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Current Neuroblastoma News and Events, Neuroblastoma News Articles.
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Antibody-drug conjugate shows efficacy against cell surface protein in neuroblastoma
Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells. (2019-03-13)

Muscle gene mutations implicated in human nasal/sinus cancer
By sequencing the entire genomes of tumor cells from six people with a rare cancer of the nose and sinus cavity, Johns Hopkins researchers report they unexpectedly found the same genetic change -- one in a gene involved in muscle formation -- in five of the tumors. (2019-02-27)

Scientists discover potential way to treat and prevent cancer in children (neuroblastoma)
The MYCN oncogene is known to be a key cause of a number of deadly solid tumour cancers, including neuroblastoma which claims more lives of children under 5 than any other cancer. In new research, a team led by Professor Michelle Haber AM, Executive Director, and Professor Murray Norris AM, Deputy Director, Children's Cancer Institute, Australia, has uncovered a previously unknown crucial link between polyamines and MYCN, offering a new way to target childhood cancers. (2019-02-01)

New nanoparticle targets tumor-infiltrating immune cells, flips switch
A team of Vanderbilt University bioengineers today announced a major breakthrough in penetrating the cells inside tumors and flipping on a switch that tells them to start fighting. (2019-01-21)

New insights into childhood cancer
Peripheral nervous system tumors, known as neuroblastoma, are one of the most common types of childhood tumors. As part of an international research endeavor, researchers from Charité - Universitätsmedizin Berlin have studied the genetic factors behind different tumor subtypes and their prognoses. Their findings enable clinicians to predict the precise clinical course of the disease, and to adapt their treatment regimens accordingly. The study has been published in the prestigious journal Science*. (2018-12-10)

A mechanistic approach to neuroblastoma prognosis and risk
A new study reveals key molecular indicators that could help doctors select the best form of treatment for patients with neuroblastoma -- the most common type of cancer in infants. (2018-12-06)

Drug combination makes cancer disappear in mice with neuroblastoma
Researchers investigating new treatments for neuroblastoma -- one of the most common childhood cancers -- have found that a combination of two drugs made tumors disappear in mice, making it more effective than any other drugs tested in these animals. The research is presented at the 30th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland. (2018-11-14)

New biomarker for Alzheimer's disease found thanks to the CRISPR technique
The scientists have found a deficiency in the protein STIM1 in brain tissue from patients with Alzheimer's disease. Its involvement in neurodegenerative processes has been verified thanks to the technique CRISPR / Cas9. Up to now, the effects of a deficiency in this protein critical to sporadic Alzheimer's were not known, and so this research provides a new biomarker for the illness, an indicator of the progression of the neurodegenerative process. (2018-10-09)

Study finds that DFMO increases survival for children with high risk neuroblastoma
A paper published September 27 in Scientific Reports shows the positive results of a phase II clinical trial using the oral medication DFMO to prevent relapse in children with High Risk Neuroblastoma (HRNB). (2018-10-01)

Finding new combination therapies for neuroblastoma
A phase 2 clinical trial has found that combining a novel compound called alisertib with chemotherapy has anti-tumor activity in children with high-risk, relapsed neuroblastoma. The New Approaches to Neuroblastoma Therapy (NANT) consortium study was led by Araz Marachelian, MD, MS, of the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles and Steven G. DuBois, MD, of the Dana-Farber Cancer Institute. Results were recently published online in the journal Clinical Cancer Research. (2018-09-28)

Zika viruses show potential as treatment for high-risk childhood cancer
Zika virus may hold potential as a cancer treatment for neuroblastoma, a rare-but-deadly childhood cancer, according to early findings from basic research published today in PLOS ONE. (2018-07-25)

Fluorescent fish genes light path to neuroblastoma
Neurodevelopmental biologist Rosa Uribe, a CPRIT Scholar who was recruited to Rice University in 2017 with a grant from the Cancer Prevention and Research Institute of Texas, has a new tool in the search for the origins of neuroblastoma, the third-most common pediatric cancer in the United States. (2018-07-09)

New model for predicting neuroblastoma outcomes incorporates early developmental signals
Motivated by a desire to better understand the molecular circuitry underlying neuroblastoma and limitations of current methods for predicting disease progression and outcome, researchers from the Kulesa Lab at the Stowers Institute for Medical Research and collaborators at the University of Michigan and Oxford University set out to construct a logic-based model incorporating information about developmental signaling pathways implicated in the disease. (2018-07-06)

