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Current Muscle News and Events, Muscle News Articles.
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Extended rest between weight lifting sets could help muscle growth
Researchers from the University of Birmingham have found that extended rest intervals between sets of weight-lifting could help with muscle growth. (2016-05-03)

Research on modern day animals reveals insights into extinct animals
Powerful head and neck retractions of vertebrate carcasses, including dinosaur fossils, have puzzled researchers as to whether they occurred just before an animal's death in agony, or after. Now experiments performed in the wild on large ostrich chick cadavers show that they occur post-mortem. (2016-05-03)

Less body fat for toddlers taking vitamin D
A healthy intake of vitamin D in the first year of life appears to set children up to have more muscle mass and less body fat as toddlers, according to a new study published in the journal Pediatric Obesity. The findings emerged from research initially aimed at confirming the importance of vitamin D for bone density. The additional benefit in terms of body composition came as a surprise for the research team. (2016-05-02)

Scientists turn skin cells into heart cells and brain cells using drugs
In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals. All previous work on cellular reprogramming required adding external genes to the cells, making this accomplishment an unprecedented feat. The research lays the groundwork for one day being able to regenerate lost or damaged cells with pharmaceutical drugs. (2016-04-28)

Breakthrough in the treatment of inherited genetic disease
Scientists at the Universities of York and Leiden have made a significant breakthrough in the treatment of an inherited genetic disorder which damages muscle and nerve cells in the body. (2016-04-28)

'Walk-DMC' aims to improve surgery outcomes for children with cerebral palsy
A University of Washington mechanical engineer has developed a new assessment of motor control in children with cerebral palsy which could help predict which patients are -- or are not -- likely to benefit from invasive surgical interventions. (2016-04-27)

UMMS scientists identify genes that control smooth muscle contraction
Researchers at UMass Medical School have identified a new molecular pathway critical for maintaining the smooth muscle tone that allows the passage of materials through the digestive system. (2016-04-22)

Confused cells lead to genetic disorders like heart problems, premature aging
It has been disorienting to the scientific and medical community as to why different subtle changes in a protein-coding gene causes many different genetic disorders in different patients -- including premature aging, nerve problems, heart problems and muscle problems. no other gene works like this. According to a new study, co-authored by Binghamton University faculty Eric Hoffman, it has to do with cell 'commitment.' (2016-04-21)

Higher muscle mass associated with lower mortality risk in heart disease patients
Research finds that cardiovascular disease patients who have high muscle mass and low fat mass have a lower mortality risk than those with other body compositions. The findings also suggest that regardless of a person's level of fat mass, a higher level of muscle mass helps reduce the risk of early death. This research could explain the 'obesity paradox,' which holds that people with a higher BMI have lower mortality levels. (2016-04-21)

Murine models of arrhythmogenic cardiomyopathy benefit from GSK3β inhibition
In this issue of JCI Insight, investigators led by Jeffrey Saffitz of Harvard Medical School and Daniel Judge of John's Hopkins School of Medicine show that the GSK3β inhibitor SB2 benefits two murine models of arrhythmogenic cardiomyopathy. (2016-04-21)

Micro heart muscle created from stem cells
Scientists at the Gladstone Institutes have invented a new way to create three-dimensional human heart tissue from stem cells. The tissue can be used to model disease and test drugs, and it opens the door for a precision medicine approach to treating heart disease. Although there are existing techniques to make three-dimensional tissues from heart cells, the new method dramatically reduces the number of cells needed, making it an easier, cheaper, and more efficient system. (2016-04-20)

Technique could help identify patients who would suffer chemo-induced heart damage
Doxorubicin is a chemotherapy drug used to treat many cancers, but it causes serious heart damage in some patients. Heart muscle cells made from the skin cells of breast cancer patients can be used to study this phenomenon. (2016-04-18)

UCLA scientists reveal how osteopontin ablation ameliorates muscular dystrophy
Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper published in The Journal of Cell Biology. The study, 'Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype' by Joana Capote and colleagues, adds support to the idea that osteopontin inhibitors could be used to treat patients with Duchenne muscular dystrophy. (2016-04-18)

AAN updates guidelines: Botulinum toxin for spasticity, headache, other brain disorders
The American Academy of Neurology has updated its 2008 guidelines on the use of botulinum toxin for spasticity, cervical dystonia, blepharospasm and migraine headache, based on recent research. The guideline is published in the April 18, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology, and will be presented at the 68th AAN Annual Meeting in Vancouver, Canada, April 15 to 21, 2016. (2016-04-18)

