Current Neuroblastoma News and Events

Current Neuroblastoma News and Events, Neuroblastoma News Articles.
Sort By: Most Relevant | Most Viewed
Page 1 of 8 | 320 Results
Drug combination increases susceptibility to chemotherapy in cases of severe neuroblastoma
Researchers at the University of Gothenburg now suggest a possible cure for children with hard-to-treat forms of neuroblastoma using a new combination of drugs. In a new study in the journal Cancer Research, they describe how a two small molecule-based drug combination likely inhibit the tumor's growth. (2021-01-07)

VRK1: a protein that reduces the survival of patients with neuroblastoma
Researchers have characterised the function of VRK1 in neuroblastoma tumour cells and have determined that this protein is essential for tumour cell growth and proliferation. ''By studying the expression of this protein in tumours, we were able to identify a priori patients where tumour progression is going to be worse, even in groups where current tools do not predict that behaviour,'' notes Francisco M. Vega. (2020-12-11)

Reductive stress in neuroblastoma cells aggregates protein and impairs neurogenesis
Cells require a balance among oxidation-reduction reactions, or redox homeostasis. Loss of that balance to create oxidative stress is often associated with neurodegeneration. Less is known about how loss of that balance at the other end of the spectrum -- reductive stress -- may affect neurons. Now researchers show for the first time that reductive stress promotes protein aggregation in neuroblastoma cells and impairs neurogenesis. (2020-12-08)

Early trial hints CAR T cells may combat solid tumors in children with neuroblastoma
A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue. (2020-11-25)

New immunotherapy shows promise against rare childhood cancer
A novel CAR T-cell therapy developed by researchers at UCL and designed to target cancerous tumours, has shown promising early results in children with neuroblastoma, a rare form of childhood cancer. (2020-11-25)

Researchers uncover crucial gene for growth of Ewing sarcoma
Researchers have discovered a gene that is critical for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues. Exploring the pharmacological inhibition of RING1B as a clinical therapy to treat Ewing sarcoma could open the door for new treatments for the rare disease. (2020-10-23)

Researchers mine data and connect the dots about processes driving neuroblastoma
St. Jude Children's Research Hospital scientists lead genome analysis to better understand one of the most common childhood solid tumors. (2020-10-14)

Therapy using immune system cells preserves vision in mice implanted with rare eye cancer
A treatment that uses immune system T cells, combined with an immune-boosting drug packaged in an injectable gel, was found to preserve the vision of mice implanted with retinoblastoma tissue. The cancer, which is most commonly diagnosed in infants and young children, is treatable in early stages but can still lead to the loss of vision in about 5% of cases. (2020-10-12)

CAR NKT cells offer a promising novel immunotherapy for solid tumors
Natural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have been developed into a novel form of immunotherapy to treat patients with cancer. (2020-10-12)

Promising treatment for aggressive childhood cancer
A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine. (2020-10-06)

MAX binding with the variant Rs72780850 in RNA helicase DDX1 for susceptibility to neuroblastoma
The researchers adopted the functional polymorphism research strategy to screen out the functional polymorphisms associated with neuroblastoma in Chinese population and elucidate its mechanism, providing data on children susceptible to neuroblastoma in China. (2020-09-11)

NUS researchers develop new system for accurate telomere profiling in less than 3 hours
The novel STAR assay developed by NUS researchers can be used to rapidly determine telomere dysregulation in cancers and age-related diseases in clinical settings. This helps clinicians to make faster diagnosis and plan targeted treatments for patients. (2020-08-25)

New treatment developed by CHOP shows success in high-risk solid tumors
In a breakthrough study, researchers at Children's Hospital of Philadelphia (CHOP) have shown that an enhanced treatment developed in their lab leads to long-term remissions in 80% to 100% of mice with drug-resistant or high-risk solid tumors. The research, which could soon lead to clinical trials, is described in Cancer Research, a journal of the American Association for Cancer Research. (2020-08-24)

Blocking copper uptake in tumor cells may be clue to boosting immune system
Australian researchers have discovered that removing copper from the blood can destroy some of the deadliest cancers that are resistant to immunotherapy using models of the disease. (2020-08-18)

