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Current Neuroblastoma News and Events, Neuroblastoma News Articles.
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U of MN study finds type of childhood cancer relates to physical problems later in life
A University of Minnesota Cancer Center study is the first to show how the prevalence of some physical impairments that childhood-cancer survivors experience as adults relate to the type of cancer they had and the treatment they received. The findings indicate long-term follow up care and physical rehabilitation may be important for more than 20 percent of childhood-cancer survivors. (2005-11-29)

Deleted genes help predict outcome in a children's cancer
A new study reports that a loss of genes on chromosome 1 or chromosome 11 raises the risk of death from the children's cancer neuroblastoma, even when other indicators seem to point to a lower-risk form of the disease. This research finding will help guide physicians to the most appropriate treatment for the cancer, which strikes the peripheral nervous system. The approach used may also be applied to customizing care for other cancers. (2005-11-23)

Fellowship funds major research project on medulloblastoma
Cure for Life FoundationTM has awarded one of the largest single fellowships on brain tumour research in Australia to a senior researcher at Children's Cancer Institute Australia (CCIA) for Medical Research in Randwick, NSW. Dr Wayne Thomas has received a three-year $600,000 Career Development and Support Fellowship to work on medulloblastoma, a solid tumour in the lower brain that occurs in young children. (2005-10-03)

Childhood cancer survivors face social challenges
A new study finds children who survive cancer have about twice the rate of educational and social problems compared to children without a history of cancer. The study finds children with brain tumors, neuroblastoma, or leukemia and children treated with cranial radiation therapy (CRT) are at greatest risk for educational difficulties and social isolation. (2005-09-12)

Failure to dispose of unneeded cells during development linked to cancer
A new research study reveals that a diverse group of apparently unrelated genes that are associated with pheochromocytoma intersect at a common pathway that drives the necessary culling of cells. Mutations in these genes disrupt the normal disposal of unneeded or damaged cells during development, thereby allowing potentially dangerous premalignant cells that should not have survived to persist. The mechanism described in the work may play a role in other forms of pediatric and hereditary cancer as well. (2005-08-15)

Study evaluates averted costs of neuroblastoma screening
By not implementing a neuroblastoma screening program between 1989 and 2002, the United States and Canada saved $574.1 million in health costs, avoided the unnecessary treatment of more than 9,200 children, and avoided false-positive findings in more than 5,000 children, according to a new study in the August 3 issue of the Journal of the National Cancer Institute. (2005-08-02)

Customized gene chip provides rapid detection of genetic changes in children's cancer
Genetics researchers have developed a customized gene chip to rapidly scan tumor samples for specific DNA changes that offer clues to prognosis in cases of neuroblastoma, a common form of children's cancer. Rather than covering the entire genome, the microarray focuses on suspect regions of chromosomes for signs of deleted genetic material known to play a role in the cancer. (2005-08-01)

Major NH&MRC grant will fund multidisciplinary research to improve the treatment of neuroblastoma
Significant funding from the NH&MRC will enable researchers at Children's Cancer Institute Australia (CCIA) for Medical Research to make progress on the treatment of one the most aggressive, drug-resistant childhood cancers -- neuroblastoma -- over the next five years. (2005-07-27)

The diagnosis of tumours in children
Determining if there exist genetic alterations that can be associated with the diagnosis and prognosis of neuroblastic tumours, responsible for 15% of child deaths due to cancer, was the aim of the Paula Lázcoz Ripoll's PhD thesis which she recently defended at the Public University of Navarra. (2005-06-28)

Fine tuning drug levels in neuroblastoma patients is effective, St. Jude researchers show
Monitoring and fine tuning the levels of the cancer drug topotecan in children with neuroblastoma holds promise for maximizing the drug's effectiveness while reducing its toxicity, according to investigators at St. Jude Children's Research Hospital. (2005-06-16)

Chromosome deletion predicts aggressive neuroblastoma
When genes are deleted on a particular section of chromosome 11, the result is an aggressive form of the childhood cancer neuroblastoma. A new study suggests that detecting this genetic deletion during the initial evaluation of children with neuroblastoma may indicate to physicians that they should recommend a more aggressive regimen of chemotherapy to fight the cancer. (2005-05-16)

Radioactive isotope is effective against neuroblastoma
Attaching a radioactive chemical to a compound that binds to tumor cells, physicians can selectively kill those cells and improve treatment for children with neuroblastoma, a cancer of the peripheral nervous system. Using a compound called MIBG in 167 patients with neuroblastoma, researchers achieved a high number of responses with very few side effects. (2005-05-16)

Healthy cleavage: How statins protect against Alzheimer disease
This week in PLoS Medicine, the international medical journal freely available online, a study shows that cholesterol-lowering statins seem to have a protective effect against Alzheimer disease. In cultured cells, statins affect cleavage of the amyloid precursor protein via the ROCK kinase. This could explain some of their beneficial effects. (2005-01-10)