IOF Committee of National Societies Medal awarded to Dr. Elias Hanna Saba
Dr. Elias Hanna Saba, Chief Executive Director of the Palestinian Osteoporosis Prevention Society, was awarded the International Osteoporosis Foundation's Committee of National Societies Medal during the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. (2016-04-17)

Sarcopenia, which affects up to 20 percent of European seniors, may increase 63 percent by 2045
Sarcopenia is a disease associated with the ageing process. Hallmark signs of the disorder are loss of muscle mass and strength, which in turn affects balance, gait and overall ability to perform tasks of daily living. This study assessed the prevalence of sarcopenia in Europe, finding that, when using the definition providing the highest prevalence estimates, the number of individuals with sarcopenia in Europe will rise by 63.8 percent in 2045. (2016-04-16)

Scientists discover how to control heart cells using a laser
Scientists from MIPT's Laboratory of the Biophysics of Excitable Systems have discovered how to control the behaviour of heart muscle cells (cardiomyocytes) using laser radiation; this study will help scientists to better understand the mechanisms of the heart and could ultimately provide a method of treating arrhythmia. The paper has been published in the journal PLOS ONE. (2016-04-13)

Testosterone therapy decreases hospital readmissions in older men with low testosterone
A new large-scale population-based study from The University of Texas Medical Branch at Galveston showed for the first time that older men using testosterone therapy were less likely to have complications that require them to go back to the hospital within a month of being discharged than men not using this therapy. The study is currently available in Mayo Clinic Proceedings. (2016-04-13)

Tropical birds develop 'superfast' wing muscles for mating, not flying
Studies in a group of tropical birds have revealed one of the fastest limb muscles on record for any animal with a backbone. The muscle, which can move the wing at more than twice the speeds required for flying, has evolved in association with extravagant courtship displays that involve rapid limb movements, according to a paper to be published in the journal eLife. (2016-04-12)

Face- and eye-muscle research sheds new light on Duchenne muscular dystrophy
Researchers at Basel University Hospital in Switzerland investigate the biochemical and physiological characteristics of orbicularis oculi, a group of facial muscles that control the eyelids and are selectively spared or involved in different neuromuscular disorders. What they found also helps to explain why another set of muscles -- the extraocular muscles that control the movement of the eye -- are not affected by Duchenne muscular dystrophy, congenital muscular dystrophy, and aging. (2016-04-11)

Same immune-system proteins may first giveth, then taketh away motor control
Princeton University researchers have found that a family of proteins with important roles in the immune system may be responsible for fine-tuning a person's motor control as they grow -- and for their gradual loss of muscle function as they age. The research potentially reveals a biological cause of weakness and instability in older people, as well as a possible future treatment that would target the proteins specifically. (2016-04-11)

Many ICU patients trade critical illness for new illness, ICU-acquired weakness
A new study found that some patients who suffer from muscle weakness six months after ICU discharge demonstrate persistent muscle wasting, even when the biologic functions that commonly cause muscles to atrophy have returned to normal. (2016-04-08)

Ivacaftor improves smooth muscle function in cystic fibrosis patients
In this issue of JCI Insight, David Stoltz of the University of Iowa and colleagues provide evidence that CTFR dysfunction directly alters the elasticity and blood supply of the airway. (2016-04-07)

Protein SIRT5 linked to healthy heart function
Cornell researchers, working in collaboration with scientists in Switzerland, have identified a strong connection between a protein, SIRT5, and healthy heart function. SIRT5 has the ability to remove a harmful protein modification known as lysine succinylation, which robs the heart of its ability to burn fatty acids efficiently to generate the energy needed for pumping. (2016-04-07)

Study examines impact of 2 new antibodies in causing, treating myasthenia gravis
A study of patients from across the nation with myasthenia gravis is helping determine the incidence of two new antibodies believed to cause the disease, and whether these patients need different treatment strategies. (2016-04-05)

Heart failure patients have improved outcomes following investigational stem cell treatment
An investigational stem cell therapy derived from patients' own blood marrow significantly improved outcomes in patients with severe heart failure, according to a study from the Cedars-Sinai Heart Institute. (2016-04-04)

