2016-06-20)

Exercise may have therapeutic potential for expediting muscle repair in older populations
Here's another reason why you should hit the gym regularly as you grow older: A new report appearing online in The FASEB Journal shows that regular exercise plays a critical role in helping muscles repair themselves as quickly as possible after injury. After only eight weeks of exercise, old mice experienced faster muscle repair and regained more muscle mass than those of the same age that had not exercised. (2016-06-17)

Lab-grown nerve cells make heart cells throb
Researchers at Johns Hopkins report that a type of lab-grown human nerve cells can partner with heart muscle cells to stimulate contractions. Because the heart-thumping nerve cells were derived from induced pluripotent stem cells, the researchers believe the cells -- known as sympathetic nerve cells -- will allow them to grow nerve cells that replicate nervous system diseases in particular patients'. (2016-06-16)

Bone hormone boosts muscle performance during exercise but declines with age
When we exercise, our bones produce a hormone called osteocalcin that increases muscle performance, according to a study publishing June 14 in a Cell Metabolism special issue on aging. Osteocalcin naturally declines in humans as we age, beginning in women at age 30 and in men at age 50. This study describes the first bone-derived hormone known to affect exercise capacity and shows that osteocalcin injections can reverse the age-related exercise capacity decline in mice. (2016-06-14)

Overcome strength-training plateau with accentuated eccentric loading
Many experienced strength trainers try to overcome a plateau by trying to adapt their strength program, however this is sometimes ineffective. In just five weeks accentuated eccentric loading training considerably improved results for experienced strength-trainers, a study recently published in Frontiers in Physiology found. (2016-06-14)

Discovery of molecular protection linked to a degenerative neuromuscular disease
In individuals with this disease, muscle cells and motor neurons die over the years because they accumulate a protein that is mutated. Researchers at IRB Barcelona discover that this protein has a self-protective mechanism through which the deleterious effects of the mutation are delayed. (2016-06-10)

One snake's prey is another's poison: Scientists pinpoint genetics of extreme resistance
Joel McGlothlin's team found that the ancestors of garter snakes gained toxin-resistant nerves almost 40 million years ago. (2016-06-09)

Using Lake Michigan turtles to measure wetland pollution
Decades of unregulated industrial waste dumping in areas of the Great Lakes have created a host of environmental and wildlife problems. Now it appears that Lake Michigan painted and snapping turtles could be a useful source for measuring the resulting pollution. (2016-06-09)

Myocardial infarction: Rush-hour for neutrophils
Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have shown that circadian oscillations in the influx of immune cells into the damaged tissue play a crucial role in exacerbating the effects of an acute heart attack in the early morning hours. (2016-06-08)

Challenges of custom-engineering living tissue to fix a heart
Jianyi 'Jay' Zhang, M.D., Ph.D., works to create new tissue that can replace or protect damaged muscle after a heart attack. He and colleagues offer perspectives on that in a paper in Science Translational Medicine, and he shares his plans to bioengineer heart tissue cell-by-cell. (2016-06-08)

Long after heart attack, chymase inhibitors could extend cell survival
Cardiologists generally agree that if someone has a heart attack, the window of opportunity to intervene closes within hours, because heart muscle dies and doesn't come back. A longer period may exist when it is feasible to amplify the heart's attempts to heal itself, researchers from Emory University School of Medicine have discovered. (2016-06-06)

Cell insights shed light on how muscle-wasting disease takes hold
Insights into how our cells control muscle development could aid understanding of muscular dystrophy and other inherited diseases. (2016-06-02)

Pulmonary artery stiffening is an early driver of pulmonary hypertension
In this issue of JCI Insight, a team led by Laura Fredenburgh of Brigham and Women's Hospital shows that alterations in pulmonary arterial stiffness occur early during disease and promote vascular remodeling by altering signaling mediated by prostaglandins, a class of hormones that regulate inflammation, smooth muscle contraction, and vasoconstrictoin. (2016-06-02)

Differences in how ALS affects eye and limb muscles act as clue
In an effort to better understand what happens during Amyotrophic Lateral Sclerosis (ALS), researchers at Umea University in Sweden have compared the impact of ALS on the eye and limb muscles. They have focused on specific proteins that are important for muscle-nerve contacts. The eye muscles appear to be better equipped to maintain their muscle-nerve contacts and are thereby less affected. (2016-06-02)

Scientific breakthrough in sports nutrition to change the game for endurance athletes
Breakthrough research, to be presented today at the American College of Sports Medicine's Annual Meeting and published in the Journal of the American Medical Athletic Association later this month, has led to the development of a revolutionary new sports shot, HOTSHOTâ„¢, that is scientifically proven to prevent and treat muscle cramps by stopping them where they start: at the nerve. (2016-06-02)

