Current Narcolepsy News and Events

Current Narcolepsy News and Events, Narcolepsy News Articles.
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Sleep disorders: Patients often underestimate their total sleep time
People with sleep disorders commonly have a misperception about their actual sleep behaviour. A research group from MedUni Vienna's Department of Neurology analysed polysomnography results to identify the types of sleep disorder that are associated with a discrepancy between self-reported and objective sleep parameters and whether there are any factors that influence this. The main finding: irrespective of age, gender or screening setting, insomnia patients are most likely to underestimate how long they sleep. (2021-01-28)

How the brain paralyzes you while you sleep
Researchers from the University of Tsukuba have discovered a group of neurons in the mouse brainstem that control muscle tone. Inhibiting these neuronal cells caused mice to move during REM sleep, reminiscent of REM sleep behavior disorders. These neurons were also responsible for episodes of cataplexy in a mouse model of narcolepsy; inhibiting them reduced the number of cataplexic bouts. These circuits could thus be a new target for treating these sleep disorders. (2021-01-14)

Journal of Clinical Sleep Medicine collection highlights 15 years of scientific discovery
Editors of the Journal of Clinical Sleep Medicine have identified some of the most significant articles in the publication's history, publishing new commentaries on them in a special 15th anniversary collection. The 15 commentaries from associate editors and members of the journal's editorial board describe the impact of the selected articles both at the time of their publication and today. (2021-01-14)

Narcolepsy drug did not increase risk of fetal malformation
Modafinil is used to treat conditions such as narcolepsy. Reports have associated the drug with an increased risk of malformation in babies born to mothers who had taken it while pregnant. Now, a large registry study involving over two million pregnant women in Sweden and Norway shows that there is no such association. The study, which is published in JAMA, was conducted by researchers at Sweden's Karolinska Institutet and the Norwegian Institute of Public Health. (2020-09-01)

Swine flu vaccination in pregnant women did not increase risk of autism in offspring
Two recent studies were unable to rule out that H1N1 ('swine flu') vaccination ('Pandemrix') and seasonal influenza vaccination given to pregnant women might be associated with autism-spectrum disorder in the offspring. Now, a large study by researchers at Karolinska Institutet in Sweden, published in the journal Annals of Internal Medicine, refutes any such association. (2020-08-31)

Meditation-relaxation therapy may offer escape from the terror of sleep paralysis
Sleep paralysis - a condition thought to explain a number of mysterious experiences including alleged cases of alien abduction and demonic night-time visits - could be treated using a technique of meditation-relaxation, suggests a pilot study published today. (2020-08-12)

Celiac disease might be cured by restoring immune tolerance to gliadin
Celiac disease affects 0.3-2.4% of people in most countries world-wide, and approx. 2% in Finland. Celiac patients suffer from a variety of symptoms, typically intestinal complaints, such as diarrhea, but are often symptom-free. Immunologist Tobias Freitag co-developed and tested nanoparticles containing gliadin for the immunomodulatory treatment of celiac disease in Professor Seppo Meri's research group at the University of Helsinki, in collaboration with industry. (2020-02-27)

The brain may actively forget during dream sleep
In a study of mice, a team of Japanese and US researchers show that REM sleep may be a time when the brain actively forgets. Their results suggest that forgetting during sleep may be controlled by neurons found deep inside the brain that were previously known for making an appetite stimulating hormone. (2019-09-19)

New proof that narcolepsy is an autoimmune disease
Researchers from the University of Copenhagen have discovered autoreactive cells in persons suffering from narcolepsy. This is a new, important proof that the sleep disorder is an autoimmune disease. This knowledge may lead to better treatment of the chronic condition, the researchers behind the new discovery believe. (2019-03-15)

Injury to a parent can lead to sleep issues in children and teens
When children face an unsettling experience, such as the injury of a parent, it can alter their sleep habits, according to new research being presented at the 2018 American Academy of Pediatrics National Conference & Exhibition. (2018-11-02)

The BMJ questions transparency of information surrounding safety of Pandemrix vaccine
An investigation published by The BMJ today raises fundamental questions about the transparency of information surrounding the safety of GlaxoSmithKline's Pandemrix vaccine used in 2009-2010. (2018-09-20)

One of the most popular ADHD drugs may cause hallucinations and other psychotic symptoms
One of the most popular ADHD drugs may cause hallucinations and other psychotic symptoms. Research published in the SJCAPP says that possible adverse symptoms may affect 1.1 percent -- 2.5 percent of ADHD patients treated with methylphenidate. (2018-08-22)

A wakefulness molecule is abundant in the brains of heroin addicts
Researchers have discovered that the brains of heroin addicts harbor a greater number of neurons that produce hypocretin, a molecule involved in arousal and wakefulness, and one lacking in abundance in people with narcolepsy. In mice with narcolepsy, these researchers went on to show, administering morphine -- an opioid similar. (2018-06-27)