MRI scan used for heart disease could also pick out aggressive cancers
A type of smart MRI scan used in people with heart disease could help assess whether children's cancers are especially aggressive and spot early signs that targeted treatments are working, a new study suggests. (2020-06-28)

St. Jude Cloud portal expands access to treasure trove of pediatric solid tumor data
St. Jude Children's Research Hospital develops the Childhood Solid Tumor Network data portal to speed discoveries and novel therapies for treatment of childhood solid tumors. (2020-06-26)

A novel radioisotope therapy for children with neuroblastoma
Researchers from Kanazawa University retrospectively analyzed children with refractory or relapsed high-risk neuroblastoma who were treated with high-dose 131I-metaiodobenzylguanidine at Kanazawa University Hospital. They showed that within a 5-year period, this therapy could provide a favorable prognosis without severe non-hematological side effects. These findings could provide new insights into a novel treatment option for patients with high-risk neuroblastoma. (2020-06-19)

Assessing cancer diagnosis in children with birth defects
In this study, led by Baylor College of Medicine and Texas Children's Hospital, researchers provide a better understanding of cancer risk in children with birth defects. (2020-05-29)

CAR T-cell therapy for solid tumors may advance cancer treatments
The full title of the research is 'The study of the mechanisms of effectiveness of T-cells CAR-T towards solid tumors'; it was supported by nonprofit RakFond (Cancer Fund) and CyStoreLab (a resident of Skolkovo). (2020-03-25)

New method for monitoring residual disease after treatment in children with neuroblastoma
Neuroblastoma is a cancer that affects children, characterized by solid tumors that develop from immature nerve cells. Over 50% of patients with high-risk neuroblastoma experience tumor relapse/regrowth. A research group led by Professor NISHIMURA Noriyuki (Graduate School of Health Sciences, Kobe University) has developed a new method to monitor the residual disease after treatment in high-risk neuroblastoma patients. The method could be utilized to evaluate treatment response and facilitate early diagnosis of tumor relapse/regrowth. (2020-02-06)

Smart algorithm finds possible future treatment for childhood cancer
Using a computer algorithm, scientists at Uppsala University have identified a promising new treatment for neuroblastoma. This form of cancer in children, which occurs in specialised nerve cells in the sympathetic nervous system, may be life-threatening. In the long term the discovery, described in the latest issue of the scientific journal Nature Communications, may result in a new form of treatment for children in whom the disease is severe or at an advanced stage. (2020-01-07)

How mysterious circular DNA causes cancer in children
Why do children develop cancer? An international team of researchers, led by Charité - Universitätsmedizin Berlin and the Memorial Sloan Kettering Cancer Center in New York, now reveal that mysterious rings of DNA known as extrachromosomal circular DNA can contribute to cancer development in children. Producing the first detailed map of circular DNA, the scientists have shed new unanticipated insights on long standing questions in the field of cancer genetics. The work has been published in Nature Genetics*. (2019-12-16)

Research sheds important light on the metastasis of neuroblastoma
Research sheds important light on the metastasis of neuroblastoma. (2019-12-10)

A step forward in the struggle against neuroblastoma, a type of childhood cancer
A protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old. (2019-11-27)

Breakthrough in understanding common childhood cancer
Scientists studying one of the most common forms of childhood cancer have made an important breakthrough in understanding how the disease progresses. (2019-11-25)

More children survive neuroblastoma
Both the survival rate and the incidence of neuroblastoma have increased in the last decennia in the Netherlands, as was shown by a study from the Princess Máxima Center. The improved chance of survival and the increase in the number of patients has been greatest in the high risk group; children older than 18 months with a stage 4 neuroblastoma. (2019-11-18)

Researchers find new way to target childhood cancer
An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at. (2019-11-12)

TTUHSC researchers publish preclinical data on new drug combination to treat neuroblastoma
Neuroblastoma, the most common cancer outside of the brain in infants and young children, often fails to respond to therapy. To improve treatment outcomes for these patients, C. Patrick Reynolds, M.D., Ph.D., director of the Texas Tech University Health Sciences Center School of Medicine's Cancer Center, and a team of colleagues completed a study using fenretinide to boost the effects of venetoclax, an inhibitor of a protein (BCL-2) that helps neuroblastoma cells survive and grow. (2019-11-08)