New muscular dystrophy drug target identified
Scientists at the University of Liverpool have discovered that muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair. This finding provides a new target for potential drug treatments for the disease, which currently has no cure. (2016-06-01)

New insights into muscular dystrophy point to potential treatment avenues
Certain stem cells in our bodies have the potential to turn into either fat or muscle. Experiments in mice suggest prospective drugs that manipulate these cells' fate could make it possible to relieve many of the symptoms of muscular dystrophy. (2016-06-01)

Researchers suggest whole-person perspective is needed to assess obesity
Authors from the Cleveland Clinic's Bariatric and Metabolic Institute recommend physicians use obesity staging models to recognize and manage weight-related health issues that may not be captured by traditional diagnosis criteria. The review article was published in the Journal of the American Osteopathic Association. (2016-05-31)

Cells engineered from muscular dystrophy patients offer clues to variations in symptoms
Johns Hopkins researchers report they have inadvertently found a way to make human muscle cells bearing genetic mutations from people with Duchenne muscular dystrophy. (2016-05-26)

New disease gene will lead to better screening for pediatric heart disease
Cardiomyopathy, or a deterioration of the ability of the heart muscle to contract, generally leads to progressive heart failure. It is frequently inherited, and, because approximately 40 percent of children born with it are likely to die within five years of diagnosis, being able to identify its genetic basis is particularly important. Now, an international team of researchers has identified a new disease gene which is implicated in the development of severe pediatric cardiomyopathies. (2016-05-23)

Calcium channels team up to activate excitable cells
Voltage-gated calcium channels open in unison, rather than independently, to allow calcium ions into and activate excitable cells such as neurons and muscle cells, researchers with UC Davis Health System and the University of Washington have found. (2016-05-18)

Simple screening test can predict heart failure severity
It is now recognized that sarcopenia, defined as the loss of muscle mass and strength, is related to heart failure. Recent research from Kumamoto University, Japan has shown that heart failure severity could be diagnosed by using a simple sarcopenia screening test that assesses age, grip strength and calf circumference. (2016-05-17)

Experimental drug against hepatitis C slows down Zika virus infection in mice
Virologists from KU Leuven, Belgium, have shown that an experimental antiviral drug against hepatitis C slows down the development of Zika in mice. The research team was led by Professor Johan Neyts from the Laboratory of Virology and Chemotherapy. (2016-05-17)

Pitchers risk greater injury if MLB cuts time between pitches, researchers warn
Proposed rule changes by Major League Baseball, designed to speed up the game by reducing time between pitches, could lead to a spike in arm injuries as players have less time to recover between throws, say researchers who have analyzed the impact of fatigue. (2016-05-16)

Another reason for wine lovers to toast resveratrol
Red wine lovers have a new reason to celebrate. Researchers have found a new health benefit of resveratrol, which occurs naturally in blueberries, raspberries, mulberries, grape skins and consequently in red wine. (2016-05-13)

UC College of Medicine researcher receives $1.7 million grant to study cardiac hypertrophy
A new $1.7 million National Institutes of Health grant will help University of Cincinnati researchers continue their investigation of the protein Human Antigen R and its possible role in cardiovascular disease, with the ultimate goal of translating this research to improve human health. (2016-05-13)

Scientists find what might be responsible for slow heart function under general anesthesia
Anesthesia is used every day, but surprisingly little is known about one of its most dangerous side effects -- depressed heart function. Now, thanks to a team of Johns Hopkins researchers who published a new research article in The FASEB Journal, this mystery is clarified... (2016-05-12)

CNIC researchers discover the molecular mechanisms that produce the heart's contractile structure
The study opens new horizons for the study of striated muscle physiology by unveiling the molecular mechanisms that control the structural identity of the cardiac and skeletal tissues. (2016-05-10)

MSU scientists put some muscle behind their research
Michigan State University researchers used an old-fashioned neurobiology technique to explore new avenues for treatments to reverse a late-onset neurodegenerative disease that robs men of the capacity to walk, run, chew and swallow. (2016-05-06)

Processed fat cells show potential as treatment for refractory ischemia patients
Patients treated with processed autologous adipose-derived regenerative cells injected into the heart muscle demonstrated symptomatic improvement and a trend towards lower rates of heart failure hospitalizations and angina, despite no improvement in left ventricle ejection fraction or ventricular volumes. (2016-05-05)

Identification of a gene signature associated with dilated cardiomyopathy
A study in this issue of JCI Insight identifies a gene signature that characterizes the transition from dilated cardiomyopathy to heart failure. (2016-05-05)

Ultrasound-estimated fat content in muscles may be an indicator of physical health
Ultrasound-estimated percent intramuscular fat of muscles in the lower extremity was inversely associated with physical activity level and positively associated with body mass index in a recent study. (2016-05-03)

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