Herpes virus offers new hope in curing cancer
In laboratory studies at Cincinnati Children's Hospital Medical Center, researchers have successfully treated the most common malignant abdominal tumor of childhood: neuroblastoma tumors. Researchers successfully treated the tumor in mouse models by administering a treatment based on a weakened version of the herpes simplex virus. (2004-11-30)

Citrus shows promise for certain childhood cancer
Orange juice and cancer don't mix. In fact, the popular citrus drink could become a cocktail to prevent or stop the deadly disease in humans. Research by Texas Agriculture Experiment Station scientists has shown that citrus compounds called limonoids targeted and stopped neuroblastoma cells in the lab. They now hope to learn the reasons for the stop-action behavior and eventually try the citrus concoction in humans. (2004-11-30)

St. Jude scientist to lead NCI Pediatric Preclinical Testing Program
The National Cancer Institute has announced the establishment of the Pediatric Preclinical Testing Program (PPTP), a program that will systematically test 10-15 agents or combinations of agents annually in preclinical models of common childhood cancers. (2004-11-09)

New version of tumor-suppressor linked to progression of childhood cancer
Researchers have discovered an unexpected role as a tumor promoter for a molecule that was previously thought to function exclusively as a cancer suppressor in neuroblastoma (NB), a highly aggressive and deadly childhood cancer. The study, published in the October issue of Cancer Cell, reveals new evidence about what stimulates progression of neuroblastoma and may provide a likely target for new anti-cancer therapies. (2004-10-18)

Other highlights in the October 6 JNCI
Other highlights in the October 6 JNCI include a study of breast density and the risk of a second breast cancer in women with DCIS, an evaluation of how new guidelines for colon cancer staging affect survival predictions, a description of a new method for characterizing dual-site tumors, and a study of a new noninvasive technique that may be able to predict neuroblastoma response to chemotherapy. (2004-10-05)

Other highlights in the September 1 JNCI
Other highlights in the September 1 JNCI include a study of how fenretinide promotes apoptosis in neuroblastoma cells, an investigation of the novel compound versipelostatin's activity in cancer cells, a study that describes a new assay for measuring the effect of immunotherapy in the cells of melanoma patients, and a commentary on a 2003 workshop that gave recommendations for the study of the health effects of diet and exercise. (2004-08-31)

News tips from The Journal of Neuroscience
Issue highlights include: FMRP and the polyribosome and Understanding deep brain: stimulation in Parkinsonism. (2004-08-18)

Other highlights in the August 18 JNCI
Other highlights in the August 18 JNCI include two studies of genes that may increase or decrease the risk of prostate cancer, an investigation of a possible predictor of neuroblastoma prognosis, a study of a new target for cancer treatments, and a study of the molecular mechanisms involved in medullary thyroid carcinoma. (2004-08-17)

Other highlights in the August 4 JNCI
Other highlights in the August 4 JNCI include a study of the relation between levels of (2004-08-03)

The Children's Hospital of Philadelphia named best hospital in U.S. for children
U.S.News & World Report today ranked The Children's Hospital of Philadelphia the best hospital in the United States for children. (2004-07-02)

Attracting an immune response to cancer
Specialized immune cells known as natural killer (NKT) cells are recruited into human tumors and may help fight the cancer according to a report in the Journal of Experimental Medicine. The chemical attractant that draws in the NKT cells was also identified and may be used in the future to prevent the growth and spread of tumors. (2004-05-03)

Survey reports fall in stem cell transplants for breast cancer
The use of stem cell transplantation in breast cancer treatment soared in the early and mid 1990s but the dramatic fall that begin in 1997 as clinical trials showed it appeared to be of little benefit continues, according to new European figures published in the April edition of Annals of Oncology. Editorial by US NIH specialist. (2004-03-30)

UVA researchers make cellular model of Parkinson's disease
For the first time, scientists at the University of Virginia Health System have engineered cells that produce the pathological hallmark found in the brain cells of all patients with Parkinson's disease - Lewy bodies, tiny balls of damaged protein, found only in the brain and discovered more than ninety years ago. (2004-02-12)

Other highlights in the January 7 issue of JNCI
Other highlights of the January 7 issue of JNCI include a meta-analysis of consolidation therapy for acute myeloid leukemia, a study of the effects of imatinib on neuroblastoma cells, and a study of the risks of rare uterine tumors associated with tamoxifen use. A listing of additional articles is also included. (2004-01-06)

EUROCARE-3 publishes new childhood cancer survival figures
The Nordic countries of Sweden, Norway, Finland and Iceland, represent a gold standard in Europe for the treatment of children's cancer. They have survival rates to which all European countries that devote similar resources and have comparable health systems can aspire, according to the EUROCARE-3 study published in Annals of Oncology. (2003-12-17)