Change in brain cells linked to opiate addiction, narcolepsy
Two discoveries -- one in the brains of people with heroin addiction and the other in the brains of sleepy mice -- shed light on chemical messengers in the brain that regulate sleep and addiction. (2018-06-27)

Study of sleeping fur seals provides insight into the function of REM sleep
All land mammals and birds have two types of sleep: rapid eye movement (REM) and non-REM (also called slow-wave sleep). Earlier evidence had suggested that REM sleep is essential for physical and mental well-being and learning, but the underlying function of REM sleep has been a mystery. Now researchers reporting in Current Biology on June 7 have new insight into the function of REM sleep, based on studies of an unlikely animal: the fur seal. (2018-06-07)

Study points to potential misuse/abuse of ADHD drugs
A new British Journal of Clinical Pharmacology study indicates that methylphenidate, a central nervous system stimulant approved to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy, may be subject to misuse and/or abuse. (2018-03-07)

Sleepless in Latin America: Blind cavefish, extreme environments and insomnia
A study led by researchers from Florida Atlantic University has found that differences in the production of the neuropeptide Hypocretin, previously implicated in human narcolepsy, may explain variation in sleep between animal species, or even between individual people. It may also provide important insight into the evolution of sleep and how we might build a brain that does not need to sleep. (2018-02-06)

To sleep or not: Researchers explore complex genetic network behind sleep duration
Scientists have identified differences in a group of genes they say might help explain why some people need a lot more sleep -- and others less -- than most. The study, conducted using fruit fly populations bred to model natural variations in human sleep patterns, provides new clues to how genes for sleep duration are linked to a wide variety of biological processes. (2017-12-14)

The risk of type 1 diabetes not increased by swine flu vaccine Pandemrix
There has been a fear that the swine flu vaccine, Pandemrix, would increase the risk of autoimmune diseases other than narcolepsy. However, a new study of children from Sweden and Finland shows that the vaccine increased neither the risk of developing autoantibodies against insulin-producing beta cells nor the occurrence of type 1 diabetes. (2017-10-09)

Wake-promoting compound validated
Narcolepsy, a serious sleep disorder in which patients often fall asleep uncontrollably, has been incurable because no effective therapeutic agents are available to date. Recent findings by Japanese scientists in the sleep institute may shed light on this challenging problem. (2017-05-29)

Identification of the neuronal suppressor of cataplexy, sudden weakening of muscle tone
Narcolepsy is a disorder caused by losing orexin neurons, marked by excessive daytime sleepiness and cataplexy, sudden weakening of muscle tone. Previously, we found two kinds of neurons preventing narcolepsy by receiving information from orexin neurons. Here, we have discovered that serotonin neuron, one of the two neurons above, inhibits cataplexy by reducing the amygdala activity, which controls emotion. Current discovery should lead to comprehension of the narcolepsy mechanism and to therapy development for cataplexy. (2017-05-13)

Research shows exercise is a boon for cancer patients
Exercise and/or psychological therapy work better than medications to reduce cancer-related fatigue and should be recommended first to patients, according to a Wilmot Cancer Institute-led study published in JAMA Oncology. (2017-03-02)

BIDMC scientists survey the state of sleep science
Sleep remains an enduring mystery with major clinical relevance, according to a review by Thomas Scammell, M.D., of Beth Israel Deaconess Medical Center (BIDMC) and colleagues. In recent decades, new technologies have allowed neuroscientists to identify multiple brain circuits that govern the sleep/wake cycle, as well as the factors that can influence it, such as caffeine and light. But the brain's complexity is still a stumbling block in understanding this ubiquitous and necessary animal behavior. Their review appeared today in the journal Neuron. (2017-02-22)

Targeted therapy for sleep disorders helps patients with muscular dystrophy
Myotonic dystrophy type 1 (DM1) is the most common adult muscular dystrophy, and many patients with DM1 suffer from various sleep and respiratory disorders. In a study in the current issue of the Journal of Neuromuscular Diseases, researchers found that because there is wide range of sleep problems, treatments do not fit a 'one size fits all' model. (2017-01-13)

Drug for narcolepsy could help food addicts lose weight
Overweight people could be given help with the discovery that a drug used for sleep disorder could also reduce the impulse for food. (2016-12-13)

ADHD medication linked to slightly increased risk of heart rhythm problems
Use of methylphenidate in children and young people with ADHD is associated with a slightly increased risk of abnormal heart rhythm (arrhythmia) shortly after the start of treatment, suggests research published by The BMJ today. (2016-05-31)

