Current Mutations News and Events

Current Mutations News and Events, Mutations News Articles.
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B cells continue to work against SARS-CoV-2 months after infection, but do not recognize mutant
A new analysis of B cells and more than 1,000 different monoclonal antibodies from 8 patients with COVID-19 shows that, contrary to previous hypotheses, protective B cell responses to the SARS-CoV-2 spike protein remain stable and continue to evolve over a 5-month period, many months after the initial period of active viral replication. (2021-02-23)

Toxins from one bacterial species contribute to genetic diversity of others
A toxin produced by bacteria as a defence mechanism causes mutations in target bacteria that could help them survive. (2021-02-23)

UIC researchers invent new gene-editing tool
Researchers have discovered a new gene-editing technique that allows for the programming of sequential cuts -- or edits -- over time. (2021-02-23)

New technique reveals switches in RNA
Scientists at the University of Groningen (The Netherlands), in collaboration with colleagues from the University of Torino (Italy), have developed a method to visualize and quantify alternative structures of RNA molecules. These alternative RNA 'shapes' can have important functional relevance in viruses and bacteria. The method was used to identify a conserved structural switch in the RNA of the SARS-CoV-2 virus. (2021-02-22)

Don't focus on genetic diversity to save our species
Scientists at the University of Adelaide have challenged the common assumption that genetic diversity of a species is a key indicator of extinction risk. Published in the journal PNAS, the scientists demonstrate that there is no simple relationship between genetic diversity and species survival. But, Dr João Teixeira and Dr Christian Huber from the University of Adelaide's School of Biological Sciences conclude, the focus shouldn't be on genetic diversity anyway, it should be on habitat protection. (2021-02-22)

CovMT: Tracking virus mutations across the world
An interactive platform helps users visualize where SARS-CoV-2 mutations start, how wide they spread and how infectious they are. (2021-02-21)

Spina bifida can be caused by uninherited genetic mutations
Genetic mutations which occur naturally during the earliest stages of an embryo's development can cause the severe birth defect spina bifida, finds a new experimental study in mice led by UCL scientists. (2021-02-19)

Metabolic mutations help bacteria resist drug treatment
MIT researchers have identified a new class of mutations that help bacteria develop antibiotic resistance. In a study of E. coli, they discovered that mutations to genes involved in metabolism can help bacteria to evade the toxic effects of several different antibiotics. (2021-02-18)

Genotoxic E. coli 'caught in the act'
Max Planck researchers and their collaborators reveal transformation of colon organoids in vitro. (2021-02-17)

Cosmetic laser may boost effectiveness of certain anti-cancer therapies
In mice treated with cancer immunotherapy, shining a cosmetic laser on a tumor boosted the therapy's effectiveness. The strategy stimulated the immune system to attack nonmutated proteins on the tumor. The findings may help investigators make cancer immunotherapy effective against currently incurable cancers. (2021-02-17)

Study demonstrates the reasons to screen children with cancer for inherited cancer genes
Experts at MSK Kids, the pediatric oncology program at MSK, have found that inherited cancer genes are more common than expected in children with cancer. (2021-02-16)

Asthma may heighten flu risk and cause dangerous mutations
A subtype of asthma in adults may cause higher susceptibility to influenza and could result in dangerous flu mutations. University of Queensland-led animal studies have found that paucigranulocytic asthma (PGA) - a non-allergic form of the condition - allows the flu virus to flourish in greater numbers in sufferers. (2021-02-16)

Going the distance--insights into how cancer cells spread
In a study published in Nature Communications, cancer researchers at Kanazawa University identify mechanisms by which malignant tumor cells extend their toxicity to distinct cell types and in turn help them spread. (2021-02-12)

Liquid biopsy for colorectal cancer could guide therapy for tumors
A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor. Such a biopsy can detect lingering disease and could serve as a guide for deciding whether a patient should undergo further treatments due to some tumor cells evading an initial attempt to eradicate the cancer. (2021-02-12)