Protein-rich diet tied to improved physical function during weight loss
New research published in the Journal of Gerontology: Medical Sciences shows that eating more protein from foods like lean beef, as part of a reduced-calorie diet, can help obese older adults with limited ability to exercise to lose weight and increase physical function. This new research, supported by the Beef Checkoff, contributes to the growing body of evidence that shows lean beef and other high-quality protein foods are beneficial for health, including overweight and obese people looking to reduce weight. (2016-04-04)

Statin intolerance objectively identified in patients
In the first major trial of its kind, Cleveland Clinic researchers used a blinded rechallenge with atorvastatin or placebo to objectively confirm the presence of muscle-related symptoms in patients with a history of intolerance to multiple statins and found that evolocumab (a PCSK9 inhibitor) was a more effective option to lower cholesterol than ezetimibe in these patients. (2016-04-03)

Trial offers objective evidence of muscle-related side effects with statins
The first major clinical trial to include a blinded, placebo-controlled 'statin re-challenge' in patients with a history of muscle-related side effects sheds new light on statin-associated muscle symptoms, according to research presented at the American College of Cardiology's 65th Annual Scientific Session. (2016-04-03)

Cholesterol lowering therapies for patients with muscle-related statin intolerance
Steven E. Nissen, M.D., of the Cleveland Clinic, and colleagues identified patients with muscle-related adverse effects from statins and compared lipid-lowering efficacy for two nonstatin therapies, ezetimibe and evolocumab. The study was published online by JAMA, and is being released to coincide with its presentation at the American College of Cardiology's 65th Annual Scientific Session & Expo. (2016-04-03)

In some men, taking testosterone while dieting may help lose fat, not muscle
In obese middle-aged men, losing weight while dieting normally depletes both fat and muscle. But adding testosterone treatment may help them lose only fat and retain their muscle, new research suggests. The study results will be presented in a poster Saturday, April 2, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston. (2016-04-03)

Growing skin in the lab
Using reprogrammed iPS cells, scientists from the RIKEN Center for Developmental Biology in Japan have, along with collaborators from Tokyo University of Science and other Japanese institutions, successfully grown complex skin tissue -- complete with hair follicles and sebaceous glands -- in the laboratory. (2016-04-01)

Motor learning tied to intelligent control of sensory neurons in muscles
Sensory neurons in human muscles provide important information used for the perception and control of movement. Learning to move in a novel context also relies on the brain's independent control of these sensors, not just of muscles, according to a new study published in the journal Current Biology. (2016-03-31)

$1 million grant from NASA funds research on astronauts' loss of muscle strength
A $1 million grant from NASA will allow UH researchers to examine changes in astronauts' muscle strength and function during extended space flights. Investigators want to know if the decline eventually levels off, a finding that would inform preparations for missions to Mars. (2016-03-31)

Exercise keeps muscles -- and you -- young: Study
A University of Guelph professor has uncovered the 'secret' to staying strong as we age -- superb fitness. Geoff Power found elderly people who were elite athletes in their youth or later in life -- and who still compete as masters athletes -- have much healthier muscles at the cellular level compared to those of non-athletes. (2016-03-30)

Questions over safety of whole body electrical stimulation
It's time to regulate the use of whole body electrical stimulation, argue doctors in The BMJ today, after treating several people for muscle damage at their hospital. (2016-03-30)

Tsukuba scientists solve Spallanzani's dilemma
Imagine losing an eye, an arm or even your spinal cord. When we are wounded, our bodies, and those of other mammals, generally respond by sealing the wound with scar tissue. The newt, however, has evolved unique strategies that allow it to repeatedly regenerate lost tissues, even as an adult. (2016-03-30)

Decoding sugar molecules offers new key for combating muscular dystrophy
A group of Japanese scientists have succeeded in decoding a sugar molecule and clarifying a mechanism linked to muscular dystrophy. Their discovery has potential implications for muscular dystrophy treatment. The results of their research were published in the journal Cell Reports on Feb. 25, 2016. (2016-03-29)

'Transient contractions' in urinary bladder may lead to therapeutic interventions for bladder dysfunction
Researchers at the University of Vermont College of Medicine have made a discovery that helps explain how we know when to empty our bladders and may lead to new therapeutic interventions for bladder dysfunction. The study, 'Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling,' by Thomas J. Heppner et al., appears in the April issue of The Journal of General Physiology. (2016-03-28)

Scientific secrets for successful aging?
OIST researchers and collaborators identify age-related differences in human blood metabolites. (2016-03-28)

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