Researchers create novel combination as potential therapy for high-risk neuroblastoma
Researchers at VCU Massey Cancer Center in Richmond, Virginia, have identified a promising target to reverse the development of high-risk neuroblastoma and potentially inform the creation of novel combination therapies for the disease. (2018-06-18)

Children with neuroblastoma have an elevated risk of long-term psychological difficulties
A new study reveals that pediatric neuroblastoma patients are at elevated risk for long-term psychological impairment. In addition, those who experience such impairment as they get older tend to require special education services and to not go on to college. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. (2018-06-11)

Childhood cancer: The four survival strategies of tumor cells
Cancer cells in children tend to develop by following four main trajectories -- and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows. The four strategies can occur simultaneously in a single tumor, according to the study that is now published in Nature Genetics. (2018-06-04)

Gadolinium deposition in the brain not dose dependent
Investigators at Children's Hospital Los Angeles have determined that in children receiving gadolinium as a contrast agent to enhance MRI examinations, signal changes attributed solely to deposition of this material in the brain are not dependent on the amount of gadolinium administered but rather these changes are seen in association with other factors such as the presence of brain tumors and treatment using brain irradiation. (2018-05-10)

Removing the enablers: Reducing number of tumor-supporting cells to fight neuroblastoma
Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages -- a type of immune cell -- can negatively affect the response to chemotherapy against neuroblastoma. Their findings suggest that combination therapy might be effective in patients with high-risk disease, even those who have limited anti-tumor T cell responses. (2018-04-23)

New biomarkers for neuroblastoma, a type of cancer in children
Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment. (2018-03-19)

Medical researchers find protein that marks difference between cancer and non-cancer cells
A discovery sheds light on how cancerous cells differ from healthy ones, and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers in the future. (2018-03-08)

Scientists tackle the aberrant epigenetic programming underlying childhood cancers
Researchers at UFRGS and the US NIH have targeted proteins that regulate chromatin in Ewing sarcoma cells, hindering malignant tumor growth. They induced chromatic relaxation by treating the cells with histone deacetylase inhibitors, reducing expression of the EWSR1-FLI-1 oncogene and other pluripotency/cell viability genes, while impairing sarcoma cell survival and growth. Decreased survival of stem-like cancer cells and re-expression of a neuronal differentiation marker were also observed. (2018-02-20)

Oestrogen causes neuroblastoma cells to mature into neurons
The female sex hormone oestrogen can perform an important role in neuroblastoma, a form of cancer mainly affecting young children. In laboratory experiments, researchers at Karolinska Institutet in Sweden demonstrate that oestrogen treatment and overexpression of the oestrogen receptor cause malignant neuroblastoma cells to mature into neuron-like cells. The study, which is published in PNAS, gives hope of new treatment possibilities. (2018-01-29)

Energy storehouses in the brain may be source of Alzheimer's, targets of new therapy
In a new study, researchers at the ASU-Banner Neurodegenerative Disease Research Center examine the effects of the disease on the functioning of mitochondria -- structures performing a variety of essential tasks, including supplying cells with energy. (2018-01-23)

'Hijacker' drives cancer in some patients with high-risk neuroblastoma
Researchers in Memphis and Boston have collaborated to show c-MYC is an oncogene that drives neuroblastoma in some high-risk patients; the findings help set the stage for much-needed precision medicines (2018-01-22)

Uncovering molecular targets for childhood cancer therapeutics
Neuroblastoma (NB) is the most common solid tumor found in children and is associated with poor prognosis; however, little is known regarding the molecular targets located in the long arm of chromosome 11 (11q). Tokyo Medical and Dental University (TMDU)-centered researchers revealed the loss or imbalance of genes ATM, MRE11A, H2AFX, and/or CHEK1 in 11q in 20.7% of NBs. Furthermore, they found 83.3% NB-derived cell lines exhibited sensitivity to PARP inhibitors. (2017-12-28)

Understanding the molecular mechanisms of ALS
Scientists have revealed more details of the molecular mechanism behind neuronal cell death in amyotrophic lateral sclerosis (ALS), a step forward to find ways to control progression of the disease. (2017-12-26)