Researchers develop platform to identify cancer mutations that may be responsive to drug therapies
A Cleveland Clinic-led team of researchers has developed a personalized genomic medicine platform that will help advance accelerate genomic medicine research and genome-informed drug discovery, according to new study results published recently in Genome Biology. (2021-02-08)

New AI tool can thwart coronavirus mutations
USC computer scientists used AI to create a new tool that rapidly identifies potential solutions to coronavirus mutations and screens vaccines much faster to give humans an advantage over the contagion. (2021-02-05)

Study highlights risk of new SARS-CoV-2 mutations emerging during chronic infection
SARS-CoV-2 mutations similar to those in the B1.1.7 UK variant could arise in cases of chronic infection, where treatment over an extended period can provide the virus multiple opportunities to evolve, say scientists. (2021-02-05)

Solving a puzzle
University of New Mexico scientists tease out the underlying mechanism of tuberous sclerosis complex (2021-02-03)

The underestimated mutation potential of retrogenes
mRNA molecules from retrogenes are reverse transcribed to DNA and incorporated into the genome. (2021-02-02)

UTEP researchers make discoveries to better understand SARS-CoV-2 virus
An effort led by Lin Li, Ph.D., assistant professor of physics at The University of Texas at El Paso, in collaboration with students and faculty from Howard University, has identified key variants that help explain the differences between the viruses that cause COVID-19 and Severe Acute Respiratory Syndrome (SARS). (2021-02-02)

Warmer climate may make new mutations more harmful
A warmer global climate can cause mutations to have more severe consequences for the health of organisms through their detrimental effect on protein function. This may have major repercussions on organisms' ability to adapt to, and survive in, the altered habitats of the future. This is shown in a new Uppsala University research study now published in the scientific journal Proceedings of the Royal Society B. (2021-02-02)

Minority patients miss out on cystic fibrosis drugs due to genetic test limitations
There is an impassioned debate taking place in medicine on whether race-based considerations should be a factor in research, diagnoses, or treatments. (2021-02-02)

Larger panel finds more gene mutations, treatment targets for leukemia
A gene panel that looks for about 10 times the number of cancer-causing genes as panels currently used to diagnose and fine tune treatment for a variety of cancers is effective at identifying problematic genes in the most common leukemia, Medical College of Georgia investigators report. (2021-02-01)

Stem cell study illuminates the cause of a devastating inherited heart disorder
Penn Medicine scientists have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM)-- one of multiple congenital disorders caused by inherited mutations in a gene called LMNA. The scientists used stem cell techniques to grow human heart muscle cells containing DCM-causing mutations in LMNA. They found that these mutations severely disrupt the structural organization of DNA in the nucleus of heart muscle cells. (2021-02-01)

Glitch in genome architecture may cause B-cell malignancies
Restoring an enzyme that maintains the way chromosomes are packed inside cells may lead to new therapies for some blood cancers, according to a new study by Columbia researchers. (2021-02-01)

BioNTech-Pfizer mRNA vaccine largely effective against UK variant, Sera from 40 patients show
In a study evaluating the BioNTech-Pfizer COVID-19 vaccine's ability to neutralize the B.1.1.7 ('UK') viral variant, researchers found no loss of immune protection compared to that against the original Wuhan reference strain. (2021-01-29)

New technique identifies important mutations behind Lynch Syndrome
A Michigan Medicine team describes a method for screening so-called genetic variants of uncertain significance in the hopes of identifying those mutations that could cause cancer. (2021-01-29)

Researchers use patients' cells to test gene therapy for rare eye disease
Scientists at the National Eye Institute (NEI) have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood. A form of Leber congenital amaurosis, the disease is caused by autosomal-dominant mutations in the CRX gene, which are challenging to treat with gene therapy. (2021-01-28)