Latest sleep research to be presented June 11-15 at APSS annual meeting in Denver
Sleep clinicians and scientists from around the world will discuss current practices in sleep medicine and the latest findings in sleep and circadian research at SLEEP 2016, the 30th anniversary meeting of the Associated Professional Sleep Societies LLC, which will be held June 11-15 at the Colorado Convention Center in Denver. (2016-05-24)

Enhancing sleep after brain injury reduces brain damage and cognitive decline in rats
Enhancing sleep after a head injury may help prevent some damage to brain cells, according to a study in rats published March 23 in The Journal of Neuroscience. Researchers at University Hospital of Zurich, Switzerland found that enhancing the slow-wave cycle of sleep after head trauma minimized damage to axons -- the thin extensions that nerve cells use to send signals to other cells -- and helped preserve normal brain function. (2016-03-22)

Individuals' medical histories predicted by their noncoding genomes, Stanford study finds
Identifying mutations in the control switches of genes can be a surprisingly accurate way to predict a person's medical history, researchers at the Stanford University School of Medicine have found. (2016-02-04)

Is being a morning person in your DNA?
23andMe, Inc., the leading personal genetics company, today announced the results of one of the largest genome-wide association studies of its kind, identifying genetic variants associated with being a morning person. Published in Nature Communications the study identified 15 locations in DNA (loci) associated with 'morningness.' (2016-02-02)

Stanford researchers find sleep gene linked to heart failure
Researchers at the Stanford University School of Medicine have identified a gene that, when working properly, appears to reduce the risk of heart failure and improve treatment outcomes, highlighting a possible target for the development of new drugs. (2015-11-30)

Stanford study: Immune response to a flu protein yields new insights into narcolepsy
An international team of researchers has found some of the first solid evidence that narcolepsy may be a so-called 'hit-and-run' autoimmune disease. (2015-07-01)

Children with TBI have poorer sleep quality and more daytime sleepiness
A new study suggests that children with traumatic brain injuries have poorer sleep and more daytime sleepiness in comparison to healthy children. (2015-06-08)

Latest sleep research to be presented June 7 - 10 at APSS annual meeting in Seattle
Sleep clinicians and scientists from around the world will discuss current practices in sleep medicine and the latest findings in sleep and circadian research at SLEEP 2015, the 29th annual meeting of the Associated Professional Sleep Societies LLC (APSS), which will be held June 7-10 at the Washington State Convention Center in Seattle. (2015-05-19)

How does Adderallâ„¢ work? (video)
More than 25 million people rely on Adderallâ„¢ and other similar drugs to help treat narcolepsy, depression and attention deficit and hyperactivity disorder. But how does amphetamine, the active ingredient in Adderallâ„¢, work? This week, Reactions explains how amphetamine helps you focus. Check out the video here: https://youtu.be/MeJRBsghMt8. (2015-05-11)

A real eye-opener: Narcolepsy bears classic autoimmune hallmarks
Narcoleptics suffer from bouts of sleepiness and sleep attacks, which impair their ability to function in daily life, but the precise cause of narcolepsy has long eluded scientists. Now a new study from the world's leading autoimmune disease expert, Tel Aviv University's professor Yehuda Shoenfeld, finds that narcolepsy bears the hallmarks of a classic autoimmune disorder and should be treated accordingly. (2015-03-09)

Many teens with clinical excessive daytime sleepiness test positive for marijuana
A new study shows that many adolescents with excessive daytime sleepiness consistent with a clinical diagnosis of narcolepsy test positive for marijuana, emphasizing the importance of drug screening when interpreting diagnostic sleep studies for teens. (2015-02-18)

Marijuana use is associated with excessive daytime sleepiness in adolescents
Ten percent of adolescents sent to a Sleep Center for evaluation of excessive daytime sleepiness with testing results consistent with narcolepsy had urine drug screens positive for marijuana -- 43 percent of children with urine drug screens positive for marijuana actually had test results consistent with narcolepsy or abnormal REM sleep patterns. (2015-02-13)

Sleep researchers at SRI International identify promising new treatment for narcolepsy
Neuroscientists at SRI International have found that a form of baclofen, a drug used to treat muscle spasticity, works better at treating narcolepsy than the best drug currently available when tested in mice. SRI Biosciences research scientists present a mouse model of narcolepsy that mimics the human disorder better than other models currently in use. The new narcolepsy model was used to investigate a novel therapeutic pathway and to identify a promising way of treating narcolepsy. (2014-05-07)

Anti-swine flu vaccination linked to increased risk of narcolepsy in young adults
Pandemrix is an influenza vaccination, created in 2009 to combat H1N1, known as Swine Flu. Now, a team of Swedish clinicians testing the vaccine for links to immune-related or neurological diseases have linked Pandemrix to an increased risk of narcolepsy in young adults. (2014-01-21)

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