Anti-RAS antibodies show poor reliability in recognizing RAS proteins
Researchers from the Greehey Children's Cancer Research Institute at UT Health San Antonio co-authored a paper published Sept. 26 in Science Signaling that looks at the reliability of a common research tool to study RAS cancer mutations. (2017-10-05)

Researchers identify gene variants linked to a high-risk children's cancer
Pediatric researchers investigating the childhood cancer neuroblastoma have identified common gene variants that raise the risk of an aggressive form of that disease. The discovery may assist doctors in better diagnosing subtypes of neuroblastoma. (2017-09-25)

When good immune cells turn bad
Investigators at CHLA have identified the molecular pathway used to foster neuroblastoma and demonstrated use of a clinically available agent, ruxolitinib, to block the pathway. (2017-09-21)

Cell surface protein may offer big target in treating high-risk childhood cancers
Oncology researchers studying high-risk children's cancers have identified a protein that offers a likely target for immunotherapy -- harnessing the immune system in medical treatments. In cell cultures and animal models, a potent drug attached to an antibody selectively zeroes in on cancer cells without harming healthy cells. (2017-09-11)

Mayo Clinic researchers identify genes fueling neuroblastoma spread
For the first time, Mayo Clinic researchers and colleagues present data on how nervous system tumors, called neuroblastomas, spread. Their paper, published in Cancer Cell, clarifies the relationship between two genes that fuel the aggressive spread of neuroblastomas. (2017-08-31)

Cancer detection with sugar molecules
Scientists from the University of Würzburg have synthesized a complex sugar molecule which specifically binds to the tumor protein Galectin-1. This could help to recognize tumors at an early stage and to combat them in a targeted manner. (2017-08-14)

Nanoparticles loaded with component of common spice kill cancer cells
Attaching curcumin, a component of the common spice turmeric, to nanoparticles can be used to target and destroy treatment-resistant neuroblastoma tumor cells, according to a new study published in Nanoscale. The study, conducted in partnership by researchers at Nemours Children's Hospital and the University of Central Florida, demonstrates a potentially novel treatment for neuroblastoma, the most common cancer in infants. (2017-07-25)

New biomarker assay detects neuroblastoma with greater sensitivity
Investigators at The Saban Research Institute of Children's Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease. Researchers provide the first systematic comparison of standard imaging evaluations versus the new assay that screens for five different neuroblastoma-associated genes and determine that the new assay improves disease assessment and provides prediction of disease progression. (2017-06-22)

New research points to potential for more targeted treatments of neuroblastoma tumors
Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer. (2017-06-19)

Discovery by NUS researchers improves understanding of cellular aging and cancer development
A team of researchers led by Dr Dennis Kappei, a Special Fellow from the Cancer Science Institute of Singapore at the National University of Singapore, has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, which are key players involved in cellular ageing. The results of the study will contribute to a better understanding of the human ageing process as well as cancer development. (2017-06-13)

Two investigational antitumor agents work better together against MPNST and neuroblastoma
A new study published last week in Oncotarget demonstrates that the combined usage of Aurora A kinase inhibitor (alisertib) and HSV1716 results in significantly increased antitumor efficacy in models of malignant peripheral nerve sheath tumor (MPNST) and neuroblastoma. (2017-02-09)

CHLA awarded grant to study immunotherapy resistance in neuroblastoma
A team of investigators at Children's Hospital Los Angeles has received a major, three-year grant from the V Foundation for Cancer Research to study the effects of chemoimmunotherapy in children with neuroblastoma. (2016-10-18)

A common nerve protein elevated in aggressive neuroblastomas
A protein produced by nerve cells appears to be elevated in the blood of those with an aggressive form of neuroblastoma. The finding could potentially lead to a prognostic test for the disease or be used to monitor its progress. (2016-10-12)

Combination therapy shows promise in fighting neuroblastoma
A study by a multidisciplinary team of researchers from The Saban Research Institute of Children's Hospital Los Angeles sheds further light on the role of the cytokine TGFβ1 in the growth of neuroblastoma, and suggests the possibility for a small molecule drug/antibody combinatorial therapy to treat this cancer. Their data has been published online by the journal Clinical Cancer Research. (2016-10-11)

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