Rare genetic syndrome identified, caused by mutations in gene SATB1
Variations in the gene SATB1 have been shown to cause a rare genetic syndrome. Different variations across the gene lead to varied effects on the cell, leading to a difference in the severity of neurodevelopmental disorders. Discovery of this genetic syndrome is hoped to provide information to families and individuals affected by SATB1-syndrome. (2021-01-28)

VCU technology could upend DNA sequencing for diagnosing certain DNA mutations
Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities. However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy. (2021-01-27)

Germline whole exome sequencing reveals the potential role of hereditary predisposition and therapeutic implications in small cell lung cancer, a tobacco-related cancer
A study presented today by Dr. Nobuyuki Takahashi of the Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, Md. at the IASLC World Conference on Lung Cancer Singapore demonstrates that small cell lung cancer (SCLC) may have an inherited predisposition and lays the foundation for understanding the interaction between genotype and tobacco exposure in exacerbating SCLC risk as well as potential therapeutic implications (2021-01-27)

Mapping mutations that escape antibodies against COVID-19 suggests prior mapping incomplete
A new approach to mapping viral mutations that 'escape' leading clinical antibodies has revealed mutations in the SARS-CoV-2 virus that allow it to evade treatments, including a single amino-acid mutation that fully escapes Regeneron's antibody cocktail. (2021-01-25)

Potential combined drug therapy for lung cancer
Researchers at Kanazawa University report in Clinical Cancer Research that in the most common type of lung cancer, certain secondary mutations occurring with another gene alteration known as ALK make the efficacy of alectinib, an otherwise commonly used drug for treating lung cancer, become unfavorable. Combining alectinib with another kind of drug can overcome this adverse effect, however. (2021-01-22)

Study updates breast cancer risk estimates for women with no family history
A new multi-institution study led by Fergus Couch, Ph.D., a Mayo Clinic pathologist, provides more accurate estimates of breast cancer risk for U.S. women who harbor inherited mutations in breast cancer predisposition genes. The findings of the CARRIERS Consortium study, published Jan. 20 in The New England Journal of Medicine, may allow health care providers to better assess the risk of breast cancer in women ? many of whom have no family history of breast cancer. (2021-01-21)

Early breeding reduced harmful mutations in sorghum
A new Cornell University study found that harmful mutations in sorghum landraces - early domesticated crops - decreased compared to their wild relatives through the course of domestication and breeding. (2021-01-20)

Researchers discover mechanism behind most severe cases of a common blood disorder
G6PD deficiency affects about 400M people worldwide and can pose serious health risks. Now, researchers think they've found the cause of the most severe cases, which could finally lead to treatments. (2021-01-19)

Filling a crucial gap in aquafarming: ion beam breeding to the rescue
Researchers at RIKEN, Japan successfully created a larger strain of zooplankton by creating mutations with a heavy ion beam, which contributes to improving the survival rate and growth of juvenile fish in aquaculture. (2021-01-15)

Algorithms designed to study language predict virus 'escape' mutations for SARS-CoV-2 and others
By bridging the conceptual divide between human language and viral evolution, researchers have developed a powerful new tool for predicting the mutations that allow viruses to 'escape' human immunity or vaccines. (2021-01-14)

Model analyzes how viruses escape the immune system
MIT researchers have devised a way to computationally model viral escape, using models that were originally developed to model language. The model can predict which sections of viral surface proteins, including those of influenza, HIV, and SARS-CoV-2, are more likely to mutate in a way that allows the virus to evade the human immune system. It can also identify sections that are less likely to mutate, making them good targets for new vaccines. (2021-01-14)

Ukraine genome survey adds missing pieces to human diversity puzzle
The largest study of genetic diversity in Ukraine was published in the open science journal GigaScience. Led by researchers at Uzhhorod National University and Oakland University in the US, the work provides genetic understanding of the historic and pre-historic migration settlements in one of the key intersections of human trade and migration between the Eurasian peoples and identifies genetic variants of medical interest in the Ukrainian population that differ from other European populations. (2021-01-13)

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