New drug target and biomarker for advanced childhood cancer discovered
Scientists announced today that they have discovered a protein produced by advanced childhood cancers that provides a new target for treatments and a new marker for the disease. Separately, researchers reported data on the crystal structures of two kinase proteins implicated in multiple cancers. The data on structure provides valuable information for the design of cancer therapeutics targeted at these proteins. (2003-11-19)

Several commonly used pesticides are toxic to mitochondria in laboratory experiments
Scientists at Emory University School of Medicine have found in laboratory experiments that several commonly used pesticides are just as toxic or even more toxic to the mitochondria of cells than the pesticide rotenone, which already has been implicated in the development of Parkinson's disease. (2003-11-08)

Sick Kids researchers link maternal folic acid intake to decrease in deadly childhood cancer
A research team at The Hospital for Sick Children (HSC) and the University of Toronto (U of T) has shown that folic acid food fortification has resulted in a 60 per cent reduction in the incidence of neuroblastoma, a deadly childhood cancer. This research is reported in the September 2003 issue of the journal Clinical Pharmacology & Therapeutics. (2003-09-25)

Other highlights in the September 17 issue of JNCI
Other highlights of the September 17 issue of JNCI include a study on PSA doubling time and risk of death from prostate cancer, a study examining risk factors for esophageal and gastric cancers, a study suggesting that the á-tocopherol may play a role in the development of esophageal and gastric cancers, a study examining antisense inhibition in mouse models of neuroblastoma, and a commentary on the design of dual-label microarrays. (2003-09-16)

Fred Hutchinson Cancer Research Center study shows retinoids kill childhood brain tumor cells
A study led by Fred Hutchinson Cancer Research Center showed that retinoids killed cancer cells from medulloblastoma tumors that had been surgically removed from patients as well as tumors that had been grafted onto mice. Through genome analysis, the scientists also identified a protein in medulloblastoma cells that is triggered by retinoids to initiate cell death, a finding that is likely to lead to the development of additional therapies for the disease. (2003-08-04)

Immune cells may help deliver cancer vaccines for children
In a finding that could lay the groundwork for future cancer vaccines for children, cancer researchers working in cell culture have shown that modified immune cells can efficiently deliver genetic material to stimulate a desirable immune response. Researchers from the Children's Hospital of Philadelphia and the Abramson Family Cancer Research Institute at the University of Pennsylvania manipulated immune cells called CD40-activated B cells to carry RNA produced by tumors and viruses. (2003-05-04)

Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators
Alliance for Cancer Gene Therapy, Inc. (ACGT), a national foundation in Stamford, Connecticut, announced today the inaugural award of national grants to three Young Investigators, totaling $1.5 million, for separate cancer gene therapy research projects; Dr. Andrew Davidoff, St. Jude Children's Research Hospital for anti-angiogenic therapy for neuroblastoma; Dr. Thomas Griffith, University of Iowa, immunotherapy/vaccine therapy for prostate cancer; Dr. Jeffrey Bartlett, Columbus Children's Reserach Hospital, tumor targeting/vector development for ovarian cancer. (2003-03-03)

New UNC study suggests multivitamin use during pregnancy cuts childhood tumor risk
The largest epidemiologic study ever conducted in North America of a childhood nervous system cancer known as neuroblastoma suggests women who take multivitamins during pregnancy can cut their children's risk of the tumor by 30 percent to 40 percent. (2002-08-29)

Other highlights in the March 6 issue of JNCI
Other highlights of the March 6 issue of JNCI include a study that found an association between the consumption of tomato products and prostate cancer risk; a study that examines the role of the Ras gene in the regression of neuroblastomas; a study that looks at the role of gastrin-releasing peptide in the development of head and neck cancers; and a study that looks at methylation of steroid receptor genes in prostate cancer tissues. (2002-03-05)

Pooling worldwide data about childhood tumors helps researchers gauge aggressiveness of treatment
Sorting types of cancer into higher- and lower-risk groups is not merely a matter of scientific interest, but a matter of life and death. Yet cancers such as neuroblastoma behave in ways that defy easy categorization. Researchers at The Children's Hospital of Philadelphia have shown that genetic factors are more important than age or disease stage in assigning risk. (2001-05-07)

Radioactive compound used to see childhood cancer may help kill it too
A radioactive compound used for decades to find certain types of cancer is now showing surprising promise in helping to kill those tumors too, new results show. All 11 children treated for neuroblastoma in the drug's first clinical test initially had a positive response with no significant side effects. (2000-12-04)

Scientists find potential new target for treatment of pediatric cancer
Antonio Iavarone and colleagues at the Albert Einstein College of Medicine demonstrate how three proteins act together to produce uncontrolled cell proliferation in some cancers. These proteins -- Id, Rb, and Myc -- in effect, derail the cell cycle. (2000-10-03)

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