Researchers identify targeted therapy that can help children with deadly nerve cancer
Mount Sinai researchers have identified a targeted therapy for adolescent patients with neuroblastoma, a deadly pediatric nerve cancer, who would otherwise have no treatment options, according to a study published in October in Cancer Cell. (2019-10-17)

Identification of genes responsible for sex-related differences in cancer aggressiveness
An understanding of the molecular basis of differences in the incidence and survival of cancer between men and women may allow the discovery of specific and more effective treatments. The study, published in Science Advances, compares the brain tumours of male and female flies at the molecular level and identifies proteins responsible for the different degree of aggressiveness. (2019-08-16)

New gene found for a deadly childhood cancer offers possibility of targeted drug therapy
Neuroblastoma accounts for 15% of total childhood cancer deaths and survival rates of high-risk neuroblastoma patients is 50%. For the first time, Australian researchers from Children's Cancer Institute have discovered that a gene called JMJD6 plays an important role in the most aggressive form of the disease. The discovery opens up a new way to treat neuroblastoma, using drugs that target this gene. (2019-07-26)

Study reveals elevated cancer risk in children with birth defects
A collaborative team of scientists led by Baylor College of Medicine has assembled the largest study to date to evaluate cancer risk in children with birth defects. (2019-06-25)

Mathematical tools to study tumors
The results obtained suggest that vitronectin can change the rigidity of the location of the tumorous cells. The changes caused by specific organisation of vitronectin can form 'pathways' that could help the tumor to migrate, with the grave problems that this would cause. For this reason, this 'basic science' study opens a possible new way of combatting this cancer which could be based in modifying the organisation of the vitronectin, so making tumors less aggressive. (2019-06-12)

Proton therapy shows efficacy, low toxicity in large cohort of children with high-risk neuroblastoma
Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania analyzed the largest cohort to date of pediatric patients with high-risk neuroblastoma treated with proton radiation therapy (PRT), finding both that proton therapy was effective at reducing tumors and demonstrated minimal toxicity to surrounding organs. (2019-04-09)

Protein BRCA1 as a stress coach
Two proteins work hand in hand to ensure that the tumor cells of neuroblastoma can grow at full speed. In Nature, a Würzburg research team shows how the proteins can do this. (2019-03-20)

Antibody-drug conjugate shows efficacy against cell surface protein in neuroblastoma
Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells. (2019-03-13)

Muscle gene mutations implicated in human nasal/sinus cancer
By sequencing the entire genomes of tumor cells from six people with a rare cancer of the nose and sinus cavity, Johns Hopkins researchers report they unexpectedly found the same genetic change -- one in a gene involved in muscle formation -- in five of the tumors. (2019-02-27)

Scientists discover potential way to treat and prevent cancer in children (neuroblastoma)
The MYCN oncogene is known to be a key cause of a number of deadly solid tumour cancers, including neuroblastoma which claims more lives of children under 5 than any other cancer. In new research, a team led by Professor Michelle Haber AM, Executive Director, and Professor Murray Norris AM, Deputy Director, Children's Cancer Institute, Australia, has uncovered a previously unknown crucial link between polyamines and MYCN, offering a new way to target childhood cancers. (2019-02-01)

New nanoparticle targets tumor-infiltrating immune cells, flips switch
A team of Vanderbilt University bioengineers today announced a major breakthrough in penetrating the cells inside tumors and flipping on a switch that tells them to start fighting. (2019-01-21)

New insights into childhood cancer
Peripheral nervous system tumors, known as neuroblastoma, are one of the most common types of childhood tumors. As part of an international research endeavor, researchers from Charité - Universitätsmedizin Berlin have studied the genetic factors behind different tumor subtypes and their prognoses. Their findings enable clinicians to predict the precise clinical course of the disease, and to adapt their treatment regimens accordingly. The study has been published in the prestigious journal Science*. (2018-12-10)

Page 1 of 8 | 320 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.